AutismKB 2.0

Annotation Detail for SSTR5


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Basic Information Top
Gene Symbol:SSTR5 ( SS-5-R )
Gene Full Name: somatostatin receptor 5
Band: 16p13.3
Quick LinksEntrez ID:6755; OMIM: 182455; Uniprot ID:SSR5_HUMAN; ENSEMBL ID: ENSG00000162009; HGNC ID: 11334
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
bipolar affective disorder
PSYCH
bipolar affective disorder.
No data
Desease Name
Somatostatin analog, resistance to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SSTR5 mRNAaffects expression 16483693
C110845 AN 238 AN 238 binds to SSTR5 proteinaffects binding 16047355
C014347 decitabine [decitabine co-treated with trichostatin A] affects the expression of SSTR5 mRNAaffects cotreatment|affects expression 18575731
C517782 pasireotide pasireotide binds to SSTR5 proteinaffects binding 16625840
D013004 Somatostatin Somatostatin results in increased expression of SSTR5 mRNAincreases expression 18575731
C012589 trichostatin A [decitabine co-treated with trichostatin A] affects the expression of SSTR5 mRNAaffects cotreatment|affects expression 18575731
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D001943 Breast Neoplasms decitabine 2.5418320071 19208741
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6619215824
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D004701 Endocrine Gland Neoplasms decitabine 15.8319294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 15.8319294695
MESH:D005909 Glioblastoma trichostatin A 4.0218801729
MESH:D049912 Growth Hormone-Secreting Pituitary Adenoma marker/mechanism
MESH:D006258 Head and Neck Neoplasms decitabine 3.6919215824
MESH:D007248 Infertility, Male decitabine 3.4017581917
MESH:D007938 Leukemia decitabine 3.2118980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.3317236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.4317679729 18460780 18704418 19010910 19387464 18206229
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.4318206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9818055864
MESH:D008223 Lymphoma decitabine 3.6419470736
MESH:D008545 Melanoma decitabine 3.8616505122 17785578
MESH:D008545 Melanoma trichostatin A 3.8616505122
MESH:D009101 Multiple Myeloma decitabine 8.3918172295
MESH:D009101 Multiple Myeloma trichostatin A 8.3918172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5419010910 18608210 16882708 19157545
MESH:D009369 Neoplasms decitabine 2.8419116145 17925555 19470736
MESH:D010051 Ovarian Neoplasms decitabine 5.5419331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 5.5419331143
MESH:D010190 Pancreatic Neoplasms decitabine 5.9919294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 5.9919294695
MESH:D047748 Pituitary ACTH Hypersecretion pasireotide 7.4016809932
MESH:D055728 Primary Myelofibrosis decitabine 13.8617616702
MESH:D055728 Primary Myelofibrosis trichostatin A 13.8617616702
MESH:D011471 Prostatic Neoplasms trichostatin A 3.9918798265 19789329
MESH:D012208 Rhabdomyosarcoma decitabine 4.7519155313
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms decitabine 3.5717967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8219087683 17616700
MESH:D014604 Uveal Neoplasms decitabine 5.4317785578
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00104 - Octreotide Anabolic Agents;Hormone Replacement Agents;Antineoplastic Agents, Hormonal;Gastrointestinal Agents
DB04894 agonist Vapreotide Antineoplastic Agents;Analgesics
No data
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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