AutismKB 2.0

Annotation Detail for ST14


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Basic Information Top
Gene Symbol:ST14 ( HAI,MT-SP1,MTSP1,PRSS14,SNC19,TADG15,TMPRSS14 )
Gene Full Name: suppression of tumorigenicity 14 (colon carcinoma)
Band: 11q24.3
Quick LinksEntrez ID:6768; OMIM: 606797; Uniprot ID:ST14_HUMAN; ENSEMBL ID: ENSG00000149418; HGNC ID: 11344
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Ichthyosis with hypotrichosis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ST14 mRNAincreases expression 16788091
D003520 Cyclophosphamide [Doxorubicin co-treated with Cyclophosphamide] affects the expression of ST14 mRNAaffects cotreatment|affects expression 16322899
D004317 Doxorubicin [Doxorubicin co-treated with Cyclophosphamide] affects the expression of ST14 mRNAaffects cotreatment|affects expression 16322899
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ST14 mRNAincreases expression 17942748
D008743 Methyl Parathion Methyl Parathion affects the expression of ST14 mRNAaffects expression 19784758
D008743 Methyl Parathion Methyl Parathion results in decreased expression of ST14 mRNAdecreases expression 19784758
D008743 Methyl Parathion Methyl Parathion results in increased expression of ST14 mRNAincreases expression 19784758
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ST14 mRNAaffects binding|increases activity|increases expression 19710929
D012643 Selenium Selenium results in increased expression of ST14 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Doxorubicin 4.5817418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000419 Albuminuria Doxorubicin 4.8721441931
MESH:D001161 Arteriosclerosis Cyclophosphamide 11.3915014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 11.3911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.5615093573 16978400 17020986 12006526 18234424 11325840 15136595 18323546 17388661
MESH:D001943 Breast Neoplasms Doxorubicin 2.5619526202 16935488 18234424 15634643 15692762 15994142 17983394 15136595 16826403 16322301 17369602 15939500 15668708 16264153 11325840 16096432 16115903 15993339 18695136 18628466 18382427 17426702 16595493 15567936
MESH:D002276 Carcinoid Tumor Doxorubicin 5.2516051944
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 3.5519701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.5516234567 18059187 16023760 17876044
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.2816152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 7.2416201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.2416201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7016731534 16242529 18627295 17329180 16269455 17007740 16651473 17974986 15811867 16278810 16109756 16612575 17351982 17519947 15505089 17308081 16364871 16455267 15792986 17924179 17131338 17928571 17382496 16952015 15476868
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0216243910 17334414
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4215861022 17681005 17333356 11677210 17110522 16105132 16919318
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D003556 Cystitis Cyclophosphamide 5.4316413132 15643279 16614059 18433785 10498854 12913760 15276878 10700343 18372110 17979934 12388444 12161096 16989017 18483878 18093676 18295254 17010015 16651033 18710439 11948286
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.3011751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2918772604
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.3317416283
MESH:D056486 Drug-Induced Liver Injury Selenium 4.3315131321
MESH:D004362 Drug Toxicity Doxorubicin 3.8718602426
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.5711006010
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5015345470
MESH:D005234 Fatty Liver pirinixic acid 8.5020131406 19236843
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9819069698
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D018316 Gliosarcoma Cyclophosphamide 5.9111389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.3916376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7015692506
MESH:D006331 Heart Diseases Doxorubicin 3.6718006777 16879835 16244372 12587719 17875725 16707910 16495754 16244371 14766674 16144979 18674790 16330681 17888722
MESH:D006333 Heart Failure Doxorubicin 12.7317481944
MESH:D006333 Heart Failure pirinixic acid 12.7320558911
MESH:D006333 Heart Failure Selenium 12.7317162251
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.6511918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.9814986274
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 19176532 19772884 18467677
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.5416135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 8.5415147373 17606976 18501091
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:C536273 Ichthyosis with hypotrichosis, autosomal recessive marker/mechanism
MESH:D007154 Immune System Diseases Cyclophosphamide 5.7716076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Cyclophosphamide 7.467193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.4617937319
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007674 Kidney Diseases Doxorubicin 3.2015699352 16775033 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.9416707910
MESH:D007676 Kidney Failure, Chronic Selenium 10.9416518626
MESH:D007938 Leukemia Cyclophosphamide 3.6110602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5917802794 18172266 17296974 17008537 18587576 17658394
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2910373061
MESH:D007970 Leukopenia Cyclophosphamide 5.3610052129 11830472
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.5416439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9016377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1716842330 17085340
MESH:D008175 Lung Neoplasms Doxorubicin 2.1517418594 6189445
MESH:D008223 Lymphoma Cyclophosphamide 8.5312854902
MESH:D008223 Lymphoma Doxorubicin 8.5316098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.9016675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 9.7811911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 9.7817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.7515458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.7515318939
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.1616388313
MESH:D008654 Mesothelioma Doxorubicin 6.6017638057
MESH:D008654 Mesothelioma Selenium 6.6015107826
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction Doxorubicin 6.0415857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 6.0419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0418259882
MESH:D009369 Neoplasms Cyclophosphamide 5.5818854779
MESH:D009369 Neoplasms pirinixic acid 5.5817405874
MESH:D009401 Nephrosis Doxorubicin 5.1316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2516889571 15640375
MESH:D056770 Netherton Syndrome marker/mechanism 20657595
MESH:D009447 Neuroblastoma Cyclophosphamide 7.6316115947 8761367 15176712
MESH:D009447 Neuroblastoma Doxorubicin 7.6315555623
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.288761367 12837982
MESH:D020258 Neurotoxicity Syndromes Methyl Parathion 5.0219784758
MESH:D009503 Neutropenia Cyclophosphamide 4.638291058
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009845 Oligospermia Cyclophosphamide 5.1116517039
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010146 Pain Cyclophosphamide 3.8518093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 3.2611332152
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D011041 Poisoning Methyl Parathion 5.3417603234
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9421297632
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.5717136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5718437689 15897917 16729912 16868541 16888761 15749863
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3716636934
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012509 Sarcoma Doxorubicin 4.2516767912 18313854 17203757 17710206 15625365 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5716326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.1316636934
MESH:D012878 Skin Neoplasms Doxorubicin 3.0615692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9316767912 15625365 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.9116517039
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.4512837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5816010429 17909728
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.8114692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.8117653716
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817334414 16364871 17638931 17678736
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Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36168
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00013 - Urokinase Thrombolytic Agents
    DB03127 - Benzamidine Serine Proteinase Inhibitors
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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