AutismKB 2.0

Annotation Detail for BRCA2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:BRCA2 ( BRCC2,BROVCA2,FACD,FAD,FAD1,FANCB,FANCD,FANCD1,GLM3,PNCA2 )
Gene Full Name: breast cancer 2, early onset
Band: 13q13.1
Quick LinksEntrez ID:675; OMIM: 600185; Uniprot ID:BRCA2_HUMAN; ENSEMBL ID: ENSG00000139618; HGNC ID: 1101
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03440Homologous recombination
hsa05212Pancreatic cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
DNA Repair
Pathway IDPathway Name
200120FOXM1 transcription factor network
No data
Pathway IDPathway Name
501013Presynaptic phase of homologous DNA pairing and strand exchange
500068Fanconi Anemia pathway
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
Cancers
Cancers of the digestive system
H00031Breast cancer
H00019Pancreatic cancer
H00027Ovarian cancer
H00238Fanconi anemia
Cancers of the breast and female genital organs
Desease IDDesease Name
1720Fanconi's anemia
1825Oligospermia
1831Prostate cancer
1894Abortion
1901Endometriosis
1934Cancer
1969Azoospermia
1823Infertility, Male
Desease Name
ovarian cancer
breast cancer, male
CANCER
stomach cancer
breast cancer
prenatal viability
Neoplasms
prophylactic breast surgery
breast cancer risk and prenatal viability
lung cancer
No data
Desease Name
Breast cancer, male, susceptibility to
Wilms tumor
Glioblastoma 3
Prostate cancer
Pre-B-cell acute lymphoblastic leukemia
Medulloblastoma
Pancreatic cancer
Breast-ovarian cancer, familial, 2
Fanconi anemia, complementation group D1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of BRCA2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BRCA2 mRNAaffects expression 16483693
D001554 Benzene BRCA2 gene SNP results in increased susceptibility to Benzeneincreases response to substance 16728435
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of BRCA2 mRNAdecreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BRCA2 mRNAdecreases expression 20382639
D002166 Camptothecin Camptothecin results in decreased expression of BRCA2 mRNAdecreases expression 10344722
D003513 Cycloheximide Cycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA2 mRNA]decreases expression|decreases reaction 10344722
D016572 Cyclosporine Cyclosporine results in decreased expression of BRCA2 mRNAdecreases expression 20106945
D003561 Cytarabine Cytarabine results in increased expression of BRCA2 mRNAincreases expression 19194470
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of BRCA2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of BRCA2 mRNA]decreases reaction|increases expression 17854601
D004317 Doxorubicin Doxorubicin results in decreased expression of BRCA2 mRNAdecreases expression 10344722
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of BRCA2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRCA2 mRNAaffects cotreatment|increases expression 17942748
D005557 Formaldehyde BRCA2 gene mutant form results in increased susceptibility to Formaldehydeincreases response to substance 18056434
D019833 Genistein Genistein results in increased expression of BRCA2 mRNAincreases expression 16434996
D019833 Genistein Genistein results in increased expression of BRCA2 proteinincreases expression 16434996
D019833 Genistein [indole-3-carbinol co-treated with Genistein] results in increased expression of BRCA2 proteinaffects cotreatment|increases expression 16434996
D017313 Fenretinide Fenretinide results in decreased expression of BRCA2 mRNAdecreases expression 16570282
C016517 indole-3-carbinol [indole-3-carbinol co-treated with Genistein] results in increased expression of BRCA2 proteinaffects cotreatment|increases expression 16434996
C016517 indole-3-carbinol indole-3-carbinol results in increased expression of BRCA2 mRNAincreases expression 16434996
C016517 indole-3-carbinol indole-3-carbinol results in increased expression of BRCA2 proteinincreases expression 16434996
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of BRCA2 mRNAincreases expression 12634122
C008493 methylselenic acid methylselenic acid results in increased expression of BRCA2 mRNAincreases expression 12517777
D015741 Metribolone Metribolone results in increased expression of BRCA2 mRNAincreases expression 17010196
D009588 Nitrogen Mustard Compounds Cycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA2 mRNA]decreases expression|decreases reaction 10344722
D009588 Nitrogen Mustard Compounds Nitrogen Mustard Compounds results in decreased expression of BRCA2 mRNAdecreases expression 10344722
D010634 Phenobarbital Phenobarbital affects the expression of BRCA2 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of BRCA2 mRNAaffects expression 19136022
C025299 polyphenols polyphenols results in decreased expression of BRCA2 mRNAdecreases expression 16293270
D011794 Quercetin Quercetin results in increased expression of BRCA2 mRNAincreases expression 15309432
C059514 resveratrol resveratrol affects the expression of BRCA2 mRNAaffects expression 15748624
D012402 Rotenone Rotenone results in increased expression of BRCA2 mRNAincreases expression 18191903
C017947 sodium arsenite sodium arsenite results in increased expression of BRCA2 mRNAincreases expression 12760830
C017947 sodium arsenite sodium arsenite affects the expression of BRCA2 mRNAaffects expression 16507464
D018038 Sodium Selenite Sodium Selenite results in decreased expression of BRCA2 mRNAdecreases expression 10344722
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRCA2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BRCA2 mRNAincreases expression 17942748
D019284 Thapsigargin Thapsigargin results in increased expression of BRCA2 mRNAincreases expression 16434996
D019284 Thapsigargin Thapsigargin results in increased expression of BRCA2 proteinincreases expression 16434996
D014415 Tunicamycin Tunicamycin results in increased expression of BRCA2 proteinincreases expression 16434996
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.326195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3214514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6417505938
MESH:D058186 Acute Kidney Injury resveratrol 3.5916538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.8518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.7020127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 12.7017418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.7014692618
MESH:D000230 Adenocarcinoma Fenretinide 12.7010697514
MESH:D000230 Adenocarcinoma Genistein 12.7011473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.216695378
MESH:D000236 Adenoma Diethylnitrosamine 10.216695378 10737359
MESH:D000236 Adenoma resveratrol 10.2115688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.4219061943 17162532 17620307 19052882 16434500 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.4217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.4216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6017306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.2621441931
MESH:D000544 Alzheimer Disease resveratrol 2.5016183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6911748828
MESH:D000741 Anemia, Aplastic Benzene 4.1511369114 17661222 14761424
MESH:D000743 Anemia, Hemolytic Quercetin 3.9817084956
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7615885639
MESH:D001169 Arthritis, Experimental resveratrol 6.7617115116
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6815336622
MESH:D050197 Atherosclerosis resveratrol 3.1016873680 17967414
MESH:D001327 Autoimmune Diseases Quercetin 4.1219761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.8919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001855 Bone Marrow Diseases Benzene 4.9316183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4014601052
MESH:D002545 Brain Ischemia resveratrol 3.9917600658
MESH:D001932 Brain Neoplasms Doxorubicin 8.2717150277
MESH:D001932 Brain Neoplasms Fenretinide 8.2716187019
MESH:D001943 Breast Neoplasms marker/mechanism 20135344
MESH:D001943 Breast Neoplasms Benzene 7.9317162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.9320146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.9317474063
MESH:D001943 Breast Neoplasms Doxorubicin 7.9318628466 15634643 16264153 16935488 15939500 19526202 18695136 11325840 15136595 15567936 16096432 18234424 18382427 16115903 15993339 15668708 15994142 17983394 16322301 16595493 17426702 17369602 16826403 15692762
MESH:D001943 Breast Neoplasms Fenretinide 7.9316601279
MESH:D001943 Breast Neoplasms Formaldehyde 7.9315986119
MESH:D001943 Breast Neoplasms Genistein 7.9316541309 17200150 16873071
MESH:D001943 Breast Neoplasms indole-3-carbinol 7.9316082211
MESH:D001943 Breast Neoplasms Quercetin 7.9318628248
MESH:D001943 Breast Neoplasms resveratrol 7.9316393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.9320435547
OMIM:612555 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2 marker/mechanism
MESH:D002105 Cadmium Poisoning Quercetin 5.2516962696
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5116051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 18.8812619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.8820007298 16878318 11831363 16807293 19822196 17428255 19701751 20432363 19539802 20512989 18210153 19519916 3084413 16681979 21159647 18971187 16779866 20935162 20524982 19919837 19052882 20084675 17138121 16830150 19208518 16540662 16328049 18056438 16502159 17162532 19171122 20101231 16288022 20514400 17173139 19383236 18506893 18785209 18393292 18691550 16569478 18788625 20727157 19107877 17978847 3581430 20214788 19394651 17761372 16698587 16935385 10672840 10737359 18978308 18665156 19418558 18494052 17055752 19335982
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 18.8818059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 18.8816270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Genistein 18.8816924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 18.8817173139 1701930 20007298 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular Quercetin 18.8812508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 18.8816227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.8816507464 15276417 17306315
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3016675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6717234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.021485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.3820419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 13.386189445
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 13.3816274795
MESH:D002294 Carcinoma, Squamous Cell resveratrol 13.3816227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.3818572023
MESH:D006332 Cardiomegaly Quercetin 6.2619794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2618670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.3415792986 17519947 16455267 17924179 17928571 16731534 16242529 15505089 16952015 17308081 16278810 16651473 15811867 16269455 16612575 17351982 17007740 17382496 16364871 15476868 17131338 16109756 17329180 18627295 17974986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8417334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 6.8416332659
MESH:D002318 Cardiovascular Diseases resveratrol 6.8415458977
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 23.7520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 23.7512371664
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 23.758243401
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 23.757505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 23.752727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 23.7519524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.964080065
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.1816154183
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5016835633
MESH:D002779 Cholestasis Cyclosporine 12.0919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.0917681005 17333356 16919318 11677210 16105132 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 12.0919176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.4615894690
MESH:D016770 Ciliophora Infections Formaldehyde 5.3512113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9816354765 15668235 8697196 12621046 15340226
MESH:D003092 Colitis resveratrol 3.8416474422
MESH:D003110 Colonic Neoplasms Genistein 7.8617182828
MESH:D003110 Colonic Neoplasms polyphenols 7.8616293270
MESH:D003110 Colonic Neoplasms Quercetin 7.8615741050 16640504 19440933 11134977 17148506 19056647 17191121
MESH:D003110 Colonic Neoplasms resveratrol 7.8616338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.6118802399 18259882
MESH:D015179 Colorectal Neoplasms Fenretinide 4.6117273769
MESH:D015179 Colorectal Neoplasms Quercetin 4.6118095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 4.6116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8117141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.5616507316
MESH:D019465 Craniofacial Abnormalities Benzene 2.5815643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5820055451 10048152 15322242
MESH:D003872 Dermatitis Benzene 4.4815902427
MESH:D017449 Dermatitis, Allergic Contact Formaldehyde 4.4415932584 16958921 15059100 12081698 14996049
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.5316285004
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.7719496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.7716873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.6520387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.6516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6517107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.7216286809
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.0419107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.0417416283
MESH:D056486 Drug-Induced Liver Injury polyphenols 11.0419370779
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 11.0415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.0420420201
MESH:D004362 Drug Toxicity Doxorubicin 7.3918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.3911462148
MESH:D004421 Dystonia Phenobarbital 3.731851702
MESH:D004487 Edema pirinixic acid 9.9212083418
MESH:D004487 Edema resveratrol 9.928985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.9212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.1912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.1917872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.2916402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.0417359293
MESH:D016889 Endometrial Neoplasms Genistein 7.0411473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.779294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8618037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5617923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.823659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.5711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.306401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.967750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.723659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.0820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.0816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005141 Eyelid Diseases Formaldehyde 6.0814996049
MESH:D005199 Fanconi Anemia marker/mechanism
MESH:D005234 Fatty Liver Cyclosporine 16.5719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 16.5720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.5715345470
MESH:D005234 Fatty Liver pirinixic acid 16.5719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2919069698
MESH:D005355 Fibrosis Cyclosporine 13.1012168785 12639820
MESH:D005355 Fibrosis Quercetin 13.1019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.1020067830
MESH:D005393 Fish Diseases Formaldehyde 5.3112113305
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D005909 Glioblastoma Doxorubicin 15.4417150277
MESH:D005909 Glioblastoma Fenretinide 15.4416187019
MESH:D005909 Glioblastoma Genistein 15.4416598420
MESH:D005909 Glioblastoma Quercetin 15.4419804834
MESH:D005910 Glioma marker/mechanism
MESH:D005910 Glioma Quercetin 2.9417643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3315692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9311294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.2818674790 16244372 16244371 17875725 17888722 16495754 16144979 18006777 12587719 16879835 14766674 16707910 16330681
MESH:D006333 Heart Failure Doxorubicin 6.4517481944
MESH:D006333 Heart Failure pirinixic acid 6.4520558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6415692506
MESH:D006402 Hematologic Diseases Benzene 4.3816183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006529 Hepatomegaly Phenobarbital 12.7116109766
MESH:D006529 Hepatomegaly pirinixic acid 12.7118467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.7115340226 16120746 12621046
MESH:D006561 Herpes Simplex resveratrol 3.8916876885
MESH:D006689 Hodgkin Disease Cytarabine 15.6116200630
MESH:D006689 Hodgkin Disease Doxorubicin 15.6118501091 15147373 17606976
MESH:D006689 Hodgkin Disease Nitrogen Mustard Compounds 15.6116794504
MESH:D006689 Hodgkin Disease sodium arsenite 15.6112676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7516354765 15340226 8697196 18606429 16959395
MESH:D006937 Hypercholesterolemia resveratrol 3.7417188708
MESH:D006943 Hyperglycemia pirinixic acid 8.3920558911
MESH:D006943 Hyperglycemia Quercetin 8.3911834736 18262572
MESH:D006949 Hyperlipidemias resveratrol 3.7616873680
MESH:D006973 Hypertension Benzene 11.4317940673
MESH:D006973 Hypertension Cyclosporine 11.4310903974
MESH:D006973 Hypertension Quercetin 11.4318356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.4318850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0517488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3617600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.9917937319
MESH:D007248 Infertility, Male sodium arsenite 5.9912646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 10.7218785209
MESH:D007249 Inflammation polyphenols 10.7216366677
MESH:D007249 Inflammation resveratrol 10.7216366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.7212200463 12878042
MESH:D007251 Influenza, Human Quercetin 10.1916624496
MESH:D007251 Influenza, Human resveratrol 10.1916624496
MESH:D007333 Insulin Resistance pirinixic acid 6.6716306350
MESH:D007333 Insulin Resistance Sodium Selenite 6.6714714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0716580747
MESH:D007627 Keloid Quercetin 4.6717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Cyclosporine 13.088314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 13.0815699352 16775033 15369732
MESH:D007674 Kidney Diseases Quercetin 13.0816962696
MESH:D007674 Kidney Diseases sodium arsenite 13.0820008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8916707910
MESH:D007680 Kidney Neoplasms Cyclosporine 2.5012371664
MESH:D007938 Leukemia Benzene 9.7618335105 15935818 17119257 14694614
MESH:D007938 Leukemia Genistein 9.7618980019 17468513
MESH:D007938 Leukemia Quercetin 9.7617468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8616085563
MESH:D007951 Leukemia, Myeloid Benzene 4.0617506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6519478238
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.3916087638
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7416707609
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.1018407596 18665156 19638242 18522880 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 6.1021047994
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.3116595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.3117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3115474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.3112741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3112878042
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1617034775
MESH:D008107 Liver Diseases Phenobarbital 6.1619363144
MESH:D008107 Liver Diseases polyphenols 6.1616698588
MESH:D008113 Liver Neoplasms Aflatoxin B1 27.882125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 27.8821137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 27.8819638242 20434301 19812893 21047994 12771043 20405173 15175105 20492335 19254457 19256749 19499222 2862719 20101389 20118626 18648771 20501860 20452335 20583210 12112319 19090486 21278145 19255062 18977376 19850985 19294768 10737359 20137499 19833225 18754104 19996281 19690152 19642983 18644402 15885732 19426721 9163691 16942905 2422723 19427195 21167192 19073162 19551842 18978307 21071580
MESH:D008113 Liver Neoplasms Phenobarbital 27.8821047994 8742319 15975961 19812893 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 27.8820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 27.8818980244
MESH:D008113 Liver Neoplasms resveratrol 27.8820405173 19321006 19812893 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 27.8816712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 27.8816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.458603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 25.4512562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.452563599 18253720 17174075 18093689 17854601 19126423 9362446 18164116 3124819 18544905 18308698 18079962 16267830 18775883 21159647 16842330 18282651 19539802 19004024 19519916 19009564 17942915
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 25.4516842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 25.452563599 17172636 6150874 18308698 1399818
MESH:D008114 Liver Neoplasms, Experimental Quercetin 25.4519519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.4512151625
MESH:D008171 Lung Diseases sodium arsenite 2.9819095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.5114698565
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.2914755239
MESH:D008175 Lung Neoplasms Benzene 12.2912562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.2920869020 17053015 20064080 18520028 6695378 20464547 18816296 20135361 18569708
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.2921163286 6695378 20970405 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 12.296189445 17418594
MESH:D008175 Lung Neoplasms Quercetin 12.2916280456
MESH:D008175 Lung Neoplasms sodium arsenite 12.2917306315 16712894 17077188 19931552 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.2919555203 11884234
MESH:D008223 Lymphoma Benzene 7.1517584886 17119257
MESH:D008223 Lymphoma Doxorubicin 7.1516098063
MESH:D016393 Lymphoma, B-Cell resveratrol 9.3717088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 9.3714737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.0917654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 8.0914749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2815621674
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.2712562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.2715688416
MESH:D008325 Mammary Neoplasms, Experimental Benzene 16.8611921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 16.8615458769
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 16.8610697514
MESH:D008325 Mammary Neoplasms, Experimental Genistein 16.8612929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 16.8611606380 8985016
MESH:D008527 Medulloblastoma marker/mechanism
MESH:D008545 Melanoma Doxorubicin 6.8916827129
MESH:D008545 Melanoma Fenretinide 6.8916270382
MESH:D008545 Melanoma resveratrol 6.8917992120
MESH:D008545 Melanoma sodium arsenite 6.8919082730 16487513
MESH:D008654 Mesothelioma Doxorubicin 2.9417638057
MESH:D008659 Metabolic Diseases resveratrol 4.1117112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.5917671175
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2315792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.0416381670
MESH:D009062 Mouth Neoplasms Fenretinide 8.0416274795
MESH:D052016 Mucositis Doxorubicin 4.4917415656
MESH:D009101 Multiple Myeloma Benzene 6.9417119195
MESH:D009101 Multiple Myeloma resveratrol 6.9416490592 17164350 17049120 16267019 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5717962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009203 Myocardial Infarction Doxorubicin 16.5619429709 15857846
MESH:D009203 Myocardial Infarction Genistein 16.5617141266
MESH:D009203 Myocardial Infarction pirinixic acid 16.5619151258
MESH:D009203 Myocardial Infarction Quercetin 16.5619595682
MESH:D009203 Myocardial Infarction resveratrol 16.5617125593 16456233 16317513 17188708 16525036 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.2417125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.2412213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.9517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.9516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.9519207477
MESH:D009205 Myocarditis resveratrol 4.4617322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1817484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.483581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.4818259882
MESH:D009369 Neoplasms Benzo(a)pyrene 14.1611141357
MESH:D009369 Neoplasms Fenretinide 14.1617353921 15958647
MESH:D009369 Neoplasms pirinixic acid 14.1617405874
MESH:D009369 Neoplasms Quercetin 14.1615185748
MESH:D009369 Neoplasms sodium arsenite 14.1611559025
MESH:D009374 Neoplasms, Experimental resveratrol 8.278985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.2720056578
MESH:D009401 Nephrosis Doxorubicin 4.4816636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.4819348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.4816889571 15640375
MESH:D009410 Nerve Degeneration Rotenone 3.6617356569 18619942 15790535
MESH:D009421 Nervous System Malformations Genistein 8.6716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6714600291
MESH:D009436 Neural Tube Defects Benzene 6.9015643154
MESH:D009436 Neural Tube Defects sodium arsenite 6.9012854658
MESH:D009447 Neuroblastoma Doxorubicin 3.1115555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7320387270
MESH:D019636 Neurodegenerative Diseases resveratrol 7.7317652729
MESH:D020078 Neurogenic Inflammation Quercetin 9.7917929310
MESH:D020078 Neurogenic Inflammation resveratrol 9.7917929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.3816303764
MESH:D009669 Nose Neoplasms Formaldehyde 5.054038687
MESH:D009765 Obesity pirinixic acid 1.7420558911
MESH:D009784 Occupational Diseases Benzene 3.9315612468 16737584 15576619 17178637 17119257 15913788 15935809 17479406 15727169
MESH:D010018 Osteomalacia Phenobarbital 4.0717016548
MESH:D010024 Osteoporosis Genistein 3.0719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 15.3216169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 15.3219495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 15.3217513867
MESH:D012516 Osteosarcoma Doxorubicin 3.8815930896
MESH:D010051 Ovarian Neoplasms marker/mechanism 17688236
MESH:D010051 Ovarian Neoplasms Benzene 13.9712562636
MESH:D010051 Ovarian Neoplasms Fenretinide 13.9716133793
MESH:D010051 Ovarian Neoplasms Genistein 13.9719005980
MESH:D010051 Ovarian Neoplasms Quercetin 13.9719005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.9715276417 17306315
MESH:D010190 Pancreatic Neoplasms marker/mechanism
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.4816540662
MESH:D010190 Pancreatic Neoplasms Fenretinide 11.4815580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.4816965848
MESH:D010190 Pancreatic Neoplasms Quercetin 11.4816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4111578682
MESH:D010300 Parkinson Disease Rotenone 2.8716412576 19114014 18619942 19232380 15451049 16140633 11445065 18191903 11535288
MESH:D020734 Parkinsonian Disorders Rotenone 3.8215795934 15927086 15574749 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8617983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Cyclosporine 19.8512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 19.852563599
MESH:D011230 Precancerous Conditions Phenobarbital 19.852563599
MESH:D011230 Precancerous Conditions Quercetin 19.8519056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.2821297632
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.6116679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6111896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms marker/mechanism
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8517292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.8516888761 16729912 15749863 16868541 15897917 18437689
MESH:D011471 Prostatic Neoplasms Fenretinide 2.8517024972
MESH:D011471 Prostatic Neoplasms Genistein 2.8516925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.8516205645
MESH:D011471 Prostatic Neoplasms Quercetin 2.8514715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 2.8516731767 17675339 15767336 17636462 17718901 17804756
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.8516039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.8518760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.0215861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.2012752131
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D051437 Renal Insufficiency Doxorubicin 3.9317922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.2816325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.0819058328
MESH:D015427 Reperfusion Injury resveratrol 6.0817520802 17058453 16314181 16317513 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012162 Retinal Degeneration Fenretinide 4.1816303925
MESH:D012509 Sarcoma Doxorubicin 3.7318313854 15625365 17710206 17203757 15675481 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4917846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.2516862918
MESH:D012595 Scleroderma, Systemic Formaldehyde 5.5914979077
MESH:D012640 Seizures Phenobarbital 2.5011442880 4039156 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.536407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 20.6510029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 20.6515692506
MESH:D012878 Skin Neoplasms Fenretinide 20.6516467112
MESH:D012878 Skin Neoplasms resveratrol 20.6515837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 20.6519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 20.6516192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2816767912 15625365 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6416709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5712854658
MESH:D013274 Stomach Neoplasms Benzene 3.2412562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.242093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2418456281
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2216321402
MESH:D024801 Tauopathies Camptothecin 5.3316930453
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.9517997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9115669648
MESH:D013953 Thymus Neoplasms Benzene 4.6610850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.737505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.7317909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.731399818
MESH:D014062 Tongue Neoplasms resveratrol 3.9616227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.5617053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 14.5617653716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 14.5616720286
MESH:D001749 Urinary Bladder Neoplasms Quercetin 14.5616720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.5617306315 16712894 11723127 16452187
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 20.6316154183
MESH:D002583 Uterine Cervical Neoplasms indole-3-carbinol 20.6316082211
MESH:D002583 Uterine Cervical Neoplasms resveratrol 20.6317473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 20.6311813266
MESH:D014594 Uterine Neoplasms Benzene 14.4812562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.4814692618
MESH:D014594 Uterine Neoplasms resveratrol 14.4817044934
MESH:D014605 Uveitis Cyclosporine 3.681336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2815869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.3816364871 17334414 17678736 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.3817488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D009396 Wilms Tumor marker/mechanism
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
Pathway ID Pathway Name
REACT:216 DNA Repair
KEGG:03440 Homologous recombination
REACT:27271 Meiotic Recombination
REACT:27235 Meiotic Recombination (mouse)
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25412
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    PA443560Breast Neoplasms
    PA152132901Hereditary Breast/Ovarian Cancer Syndrome
    PA445204Ovarian Neoplasms
    PA446745Breast Neoplasms, Male
    PA444144Fallopian Tube Neoplasms
    PA445218Pancreatic Neoplasms
    PA445062Neoplasms
    PA445425Prostatic Neoplasms
    Releated drug ID Related drug Name
    PA449014cisplatin
    PA449383docetaxel
    PA451581tamoxifen
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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