AutismKB 2.0

Annotation Detail for SRP72


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Basic Information Top
Gene Symbol:SRP72 ( - )
Gene Full Name: signal recognition particle 72kDa
Band: 4q12
Quick LinksEntrez ID:6731; OMIM: 602122; Uniprot ID:SRP72_HUMAN; ENSEMBL ID: ENSG00000174780; HGNC ID: 11303
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03060Protein export
Pathway IDPathway Name
Diabetes pathways
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SRP72 mRNAincreases expression 16788091
C041594 4-nonylphenol 4-nonylphenol affects the expression of SRP72 mRNAaffects expression 15792627
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SRP72 mRNAdecreases expression 20504355
D016572 Cyclosporine Cyclosporine results in increased expression of SRP72 mRNAincreases expression 20106945
D005472 Fluorouracil Fluorouracil results in increased expression of SRP72 mRNAincreases expression 16584549
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SRP72 mRNAaffects cotreatment|increases expression 17183730
C030110 oxaliplatin oxaliplatin results in decreased expression of SRP72 mRNAdecreases expression 17762391
D018038 Sodium Selenite Sodium Selenite results in increased expression of SRP72 mRNAincreases expression 18175754
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SRP72 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in decreased expression of SRP72 mRNAdecreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of SRP72 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5320464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.5317638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000740 Anemia Fluorouracil 3.8715504547 16511603 17963324
MESH:D001008 Anxiety Disorders Valproic Acid 9.3217497229
MESH:D001008 Anxiety Disorders vinclozolin 9.3219015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder Valproic Acid 1.9918940202 17688650 18396377 18985861 18775368 18316065 18177632 17507914 19232924 15238991 19460635 18558336 16609825 17157402 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1620146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.1615136595 16557594 16595493 16110121 18357371 18608205 19217205
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 3.7017121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1017088986 17045692 16332177 18930000 17971768 16799960
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7918986760 17066447 16280240 16757204
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9715894690
MESH:D003110 Colonic Neoplasms Fluorouracil 4.2717016597 15001691 16340194 17725105 17018589 16510598 17287894 18772588 17169374 17172411
MESH:D003110 Colonic Neoplasms oxaliplatin 4.2716024531 16004971 16510598
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.9816282729 17255274 17401013 16303861 20501625 17016601 18802399 15148649 16524972 17454858 17695437 17094418 18448328 18383874 16331619 18288408 18949393 16391804 15289873 18509181 17594712 14970324
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9818448328 17695437 18509181 17401013 17594712 17255274
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9316285004
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.1915131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.191733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.747562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6216785472 16481741 16337965 17638652 15173087
MESH:D005234 Fatty Liver Cyclosporine 8.3319224547
MESH:D005234 Fatty Liver Valproic Acid 8.3314986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3318558336 8888407
MESH:D005355 Fibrosis Cyclosporine 3.3612168785 12639820
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5015102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia oxaliplatin 4.4917418472
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007333 Insulin Resistance Sodium Selenite 3.3814714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.438314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8812371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.8816985049
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8021137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 4.8015113037 16603448 18383874 17045692
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5118816296 20064080 20464547 6695378 17053015 18520028 18569708 20869020 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 2.5115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2414737004
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.9716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.9718986760 16757204
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3211141357
MESH:D009369 Neoplasms Fluorouracil 5.3216928823 18239605 18600527
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7219003803 16929163 16500647 15113037
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.5320603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.5319015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5517292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5518626508 19082440
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5518760546
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1618286688 16160472 18722050 15538739
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8517978042 1511512 16876388 11044598 14763951 3137016 15475178 11738929
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4419755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4620155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4616951190 17498489 18396642 17172411 19015929 16424979 19084572 15786421 17522103 18567086
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:03060 Protein export
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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