AutismKB 2.0

Annotation Detail for SSTR3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SSTR3 ( - )
Gene Full Name: somatostatin receptor 3
Band: 22q13.1
Quick LinksEntrez ID:6753; OMIM: 182453; Uniprot ID:SSR3_HUMAN; ENSEMBL ID: ENSG00000183473; HGNC ID: 11332
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SSTR3 mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen results in decreased expression of SSTR3 mRNAdecreases expression 17088403
D000082 Acetaminophen U 0126 inhibits the reaction [Acetaminophen results in decreased expression of SSTR3 mRNA]decreases expression|decreases reaction 17088403
D000082 Acetaminophen WAY 100635 inhibits the reaction [Acetaminophen results in decreased expression of SSTR3 mRNA]decreases expression|decreases reaction 17088403
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SSTR3 mRNAaffects expression 16483693
D001280 Atrazine Atrazine affects the expression of SSTR3 mRNAaffects expression 16221967
C006780 bisphenol A bisphenol A results in decreased expression of SSTR3 mRNAdecreases expression 16162846
C006780 bisphenol A bisphenol A results in increased expression of SSTR3 mRNAincreases expression 16162846
C006780 bisphenol A RY 008 inhibits the reaction [bisphenol A results in decreased expression of SSTR3 mRNA]decreases expression|decreases reaction 16162846
C006780 bisphenol A zolpidem affects the reaction [bisphenol A affects the expression of SSTR3 mRNA]affects expression|affects reaction 16162846
D001761 Bleomycin Bleomycin results in decreased expression of SSTR3 mRNAdecreases expression 15808516
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of SSTR3 mRNAaffects cotreatment|affects expression 18636392
D003840 Deoxycholic Acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SSTR3 mRNAaffects cotreatment|increases expression 16556975
D005445 Flunitrazepam Flunitrazepam affects the expression of SSTR3 mRNAaffects expression 16162846
C030691 gluconic acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SSTR3 mRNAaffects cotreatment|increases expression 16556975
C429627 L796778 L796778 binds to and results in increased activity of SSTR3 proteinaffects binding|increases activity 16162846
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of SSTR3 mRNAaffects cotreatment|affects expression 18636392
C517782 pasireotide pasireotide binds to SSTR3 proteinaffects binding 16625840
C025299 polyphenols polyphenols results in decreased expression of SSTR3 mRNAdecreases expression 16293270
C042957 Ro 15-4513 Ro 15-4513 affects the expression of SSTR3 mRNAaffects expression 16162846
C113975 RY 008 RY 008 affects the expression of SSTR3 mRNAaffects expression 16162846
C113975 RY 008 RY 008 inhibits the reaction [bisphenol A results in decreased expression of SSTR3 mRNA]decreases expression|decreases reaction 16162846
D018038 Sodium Selenite Sodium Selenite results in decreased expression of SSTR3 mRNAdecreases expression 18175754
D013004 Somatostatin Somatostatin results in increased expression of SSTR3 mRNAincreases expression 18575731
C113580 U 0126 U 0126 inhibits the reaction [Acetaminophen results in decreased expression of SSTR3 mRNA]decreases expression|decreases reaction 17088403
C090413 WAY 100635 WAY 100635 inhibits the reaction [Acetaminophen results in decreased expression of SSTR3 mRNA]decreases expression|decreases reaction 17088403
C049109 zolpidem zolpidem affects the expression of SSTR3 mRNAaffects expression 16162846
C049109 zolpidem zolpidem affects the reaction [bisphenol A affects the expression of SSTR3 mRNA]affects expression|affects reaction 16162846
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D000168 Acrocephalosyndactylia U 0126 5.3617694057
MESH:D055371 Acute Lung Injury Bleomycin 9.4517118201
MESH:D055371 Acute Lung Injury Chlorine 9.4520601635
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.1211874814
MESH:D000544 Alzheimer Disease Ozone 2.4215513908
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D000860 Anoxia Bleomycin 5.3015782499
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5315570426
MESH:D001249 Asthma Ozone 2.6016373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001862 Bone Resorption bisphenol A 3.7611985600
MESH:D001943 Breast Neoplasms bisphenol A 2.4917123778
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5914754758 18315731 19059883 15516495 18417511 16777450 17626835
MESH:D002100 Cachexia Ozone 4.6316183385
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.373084413
MESH:D002278 Carcinoma in Situ bisphenol A 4.8817123778
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 3.576189445
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6415894690
MESH:D003110 Colonic Neoplasms Deoxycholic Acid 4.4116213893
MESH:D003110 Colonic Neoplasms polyphenols 4.4116293270
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6816285004
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1314986274 16109766 11739529 15619225 19739265 19164858 14550746 2444490 18071297 19370779 11461765 12392966 11529661 16393943 11287661 19923254 12153990 12594235 19416960 17562736 11834606 16081117 11421492 16177239 17906064 12958197 10663392 16485898 18713872 10774834 12540782 19085960 14725611 19420014 16227642 11743745 16781746 17522070 10915739 15968718 12705907
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.1319370779
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.1315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004417 Dyspnea Chlorine 4.5220016425
MESH:D004487 Edema Bleomycin 4.1517118201
MESH:D005739 Gas Poisoning Chlorine 4.9020016425
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D006689 Hodgkin Disease Bleomycin 4.2815147373 18501091 17606976
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D007248 Infertility, Male Atrazine 3.6412948887
MESH:D007249 Inflammation Bleomycin 5.6517118201
MESH:D007249 Inflammation polyphenols 5.6516366677
MESH:D007333 Insulin Resistance bisphenol A 7.3116393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.3114714311
MESH:D007674 Kidney Diseases Acetaminophen 2.1412587719 15629191
MESH:D007948 Leukemia, Monocytic, Acute U 0126 5.2016972261
MESH:D008107 Liver Diseases Acetaminophen 4.0619460945 16611625 19014921 12587719 19784758 11587558 12969438 16610002
MESH:D008107 Liver Diseases polyphenols 4.0616698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1416871587 17185352
MESH:D008114 Liver Neoplasms, Experimental Deoxycholic Acid 4.146150874
MESH:D008171 Lung Diseases Ozone 3.308266340 19066396
MESH:D055370 Lung Injury Ozone 3.7420417186
MESH:D008175 Lung Neoplasms Bleomycin 3.036189445
MESH:D008175 Lung Neoplasms Ozone 3.038597069 7614698
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9514737004
MESH:D008545 Melanoma Bleomycin 3.2415577320
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008654 Mesothelioma Atrazine 3.481916698
MESH:D008679 Metaplasia Ozone 5.0010496685
MESH:D009421 Nervous System Malformations bisphenol A 3.8711399458 16427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7818514411
MESH:D010049 Ovarian Diseases bisphenol A 4.8811985600
MESH:D010051 Ovarian Neoplasms U 0126 3.3716211241
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010300 Parkinson Disease Atrazine 3.2317218051
MESH:D010538 Peritonitis Ozone 4.0216369182
MESH:D047748 Pituitary ACTH Hypersecretion pasireotide 6.8716809932
MESH:D011014 Pneumonia Bleomycin 11.0516317386 17071938 18024389
MESH:D011014 Pneumonia Ozone 11.0518007984 18381685 18929643
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.8410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1020887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.4216740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.4218760546
MESH:D011629 Puberty, Precocious bisphenol A 4.6810548101
MESH:D011654 Pulmonary Edema Bleomycin 5.2115808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.8321435439 11554783 16115399 17434272 18162602 12624602 16314464 14609568 15541506 17177178 17241526 18008008 15322207 12574379
MESH:D012120 Respiration Disorders Chlorine 5.1118579056
MESH:D012135 Respiratory Sounds Atrazine 4.4111874814
MESH:D012640 Seizures zolpidem 4.959754883
MESH:D012893 Sleep Disorders zolpidem 6.2419395429
MESH:D007319 Sleep Initiation and Maintenance Disorders zolpidem 6.039066939 15341891 17225163
MESH:D019966 Substance-Related Disorders bisphenol A 3.8816045194 16684133
MESH:D013375 Substance Withdrawal Syndrome zolpidem 6.019754883
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.1517997062
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D014591 Uterine Diseases bisphenol A 4.9014652134
MESH:D015431 Weight Loss Bleomycin 5.5312624602
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved