AutismKB 2.0

Annotation Detail for SSTR2


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Basic Information Top
Gene Symbol:SSTR2 ( - )
Gene Full Name: somatostatin receptor 2
Band: 17q25.1
Quick LinksEntrez ID:6752; OMIM: 182452; Uniprot ID:SSR2_HUMAN; ENSEMBL ID: ENSG00000180616; HGNC ID: 11331
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04971Gastric acid secretion
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SSTR2 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SSTR2 mRNAaffects expression 16483693
C110845 AN 238 AN 238 binds to SSTR2 proteinaffects binding 16047355
D001280 Atrazine Atrazine affects the expression of SSTR2 mRNAaffects expression 16221967
D001761 Bleomycin Bleomycin results in decreased expression of SSTR2 mRNAdecreases expression 15808516
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of SSTR2 mRNAdecreases expression 15620428
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of SSTR2 mRNAdecreases expression 15620428
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SSTR2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SSTR2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SSTR2 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of SSTR2 mRNAdecreases expression 18035473
D006851 Hydrochloric Acid SSTR2 protein affects the susceptibility to Hydrochloric Acidaffects response to substance 17363388
C121854 L 779976 L 779976 binds to and results in increased activity of SSTR2 proteinaffects binding|increases activity 16162846
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SSTR2 mRNAdecreases expression 19285098
D015282 Octreotide SSTR2 protein affects the susceptibility to Octreotideaffects response to substance 17363388
C474055 octylphenol octylphenol results in increased expression of SSTR2 mRNAincreases expression 15620428
C517782 pasireotide pasireotide binds to SSTR2 proteinaffects binding 16625840
D010852 Picrotoxin Picrotoxin results in increased expression of SSTR2 mRNAincreases expression 15170462
D013004 Somatostatin Somatostatin results in increased expression of SSTR2 mRNAincreases expression 18575731
D013629 Tamoxifen Tamoxifen affects the expression of SSTR2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SSTR2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SSTR2 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 8.516734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5114514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 10.5218287403
MESH:D000138 Acidosis Hydrochloric Acid 10.5220872349 16144966 19262391 12771618 15920416 11574821
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 5.7117183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 5.7620597076
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D055371 Acute Lung Injury Bleomycin 9.7617118201
MESH:D055371 Acute Lung Injury Hydrochloric Acid 9.7611953099 19060228 11850527 16759491 19760209 19094174 15970105
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8014692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.713712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3216835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.1611874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 5.2615146954
MESH:D000860 Anoxia Bleomycin 11.5515782499
MESH:D000860 Anoxia Hydrochloric Acid 11.5515090967
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6215885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9611289319 1440618
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 9.1715920416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9718425577 20135344 17440819 16273361 19189212 18855134 17261762 16202921 19066611 19155303 17049068 19142967 19288272 18629630 19487384 19103187 20065188 18351453 18815881 19059307 15668708 11161223 19200415 21152245 19221464 18821012 18997820 20859285 17893378 20005174 15565566 21138602 19084267 20544844 19011961 19189210 19410462 17242785 19289846 18984771 20390343 16873071 16818667 19115204 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 4.5312378975
MESH:D001986 Bronchial Spasm Hydrochloric Acid 5.4115578804
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.953581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 2.9516924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 3.586189445
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3316120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.717505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.6919486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6917681005 17333356 16919318 11677210 17110522 16105132 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815340226 15668235 12621046 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.3816037377
MESH:D003556 Cystitis Hydrochloric Acid 5.4112599022 20719367 12853844 19279288
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 5.7617714534
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.748156756 14531868 12868966 11298694 11906362 8970840 2524372 18759878
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 4.0216882537
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.432952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4219279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.6318648102 6679447 9653073 18692083 18289764 7440962 6482804 9328219 1440618 16192314 9022650 11289319 8291058
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004487 Edema Bleomycin 6.9817118201
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.7312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.7319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0020544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D004935 Esophageal Diseases Hydrochloric Acid 5.7319566590
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.093581430
MESH:D004941 Esophagitis Hydrochloric Acid 5.9312928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 5.9614621274 11346197 20516732
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.4915345470
MESH:D005234 Fatty Liver Tamoxifen 7.4914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1219069698
MESH:D005355 Fibrosis Hydrochloric Acid 8.8518497604
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8520067830
MESH:D005739 Gas Poisoning Hydrochloric Acid 5.4112378975
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 5.2620545468 19951613 19957777 20616304 12212954 20516732
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006356 Heartburn Hydrochloric Acid 5.7319566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3011294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.456705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8312621046 16120746 15340226
MESH:D006689 Hodgkin Disease Bleomycin 4.3115147373 18501091 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 15340226 8697196 16354765 18606429
MESH:D006940 Hyperemia Hydrochloric Acid 5.5912646421
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818850075 18670907
MESH:D006975 Hypertension, Portal Hydrochloric Acid 5.2816984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.4119262391
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D007022 Hypotension Hydrochloric Acid 4.6911574821
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Atrazine 6.7612948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7617937319
MESH:D007249 Inflammation Bleomycin 15.5517118201
MESH:D007249 Inflammation Flavonoids 15.5517296493
MESH:D007249 Inflammation Hydrochloric Acid 15.5511574821
MESH:D007249 Inflammation Tamoxifen 15.5519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.5512878042 12200463
MESH:D007410 Intestinal Diseases Hydrochloric Acid 4.9111574821
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.969022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.206582329
MESH:D007680 Kidney Neoplasms Tamoxifen 7.2018625569
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 6.3116498863
MESH:D007826 Laryngismus Hydrochloric Acid 6.3111510729
MESH:D008064 Lipidoses Tamoxifen 3.1117567588 15342952
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 4.0316984587
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.159327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Octreotide 3.7512890342
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.7518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7512878042
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 7.4111940454
MESH:D008113 Liver Neoplasms Tamoxifen 7.4116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.593712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5912151625
MESH:D008171 Lung Diseases Hydrochloric Acid 4.2416784557
MESH:D055370 Lung Injury Hydrochloric Acid 4.6921114838 19262391 20597076 18339021 17627322 18497604 11395602 15044056 15090967 21311175 19644408 16129981 15607125 18573544
MESH:D008175 Lung Neoplasms Bleomycin 3.516189445
MESH:D008175 Lung Neoplasms Tamoxifen 3.5118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5111884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5819196723 16827153 19196722 14580682 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.4919453300
MESH:D008545 Melanoma Bleomycin 3.7315577320
MESH:D008545 Melanoma Tamoxifen 3.7312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1215990972
MESH:D008654 Mesothelioma Atrazine 3.501916698
MESH:D009203 Myocardial Infarction Hydrochloric Acid 3.7818534312
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.613581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9419196722 19200415 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.876679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.174026338 6482804
MESH:D009784 Occupational Diseases Hydrochloric Acid 9.1712378975
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010300 Parkinson Disease Atrazine 3.2517218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D047748 Pituitary ACTH Hypersecretion pasireotide 6.9116809932
MESH:D011014 Pneumonia Bleomycin 5.3517071938 16317386 18024389
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 5.3118497604 15970105 15607125 18573544
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 5.9620597076
MESH:D011654 Pulmonary Edema Bleomycin 11.2515808516
MESH:D011654 Pulmonary Edema Hydrochloric Acid 11.2515090967
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.8415541506 15322207 16115399 21435439 18162602 17177178 16314464 14609568 12624602 18008008 12574379 17434272 17241526 11554783
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 4.6916784557 18549715 16129981 18339021 17627322
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 6.3111510729
MESH:D012135 Respiratory Sounds Atrazine 4.4511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 5.1120516732
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012640 Seizures Picrotoxin 3.958635557 8954991
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.3716709447
MESH:D013088 Spermatocele Tamoxifen 11.3716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9819457130
MESH:D013276 Stomach Ulcer Hydrochloric Acid 4.1715309881 16755016 17189318
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.836582329 6587162 1399818 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.958074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.9516712894 17572228 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D015431 Weight Loss Bleomycin 5.5812624602
Pathway ID Pathway Name
KEGG:04971 Gastric acid secretion
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00104 binder Octreotide Anabolic Agents;Hormone Replacement Agents;Antineoplastic Agents, Hormonal;Gastrointestinal Agents
DB04894 agonist Vapreotide Antineoplastic Agents;Analgesics
No data
No data
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Simple Query:


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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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