AutismKB 2.0

Annotation Detail for SSBP1


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Basic Information Top
Gene Symbol:SSBP1 ( Mt-SSB,SOSS-B1,SSBP,mtSSB )
Gene Full Name: single-stranded DNA binding protein 1
Band: 7q34
Quick LinksEntrez ID:6742; OMIM: 600439; Uniprot ID:SSBP_HUMAN; ENSEMBL ID: ENSG00000106028; HGNC ID: 11317
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03440Homologous recombination
hsa03030DNA replication
hsa03430Mismatch repair
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C074153 1,4-phenylenebis(methylene)selenocyanate 1,4-phenylenebis(methylene)selenocyanate affects the expression of SSBP1 proteinaffects expression 18444160
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SSBP1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SSBP1 mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen affects the expression of SSBP1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SSBP1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of SSBP1 mRNAdecreases expression 16835338
C006632 arsenic trioxide arsenic trioxide results in increased expression of SSBP1 mRNAincreases expression 20458559
C099555 CD 437 CD 437 results in decreased expression of SSBP1 mRNAdecreases expression 12958071
C018021 cobaltous chloride cobaltous chloride results in decreased expression of SSBP1 proteindecreases expression 16622835
D003513 Cycloheximide Cycloheximide results in increased expression of SSBP1 mRNAincreases expression 19684285
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of SSBP1 mRNAaffects cotreatment|increases expression 19684285
C006253 pirinixic acid pirinixic acid results in decreased expression of SSBP1 mRNAdecreases expression 18445702
D012645 Selenomethionine Selenomethionine affects the expression of SSBP1 proteinaffects expression 18444160
D018038 Sodium Selenite Sodium Selenite results in increased expression of SSBP1 mRNAincreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of SSBP1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of SSBP1 mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SSBP1 mRNAincreases expression 19684285
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma 1,4-phenylenebis(methylene)selenocyanate 5.1712844480
MESH:D000230 Adenocarcinoma arsenic trioxide 5.1711798837 19825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0716835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.2817306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.8716251483 12569548 16835338 18414634
MESH:D050197 Atherosclerosis Arsenic 3.2612928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.4616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7120435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3611589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6115504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.623084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.6216507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.6215073043 16217749 11135700 15553829 14691202
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1412490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7015504454 17687452 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1018640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.4715738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.3316973168 18022660
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis pirinixic acid 2.8519176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1115668235 15340226 12621046 16354765 8697196
MESH:D003110 Colonic Neoplasms 1,4-phenylenebis(methylene)selenocyanate 3.9610753194
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4810525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4815322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1315213294
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 4.0716823706 15059100 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0211421492 11461765 19923254 17906064 14550746 16177239 19164858 11743745 16485898 12705907 17562736 14986274 10774834 14725611 19420014 16781746 12594235 10915739 16393943 19085960 17522070 19739265 12392966 11739529 15968718 18071297 12153990 12958197 2444490 11529661 15619225 16227642 19370779 12540782 16081117 18713872 11287661 10663392 19416960 11834606 16109766
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.0215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3212903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver arsenic trioxide 7.8215073043
MESH:D005234 Fatty Liver pirinixic acid 7.8219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9920067830
MESH:D005534 Foot Diseases Arsenic 5.626392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3016904648
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly pirinixic acid 8.4019772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4015340226 16120746 12621046
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8117440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1118606429 16354765 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4817050553
MESH:D006973 Hypertension Arsenic 5.269931084 11953799 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2618670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.6216093927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.3714714311
MESH:D007414 Intestinal Neoplasms 1,4-phenylenebis(methylene)selenocyanate 5.6910753194
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007642 Keratosis Arsenic 5.0416930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.2112587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0016705839
MESH:D007938 Leukemia arsenic trioxide 2.8415070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1417050201 19850784 20471514 16467208 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.8417339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.8412679006 19225113 17869043 17217047 11161223 17107899 19035177 19642359 12712474 16331271 17649720 15748426 15213294 12018890 11468182 16330433 17712046 15336539 9834237 16966277 15622746 16891316 16823087 19075265 16112521
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3916882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1412878042
MESH:D008107 Liver Diseases Acetaminophen 4.0919784758 16611625 19014921 16610002 12587719 11587558 12969438 19460945
MESH:D008107 Liver Diseases Arsenic 4.0911134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 10.7816368122
MESH:D008113 Liver Neoplasms arsenic trioxide 10.7814682389
MESH:D008113 Liver Neoplasms pirinixic acid 10.7820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7816984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.8620377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3715213294
MESH:D008175 Lung Neoplasms Arsenic 3.4619168569 17306315 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4611798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4619555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D008325 Mammary Neoplasms, Experimental 1,4-phenylenebis(methylene)selenocyanate 4.6212844480
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1219417148 19549372 15949261 11468182 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1616105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Arsenic 9.0815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9118551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0016624393
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009436 Neural Tube Defects Arsenic 7.5116620997
MESH:D009436 Neural Tube Defects arsenic trioxide 7.5110525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.4117056641
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4516049721 12819281
MESH:D010051 Ovarian Neoplasms Arsenic 8.1217306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.1216624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms CD 437 8.1217474084
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.1919927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.046392382 16905509 15371236
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Arsenic 2.6516140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6519131511
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6518760546
MESH:D011507 Proteinuria Arsenic 4.0421343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0016646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5518551238
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 2.7517453740 15952646 17050553 17938729 17548696 6392382 16353154 19834688 18709164 16702368 16759981
MESH:D012878 Skin Neoplasms Arsenic 5.7517976673 17029826 17050553 16251483 19538983 15504454
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7516192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1119014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0115213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.0916049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 12.0915987713 19429237 17976673 11144890 19322015 18640142 17306315
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.0912845720 11780464 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms CD 437 12.0916720286
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3710091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014652 Vascular Diseases Arsenic 4.7917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
Pathway ID Pathway Name
KEGG:03030 DNA replication
KEGG:03440 Homologous recombination
KEGG:03430 Mismatch repair
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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