AutismKB 2.0

Annotation Detail for STIM1


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Basic Information Top
Gene Symbol:STIM1 ( D11S4896E,GOK )
Gene Full Name: stromal interaction molecule 1
Band: 11p15.4
Quick LinksEntrez ID:6786; OMIM: 605921; Uniprot ID:STIM1_HUMAN; ENSEMBL ID: ENSG00000167323; HGNC ID: 11386
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Hemostasis
Pathway IDPathway Name
200062TCR signaling in naive CD8+ T cells
200022TCR signaling in naive CD4+ T cells
No data
No data
Related Diseases/Disorders Top
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Desease Name
Immune dysfunction, with T-cell inactivation due to calcium entry defect 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of STIM1 mRNAaffects expression 21346803
D002118 Calcium STIM1 protein affects the abundance of Calciumaffects abundance 18439569
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of STIM1 mRNAaffects expression 17484886
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of STIM1 mRNAdecreases expression 16934159
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of STIM1 mRNAaffects expression 17555576
D015759 Ionomycin [Thapsigargin co-treated with Ionomycin] promotes the reaction [STIM1 protein binds to ATP2A3 protein]affects binding|affects cotreatment|increases reaction 18439569
D007854 Lead [ORAI1 protein binds to STIM1 protein] which results in increased transport of and affects the susceptibility to Leadaffects binding|affects response to substance|increases transport 19429662
D013629 Tamoxifen Tamoxifen affects the expression of STIM1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of STIM1 mRNAaffects expression 16962184
D019284 Thapsigargin [Thapsigargin co-treated with Ionomycin] promotes the reaction [STIM1 protein binds to ATP2A3 protein]affects binding|affects cotreatment|increases reaction 18439569
D014212 Tretinoin Tretinoin results in increased expression of STIM1 proteinincreases expression 17090780
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of STIM1 mRNAincreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3716456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.8319288272 19244106 18425577 17893378 19200415 19155303 19487384 19221464 17261762 19142967 21152245 16273361 19066611 18351453 18821012 18629630 18997820 11161223 17049068 18815881 19103187 18855134 20065188 19059307 20390343 16202921 19189210 20135344 19084267 19189212 20544844 20859285 19115204 19410462 15668708 17440819 17242785 19011961 16818667 15565566 19289846 21138602 20005174 16873071 18984771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8316873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9215721981 16227642 10355542 15673190 3786805 18705752 16050911 16097048 16011737 15700767 16124888 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7118788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.711917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.1517460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9515861022 16105132 11677210 16919318 17333356 17681005 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9015340226 15668235 16354765 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.909407595
MESH:D003092 Colitis Tretinoin 10.2517035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 10.2516867261 11698051 18200517 16474422 17991707 18023891 17936198 16782535 16804969
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4717276891
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Lead 4.0119769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.0120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.019224671 9664655 9142499 10589399 9211117 17551590 9125849 16925845 14991402 8800419
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D003704 Dementia Lead 5.3616140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.2615027814 21278145 9327722 6884620 3732212 4309450 7440962 10915739 11566570 2869522 19085960 7179309 17522070 10092053 15998439 19336974 15968718 3786805 16227642 16177239 7120509 6623471
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 9.2617851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5315322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6720544844 16202921 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D020329 Essential Tremor Lead 6.0814594619 18007985
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.1116938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.7512631006 15959796 12795759 19224547 16045604 16239168 61145 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.7515345470
MESH:D005234 Fatty Liver Tamoxifen 13.7514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005317 Fetal Growth Retardation Lead 5.6619769572
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 22.4218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.4220067830
MESH:D005355 Fibrosis Tretinoin 22.4217994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 22.4217994277
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.729664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216354765 18606429 8697196 15340226 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.3016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
OMIM:612783 IMMUNE DYSFUNCTION WITH T-CELL INACTIVATION DUE TO CALCIUM ENTRY DEFECT 2 marker/mechanism
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3917937319
MESH:D007248 Infertility, Male Lead 7.3916780224
MESH:D007249 Inflammation Tamoxifen 5.0719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.6118200517
MESH:D007410 Intestinal Diseases Tretinoin 10.4617994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 10.4617994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.3015992940 17551590
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6916705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6918625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.2216316344
MESH:D007855 Lead Poisoning Lead 6.0816700817
MESH:D007859 Learning Disorders Lead 5.3216384672
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8119285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2217217047 16891316 17712046 17294898 17107899 16935935 16766008 16823087 17368321 16788101 15748426 17649720 9834237 16140955 19035177 19225113 19642359 12679006 16331271 17506722 17339181 19075265 19029980 17301526 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008064 Lipidoses Tamoxifen 3.2315342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8611408273 16943688 17174718 11903743 17334410 21278145 16221502 16239168 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0416097048 17766677 17944888 15925388 12958196 17805973 20821823 16638106 16116963 18279442 15650968 17698563 15052691 15123356 18317297 16027843 18420326 18395914 18277467 12546737 18705752 18429990 16011737 17640975 15959796 15818738 12586293 17481882 16033810 17761835 18481824 18412020 18472332 12389079 15893842 17708605 15996030 12666154 18166357 18472094 15057751 17525996 18395095 17823541 12741479 18210741 17565644 14512876 16015684 12445421 14748882 15338365 17900296 15673190 14724832 18156304 18263696 10355542 17976157 15362042 12609069 13678700 11481614 17557913 14716833 17631135 12667390 12898905 16248980 14716496 12445418 12649538 12632514 18054572 17721639 15931870 16136751 17714472 18251166 18205269 18376398 17869086 18187930 16192424 15370692 14620537 18418968 15730626 12632512 17922224 15876570 18339082 18006644
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0418397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1017285989 16964402 15720792 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7914706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6119294768
MESH:D008113 Liver Neoplasms Tamoxifen 7.6116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6116984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9812151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2811884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6911731420 19196722 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Tamoxifen 3.3412393984 19393235
MESH:D008545 Melanoma Tretinoin 3.3416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008569 Memory Disorders Lead 5.2917263510 16384672
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Tretinoin 2.4616594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9414600291
MESH:D009421 Nervous System Malformations Tretinoin 9.949125849
MESH:D009436 Neural Tube Defects Tretinoin 3.129142499
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5312819281 16049721
MESH:D010024 Osteoporosis Calcium 3.8417882678
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Tretinoin 2.9916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.3217698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Lead 10.5016384672
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.5011222880 11399792 11896295 11118676
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1315067354
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6018551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D012878 Skin Neoplasms Tretinoin 5.7216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1117045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D014202 Tremor Lead 5.6621145352
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1716049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1716712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
Pathway ID Pathway Name
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36195
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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