AutismKB 2.0

Annotation Detail for ZFP36L1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ZFP36L1 ( BRF1,Berg36,ERF-1,ERF1,RNF162B,TIS11B,cMG1 )
Gene Full Name: zinc finger protein 36, C3H type-like 1
Band: 14q24.1
Quick LinksEntrez ID:677; OMIM: 601064; Uniprot ID:TISB_HUMAN; ENSEMBL ID: ENSG00000185650; HGNC ID: 1107
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
No data
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Related Diseases/Disorders Top
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Desease Name
Celiac Disease
IMMUNE
Desease Name
Celiac disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of ZFP36L1 mRNAaffects expression 18281256
D000082 Acetaminophen Acetaminophen affects the expression of ZFP36L1 mRNAaffects expression 15606129
17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ZFP36L1 mRNAdecreases expression 15725085
C006780 bisphenol A bisphenol A results in decreased expression of ZFP36L1 mRNAdecreases expression 16474171
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of ZFP36L1 mRNAincreases expression 16934159
D003474 Curcumin Curcumin results in decreased expression of ZFP36L1 mRNAdecreases expression 15713895
D016572 Cyclosporine Cyclosporine results in decreased expression of ZFP36L1 mRNAdecreases expression 20106945
C014347 decitabine [decitabine co-treated with Depsipeptides] results in decreased expression of ZFP36L1 mRNAaffects cotreatment|decreases expression 17064661
D047630 Depsipeptides [decitabine co-treated with Depsipeptides] results in decreased expression of ZFP36L1 mRNAaffects cotreatment|decreases expression 17064661
D016190 Carboplatin Carboplatin results in decreased expression of ZFP36L1 mRNAdecreases expression 18172885
D002945 Cisplatin ZFP36L1 protein results in increased susceptibility to Cisplatinincreases response to substance 15880358
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ZFP36L1 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ZFP36L1 mRNA]decreases reaction|increases expression 17942915
D004958 Estradiol Estradiol results in decreased expression of ZFP36L1 mRNAdecreases expression 16474171
20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ZFP36L1 mRNAaffects expression 17555576
D019833 Genistein Genistein results in decreased expression of ZFP36L1 mRNAdecreases expression 16474171
D007657 Ketone Bodies Ketone Bodies results in decreased expression of ZFP36L1 mRNAdecreases expression 16807920
C017557 nickel subsulfide nickel subsulfide results in decreased expression of ZFP36L1 mRNAdecreases expression 12760830
C029938 nickel sulfate nickel sulfate results in decreased expression of ZFP36L1 mRNAdecreases expression 16780908
D010634 Phenobarbital Phenobarbital results in decreased expression of ZFP36L1 mRNAdecreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ZFP36L1 mRNAaffects binding|decreases expression|increases activity 19710929
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in decreased expression of ZFP36L1 mRNAdecreases expression 16474171
D011374 Progesterone Progesterone results in increased expression of ZFP36L1 mRNAincreases expression 18037150
C488333 Ro 65-7199 Ro 65-7199 affects the expression of ZFP36L1 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of ZFP36L1 mRNAaffects expression 14610520
C017947 sodium arsenite sodium arsenite results in increased expression of ZFP36L1 mRNAincreases expression 12634122
12760830
C016104 sodium bichromate sodium bichromate results in decreased expression of ZFP36L1 mRNAdecreases expression 12760830
D013629 Tamoxifen Tamoxifen affects the expression of ZFP36L1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of ZFP36L1 mRNAaffects expression 16962184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ZFP36L1 mRNAincreases expression 16611356
16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ZFP36L1 mRNAincreases expression 16960034
C025643 vinclozolin vinclozolin affects the expression of ZFP36L1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2814745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.426195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4211752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.7217670903 12690470 15814532
MESH:D055371 Acute Lung Injury nickel sulfate 8.3416100012 12718980 19131640 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 8.3418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 12.8011798837 19825857
MESH:D000230 Adenocarcinoma Cisplatin 12.8011798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 12.8011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.8014692618
MESH:D000230 Adenocarcinoma Genistein 12.8011473722
MESH:D000236 Adenoma Diethylnitrosamine 2.7010737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.6816434500 18056438 19052882 17620307 19061943 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.6817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.6816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.6816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6417306315 16712894
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8117887948
MESH:D000544 Alzheimer Disease Curcumin 2.5615590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7211748828
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5015885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6716807698
MESH:D050197 Atherosclerosis Curcumin 3.1718704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Curcumin 4.2319761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.9116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.9119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.9112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6214601052
MESH:D001862 Bone Resorption bisphenol A 3.6311985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0717868700
MESH:D001930 Brain Injuries Progesterone 4.0015665606 15380490 15845082
MESH:D002545 Brain Ischemia Curcumin 4.0716770732
MESH:D001932 Brain Neoplasms Curcumin 3.7117596214
MESH:D001943 Breast Neoplasms bisphenol A 6.7217123778
MESH:D001943 Breast Neoplasms Cisplatin 6.7219526202 18382427
MESH:D001943 Breast Neoplasms Curcumin 6.7219250217 18462866 16243823 18593918
MESH:D001943 Breast Neoplasms decitabine 6.7218320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.7217474063
MESH:D001943 Breast Neoplasms Estradiol 6.7217261762 17289903 18497071 12948864 19861407 16675129 14630087 17018787
MESH:D001943 Breast Neoplasms Genistein 6.7217200150 16541309 16873071
MESH:D001943 Breast Neoplasms Progesterone 6.7215562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 6.7219288272 19289846 15565566 21152245 17893378 19059307 20544844 16273361 19487384 20065188 21138602 18821012 19084267 19244106 18815881 18855134 19011961 19189210 19410462 11161223 19221464 19103187 15668708 16818667 17049068 20135344 19115204 20005174 19066611 16873071 18425577 18984771 19142967 20859285 19155303 17440819 18351453 17242785 19200415 16202921 18997820 18629630 20390343 17261762 19189212
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002277 Carcinoma Curcumin 7.6018593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2519066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.013084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 19.0111135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 19.0117982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.0118665156 16502159 18056438 19394651 19383236 21159647 18788625 10672840 20727157 20084675 16698587 3581430 20101231 19539802 16540662 19519916 18691550 18785209 18971187 18393292 16681979 17978847 19107877 20935162 20514400 18978308 18494052 17428255 20432363 19171122 16878318 19335982 16830150 20214788 19418558 16807293 10737359 19208518 17162532 16288022 16328049 17138121 20512989 20524982 11831363 16569478 19701751 20007298 17055752 16935385 19919837 17173139 18506893 3084413 16779866 19052882 18210153 19822196 17761372
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.0116924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.0116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 19.016705139 1701930 20935162 20007298 17173139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.0115276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 19.0116924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7217123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 8.6616685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 8.6612023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 8.6618414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8912490120
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 10.2018337622 6189445 17066447
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.2018462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.2019215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.2018572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.1316332659
MESH:D002386 Cataract Acetaminophen 2.4310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.5512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.557505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.5518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.5520056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.994080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5916835633
MESH:D002779 Cholestasis Cyclosporine 12.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.2317681005 15861022 16105132 17110522 11677210 16919318 17333356
MESH:D002779 Cholestasis pirinixic acid 12.2319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.998697196 15340226 16354765 12621046 15668235
MESH:D003092 Colitis Curcumin 3.9216782535 18200517 16804969
MESH:D003103 Coloboma Curcumin 4.3118809619
MESH:D003110 Colonic Neoplasms Curcumin 5.6119359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 5.6117616700
MESH:D003110 Colonic Neoplasms Genistein 5.6117182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.6420501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.6415273666
MESH:D015179 Colorectal Neoplasms decitabine 4.6418981723
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.6415531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8414669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.6418497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.3910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3920055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.0914966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8515213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.4716140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1019031437
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.4311298694 16780908 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.6918403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.6920387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.6916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.6917107852
MESH:D003928 Diabetic Nephropathies Curcumin 13.7618204486
MESH:D003928 Diabetic Nephropathies Estradiol 13.7619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.7619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2317187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.3111287661 11421492 11461765 17562736 11739529 11834606 19416960 16109766 17906064 16227642 16781746 18713872 10915739 19370779 18071297 12594235 14550746 16177239 11743745 16485898 12540782 19923254 14725611 15619225 19739265 11529661 12705907 12392966 19085960 14986274 16393943 15968718 12958197 19420014 16081117 12153990 17522070 19164858 2444490 10663392 10774834
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 8.3117851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.3119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004362 Drug Toxicity Cisplatin 7.5412231392 19839026 12649298 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5411462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8017351913
MESH:D004421 Dystonia Phenobarbital 3.761851702
MESH:D004487 Edema pirinixic acid 5.7712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.7711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.8712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.8717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.8719031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8519294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.3316402032
MESH:D016889 Endometrial Neoplasms Estradiol 11.4818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 11.4811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.4819155303 20544844 17893378 16202921
MESH:D004715 Endometriosis Progesterone 8.1716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.1710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.853659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6111558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.326401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.763659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8516302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4812903497
MESH:D004938 Esophageal Neoplasms Cisplatin 4.4816481741 16785472 17638652 15464296 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver arsenic trioxide 33.3515073043
MESH:D005234 Fatty Liver Curcumin 33.3519297423
MESH:D005234 Fatty Liver Cyclosporine 33.3519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 33.3521071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.3515345470
MESH:D005234 Fatty Liver pirinixic acid 33.3520131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 33.3519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9219069698
MESH:D005355 Fibrosis Curcumin 13.2918705752
MESH:D005355 Fibrosis Cyclosporine 13.2912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.2920067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0116904648
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4418462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0316417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005909 Glioblastoma Curcumin 6.8217596214
MESH:D005909 Glioblastoma Genistein 6.8216598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 12.0715102660 15464296
MESH:D006258 Head and Neck Neoplasms Curcumin 12.0718829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 12.0719215824
MESH:D034381 Hearing Loss Cisplatin 4.0819898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2115464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1911294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 18.6016109766
MESH:D006529 Hepatomegaly Phenobarbital 18.6016109766
MESH:D006529 Hepatomegaly pirinixic acid 18.6018467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.6016120746 12621046 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7817701891
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D006689 Hodgkin Disease Cisplatin 6.8216170182 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 6.8212676792
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7815340226 8697196 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.5016870215
MESH:D006937 Hypercholesterolemia Curcumin 3.8218704882
MESH:D006943 Hyperglycemia pirinixic acid 2.9620558911
MESH:D006973 Hypertension Cyclosporine 4.6110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male decitabine 14.6217581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.6217937319
MESH:D007248 Infertility, Male sodium arsenite 14.6215346721 12646999
MESH:D007248 Infertility, Male vinclozolin 14.6216467254
MESH:D007249 Inflammation Curcumin 14.4017151092 16956363 18403477
MESH:D007249 Inflammation Diethylnitrosamine 14.4018785209
MESH:D007249 Inflammation Progesterone 14.4015869954
MESH:D007249 Inflammation Tamoxifen 14.4019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.4012200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1018596194 18200517
MESH:D007333 Insulin Resistance bisphenol A 11.3316393666
MESH:D007333 Insulin Resistance Estradiol 11.3316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.3316306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.9910783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.8715464296
MESH:D007674 Kidney Diseases Acetaminophen 17.4515629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 17.4519839026 18289764 12231392 15190930 12649298
MESH:D007674 Kidney Diseases Cyclosporine 17.458314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 17.4515618244
MESH:D007674 Kidney Diseases sodium arsenite 17.4520008137
MESH:D007680 Kidney Neoplasms Cyclosporine 11.1512371664
MESH:D007680 Kidney Neoplasms Estradiol 11.1515610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.1518625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5311231351
MESH:D007889 Leiomyoma Curcumin 4.3318555241
MESH:D007938 Leukemia arsenic trioxide 13.9215070760
MESH:D007938 Leukemia Curcumin 13.9218462866
MESH:D007938 Leukemia decitabine 13.9219235587 18980019
MESH:D007938 Leukemia Genistein 13.9217468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.9817077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.9816106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2414633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.8019077051
MESH:D007951 Leukemia, Myeloid decitabine 8.8019117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8219850784 16968895 20471514 16467208 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.8219010910 18206229 19387464 17679729 18460780 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1918055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0516891316 17869043 11468182 16823087 11161223 19075265 15336539 12679006 19035177 15213294 17649720 16966277 16112521 19225113 17107899 16330433 15622746 12712474 12018890 9834237 17712046 17217047 19642359 16331271 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.8816882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.8816106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4716417039
MESH:D008064 Lipidoses Tamoxifen 2.9717567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.1620032147 19638242 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 6.1621047994
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.2817355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.2817823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.2818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2812878042
MESH:D008107 Liver Diseases Acetaminophen 8.8019784758 16610002 19460945 11587558 19014921 12969438 12587719 16611625
MESH:D008107 Liver Diseases Curcumin 8.8016956363
MESH:D008107 Liver Diseases Diethylnitrosamine 8.8017034775
MESH:D008107 Liver Diseases Phenobarbital 8.8019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0117185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 20.3414682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.3412112319 2862719 12771043 19850985 19426721 19255062 19833225 20118626 19256749 19996281 20452335 18978307 19073162 20434301 21278145 20501860 18648771 15885732 19638242 19294768 21047994 20583210 19690152 19090486 20405173 19551842 21167192 2422723 19499222 15175105 19812893 21071580 9163691 19254457 10737359 18644402 18977376 19427195 19642983 16942905 18754104 20101389 20137499 20492335
MESH:D008113 Liver Neoplasms Phenobarbital 20.348742319 19482888 15975961 19073162 21047994 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 20.3420007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 20.3416712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 20.3416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.3416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.9320377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.9318308698 19539802 9362446 18282651 17942915 2563599 18253720 16267830 18079962 21159647 18093689 19519916 18544905 16842330 3124819 19004024 18775883 19009564 19126423 17854601 18164116 17174075
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.9317172636 1399818 2563599 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 16.931423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.9312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1515213294
MESH:D008171 Lung Diseases sodium arsenite 3.0019095001
MESH:D008175 Lung Neoplasms arsenic trioxide 10.1719825857 11798837
MESH:D008175 Lung Neoplasms Cisplatin 10.1711798837 17225452 6189445
MESH:D008175 Lung Neoplasms Curcumin 10.1719359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.176695378 21163286 20970405 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 10.1717077188 16712894 17306315 19931552 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 10.1718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.1711884234 19555203
MESH:D008223 Lymphoma Curcumin 7.1618462866
MESH:D008223 Lymphoma decitabine 7.1619470736
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4416173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.9017203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.9012929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.9017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.9019196722 14580682 19196723 11731420 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.7619453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7619453300
MESH:D008545 Melanoma Carboplatin 11.8716225601 11712820 16342250 12040289
MESH:D008545 Melanoma Cisplatin 11.8716809738 12374674 16432458 17023156 12393984 16248763 15577323 18176117 18505091 11135225 18332650 12883367 17761969
MESH:D008545 Melanoma Curcumin 11.8717885582 18462866
MESH:D008545 Melanoma decitabine 11.8717785578 16505122
MESH:D008545 Melanoma sodium arsenite 11.8719082730 16487513
MESH:D008545 Melanoma Tamoxifen 11.8719393235 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.6315990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.6315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D008569 Memory Disorders Curcumin 3.9017263510
MESH:D008654 Mesothelioma Cisplatin 3.1417638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D009101 Multiple Myeloma arsenic trioxide 11.1119549372 11468182 14977855 15949261 19417148
MESH:D009101 Multiple Myeloma Curcumin 11.1119372569
MESH:D009101 Multiple Myeloma decitabine 11.1118172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.6517962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.0016105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.0019010910 16882708 18608210 19157545
MESH:D009203 Myocardial Infarction Genistein 5.3117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.3119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.0216810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.0217141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.0216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2117484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.4916624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.4918495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.383581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4319410462
MESH:D009369 Neoplasms Carboplatin 14.3717925555 18854779
MESH:D009369 Neoplasms Cisplatin 14.3716773208
MESH:D009369 Neoplasms decitabine 14.3719470736 17925555 19116145
MESH:D009369 Neoplasms pirinixic acid 14.3717405874
MESH:D009369 Neoplasms sodium arsenite 14.3711559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4120056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.9512497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.9519200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2315464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0619348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 21.3811399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 21.3816427766 11399458
MESH:D009421 Nervous System Malformations Genistein 21.3816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.3814600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.3618462866
MESH:D009436 Neural Tube Defects arsenic trioxide 6.7710525206
MESH:D009436 Neural Tube Defects sodium arsenite 6.7712854658
MESH:D009447 Neuroblastoma Cisplatin 3.318761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.4818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.4820387270
MESH:D017599 Neuroectodermal Tumors Carboplatin 10.9212837982
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.928761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8520387270
MESH:D009765 Obesity Curcumin 4.3719297423
MESH:D009765 Obesity pirinixic acid 4.3720558911
MESH:D010018 Osteomalacia Phenobarbital 4.1017016548
MESH:D010024 Osteoporosis Curcumin 6.8318719352
MESH:D010024 Osteoporosis Genistein 6.8319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8416169203
MESH:D010049 Ovarian Diseases bisphenol A 4.7211985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 25.6616624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Cisplatin 25.666897625 15464296 19769630 17225452
MESH:D010051 Ovarian Neoplasms Curcumin 25.6618462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 25.6619259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 25.6619401270
MESH:D010051 Ovarian Neoplasms Genistein 25.6619005980
MESH:D010051 Ovarian Neoplasms Progesterone 25.6616525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 25.6615276417 17306315
MESH:D010146 Pain Acetaminophen 2.1916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 19.2515580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 19.2519003803
MESH:D010190 Pancreatic Neoplasms Curcumin 19.2519401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms decitabine 19.2519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 19.2516540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 19.2516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9219927285
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3016702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.0615464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.0817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.0012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.002563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.002563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.7210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.7211118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.7218042343 19015723 18220299
MESH:D055728 Primary Myelofibrosis decitabine 4.4717616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.7720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.7720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4019131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4016740699
MESH:D011471 Prostatic Neoplasms Curcumin 2.4010851300 18226269 18156803 12497104 11398177 15129424 18769126
MESH:D011471 Prostatic Neoplasms Estradiol 2.4016740699
MESH:D011471 Prostatic Neoplasms Genistein 2.4015256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.4015721890
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4016039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4015067354
MESH:D011472 Prostatitis vinclozolin 4.6718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.0516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.2312752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5210548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.3019168576
MESH:D051437 Renal Insufficiency Cisplatin 4.1515464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7818379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.1619155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012509 Sarcoma Curcumin 3.8918462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.5116646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.5114601052
MESH:D012640 Seizures Phenobarbital 2.523137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.566407741
MESH:D018805 Sepsis Curcumin 3.8618389075
MESH:D012878 Skin Neoplasms sodium arsenite 5.1819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1816192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.0815464296
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6716709447
MESH:D013088 Spermatocele Tamoxifen 10.6716709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.9916503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.9919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6012854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5317007042
MESH:D013274 Stomach Neoplasms Cisplatin 4.5317522103 18396642 15958060
MESH:D013274 Stomach Neoplasms decitabine 4.5319037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5318456281
MESH:D013276 Stomach Ulcer Curcumin 3.2716631530 19188055
MESH:D019966 Substance-Related Disorders bisphenol A 3.7216045194 16684133
MESH:D015173 Supratentorial Neoplasms Carboplatin 5.5512837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.3917225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.4919014326
MESH:D013964 Thyroid Neoplasms decitabine 15.4917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.497505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.491399818
MESH:D013978 Tibial Fractures Estradiol 4.4219048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 18.5311780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 18.5317225452 15464296 12973940
MESH:D001749 Urinary Bladder Neoplasms Curcumin 18.5318593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 18.5319087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.5316712894 11723127 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.5317572228 8653321 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 5.0018462866
MESH:D014581 Urticaria Acetaminophen 2.7410982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.8516803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.8511813266
MESH:D014591 Uterine Diseases bisphenol A 4.7414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D014604 Uveal Neoplasms decitabine 4.6517785578
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.3515577323
MESH:D014652 Vascular Diseases sodium arsenite 4.1617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3015869587 14671159
MESH:D014839 Vomiting Cisplatin 4.4511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
Pathway ID Pathway Name
REACT:21257 Metabolism of RNA
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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