AutismKB 2.0

Annotation Detail for SRPK2


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Basic Information Top
Gene Symbol:SRPK2 ( FLJ36101,SFRSK2 )
Gene Full Name: SRSF protein kinase 2
Band: 7q22.3
Quick LinksEntrez ID:6733; OMIM: 602980; Uniprot ID:SRPK2_HUMAN; ENSEMBL ID: ENSG00000135250; HGNC ID: 11306
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SRPK2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SRPK2 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SRPK2 mRNAdecreases expression 16788091
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SRPK2 mRNAdecreases expression 20106945
20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SRPK2 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SRPK2 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SRPK2 mRNAaffects expression 17484886
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of SRPK2 mRNAincreases expression 12057914
C002950 methylformamide methylformamide analog results in increased expression of SRPK2 mRNAincreases expression 17040096
C002950 methylformamide methylformamide results in increased expression of SRPK2 mRNAincreases expression 17040096
D009151 Mustard Gas Mustard Gas results in decreased expression of SRPK2 mRNAdecreases expression 15674843
D020849 Raloxifene Raloxifene affects the expression of SRPK2 mRNAaffects expression 16079270
C004648 testosterone enanthate testosterone enanthate affects the expression of SRPK2 mRNAaffects expression 17440010
D014212 Tretinoin Tretinoin results in decreased expression of SRPK2 mRNAdecreases expression 16788091
D014635 Valproic Acid Valproic Acid results in increased expression of SRPK2 mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in decreased expression of SRPK2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.548875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.0618653653 11850527
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9920127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.676695378
MESH:D000419 Albuminuria Raloxifene 4.6317451421 17308373
MESH:D000505 Alopecia Tretinoin 3.6415955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5515800139
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Mustard Gas 5.0110378619
MESH:D001249 Asthma Tretinoin 5.0116456186
MESH:D001321 Autistic Disorder Valproic Acid 2.0019460635 18177632 18396377 15238991 19232924 18985861 17157402 20603192 17507914 18940202 18316065 16609825 17688650 18775368 18558336
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0920046352 17594078
MESH:D001768 Blister Mustard Gas 5.2119167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6416197459 16206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.428888407
MESH:D001930 Brain Injuries Raloxifene 4.5216580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9320146248 17474063
MESH:D001943 Breast Neoplasms Raloxifene 1.9317893378 16837676 15758505 17440819 17242785 17261762 16912660 17952589 15572757 15775269 17049068 17595753
MESH:D001943 Breast Neoplasms Tretinoin 1.9316166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0410378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6416813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.083786805 18705752 15700767 10355542 15673190 16124888 16050911 16097048 16227642 16011737 16192424 15721981
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.0816050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6116705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6118788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.611917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5920419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5916096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4615775269
MESH:D002386 Cataract Tretinoin 3.1117460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.716135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7120889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6416129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D002972 Cleft Palate Tretinoin 2.689407595
MESH:D003072 Cognition Disorders Raloxifene 4.6615800139
MESH:D003092 Colitis Tretinoin 3.7517035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8616925845 9664655 9142499 8800419 9211117 17551590 9224671 10589399 9125849 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.868888407 16575769 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8619769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1917474826
MESH:D003928 Diabetic Nephropathies Raloxifene 3.9617308373 15920148 17451421
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.0618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.0610092053 19085960 7120509 11566570 6884620 4309450 19336974 16227642 6623471 15968718 15998439 9327722 10915739 17522070 3786805 16177239 15027814 7440962 7179309 2869522 21278145 3732212
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.061733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:C538011 Eales disease Vitamin E 4.779068938
MESH:D004487 Edema Mustard Gas 7.2911428647 9260866 11428631 11402378
MESH:D004487 Edema Raloxifene 7.2915860553
MESH:D004489 Edema, Cardiac Tretinoin 4.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.0315845917
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1216569247
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4515328337 15821434 17637181
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.193659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9520417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.617562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D004890 Erythema Mustard Gas 5.219357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3716530937
MESH:D005124 Eye Abnormalities Tretinoin 3.6016938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.4016239168 15959796 17595544 12631006 16045604 12795759 61145 19224547
MESH:D005234 Fatty Liver Raloxifene 13.4017473493
MESH:D005234 Fatty Liver Valproic Acid 13.4019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.178888407 18558336
MESH:D005334 Fever Lipopolysaccharides 4.049205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9518705752
MESH:D005355 Fibrosis Tretinoin 8.9517994277
MESH:D005909 Glioblastoma Tretinoin 3.0217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.2620471113
MESH:D006330 Heart Defects, Congenital Tretinoin 11.269664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 11.2616080930
MESH:D006331 Heart Diseases Raloxifene 3.5511110106
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4116366002
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6319110552 19900420
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7116863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8117440010
MESH:D019584 Hot Flashes Vitamin E 4.0314716179
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006930 Hyperalgesia Tretinoin 3.2316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006973 Hypertension Raloxifene 2.8715787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
MESH:D007249 Inflammation Lipopolysaccharides 5.479205823 17963957 17237260 12878042 17255318
MESH:D007249 Inflammation Mustard Gas 5.4717524151 11428631 9357497 9260866 11428620 16001271 11402378 8975870 11428647
MESH:D007251 Influenza, Human Vitamin E 4.2816624496
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6617255318
MESH:D007569 Jaw Abnormalities Tretinoin 3.9315992940 17551590
MESH:D007674 Kidney Diseases Vitamin E 2.8212488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.4416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.4416705839
MESH:D007889 Leiomyoma Raloxifene 4.5316973256
MESH:D007938 Leukemia Tretinoin 2.7817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7316932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9017596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9017596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1716823087 9834237 16788101 17217047 19075265 17339181 16891316 17712046 17301526 19225113 17361223 16331271 17294898 16766008 17107899 17368321 17649720 19642359 16935935 12679006 17506722 19029980 19035177 15748426 16140955
MESH:D007970 Leukopenia Lipopolysaccharides 4.7515821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.339224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8221278145 17174718 11408273 17157831 17334410 16943688 16239168 11903743 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0312632514 12898905 15362042 12389079 12741479 17869086 12958196 18054572 17805973 15959796 18339082 14716833 17631135 18277467 15730626 17900296 17766677 17922224 18279442 17557913 10355542 18395095 16192424 18472094 18317297 18420326 13678700 14724832 15123356 18705752 15876570 15057751 15673190 12649538 16027843 16097048 17761835 11481614 17640975 16015684 15996030 17714472 17944888 18251166 18429990 17976157 15338365 18376398 12586293 17565644 18481824 18412020 17721639 12609069 18156304 17823541 16248980 12666154 18166357 12445418 18418968 16136751 18187930 15370692 17525996 14512876 12445421 16116963 18205269 16033810 12667390 15931870 18210741 15650968 12632512 18472332 17708605 17481882 16638106 15818738 18263696 15052691 14716496 16011737 14620537 18006644 20821823 12546737 14748882 15925388 18395914 17698563 15893842
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.0312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0316248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0316169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0916964402 15720792 17285989 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7216899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.487678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4821137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.4819294768
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.972876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9715583823 12014681
MESH:D008171 Lung Diseases Mustard Gas 7.6118702808 18161513
MESH:D008171 Lung Diseases Vitamin E 7.6116863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D055370 Lung Injury Lipopolysaccharides 4.0521114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5020135361 18520028 18569708 20464547 18816296 17053015 6695378 20869020 20064080
MESH:D008175 Lung Neoplasms Mustard Gas 3.508781369 3148597
MESH:D008175 Lung Neoplasms Vitamin E 3.5011062179
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D008881 Migraine Disorders Valproic Acid 3.2118803445 18765137
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6215863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009101 Multiple Myeloma Raloxifene 3.4616497877
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.4517596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4517596541
MESH:D009232 Myxoma Raloxifene 5.6216343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.527678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms Tretinoin 5.0316594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 3.819125849
MESH:D009436 Neural Tube Defects Tretinoin 7.369142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.368888407 16359493
MESH:D009503 Neutropenia Mustard Gas 4.0016761898 7688884
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9816049721
MESH:D010024 Osteoporosis Raloxifene 3.4119059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2617893378 15579764 17823083 15758505
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3516936753
MESH:D010146 Pain Tretinoin 2.9216870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4715976015
MESH:D011014 Pneumonia Lipopolysaccharides 4.6011605937 12224865
MESH:D011041 Poisoning Mustard Gas 3.8315727166
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.8820603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5917292933
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5915731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5915084515
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011537 Pruritus Mustard Gas 4.1418058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.6012752131 11422049
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9417894541 17720292 17266442 17620002 10334151
MESH:D011693 Purpura Raloxifene 5.6215770314
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7510835634
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.9716283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.9719155313
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 9.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.9318551238
MESH:D012640 Seizures Valproic Acid 9.9311044598 16876388 11738929 1511512 17978042 14763951 3137016 15475178
MESH:D012871 Skin Diseases Mustard Gas 5.0516961503 12880345 15451306
MESH:D012871 Skin Diseases Vitamin E 5.0518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.5510029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.558532709
MESH:D012878 Skin Neoplasms Tretinoin 9.5516467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3520155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3517261132
MESH:D020521 Stroke Raloxifene 8.7816837676
MESH:D020521 Stroke Vitamin E 8.7816517955
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1915821434
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0517045167 16026305
MESH:D013978 Tibial Fractures Raloxifene 5.2719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8116051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D014376 Tuberculosis Tretinoin 3.2416040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.0216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.0216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.0217053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 12.0217572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6716752155
MESH:D054556 Venous Thromboembolism Raloxifene 5.2716837676
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6216343187
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00173 - Adenine Dietary supplement;Micronutrient
DB02733 - Purvalanol
DB03431 - Adenosine-5'-Diphosphate
DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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