AutismKB 2.0

Annotation Detail for STAT4


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Basic Information Top
Gene Symbol:STAT4 ( SLEB11 )
Gene Full Name: signal transducer and activator of transcription 4
Band: 2q32.2-q32.3
Quick LinksEntrez ID:6775; OMIM: 600558; Uniprot ID:STAT4_HUMAN; ENSEMBL ID: ENSG00000138378; HGNC ID: 11365
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
No data
Pathway IDPathway Name
200034IL12-mediated signaling events
200184Downstream signaling in naive CD8+ T cells
200131IL23-mediated signaling events
200023IL27-mediated signaling events
200197IL12 signaling mediated by STAT4
Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00047PDGF signaling pathway
P00038JAK/STAT signaling pathway
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
rheumatoid arthritis
diabetes, type 1
Asthma
systemic lupus erythematosus
IMMUNE
Arthritis, Rheumatoid
psoriasis
Desease Name
Systemic sclerosis
Rheumatoid arthritis
Systemic lupus erythematosus
Desease Name
Systemic lupus erythematous, association with susceptibility to, 11
Rheumatoid arthritis, association with
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of STAT4 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of STAT4 mRNAdecreases expression 12205029
D003913 Dextroamphetamine SOD1 inhibits the reaction [Dextroamphetamine results in decreased expression of STAT4 mRNA]decreases expression|decreases reaction 12205029
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of STAT4 mRNAdecreases expression 18687144
C007020 chlorophyllin chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT4 protein]decreases reaction|increases activity 16275627
D003474 Curcumin Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein]increases phosphorylation|increases reaction 17979888
D003474 Curcumin Curcumin results in decreased expression of STAT4decreases expression 18462866
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of STAT4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAT4 mRNAaffects cotreatment|increases expression 17942748
C054591 hachimijiogan hachimijiogan results in decreased phosphorylation of STAT4 proteindecreases phosphorylation 12022442
C038753 leptomycin B leptomycin B affects the localization of STAT4 proteinaffects localization 15004198
D008070 Lipopolysaccharides chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT4 protein]decreases reaction|increases activity 16275627
D008770 Methylnitrosourea STAT4 gene mutant form results in increased susceptibility to Methylnitrosoureaincreases response to substance 11418001
C029938 nickel sulfate nickel sulfate results in increased expression of STAT4 mRNAincreases expression 16780908
D010672 Phenytoin Phenytoin results in decreased expression of STAT4 mRNAdecreases expression 14741686
D018038 Sodium Selenite Sodium Selenite results in increased expression of STAT4 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAT4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of STAT4 mRNAincreases expression 18684927
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased phosphorylation of STAT4 proteinincreases phosphorylation 18684927
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 8.9610563481 8986270 9118846 3425630 9677735 6195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.6818653653 11850527
MESH:D055371 Acute Lung Injury nickel sulfate 9.6811954676 16100012 19131640 12718980
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.6414692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 4.6415113128 15688392
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.1817887948
MESH:D000544 Alzheimer Disease Curcumin 2.6315590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 20453842
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7516807698
MESH:D050197 Atherosclerosis Curcumin 7.2618704882
MESH:D050197 Atherosclerosis Phenytoin 7.2615136057
MESH:D001327 Autoimmune Diseases Curcumin 4.5619761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D002545 Brain Ischemia Curcumin 4.4116770732
MESH:D001932 Brain Neoplasms Curcumin 3.9917596214
MESH:D001943 Breast Neoplasms Curcumin 2.0218593918 19250217 16243823 18462866
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.0211306469 14633655 16253758
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002277 Carcinoma Curcumin 8.4318593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4316835633
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9918414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.7718462866
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 16120746 18670907
MESH:D002386 Cataract Methylnitrosourea 4.0212484553
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 3.832727394 7505956
MESH:D002493 Central Nervous System Diseases Phenytoin 5.374080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9111677210 17110522 16105132 15861022 17681005 17333356 16919318
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.9511748493
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D002971 Cleft Lip Phenytoin 4.182227380
MESH:D002972 Cleft Palate Phenytoin 6.236862529 1687470 3877104 6856622 10789828 2227380
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.2316354765 8697196 12621046 15340226 15668235
MESH:D003092 Colitis Curcumin 4.2518200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 11.5118809619
MESH:D003103 Coloboma Phenytoin 11.519212184
MESH:D003110 Colonic Neoplasms Curcumin 2.5116340194 19359593
MESH:D000013 Congenital Abnormalities Phenytoin 9.5510627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.5514669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.9718497527
MESH:D019465 Craniofacial Abnormalities Phenytoin 2.868986270 9212184 19952982
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8615322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.7416823706 11298694 16780908
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.4518403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.0618204486
OMIM:607208 DRAVET SYNDROME Phenytoin 5.4611748493
MESH:D003875 Drug Eruptions Phenytoin 5.5715024534
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 3.8615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004381 Duodenal Ulcer Curcumin 4.1117351913
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.5812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 9.5817654737
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4815821434 17637181 15328337
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 5.2620235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.336251365 1399206
MESH:D004828 Epilepsies, Partial Phenytoin 5.0117116037 11558140
MESH:D004827 Epilepsy Phenytoin 3.96821787 11434505 20417680
MESH:D017029 Epilepsy, Complex Partial Phenytoin 5.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 5.153659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Curcumin 8.0719297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0715345470
MESH:D005313 Fetal Death Phenytoin 10.9810627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 10.9811858732
MESH:D005334 Fever Lipopolysaccharides 4.069205823 11852909
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.3111555667
MESH:D005355 Fibrosis Curcumin 9.0318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0320067830
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.7718462866
MESH:D005885 Gingival Hyperplasia Phenytoin 5.759029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.3316390469 14659971
MESH:D005909 Glioblastoma Curcumin 3.5117596214
MESH:D005910 Glioma Methylnitrosourea 3.589825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.6918462866 18829502
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3611294989 10048152
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.1117701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 15340226 16959395 18606429 16354765
MESH:D006937 Hypercholesterolemia Curcumin 4.1118704882
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.7210459572
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0617937319
MESH:D007248 Infertility, Male Methylnitrosourea 7.067193160
MESH:D007249 Inflammation Curcumin 8.5718403477 16956363 17151092
MESH:D007249 Inflammation Lipopolysaccharides 8.5717237260 12878042 17255318 9205823 17963957
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5712878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2318200517 18596194
MESH:D007333 Insulin Resistance Sodium Selenite 3.3114714311
MESH:D007414 Intestinal Neoplasms Curcumin 4.2710783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007889 Leiomyoma Curcumin 4.6318555241
MESH:D007938 Leukemia Curcumin 3.2618462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.2616106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.8316106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.7815821434
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.2415526292
MESH:D008105 Liver Cirrhosis, Biliary marker/mechanism 21399635
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.6117355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.6112878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6112878042
MESH:D008107 Liver Diseases Curcumin 4.7216956363
MESH:D008107 Liver Diseases Phenytoin 4.7214986274
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1412151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.5416080182
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.5517365036
MESH:D055370 Lung Injury Lipopolysaccharides 9.5521114838
MESH:D008175 Lung Neoplasms Curcumin 3.6019359593 16243823 18462866
MESH:D008175 Lung Neoplasms Methylnitrosourea 3.6018062963
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6019555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism 18204446 19838193
MESH:D008223 Lymphoma Curcumin 8.1218462866
MESH:D008223 Lymphoma Methylnitrosourea 8.1216257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 10.6514633661
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 10.6514737004
MESH:D016399 Lymphoma, T-Cell Curcumin 4.7716173963
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.6116944150 11807958 15688392 16619500 14999141 15113128 10838139 15313902 17020996 16827153 14633655 17131329 16051031 12931682 10767621 11751437 19196723
MESH:D008545 Melanoma Curcumin 2.4218462866 17885582
MESH:D008569 Memory Disorders Curcumin 4.2217263510
MESH:D008607 Mental Retardation Phenytoin 3.689212184
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2016966607 16166281 18303189
MESH:D009041 Motion Sickness Dextroamphetamine 5.621613127
MESH:D009101 Multiple Myeloma Curcumin 3.5519372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.0017962980
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.6017484760
MESH:D009224 Myotonia Congenita Phenytoin 5.491896199
MESH:D009361 Neoplasm Invasiveness Curcumin 4.4318495463
MESH:D009369 Neoplasms Methylnitrosourea 3.3315533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.5412696579
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.6312497104
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.7318462866
MESH:D009436 Neural Tube Defects Phenytoin 4.169118846
MESH:D009442 Neurilemmoma Methylnitrosourea 5.5711555667
MESH:D009765 Obesity Curcumin 2.7619297423
MESH:D010018 Osteomalacia Phenytoin 5.4917016548
MESH:D010024 Osteoporosis Curcumin 3.5018719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8319020741 18462866
MESH:D010146 Pain Phenytoin 4.0215215642
MESH:D010190 Pancreatic Neoplasms Curcumin 5.8319401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 5.8316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9610923243
MESH:D011014 Pneumonia Lipopolysaccharides 4.6411605937 12224865
MESH:D017689 Polydactyly Phenytoin 5.099212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Curcumin 2.7612497104 18769126 15129424 18226269 11398177 18156803 10851300
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.7615682402 12376480
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.7618760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
MESH:D019310 Pseudolymphoma Phenytoin 5.648603615 1419762 12752131
MESH:D011656 Pulmonary Emphysema Curcumin 4.5819168576
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0515814490 17365031 17322281 17975199
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.0810666014 18379247
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.4518155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.5711555667
MESH:D012509 Sarcoma Curcumin 4.1718462866
MESH:D012595 Scleroderma, Systemic marker/mechanism 20383147
MESH:D012640 Seizures Phenytoin 3.7710029267 3691417 3137016 16876388 11044598 9844417 15946322 19919933
MESH:D018805 Sepsis Curcumin 4.1218389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 5.2320235791
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.6918593901 15930296 16257854
MESH:D013276 Stomach Ulcer Curcumin 3.5519188055 16631530
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2115821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.3111418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 3.967505956 3078959
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.9118593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.3518462866
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5915869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36185
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA443815Crohn Disease
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443434Arthritis, Rheumatoid
    PA446149Panniculitis, Lupus Erythematosus
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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