AutismKB 2.0

Annotation Detail for STAT5A


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Basic Information Top
Gene Symbol:STAT5A ( MGF,STAT5 )
Gene Full Name: signal transducer and activator of transcription 5A
Band: 17q21.2
Quick LinksEntrez ID:6776; OMIM: 601511; Uniprot ID:STA5A_HUMAN; ENSEMBL ID: ENSG00000126561; HGNC ID: 11366
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04012ErbB signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by PDGF
Signaling in Immune system
Pathway IDPathway Name
200034IL12-mediated signaling events
200031CD40/CD40L signaling
200033Signaling events mediated by PTP1B
200183Trk receptor signaling mediated by PI3K and PLC-gamma
200009ErbB4 signaling events
200131IL23-mediated signaling events
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200157EPO signaling pathway
200015GMCSF-mediated signaling events
200127PDGFR-beta signaling pathway
200082IL2-mediated signaling events
200083CXCR4-mediated signaling events
200066Angiopoietin receptor Tie2-mediated signaling
200065Signaling events mediated by TCPTP
200018IL4-mediated signaling events
200023IL27-mediated signaling events
200190RAC1 signaling pathway
Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00047PDGF signaling pathway
P00038JAK/STAT signaling pathway
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of STAT5A mRNAincreases expression 20826375
D000082 Acetaminophen Acetaminophen affects the expression of STAT5A mRNAaffects expression 17562736
C095512 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [GH1 protein results in increased phosphorylation of STAT5A protein]decreases reaction|increases phosphorylation 18388193
D000643 Ammonium Chloride Ammonium Chloride affects the expression of STAT5A mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of STAT5A proteindecreases expression 18349030
C015001 arsenite arsenite results in decreased expression of STAT5A mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of STAT5A mRNA]affects reaction|decreases expression 18929588
C030233 benzo(a)pyrene-1,6-quinone benzo(a)pyrene-1,6-quinone results in increased phosphorylation of STAT5A proteinincreases phosphorylation 19166869
C018003 benzo(a)pyrene-3,6-quinone benzo(a)pyrene-3,6-quinone results in increased phosphorylation of STAT5A proteinincreases phosphorylation 19166869
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of STAT5A mRNAaffects cotreatment|decreases expression 18164116
C006780 bisphenol A bisphenol A results in increased expression of STAT5A mRNAincreases expression 20826375
D001971 Bromocriptine Bromocriptine affects the localization of STAT5A proteinaffects localization 17884938
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of STAT5A mRNAdecreases expression 12766906
D003474 Curcumin Curcumin results in decreased expression of STAT5A proteindecreases expression 16959222
D003474 Curcumin Curcumin results in increased cleavage of STAT5A proteinincreases cleavage 16959222
D003474 Curcumin Curcumin results in decreased expression of STAT5Adecreases expression 18462866
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of STAT5A mRNAaffects cotreatment|decreases expression 18164116
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of STAT5A mRNAincreases expression 15591538
D004958 Estradiol Estradiol affects the expression of STAT5A mRNAaffects expression 15598610
D004958 Estradiol [Estradiol co-treated with Progesterone] results in increased expression of STAT5A proteinaffects cotreatment|increases expression 17884938
D004958 Estradiol Estradiol results in increased expression of STAT5A mRNAincreases expression 20826375
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of STAT5A mRNAaffects expression 14976129
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of STAT5A mRNAincreases expression 16467188
12072388
C029938 nickel sulfate nickel sulfate results in increased expression of STAT5A mRNAincreases expression 16780908
D009569 Nitric Oxide Nitric Oxide results in decreased expression of STAT5A proteindecreases expression 16886906
D009569 Nitric Oxide STAT5A protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]affects reaction|decreases expression 16886906
C406545 pegvisomant pegvisomant inhibits the reaction [GH1 protein results in increased phosphorylation of STAT5A protein]decreases reaction|increases phosphorylation 18388193
C006253 pirinixic acid pirinixic acid results in increased expression of STAT5A mRNAincreases expression 18301758
D011374 Progesterone Progesterone affects the localization of STAT5A proteinaffects localization 16175315
D011374 Progesterone Progesterone results in increased expression of STAT5A proteinincreases expression 16175315
D011374 Progesterone [Estradiol co-treated with Progesterone] results in increased expression of STAT5A proteinaffects cotreatment|increases expression 17884938
D011374 Progesterone STAT5A protein affects the abundance of Progesteroneaffects abundance 15471942
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of STAT5A mRNAdecreases expression 16678137
D014801 Vitamin A Vitamin A affects the phosphorylation of and affects the localization of STAT5A proteinaffects localization|affects phosphorylation 15963505
D014810 Vitamin E Vitamin E results in increased expression of STAT5A mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000015 Abnormalities, Multiple Vitamin A 4.6910992263
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D055371 Acute Lung Injury nickel sulfate 8.5519131640 12718980 16100012 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 8.5518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.7519825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 6.7511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7514692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.5219389873
MESH:D000236 Adenoma Diethylnitrosamine 6.526695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.4518056438 19061943 17162532 16434500 17620307 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.4516434500
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8917887948
MESH:D000544 Alzheimer Disease Curcumin 4.5715590663
MESH:D000544 Alzheimer Disease Nitric Oxide 4.5717556102
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3015469931
MESH:D000740 Anemia Vitamin A 4.3516960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.6316960172
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6916807698
MESH:D001249 Asthma Vitamin A 3.3016732791
MESH:D050197 Atherosclerosis Curcumin 3.2118704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Curcumin 4.3019761891
MESH:D001480 Basal Ganglia Diseases Bromocriptine 6.5715303389
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.4216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4219483382
MESH:D001862 Bone Resorption bisphenol A 3.6911985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1417868700
MESH:D001930 Brain Injuries Progesterone 4.0715665606 15845082 15380490
MESH:D002545 Brain Ischemia Curcumin 4.1416770732
MESH:D001932 Brain Neoplasms Curcumin 3.7717596214
MESH:D001943 Breast Neoplasms bisphenol A 3.6517123778
MESH:D001943 Breast Neoplasms Curcumin 3.6516243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6517474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.6517129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 3.6512948864 17261762 18497071 16675129 19861407 17289903 17018787 14630087
MESH:D001943 Breast Neoplasms Nitric Oxide 3.6515631943
MESH:D001943 Breast Neoplasms Progesterone 3.6515562024 17614352 16175315
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 5.4117426644 17377406
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7416050911
MESH:D002277 Carcinoma Curcumin 3.6818593918
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.533084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.5315073043 16217749 15553829 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.5317162532 16807293 19171122 21159647 20101231 18691550 3084413 19335982 16288022 17761372 17173139 18494052 10672840 19383236 19418558 17428255 16540662 3581430 20214788 18785209 16569478 20524982 18971187 20432363 17138121 20935162 16830150 18056438 20514400 11831363 16935385 16681979 20727157 19822196 18210153 19519916 16698587 20084675 17055752 19107877 17978847 16779866 19539802 20007298 10737359 19394651 19701751 18506893 18978308 16328049 18665156 19052882 18393292 18788625 20512989 19919837 19208518 16502159 16878318
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.5315948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.5316924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8017123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9118414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.7118462866
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.2617174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.2618566989
MESH:D015362 Child Nutrition Disorders Vitamin A 5.2816153327
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5219052882
MESH:D002779 Cholestasis Ethinyl Estradiol 18.1917681005 15861022 11677210 17110522 16919318 17333356 16105132
MESH:D002779 Cholestasis Nitric Oxide 18.1916919318
MESH:D002779 Cholestasis pirinixic acid 18.1919176532
MESH:D002779 Cholestasis Vitamin A 18.1916175620
MESH:D002972 Cleft Palate Vitamin A 3.6016054864
MESH:D003092 Colitis Curcumin 3.9918200517 16804969 16782535
MESH:D003103 Coloboma Curcumin 4.3818809619
MESH:D003110 Colonic Neoplasms arsenite 5.8415037631
MESH:D003110 Colonic Neoplasms Curcumin 5.8416340194 19359593
MESH:D003110 Colonic Neoplasms Vitamin A 5.8416267017 17219422
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D016510 Corneal Neovascularization Curcumin 4.7118497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8610525206
MESH:D019465 Craniofacial Abnormalities Vitamin A 3.8610992263
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8619769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3716002989 12952375
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9215213294
MESH:D015140 Dementia, Vascular Nitric Oxide 5.7717556102
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.4916780908 11298694 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4516506275
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.4418403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4420387270
MESH:D003928 Diabetic Nephropathies Curcumin 8.5018204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.5019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3017187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5616227642 18071297 16177239 19739265 14986274 16393943 19085960 17562736 15968718 19420014 16081117 18713872 16109766 17906064 11834606 19416960 17522070 11287661 11421492 11739529 10774834 12594235 15619225 11529661 12392966 11743745 12958197 19370779 12705907 16781746 10663392 19164858 16485898 10915739 2444490 12153990 19923254 14725611 14550746 12540782 11461765
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.5619107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D015352 Dry Eye Syndromes Vitamin A 5.6116146918
MESH:D004381 Duodenal Ulcer Curcumin 3.8717351913
MESH:C538011 Eales disease Vitamin A 12.489068938
MESH:C538011 Eales disease Vitamin E 12.489068938
MESH:D004480 Ectromelia Vitamin A 5.6316054864
MESH:D004487 Edema pirinixic acid 2.3112083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.4212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.4217692515
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5016402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.1316804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 7.1318566989 11473722 19148513
MESH:D004715 Endometriosis Progesterone 3.6016134523
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2612903497
MESH:D005234 Fatty Liver arsenic trioxide 28.4715073043
MESH:D005234 Fatty Liver arsenite 28.4718296743
MESH:D005234 Fatty Liver Curcumin 28.4719297423
MESH:D005234 Fatty Liver Diethylnitrosamine 28.4720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.4715345470
MESH:D005234 Fatty Liver pirinixic acid 28.4719236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5416002989 16611131 15751030 16513791 16534752
MESH:D005327 Fetal Resorption Vitamin A 5.1716054864
MESH:D005355 Fibrosis arsenite 8.5818296743
MESH:D005355 Fibrosis Curcumin 8.5818705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0816904648
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5018462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7516452187
MESH:D005909 Glioblastoma Curcumin 3.3517596214
MESH:D006261 Headache Nitric Oxide 4.9811554966 11284996
MESH:D006258 Head and Neck Neoplasms Curcumin 3.5318829502 18462866
MESH:D006330 Heart Defects, Congenital Vitamin A 6.8210992263 16080930
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8216080930
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006529 Hepatomegaly pirinixic acid 2.8119176532 18467677 16221962 19772884
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8517701891
MESH:D006548 Hernia, Diaphragmatic Vitamin A 5.9515707848 16877224 16490937 16863852 17436238 16292552
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.9516863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D015658 HIV Infections Vitamin A 3.7216960176
MESH:D006679 HIV Seropositivity Vitamin A 5.4117209195
MESH:D019584 Hot Flashes Estradiol 9.4117088409
MESH:D019584 Hot Flashes Vitamin E 9.4114716179
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006937 Hypercholesterolemia Curcumin 3.8818704882
MESH:D006940 Hyperemia Nitric Oxide 5.4211156591
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2514722030 12960047
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.2815838368
MESH:D006986 Hypervitaminosis A Vitamin A 5.9816054864
MESH:D007021 Hypospadias Diethylstilbestrol 10.6116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.6116569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2115869954
MESH:D007246 Infertility Diethylstilbestrol 4.1715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3617937319
MESH:D007249 Inflammation Curcumin 7.8717151092 16956363 18403477
MESH:D007249 Inflammation Diethylnitrosamine 7.8718785209
MESH:D007249 Inflammation Progesterone 7.8715869954
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1318200517 18596194
MESH:D007251 Influenza, Human Vitamin E 4.0216624496
MESH:D007333 Insulin Resistance bisphenol A 11.6016393666
MESH:D007333 Insulin Resistance Estradiol 11.6016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.6016306350
MESH:D007410 Intestinal Diseases Nitric Oxide 4.7411713966 11574821 10210152
MESH:D007414 Intestinal Neoplasms Curcumin 4.0510783313
MESH:D019586 Intracranial Hypertension Vitamin A 5.6315955940
MESH:D007674 Kidney Diseases Acetaminophen 9.4012587719 15629191
MESH:D007674 Kidney Diseases Estradiol 9.4015618244
MESH:D007674 Kidney Diseases Vitamin E 9.4012488133
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.0315003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 7.0315610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8717184923
MESH:D007889 Leiomyoma Curcumin 4.3918555241
MESH:D007896 Leishmaniasis Nitric Oxide 4.4917218153
MESH:D007938 Leukemia arsenic trioxide 6.2015070760
MESH:D007938 Leukemia Curcumin 6.2018462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.1917077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.1916106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1116968895 16467208 19850784 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.099834237 16891316 12712474 17217047 17712046 17869043 17107899 15622746 16112521 17649720 19642359 15213294 16330433 19225113 19035177 19075265 11468182 16823087 12018890 11161223 12679006 15336539 16331271 15748426 16966277
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.1016882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.1016106398
MESH:D017880 Limb Deformities, Congenital Vitamin A 4.1816054864
MESH:D008103 Liver Cirrhosis arsenite 10.6318296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.6320032147 18522880 18665156 18407596 19638242
MESH:D008103 Liver Cirrhosis Vitamin A 10.6316256175
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.5017355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 6.5016248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.5016169303
MESH:D008107 Liver Diseases Acetaminophen 9.0219460945 16610002 12969438 19014921 19784758 11587558 16611625 12587719
MESH:D008107 Liver Diseases Curcumin 9.0216956363
MESH:D008107 Liver Diseases Diethylnitrosamine 9.0217034775
MESH:D008107 Liver Diseases Vitamin A 9.0216175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.9716762690
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0717185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 13.4814682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 13.4821295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.4821047994 19090486 20405173 19690152 9163691 19294768 19427195 19551842 21278145 20118626 19073162 20501860 19499222 15175105 19812893 18644402 19256749 20583210 10737359 18648771 19638242 20101389 19833225 19996281 20452335 12112319 15885732 18978307 16942905 2862719 20492335 19850985 19426721 2422723 21167192 19255062 19642983 18754104 20434301 20137499 19254457 18977376 21071580 12771043
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.4815890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 13.4816377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.2420377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.2418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.2421159647 18282651 18544905 19539802 18775883 19519916 18079962 2563599 3124819 18308698 19004024 17854601 18164116 9362446 18253720 16842330 19126423 19009564 18093689 16267830 17942915 17174075
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 13.2417113696
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2115213294
MESH:D008171 Lung Diseases Vitamin A 7.3616863852
MESH:D008171 Lung Diseases Vitamin E 7.3616863852
MESH:D055370 Lung Injury Nitric Oxide 4.5311395602
MESH:D008175 Lung Neoplasms arsenic trioxide 6.3611798837 19825857
MESH:D008175 Lung Neoplasms arsenite 6.3616809336
MESH:D008175 Lung Neoplasms Curcumin 6.3619359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.3621163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Vitamin E 6.3611062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9615166399
MESH:D008223 Lymphoma Curcumin 11.9918462866
MESH:D008223 Lymphoma Diethylstilbestrol 11.9915700306
MESH:D008223 Lymphoma Nitric Oxide 11.9916166326
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5016173963
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3216002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.6616891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.6617203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.2919453300
MESH:D008545 Melanoma Curcumin 2.3917885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008569 Memory Disorders Curcumin 3.9717263510
MESH:D008881 Migraine Disorders Nitric Oxide 4.1511701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.9311304026 14659530
MESH:D009101 Multiple Myeloma arsenic trioxide 11.5019549372 14977855 15949261 19417148 11468182
MESH:D009101 Multiple Myeloma Curcumin 11.5019372569
MESH:D009101 Multiple Myeloma Vitamin A 11.5016374440
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7317962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0316882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7716411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.7116624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.7118495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.493581430 9029167
MESH:D009369 Neoplasms Diethylstilbestrol 4.7315313581
MESH:D009369 Neoplasms pirinixic acid 4.7317405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.3412497104
MESH:D009389 Neovascularization, Pathologic arsenite 9.5115738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.5117289903
MESH:D009421 Nervous System Malformations bisphenol A 15.4111399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.4111399458
MESH:D009421 Nervous System Malformations Estradiol 15.4116427766 11399458
MESH:D009423 Nervous System Neoplasms Curcumin 5.4418462866
MESH:D009436 Neural Tube Defects arsenic trioxide 7.2610525206
MESH:D009436 Neural Tube Defects Vitamin A 7.2617400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D009765 Obesity Curcumin 4.4419297423
MESH:D009765 Obesity pirinixic acid 4.4420558911
MESH:D010024 Osteoporosis Curcumin 3.3518719352
MESH:D010049 Ovarian Diseases bisphenol A 4.8011985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.8112452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 10.8119020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 10.8119401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.8117393432 16525653
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.2715580305
MESH:D010190 Pancreatic Neoplasms Curcumin 8.2719196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.2716540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010300 Parkinson Disease Bromocriptine 4.719918342 18328768
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4816977796 15687265
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 5.1418573544
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.392563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.2110548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.2117184923
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.9820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.9820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8819131511
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Curcumin 1.8811398177 12497104 18226269 15129424 18156803 10851300 18769126
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8815846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.1216919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.5910548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.3619168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8518379247 10666014
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.6116877224
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7918045962
MESH:D012509 Sarcoma Curcumin 3.9518462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7816646077
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.259673227
MESH:D018805 Sepsis Curcumin 3.9218389075
MESH:D012871 Skin Diseases Vitamin A 5.0918709164
MESH:D012871 Skin Diseases Vitamin E 5.0918709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.608532709
MESH:D013088 Spermatocele Diethylstilbestrol 11.0716709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 11.0716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0915862959 16503802
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.3917007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3918456281
MESH:D013276 Stomach Ulcer Curcumin 7.2316631530 19188055
MESH:D013276 Stomach Ulcer Nitric Oxide 7.2315138204
MESH:D020521 Stroke Vitamin E 3.3716517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.7916684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.7119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.717505956
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7715213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.0220435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.0218593936
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.0216452187 17306315 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 5.0718462866
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8716175088
MESH:D014591 Uterine Diseases bisphenol A 13.1714652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 13.1714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.8616690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8614692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2516513791 16002989
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D014802 Vitamin A Deficiency Vitamin A 5.1016175781 16146918 16960172
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:05220 Chronic myeloid leukemia
KEGG:04012 ErbB signaling pathway
KEGG:04630 Jak-STAT signaling pathway
KEGG:05162 Measles
KEGG:05200 Pathways in cancer
REACT:16888 Signaling by PDGF
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA338
    • No data
    No data
    Releated drug ID Related drug Name
    PA10804imatinib
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    PA452347glucocorticoids
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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