AutismKB 2.0

Annotation Detail for SSB


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Basic Information Top
Gene Symbol:SSB ( LARP3,La )
Gene Full Name: Sjogren syndrome antigen B (autoantigen La)
Band: 2q31.1
Quick LinksEntrez ID:6741; OMIM: 109090; Uniprot ID:LA_HUMAN; ENSEMBL ID: ENSG00000138385; HGNC ID: 11316
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
No data
No data
No data
Pathway IDPathway Name
500585RNA Polymerase III Transcription Termination
500578RNA Polymerase III Transcription
500579RNA Polymerase III Abortive And Retractive Initiation
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SSB mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SSB mRNAaffects expression 16483693
D002995 Clofibric Acid Clofibric Acid affects the expression of SSB mRNAaffects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SSB mRNAdecreases expression 17555576
C017947 sodium arsenite sodium arsenite results in decreased expression of SSB mRNAdecreases expression 19072884
D018038 Sodium Selenite Sodium Selenite results in increased expression of SSB mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of SSB mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of SSB mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2817306315 16712894
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001943 Breast Neoplasms Tamoxifen 2.1818821012 19011961 20135344 16202921 19288272 18629630 16273361 15565566 18997820 20544844 19059307 19115204 20065188 17440819 20005174 19200415 20859285 19084267 19155303 19142967 11161223 16873071 19066611 19189212 17242785 19189210 18984771 15668708 18351453 21152245 18425577 18855134 19103187 17893378 19244106 18815881 16818667 19221464 19289846 21138602 20390343 19487384 17261762 17049068 19410462
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.7816507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7816924424
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.286135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.2819524636 20056578
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0515861022 17681005 17333356 16919318 17110522 11677210 16105132
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.1715131321
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.9019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1917893378 19155303 16202921 20544844
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5115345470
MESH:D005234 Fatty Liver Tamoxifen 8.5114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0216452187
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1217440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.3612676792
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1617937319
MESH:D007248 Infertility, Male sodium arsenite 7.1615346721 12646999
MESH:D007249 Inflammation Tamoxifen 2.4619457130
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007674 Kidney Diseases sodium arsenite 2.9220008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0716705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.0718625569
MESH:D008064 Lipidoses Tamoxifen 3.3215342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.407678174
MESH:D008113 Liver Neoplasms Clofibric Acid 11.4017602206
MESH:D008113 Liver Neoplasms sodium arsenite 11.4016712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 11.4016684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.682876786 6135515 2876784
MESH:D008171 Lung Diseases sodium arsenite 3.3219095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.5517077188 19931552 15276417 16712894 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 2.5518625569
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7614580682 19196722 11731420 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma sodium arsenite 3.4319082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.4312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms sodium arsenite 2.6011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9720056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19200415 19196722
MESH:D009436 Neural Tube Defects sodium arsenite 3.2912854658
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4915276417 17306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5516039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5518760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5515067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012878 Skin Neoplasms sodium arsenite 2.7918572023 19524636
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9812854658
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8016049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.8011723127 16452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.8017572228 8653321 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9911813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014652 Vascular Diseases sodium arsenite 4.7617056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
Pathway ID Pathway Name
KEGG:05322 Systemic lupus erythematosus
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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