AutismKB 2.0

Annotation Detail for SSR2


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Basic Information Top
Gene Symbol:SSR2 ( DKFZp686F19123,TLAP,TRAP-BETA,TRAPB )
Gene Full Name: signal sequence receptor, beta (translocon-associated protein beta)
Band: 1q22
Quick LinksEntrez ID:6746; OMIM: 600867; Uniprot ID:SSRB_HUMAN; ENSEMBL ID: ENSG00000163479; HGNC ID: 11324
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
Pathway IDPathway Name
Diabetes pathways
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SSR2 mRNAdecreases expression 12958071
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of SSR2 mRNAdecreases expression 16623957
C099555 CD 437 CD 437 results in decreased expression of SSR2 mRNAdecreases expression 12958071
D016572 Cyclosporine Cyclosporine results in increased expression of SSR2 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of SSR2 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SSR2 mRNAincreases expression 17942748
17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SSR2 mRNAaffects cotreatment|increases expression 17942748
D016627 Oxidopamine Oxidopamine results in increased expression of SSR2 mRNAincreases expression 12486162
D008628 Mercury Mercury results in decreased expression of SSR2 mRNAdecreases expression 16823088
C041786 palm oil palm oil results in decreased expression of SSR2 mRNAdecreases expression 18042831
C009277 sodium arsenate sodium arsenate results in increased expression of SSR2 mRNAincreases expression 16882884
D018038 Sodium Selenite Sodium Selenite results in increased expression of SSR2 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of SSR2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SSR2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001161 Arteriosclerosis Dietary Fats 10.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.7114699433
MESH:D001321 Autistic Disorder Arachidonic Acid 2.7318582451
MESH:D001321 Autistic Disorder Mercury 2.7317497416
MESH:D001327 Autoimmune Diseases Mercury 4.9816634805
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.8320435547
MESH:D001943 Breast Neoplasms Tamoxifen 1.8316273361 19189210 18997820 20390343 16818667 20005174 18629630 21138602 18855134 17049068 11161223 16873071 19103187 15565566 18351453 20859285 17893378 17261762 18815881 19115204 19289846 19189212 20135344 20544844 19084267 19487384 19066611 19200415 19155303 17440819 19059307 19288272 19142967 19410462 15668708 21152245 19221464 18984771 20065188 19011961 17242785 16202921 19244106 18425577 18821012
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8316924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4810334427
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5812371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 7.9819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9817110522 11677210 16105132 16919318 17681005 17333356 15861022
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 12621046 15668235 8697196 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.8010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8015322242 20055451 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.9016823706
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 6.4818186108
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.4815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004487 Edema Arachidonic Acid 7.389599246 11698051 9831321 7990266 16716910 15177302
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1017893378 20544844 19155303 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 19.4619224547
MESH:D005234 Fatty Liver Dietary Fats 19.4617967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4615345470
MESH:D005234 Fatty Liver Tamoxifen 19.4619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005334 Fever Arachidonic Acid 4.7311852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Cyclosporine 15.3512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 15.3518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.3520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D018149 Glucose Intolerance sodium arsenate 5.1719446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0016120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 18606429 8697196 16354765 16959395
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Arachidonic Acid 12.3415177302 17371808 9831321
MESH:D007249 Inflammation Dietary Fats 12.3420412841
MESH:D007249 Inflammation Tamoxifen 12.3419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.3412200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.6618457598 11836018
MESH:D007333 Insulin Resistance Sodium Selenite 7.6614714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.4418776723 10903974 8314463
MESH:D007674 Kidney Diseases Mercury 6.4417934191
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5312371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.5318625569
MESH:D008064 Lipidoses Tamoxifen 3.2115342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9218296743
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3012878042
MESH:D008113 Liver Neoplasms Tamoxifen 4.4916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2711884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6714580682 19196723 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.9418186108
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects sodium arsenate 4.0111749123 18186108 19446573 10525206
MESH:D019636 Neurodegenerative Diseases Oxidopamine 4.8318514411
MESH:D009765 Obesity Dietary Fats 2.3017217161 19632207 20132043 18674790 21332399 18457598 20518802 16723640 11836018
MESH:D010051 Ovarian Neoplasms CD 437 3.3417474084
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 5.5611771942 15893579
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2718760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.5416720286
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5416712894 17572228 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:04141 Protein processing in endoplasmic reticulum
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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