AutismKB 2.0

Annotation Detail for SST


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Basic Information Top
Gene Symbol:SST ( SMST )
Gene Full Name: somatostatin
Band: 3q27.3
Quick LinksEntrez ID:6750; OMIM: 182450; Uniprot ID:SMS_HUMAN; ENSEMBL ID: ENSG00000157005; HGNC ID: 11329
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04971Gastric acid secretion
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500405Peptide ligand-binding receptors
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C530925 1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea 1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea results in increased secretion of SST proteinincreases secretion 18508045
C499293 (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide results in decreased secretion of SST proteindecreases secretion 16953190
D000082 Acetaminophen Acetaminophen affects the expression of SST mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SST mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SST mRNAdecreases expression 12414654
D002211 Capsaicin AMN protein inhibits the reaction [Capsaicin results in increased expression of SST protein]decreases reaction|increases expression 16938409
D002211 Capsaicin Capsaicin results in increased expression of SST proteinincreases expression 16938409
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SST mRNAincreases expression 17805973
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of SST mRNAaffects cotreatment|increases expression 18636392
D003024 Clozapine Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]decreases expression|decreases reaction 16567023
D003024 Clozapine Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]decreases expression|decreases reaction 16567023
C014347 decitabine decitabine affects the methylation of SST promoteraffects methylation 17999418
D016291 Dizocilpine Maleate Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]decreases expression|decreases reaction 16567023
D016291 Dizocilpine Maleate Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]decreases expression|decreases reaction 16567023
D016291 Dizocilpine Maleate Dizocilpine Maleate results in decreased expression of SST mRNAdecreases expression 16567023
D016291 Dizocilpine Maleate Dizocilpine Maleate results in decreased expression of SST proteindecreases expression 16567023
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SST mRNAaffects cotreatment|increases expression 17942748
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of SST proteinincreases expression 16534498
D005839 Gentamicins SST protein results in decreased susceptibility to Gentamicinsdecreases response to substance 19294753
D006632 Histamine SST protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]decreases reaction|increases secretion 11164953
D006632 Histamine SST protein inhibits the reaction [GAST protein results in increased secretion of Histamine]decreases reaction|increases secretion 11164953
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of SST mRNAdecreases expression 12414654
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of SST proteinincreases expression 17291600
D008070 Lipopolysaccharides resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SST protein]decreases reaction|increases expression 17291600
D015282 Octreotide Octreotide results in decreased secretion of SST proteindecreases secretion 16601281
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of SST mRNAaffects cotreatment|increases expression 18636392
D010269 Paraquat Paraquat affects the expression of SST mRNAaffects expression 15206577
C006253 pirinixic acid pirinixic acid results in decreased expression of SST mRNAdecreases expression 17426115
D011188 Potassium Potassium results in increased secretion of SST proteinincreases secretion 16601281
D011374 Progesterone Progesterone results in decreased expression of SST mRNAdecreases expression 17404688
D011374 Progesterone Progesterone results in increased expression of SST mRNAincreases expression 16376865
C024353 resiniferatoxin resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SST protein]decreases reaction|increases expression 17291600
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SST mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SST mRNAincreases expression 16922920
D013806 Theophylline Theophylline results in increased secretion of SST proteinincreases secretion 16601281
D014212 Tretinoin Tretinoin results in increased expression of SST proteinincreases expression 16473924
C025643 vinclozolin vinclozolin affects the expression of SST mRNAaffects expression 19015723
D014801 Vitamin A [Vitamin A co-treated with INHBA protein] results in increased expression of SST mRNAaffects cotreatment|increases expression 17244017
D014801 Vitamin A Vitamin A affects the expression of SST proteinaffects expression 16757122
D024483 Vitamin K 3 Vitamin K 3 results in decreased expression of SST mRNAdecreases expression 12414654
D015054 Zymosan SST protein inhibits the reaction [Zymosan results in increased expression of TNF protein]decreases reaction|increases expression 15834315
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 7.7118926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7111752688 15322242 14514962
MESH:D000015 Abnormalities, Multiple Vitamin A 4.6010992263
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6417505938
MESH:D058186 Acute Kidney Injury Capsaicin 13.4118460982
MESH:D058186 Acute Kidney Injury Gentamicins 13.4111274264
MESH:D058186 Acute Kidney Injury resiniferatoxin 13.4118460982
MESH:D055371 Acute Lung Injury Chlorine 13.7520601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 13.7511850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 13.7518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7414692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 3.5710737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.716705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9216835633
MESH:D000380 Agranulocytosis Clozapine 4.7714617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.4711874814
MESH:D000505 Alopecia Capsaicin 8.8117569567
MESH:D000505 Alopecia Tretinoin 8.8115955085
MESH:D000544 Alzheimer Disease Ozone 2.3715513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 13.5511748828
MESH:D000740 Anemia Vitamin A 13.5516960172
MESH:D000740 Anemia Zymosan 13.5518664788
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.5416960172
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4119015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1811256880
MESH:D001169 Arthritis, Experimental 1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea 16.1918508045
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 16.1915885639
MESH:D001169 Arthritis, Experimental Tretinoin 16.1916412693
MESH:D001169 Arthritis, Experimental Zymosan 16.1915142272 16872482 17659584 15188379 15944321
MESH:D001172 Arthritis, Rheumatoid Ozone 4.4215570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4216292516
MESH:D001249 Asthma Histamine 14.0016387687
MESH:D001249 Asthma Ozone 14.0017854713 16373670
MESH:D001249 Asthma Theophylline 14.0012113382 9701106
MESH:D001249 Asthma Tretinoin 14.0016456186
MESH:D001249 Asthma Vitamin A 14.0016732791
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001471 Barrett Esophagus marker/mechanism 17999418
MESH:D001471 Barrett Esophagus Tretinoin 4.1216935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.7419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.7412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.7416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001919 Bradycardia Capsaicin 4.7618207255
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0417868700
MESH:D001930 Brain Injuries Progesterone 3.9715380490 15665606 15845082
MESH:D002545 Brain Ischemia Capsaicin 4.6819211983
MESH:D001943 Breast Neoplasms decitabine 1.9119208741 18320071
MESH:D001943 Breast Neoplasms Progesterone 1.9116175315 17614352 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9116873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4514754758 18315731 19059883 15516495 18417511 16777450 17626835
MESH:D001986 Bronchial Spasm Histamine 5.5218298128
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 12.0316813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 12.0317377406 17426644
MESH:D002100 Cachexia Ozone 4.4416183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4918705752 15721981 16124888 15700767 16011737 16227642 16097048 10355542 16050911 15673190 3786805 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8616168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 6.1710737359 3084413 6705139 17761372 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.173084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.1718788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.171917145
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.4719215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.4716096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.3116936243
MESH:D002386 Cataract Acetaminophen 6.6510977129
MESH:D002386 Cataract Tretinoin 6.6517460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2916129372
MESH:D002637 Chest Pain Theophylline 5.5715238202
MESH:D015362 Child Nutrition Disorders Vitamin A 5.1816153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 12.2815861022 16105132 17110522 17681005 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 12.2819176532
MESH:D002779 Cholestasis Vitamin A 12.2816175620
MESH:D002822 Choriocarcinoma Tretinoin 4.8616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.1815340226 8697196 16354765 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 9.189407595
MESH:D002972 Cleft Palate Vitamin A 9.1816054864
MESH:D003072 Cognition Disorders Clozapine 4.6817123785
MESH:D003092 Colitis Tretinoin 3.4217035595
MESH:D003110 Colonic Neoplasms decitabine 3.9717616700
MESH:D003110 Colonic Neoplasms Vitamin A 3.9717219422 16267017
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8117141729 14669216
MESH:D003371 Cough Capsaicin 4.8810350223
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6920055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.699211117 9664655 9224671 9142499 16925845 14991402 10589399 8800419 17551590 9125849
MESH:D019465 Craniofacial Abnormalities Vitamin A 3.6910992263
MESH:D003456 Cryptorchidism vinclozolin 4.0614966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4216506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.2516402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2517107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.2017187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2515331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.5910915739 11421492 11739529 10774834 14986274 19164858 16177239 15968718 11287661 17522070 19416960 16485898 11743745 19420014 11461765 19923254 14550746 12392966 17906064 16393943 19085960 19370779 18713872 17562736 19739265 15619225 10663392 2444490 16109766 12594235 16227642 11834606 12540782 16781746 14725611 12958197 18071297 12153990 11529661 12705907 16081117
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.592869522 21278145 10092053 9327722 15027814 19336974 7179309 17522070 6884620 7440962 15998439 16227642 6623471 4309450 3786805 10915739 11566570 7120509 3732212 16177239 19085960 15968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Gentamicins 7.6811033412 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6811462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.5116146918
MESH:D004381 Duodenal Ulcer Capsaicin 4.4111535926 10671773
MESH:D050171 Dyslipidemias Clozapine 3.9716402076
MESH:D004417 Dyspnea Chlorine 4.3320016425
MESH:C538011 Eales disease Vitamin A 5.329068938
MESH:D004480 Ectromelia Vitamin A 5.5216054864
MESH:D004487 Edema (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide 14.4416953190
MESH:D004487 Edema pirinixic acid 14.4412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.4411000095 12711302
MESH:D004487 Edema Zymosan 14.447907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.9415322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.9418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.1012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.1017692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8219294695
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9216569247
MESH:D004715 Endometriosis Progesterone 8.0816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.089294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1017637181 15328337 15821434
MESH:D004802 Eosinophilia Histamine 4.7612689652
MESH:D004935 Esophageal Diseases Capsaicin 5.4119566590
MESH:D004938 Esophageal Neoplasms marker/mechanism 17999418
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.1116938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 11.5216239168 12795759 16045604 15959796 61145 17595544 19224547 12631006
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.5215345470
MESH:D005234 Fatty Liver pirinixic acid 11.5219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005327 Fetal Resorption Vitamin A 5.0616054864
MESH:D005334 Fever Lipopolysaccharides 3.7611852909 9205823
MESH:D005355 Fibrosis Carbon Tetrachloride 13.0918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.0920067830
MESH:D005355 Fibrosis Tretinoin 13.0917994277
MESH:D005739 Gas Poisoning Chlorine 4.7120016425
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6416973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0016417039
MESH:D005909 Glioblastoma Capsaicin 6.8918405923
MESH:D005909 Glioblastoma Tretinoin 6.8917312396
MESH:D005911 Gliosis Paraquat 4.8611124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.1719215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1716096774
MESH:D034381 Hearing Loss Gentamicins 4.6419130971 15968427 18024279 17868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8616084493
MESH:D006356 Heartburn Capsaicin 5.4119566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.3510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.359664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin A 10.3516080930 10992263
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.026705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.146705139
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 8.7319110552 19900420
MESH:D006505 Hepatitis Zymosan 8.7319110552
MESH:D006529 Hepatomegaly pirinixic acid 7.3016221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3015340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.5115707848 17436238 16292552 16863852 16490937 16877224
MESH:D015658 HIV Infections Vitamin A 3.6716960176
MESH:D006679 HIV Seropositivity Vitamin A 5.3017209195
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7516959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 11.8216870215
MESH:D006930 Hyperalgesia Capsaicin 11.8217043245 17434803
MESH:D006930 Hyperalgesia Tretinoin 11.8216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2416899240
MESH:D053565 Hypercalciuria Gentamicins 5.4117652376
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2816778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006948 Hyperkinesis Clozapine 4.6116046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8015338365
MESH:D006986 Hypervitaminosis A Vitamin A 5.8716054864
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.5619822448
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1912013081
MESH:D007248 Infertility, Male decitabine 19.0617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 19.0617937319
MESH:D007248 Infertility, Male Paraquat 19.064850670
MESH:D007248 Infertility, Male Theophylline 19.0616988215
MESH:D007248 Infertility, Male vinclozolin 19.0616467254
MESH:D007249 Inflammation Capsaicin 14.2516956363
MESH:D007249 Inflammation Lipopolysaccharides 14.2517237260 9205823 17255318 12878042 17963957
MESH:D007249 Inflammation Progesterone 14.2515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.2512878042 12200463
MESH:D007249 Inflammation Zymosan 14.2511289658 8014878
MESH:D007333 Insulin Resistance pirinixic acid 2.4416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4817994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.5215955940
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3617255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.5417553498
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.0516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.0517551590 15992940
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.4318842672
MESH:D007674 Kidney Diseases Acetaminophen 5.7815629191 12587719
MESH:D007674 Kidney Diseases Gentamicins 5.7819349640 18289764 17934191
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0116518626
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 5.0811231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.2310219319
MESH:D007938 Leukemia decitabine 5.9418980019 19235587
MESH:D007938 Leukemia Tretinoin 5.9417143497
MESH:D007951 Leukemia, Myeloid decitabine 8.6917236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 8.6916932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.7718206229 18704418 19387464 18460780 19010910 17679729
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7719850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1618055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9619029980 17339181 17506722 19642359 9834237 17217047 17301526 17712046 16823087 16331271 17294898 16766008 19225113 16140955 19075265 17368321 12679006 17107899 16788101 15748426 17361223 16891316 17649720 16935935 19035177
MESH:D007970 Leukopenia Lipopolysaccharides 4.4015821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4416417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.819224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.8116054864
MESH:D008064 Lipidoses Clozapine 3.7517567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4516943688 17174718 16239168 17334410 11408273 17157831 16221502 11903743 21278145
MESH:D008103 Liver Cirrhosis Vitamin A 6.4516256175
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.3115338365 18472332 17721639 17481882 15673190 15925388 10355542 12445418 17976157 12389079 14716833 15931870 18263696 16248980 12445421 16015684 18412020 15650968 16027843 18210741 12958196 15893842 16011737 17823541 14724832 16116963 18156304 18054572 18429990 14620537 17708605 17869086 15959796 17922224 12667390 16136751 18251166 15370692 17766677 12649538 18187930 15052691 12632512 14716496 17761835 12666154 15123356 17698563 12586293 18395914 12898905 14512876 18420326 16638106 16097048 14748882 17900296 18277467 12609069 18472094 18395095 17565644 16192424 18317297 17714472 18006644 17640975 16033810 18166357 18418968 15057751 18705752 17805973 18481824 13678700 18205269 17631135 11481614 15818738 15362042 20821823 12632514 18376398 15996030 15876570 17557913 17944888 15730626 18339082 12741479 17525996 12546737 18279442
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.3112878042
MESH:D008106 Liver Cirrhosis, Experimental Octreotide 10.3112890342
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.3115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.3112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.3118397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 10.3116248980
MESH:D008107 Liver Diseases Acetaminophen 8.7919014921 16611625 11587558 12587719 16610002 19784758 19460945 12969438
MESH:D008107 Liver Diseases Capsaicin 8.7916956363
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.7916246199 17285989 15720792 16964402 15830285
MESH:D008107 Liver Diseases Vitamin A 8.7916175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.8716762690
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.5614706259 16899240
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 9.7516273603 11376686 18001218 10672840 14678523 10737359
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 9.7519294768
MESH:D008113 Liver Neoplasms pirinixic acid 9.7520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.7516984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 12.691399818 6150874 534488
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.6912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.6912151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 12.6917113696
MESH:D008171 Lung Diseases Ozone 7.2019066396 8266340
MESH:D008171 Lung Diseases Vitamin A 7.2016863852
MESH:D055370 Lung Injury Lipopolysaccharides 8.2821114838
MESH:D055370 Lung Injury Ozone 8.2820417186
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 3.3311376686
MESH:D008175 Lung Neoplasms Ozone 3.337614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3319555203 11884234
MESH:D008223 Lymphoma decitabine 3.2119470736
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.6817203775 11408345
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma decitabine 6.9616505122 17785578
MESH:D008545 Melanoma Histamine 6.9617709802
MESH:D008545 Melanoma Tretinoin 6.9616752155
MESH:D008545 Melanoma Vitamin K 3 6.9619082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008591 Meningomyelocele Tretinoin 4.1416940565
MESH:D001523 Mental Disorders Clozapine 3.6616856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.1719142101
MESH:D008679 Metaplasia Ozone 4.8110496685
MESH:D009101 Multiple Myeloma Capsaicin 11.1917505005
MESH:D009101 Multiple Myeloma decitabine 11.1918172295
MESH:D009101 Multiple Myeloma Vitamin A 11.1916374440
MESH:D009102 Multiple Organ Failure therapeutic 15834315
MESH:D009102 Multiple Organ Failure Zymosan 4.9315259001 17724436 18160304 15241586 12130978 12879239 15834315 15213630 10479408 10890648
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 5.9818694830
MESH:D009190 Myelodysplastic Syndromes decitabine 6.9219010910 18608210 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7216411023
MESH:D009369 Neoplasms decitabine 7.4017925555 19470736 19116145
MESH:D009369 Neoplasms pirinixic acid 7.4017405874
MESH:D009369 Neoplasms Tretinoin 7.4016594593 16946489
MESH:D009410 Nerve Degeneration Paraquat 3.4916893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.589125849
MESH:D009436 Neural Tube Defects Tretinoin 7.019142499
MESH:D009436 Neural Tube Defects Vitamin A 7.0117400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6318514411
MESH:D020078 Neurogenic Inflammation Capsaicin 4.8217961222
MESH:D009765 Obesity Capsaicin 7.1619056576
MESH:D009765 Obesity Clozapine 7.1619142110 18515891
MESH:D009765 Obesity pirinixic acid 7.1620558911
MESH:D010051 Ovarian Neoplasms decitabine 7.3719259094 19331143
MESH:D010051 Ovarian Neoplasms Progesterone 7.3716525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 7.3716936753
MESH:D010146 Pain Acetaminophen 9.9816870215
MESH:D010146 Pain Capsaicin 9.9817043245 17434803 16996476 17084039 19081190 18987195
MESH:D010146 Pain Tretinoin 9.9816870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.0119294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.0115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4111578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.8012065085
MESH:D010300 Parkinson Disease Paraquat 2.7116140633 11181820 15824117 12911755 16510128 11445065 15451049 11124998
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1416190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D010523 Peripheral Nervous System Diseases resiniferatoxin 5.7318219259
MESH:D010538 Peritonitis Ozone 9.4516369182
MESH:D010538 Peritonitis Zymosan 9.4519641140 11985352 18760300 19088179 18977430 17371808 14761945 15259001 17826846 15979727 18557954
MESH:D011014 Pneumonia Lipopolysaccharides 16.8611605937 12224865
MESH:D011014 Pneumonia Ozone 16.8618007984 18381685 18929643
MESH:D011014 Pneumonia Paraquat 16.8612504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5011896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.5018042343 19015723 18220299
MESH:D055728 Primary Myelofibrosis decitabine 4.4417616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6418220299
MESH:D011472 Prostatitis vinclozolin 4.6418629315
MESH:D011507 Proteinuria Gentamicins 8.6415033597
MESH:D011507 Proteinuria Tretinoin 8.6416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0215861022 16919318
MESH:D011618 Psychotic Disorders Clozapine 3.9715331141
MESH:D011625 Pterygium Tretinoin 4.5016723453
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 4.9118983928
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8017997886 16324872
MESH:D051437 Renal Insufficiency Gentamicins 4.7117132701 15728788
MESH:D015427 Reperfusion Injury Capsaicin 10.4618460982 19211983
MESH:D015427 Reperfusion Injury pirinixic acid 10.4619058328
MESH:D015427 Reperfusion Injury resiniferatoxin 10.4618460982
MESH:D012120 Respiration Disorders Chlorine 4.9118579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6411700416
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.5116877224
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5410835634
MESH:D012135 Respiratory Sounds Paraquat 3.7711874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012162 Retinal Degeneration Paraquat 3.6516458197
MESH:D012173 Retinitis Gentamicins 5.9818644591
MESH:D012208 Rhabdomyosarcoma decitabine 10.0419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.0416116481 16283617
MESH:D012220 Rhinitis Histamine 4.7312689652
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7518045962
MESH:D012559 Schizophrenia Clozapine 2.7020521320 20580759 17667964 17726453 19369910 16141801 17123785 18855531 18806925 20107430 11151749 11763009 20452607 20168265 20521326
MESH:D012640 Seizures Dizocilpine Maleate 4.2811218047 17157343 12660363
MESH:D018805 Sepsis Zymosan 4.4111441115
MESH:D012871 Skin Diseases Vitamin A 3.2818709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.4212065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.428532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.4216192470
MESH:D012878 Skin Neoplasms Tretinoin 12.4216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6416709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.9816503802 15862959
MESH:D013274 Stomach Neoplasms decitabine 2.4719037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.4717261132
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.4217997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9115821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms decitabine 6.5617967635
MESH:D013964 Thyroid Neoplasms Tretinoin 6.5617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.5316051514
MESH:D014376 Tuberculosis Tretinoin 3.0516040207
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 5.1415867355 15289314 1399818
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.1419087683 17616700
MESH:D014581 Urticaria Acetaminophen 8.2210982225
MESH:D014581 Urticaria Histamine 8.2218298128
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0214692618
MESH:D014604 Uveal Neoplasms decitabine 11.8317785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.8316752155
MESH:D014605 Uveitis Zymosan 5.1011006244
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2814671159 15869587
MESH:D015837 Vestibular Diseases Gentamicins 5.2418776599
MESH:D014802 Vitamin A Deficiency Vitamin A 5.0016146918 16175781 16960172
MESH:D014820 Vitiligo Tretinoin 3.7816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D015430 Weight Gain Clozapine 4.2220564506 20107430 16402076 17502770 16141801 20521320
MESH:D015431 Weight Loss Clozapine 4.7817933447
MESH:D009396 Wilms Tumor Tretinoin 3.7216287080
Pathway ID Pathway Name
KEGG:04971 Gastric acid secretion
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36153
    • Releated gene ID Related gene Name
    PA26864CREB1
    PA30729MECP2
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00847 binder Cysteamine Radiation-Protective Agents;Nephropathic cystinosis therapy
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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