AutismKB 2.0

Annotation Detail for STAT2


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Basic Information Top
Gene Symbol:STAT2 ( ISGF-3,MGC59816,P113,STAT113 )
Gene Full Name: signal transducer and activator of transcription 2, 113kDa
Band: 12q13.2
Quick LinksEntrez ID:6773; OMIM: 600556; Uniprot ID:STAT2_HUMAN; ENSEMBL ID: ENSG00000170581; HGNC ID: 11363
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04630Jak-STAT signaling pathway
hsa04062Chemokine signaling pathway
No data
Pathway IDPathway Name
200083CXCR4-mediated signaling events
200023IL27-mediated signaling events
Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00047PDGF signaling pathway
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C005975 3,4-dihydroxyphenylethanol [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNAaffects cotreatment|decreases expression 16797527
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of STAT2 mRNAincreases expression 18648102
D015081 2-Naphthylamine 2-Naphthylamine results in decreased expression of STAT2 mRNAdecreases expression 18247414
D001151 Arsenic Arsenic affects the expression of STAT2 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of STAT2 mRNAdecreases expression 18247414
C055162 clopidogrel clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of STAT2 mRNA]decreases reaction|increases expression 19172522
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of STAT2 mRNAdecreases expression 19638242
D004317 Doxorubicin Doxorubicin results in increased expression of STAT2 mRNAincreases expression 16001973
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of STAT2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of STAT2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAT2 mRNAaffects cotreatment|increases expression 17942748
C006552 kaempferol [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNAaffects cotreatment|decreases expression 16797527
D008070 Lipopolysaccharides clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of STAT2 mRNA]decreases reaction|increases expression 19172522
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of STAT2 mRNAincreases expression 17321000
D009538 Nicotine Nicotine results in decreased expression of STAT2 mRNAdecreases expression 18247414
C006253 pirinixic acid pirinixic acid results in decreased expression of STAT2 mRNAdecreases expression 17321000
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in decreased expression of STAT2 mRNA]affects reaction|decreases expression 17321000
D011794 Quercetin [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNAaffects cotreatment|decreases expression 16797527
D013629 Tamoxifen Tamoxifen affects the expression of STAT2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAT2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of STAT2 mRNAincreases expression 17942748
D014212 Tretinoin STAT1 protein affects the reaction [Tretinoin results in increased expression of STAT2 protein]affects reaction|increases expression 16918696
D014635 Valproic Acid Valproic Acid results in increased expression of STAT2 mRNAincreases expression 19101580
D014810 Vitamin E [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNAaffects cotreatment|decreases expression 16797527
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT2 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0311752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.038875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8419490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.749612607
MESH:D054058 Acute Coronary Syndrome clopidogrel 5.9219106084
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.7618653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.7618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9420127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 6.9417418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9414692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.833712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.836695378
MESH:D000236 Adenoma Diethylnitrosamine 10.8310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.7918056438 17620307 17162532 19061943 16434500 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.7916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.7916835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1317306315
MESH:D000419 Albuminuria Doxorubicin 4.4621441931
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000544 Alzheimer Disease Nicotine 3.2616627626
MESH:D000550 Amblyopia Valproic Acid 5.1517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1617084956
MESH:D001008 Anxiety Disorders Valproic Acid 3.5017497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8418414634 16251483 16835338 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.0216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8915336622
MESH:D050197 Atherosclerosis Arsenic 3.2019371607 12928151
MESH:D001321 Autistic Disorder Valproic Acid 2.0117157402 18177632 17507914 18985861 17688650 18775368 20603192 15238991 18316065 18940202 18558336 19232924 19460635 18396377 16609825
MESH:D001327 Autoimmune Diseases Quercetin 4.3219761891
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9411289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.0317594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.7919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.7912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.7916197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.838888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6214601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.7317150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6717474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.6717474063
MESH:D001943 Breast Neoplasms Doxorubicin 4.6717369602 15993339 19526202 15634643 16115903 18695136 11325840 17983394 18628466 15994142 16096432 16595493 18382427 15668708 16935488 15939500 16264153 15567936 15136595 15692762 18234424 16826403 17426702 16322301
MESH:D001943 Breast Neoplasms kaempferol 4.6716756079
MESH:D001943 Breast Neoplasms Quercetin 4.6718628248
MESH:D001943 Breast Neoplasms Tamoxifen 4.6719084267 19011961 18821012 19288272 18984771 18425577 20065188 19487384 19059307 17049068 18997820 19200415 16273361 21138602 15565566 16873071 19244106 17440819 16202921 19410462 19142967 20859285 20005174 15668708 18629630 20390343 17242785 17261762 19066611 21152245 19155303 20135344 18815881 19189212 17893378 18855134 11161223 19221464 18351453 16818667 19103187 19289846 20544844 19115204 19189210
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6720435547
MESH:D001943 Breast Neoplasms Tretinoin 4.6716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002105 Cadmium Poisoning Quercetin 5.4616962696
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8416050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5417687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.897296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.8917306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.8918691550 20101231 20432363 19171122 20727157 19519916 19919837 20512989 16569478 16807293 16502159 18506893 20514400 19701751 16681979 18978308 10737359 20084675 10672840 17173139 18665156 19394651 19418558 19335982 16878318 3581430 18788625 18393292 3084413 17138121 20214788 16288022 18971187 21159647 16935385 17761372 16328049 16540662 19208518 20007298 17055752 16830150 18056438 19822196 18785209 16779866 17428255 19539802 18210153 17162532 20935162 19383236 19107877 16698587 17978847 20524982 19052882 18494052 11831363
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.8917876044 16023760 18059187 16234567
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.8919519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.8916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.891917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8717234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.417296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.411485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.6115504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.6120419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.616189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.6116096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 9.2418640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.2417572228
MESH:D006332 Cardiomegaly Quercetin 6.6419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6418670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4717974986 18627295 15811867 16455267 17382496 17519947 16952015 15476868 16278810 17131338 17928571 16364871 17007740 17308081 16269455 17329180 16109756 16612575 15505089 16651473 16731534 17351982 15792986 16242529 17924179
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9217334414 16243910
MESH:D002318 Cardiovascular Diseases Arsenic 12.2015738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases clopidogrel 12.2020180610
MESH:D002318 Cardiovascular Diseases kaempferol 12.2016756079
MESH:D002340 Carotid Artery Diseases Arsenic 4.2316973168 18022660
MESH:D002386 Cataract Tretinoin 3.0417460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.497505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.4917174075 2727394 21159647 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.999022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.9916105132 17110522 17681005 16919318 11677210 15861022 17333356
MESH:D002779 Cholestasis pirinixic acid 12.9919176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6412621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.649407595
MESH:D003092 Colitis Tretinoin 3.6217035595
MESH:D003110 Colonic Neoplasms Quercetin 2.4119440933 11134977 17148506 19056647 16640504 17191121 15741050
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.7018259882 18802399
MESH:D015179 Colorectal Neoplasms Quercetin 2.7018852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3220055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.329125849 8800419 17551590 14991402 10589399 9142499 9211117 16925845 9664655 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.3216575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.3219769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2819031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7212868966 8970840 2524372 11298694 18759878 11906362 14531868 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.413621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.6619496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1517107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4019279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.7418289764 18692083 6679447 9653073 7440962 1440618 16192314 9022650 6482804 8291058 9328219 18648102 11289319
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.7419107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.7417416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.7420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.741733752 19641884
MESH:D004362 Drug Toxicity Doxorubicin 13.4118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.4111462148
MESH:D004362 Drug Toxicity Zidovudine 13.4115040536
MESH:D004421 Dystonia Valproic Acid 3.961851702
MESH:D020821 Dystonic Disorders Nicotine 5.8417881519
MESH:C538011 Eales disease Vitamin E 4.629068938
MESH:D004487 Edema pirinixic acid 6.2712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.6718230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.6718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.6612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.6619031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.1617359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.1616202921 20544844 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 12.1616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0818037988
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3115821434 17637181 15328337
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.073659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.8416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.517562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.217750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.983659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.293581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.619664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 29.6720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.6715345470
MESH:D005234 Fatty Liver pirinixic acid 29.6720131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 29.6714986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 29.6719224547 14986274
MESH:D005234 Fatty Liver Zidovudine 29.6718299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.0418558336 8888407
MESH:D005334 Fever Lipopolysaccharides 3.9311852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.946705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4414745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.1619069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.1619069698
MESH:D005355 Fibrosis Quercetin 14.3219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.3220067830
MESH:D005355 Fibrosis Tretinoin 14.3217994277
MESH:D005534 Foot Diseases Arsenic 5.486392382
MESH:D005909 Glioblastoma Doxorubicin 11.6117150277
MESH:D005909 Glioblastoma Quercetin 11.6119804834
MESH:D005909 Glioblastoma Tretinoin 11.6117312396
MESH:D005910 Glioma Quercetin 3.0217643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.957505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.6515692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.6516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 15.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.5811294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 15.589664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 15.5816080930
MESH:D006331 Heart Diseases Doxorubicin 3.4212587719 16330681 18006777 17875725 18674790 17888722 16144979 16879835 14766674 16244371 16495754 16707910 16244372
MESH:D006333 Heart Failure Doxorubicin 6.8717481944
MESH:D006333 Heart Failure pirinixic acid 6.8720558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8215692506
MESH:D006402 Hematologic Diseases Zidovudine 4.6312579204
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3016366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.436705139
MESH:D006529 Hepatomegaly pirinixic acid 7.9719176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9712621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6716863852 16490937
MESH:D015658 HIV Infections Zidovudine 3.4417358032 11698656 11141242 11363243 20032539
MESH:D006689 Hodgkin Disease Doxorubicin 3.3315147373 18501091 17606976
MESH:D019584 Hot Flashes Vitamin E 3.8914716179
MESH:D006849 Hydrocephalus Valproic Acid 4.7817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9616959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.1416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006943 Hyperglycemia kaempferol 15.3418262572
MESH:D006943 Hyperglycemia pirinixic acid 15.3420558911
MESH:D006943 Hyperglycemia Quercetin 15.3411834736 18262572
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3817050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8515034207
MESH:D006973 Hypertension Arsenic 8.4916076760 9931084 11953799
MESH:D006973 Hypertension Quercetin 8.4918356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.4918850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.4816093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4317937319
MESH:D007249 Inflammation Diethylnitrosamine 11.5918785209
MESH:D007249 Inflammation Lipopolysaccharides 11.5917237260 12878042 17255318 9205823 17963957
MESH:D007249 Inflammation Tamoxifen 11.5919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.5912878042 12200463
MESH:D007251 Influenza, Human Quercetin 10.8016624496
MESH:D007251 Influenza, Human Vitamin E 10.8016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.5517255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.949022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.6616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.6617551590 15992940
MESH:D007627 Keloid Quercetin 4.8717086741
MESH:D007642 Keratosis Arsenic 4.9016930632 12749816
MESH:D007674 Kidney Diseases Doxorubicin 9.9315699352 15369732 16775033
MESH:D007674 Kidney Diseases Quercetin 9.9316962696
MESH:D007674 Kidney Diseases Vitamin E 9.9312488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0716707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.096582329
MESH:D007680 Kidney Neoplasms Tamoxifen 12.0918625569
MESH:D007680 Kidney Neoplasms Zidovudine 12.0912579204
MESH:D007938 Leukemia kaempferol 10.4417468513
MESH:D007938 Leukemia Quercetin 10.4417468513
MESH:D007938 Leukemia Tretinoin 10.4417143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0816085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.3320370541
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6216932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8316294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8316294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.5717339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5717506722 17712046 17217047 9834237 19225113 16766008 17361223 16823087 12679006 17107899 16891316 17339181 17301526 17368321 16140955 19075265 16935935 16331271 19029980 16788101 15748426 17294898 19035177 19642359 17649720
MESH:D007970 Leukopenia Lipopolysaccharides 4.6115821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008064 Lipidoses Tamoxifen 3.0915342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7818522880 20032147 18665156 19638242 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 13.0916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 13.0912878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 13.0915474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 13.0912741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 13.0918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 13.0912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 13.0916248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 13.0916169303
MESH:D008107 Liver Diseases Arsenic 4.1611134558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1617034775
MESH:D008113 Liver Neoplasms Arsenic 21.4116368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.4120195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.4121278145 19551842 20405173 15175105 12112319 18648771 19690152 18977376 10737359 19294768 20492335 19090486 19642983 20118626 19073162 2422723 2862719 19254457 19638242 20501860 19812893 18978307 20137499 18644402 16942905 20101389 21047994 19427195 19996281 19850985 21071580 9163691 19255062 20583210 19833225 19426721 19499222 20452335 20434301 19256749 18754104 21167192 12771043 15885732
MESH:D008113 Liver Neoplasms pirinixic acid 21.4120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 21.4118980244
MESH:D008113 Liver Neoplasms Tamoxifen 21.4116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.4116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.076587162 598648 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.0719126423 2563599 16842330 19009564 18253720 19539802 17942915 17174075 9362446 19519916 18308698 16267830 3124819 18775883 18079962 19004024 18164116 21159647 18282651 18544905 17854601 18093689
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 18.0716842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 18.0719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.0712151625
MESH:D008171 Lung Diseases Vitamin E 3.1216863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1817228818
MESH:D055370 Lung Injury Lipopolysaccharides 3.9221114838
MESH:D008175 Lung Neoplasms Arsenic 15.2517306315 17976673 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.2518816296 17053015 20135361 18520028 6695378 18569708 20869020 20464547 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.2520970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 15.256189445 17418594
MESH:D008175 Lung Neoplasms Quercetin 15.2516280456
MESH:D008175 Lung Neoplasms Tamoxifen 15.2518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.2519555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 15.2511062179
MESH:D008175 Lung Neoplasms Zidovudine 15.2518800350
MESH:D008223 Lymphoma Doxorubicin 3.4016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4815621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6719428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.9515458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.9516827153 14580682 19196723 19196722 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.4719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma Doxorubicin 5.0416827129
MESH:D008545 Melanoma Tamoxifen 5.0419393235 12393984
MESH:D008545 Melanoma Tretinoin 5.0416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1015990972
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D008654 Mesothelioma Doxorubicin 3.0217638057
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.7617358032
MESH:D008881 Migraine Disorders Valproic Acid 3.1318803445 18765137
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4215792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D052016 Mucositis Doxorubicin 4.7017415656
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.948888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.2317596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.2317596541
MESH:D009203 Myocardial Infarction Doxorubicin 9.2915857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 9.2919151258
MESH:D009203 Myocardial Infarction Quercetin 9.2919595682
MESH:D017202 Myocardial Ischemia Arsenic 8.7615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2116411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.2119207477
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 17.583581430
MESH:D009362 Neoplasm Metastasis clopidogrel 17.5811875746
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 17.589029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 17.5818259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 17.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 15.2911141357
MESH:D009369 Neoplasms Nicotine 15.2916365874
MESH:D009369 Neoplasms pirinixic acid 15.2917405874
MESH:D009369 Neoplasms Quercetin 15.2915185748
MESH:D009369 Neoplasms Tretinoin 15.2916946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9219200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Nicotine 4.9116365874
MESH:D009401 Nephrosis Doxorubicin 4.6816899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9216889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2214600291
MESH:D009421 Nervous System Malformations Tretinoin 9.229125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 16.876679447
MESH:D009436 Neural Tube Defects Arsenic 16.8716620997
MESH:D009436 Neural Tube Defects Tretinoin 16.879142499
MESH:D009436 Neural Tube Defects Valproic Acid 16.8716359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.2215555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2720387270
MESH:D020078 Neurogenic Inflammation Arsenic 10.4117056641
MESH:D020078 Neurogenic Inflammation Quercetin 10.4117929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0420387270
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.344026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.943988306
MESH:D010024 Osteoporosis kaempferol 4.2916756079
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.1319495926
MESH:D012516 Osteosarcoma Doxorubicin 4.0415930896
MESH:D010051 Ovarian Neoplasms Arsenic 7.8317306315
MESH:D010051 Ovarian Neoplasms Quercetin 7.8319005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.8316936753
MESH:D010146 Pain Tretinoin 2.8316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.4716540662
MESH:D010190 Pancreatic Neoplasms Quercetin 8.4716965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.4715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.407296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.9015371236 6392382 16905509
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.396228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0817638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.4711605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.972563599
MESH:D011230 Precancerous Conditions Quercetin 8.9719056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.1811118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.1820603192
MESH:D011471 Prostatic Neoplasms Arsenic 1.8916140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8916888761 15897917 15749863 18437689 16868541 16729912
MESH:D011471 Prostatic Neoplasms Quercetin 1.8917292933 14715546
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011507 Proteinuria Arsenic 9.0021343184
MESH:D011507 Proteinuria Tretinoin 9.0016636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2316919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.4612752131 11422049
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D051437 Renal Insufficiency Doxorubicin 4.1317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6710835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.313692021
MESH:D012170 Retinal Vein Occlusion clopidogrel 6.0419371211
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5816283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.5819155313
MESH:D012509 Sarcoma Doxorubicin 3.9118313854 16767912 17203757 17710206 15675481 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7017846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.4616862918
MESH:D012559 Schizophrenia Valproic Acid 2.0619110320 15737665
MESH:D012640 Seizures Nicotine 6.2117873105
MESH:D012640 Seizures Valproic Acid 6.2111738929 3137016 14763951 15475178 16876388 11044598 1511512 17978042
MESH:D012871 Skin Diseases Arsenic 4.9617050553 16702368 17548696 6392382 17938729 19834688 15952646 16759981 16353154 17453740 18709164
MESH:D012871 Skin Diseases Vitamin E 4.9618709164
MESH:D012878 Skin Neoplasms Arsenic 17.4917029826 16251483 17976673 19538983 15504454 17050553
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.4910029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 17.4915692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.4916192470
MESH:D012878 Skin Neoplasms Tretinoin 17.4916467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4816767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2916709447
MESH:D013088 Spermatocele Tamoxifen 11.2916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9519457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.672093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6718456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.6717261132
MESH:D013274 Stomach Neoplasms Zidovudine 4.6717696246
MESH:D020521 Stroke Vitamin E 3.4516517955
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0815821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 16.551399818 3712494 7505956 6582329 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.557505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 16.5517909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 16.5517045167 16026305
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.6611259349 16720336 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 5.3615735609 17979512 18305452 18041664
MESH:D014062 Tongue Neoplasms Tretinoin 3.7116051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.1517262798
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.443119515
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 23.6411144890
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 23.648074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 23.6411144890 18640142 17306315 19429237 19322015 15987713 17976673
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 23.6417053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 23.6417653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 23.6416720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 23.648653321 16712894 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.568888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5316752155
MESH:D014625 Vaginal Neoplasms Zidovudine 4.6712579204
MESH:D014652 Vascular Diseases Arsenic 4.6517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1317638931 16364871 17678736 17334414
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:05160 Hepatitis C
KEGG:04630 Jak-STAT signaling pathway
KEGG:05162 Measles
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36184
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA445451Psoriasis
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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