AutismKB 2.0

Annotation Detail for SSR4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SSR4 ( TRAPD )
Gene Full Name: signal sequence receptor, delta (translocon-associated protein delta)
Band: Xq28
Quick LinksEntrez ID:6748; OMIM: 300090; Uniprot ID:SSRD_HUMAN; ENSEMBL ID: ENSG00000180879; HGNC ID: 11326
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
Pathway IDPathway Name
Diabetes pathways
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SSR4 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SSR4 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in increased expression of SSR4 mRNAincreases expression 20106945
D000431 Ethanol Ethanol results in decreased expression of SSR4 mRNAdecreases expression 17920746
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SSR4 mRNAincreases expression 17942748
16174780
17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SSR4 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SSR4 mRNAincreases expression 16174780
D016627 Oxidopamine Oxidopamine results in increased expression of SSR4 mRNAincreases expression 12486162
D007657 Ketone Bodies Ketone Bodies results in increased expression of SSR4 mRNAincreases expression 16807920
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SSR4 mRNAincreases expression 17616710
D010795 Phthalic Acids Phthalic Acids results in decreased expression of SSR4 mRNAdecreases expression 15728792
D013629 Tamoxifen Tamoxifen affects the expression of SSR4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SSR4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SSR4 mRNAincreases expression 17942748
D014810 Vitamin E Vitamin E results in decreased expression of SSR4 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.9917676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9911752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 10.9918287403
MESH:D000138 Acidosis Ethanol 10.9911192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4915451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000853 Anophthalmos Ethanol 4.9615513904
MESH:D001008 Anxiety Disorders Ethanol 4.0911141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 9.1714699433
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 9.1720106747
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.191440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9519059307 19410462 19487384 11161223 20065188 17893378 17242785 19115204 19142967 19189210 18629630 19189212 18984771 20390343 18821012 17261762 18997820 19221464 16202921 18815881 17049068 20135344 19289846 19155303 19244106 19200415 18425577 15565566 19066611 15668708 19103187 19288272 16273361 21152245 16818667 18351453 17440819 19084267 20005174 21138602 18855134 16873071 20544844 19011961 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002056 Burns Ethanol 4.7916374292
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.743581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.7415289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7416924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Ethanol 7.0419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0418670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.827505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.8719486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.8719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8717333356 16919318 15861022 17681005 17110522 16105132 11677210
MESH:D002971 Cleft Lip Ethanol 3.6415513904
MESH:D002972 Cleft Palate Ethanol 6.0915513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0915340226 16354765 15668235 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 3.8910194807 19302082 15451040 11198716 11873399 15451039 15513904
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8920055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8919769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9411298694 8156756 8970840 11906362 12868966 2524372 18759878 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.429653073 6679447 18648102 1440618 18289764 9022650 18692083 7440962 8291058 11289319 9328219 16192314 6482804
MESH:D056486 Drug-Induced Liver Injury Ethanol 6.4211566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1117893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.533581430
MESH:D004938 Esophageal Neoplasms Ethanol 7.5316704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.5315150132 16704527 15878914 15547721 15547733 15264214 16510608 15623463 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 19.7319224547
MESH:D005234 Fatty Liver Ethanol 19.7318620774 16409862 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.7315345470
MESH:D005234 Fatty Liver Tamoxifen 19.7314986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8417920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4516946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Cyclosporine 8.9512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Ethanol 4.8715046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7511294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7516080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0312621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Ethanol 3.8018783367
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Tamoxifen 5.0719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.3916624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 10.4915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.228314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.2212488133
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.926582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9212371664
MESH:D007680 Kidney Neoplasms Tamoxifen 12.9218625569
MESH:D007859 Learning Disorders Ethanol 4.3515451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8917676605
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008103 Liver Cirrhosis Ethanol 3.4315289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2518295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.269327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 5.0718166357
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0716169303
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7917347304 17207112
MESH:D008113 Liver Neoplasms Tamoxifen 4.5216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5216984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.95598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms Tamoxifen 3.4518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.4511062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6914580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008569 Memory Disorders Ethanol 4.3118411066 15451040
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.833581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719196722 19189210 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D019636 Neurodegenerative Diseases Oxidopamine 4.8518514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.526482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0012384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 5.6011771942 15893579
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2315067354
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2315084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012640 Seizures Ethanol 3.249754883
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms Ethanol 2.8418456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.8412958204 17575124
MESH:D013276 Stomach Ulcer Ethanol 3.6417189318 16755016 9211565 17918041 9562338 11906479
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.369754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.973712494 6582329 1399818 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.168074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1617572228 16712894 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved