AutismKB 2.0

Annotation Detail for STK4


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Basic Information Top
Gene Symbol:STK4 ( DKFZp686A2068,KRS2,MST1,YSK3 )
Gene Full Name: serine/threonine kinase 4
Band: 20q13.12
Quick LinksEntrez ID:6789; OMIM: 604965; Uniprot ID:STK4_HUMAN; ENSEMBL ID: ENSG00000101109; HGNC ID: 11408
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa05223Non-small cell lung cancer
hsa05200Pathways in cancer
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of STK4 mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of STK4 mRNAdecreases expression 20018196
19150397
D005472 Fluorouracil STK4 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
C051890 irinotecan irinotecan analog results in decreased expression of STK4 mRNAdecreases expression 18927307
C051890 irinotecan irinotecan metabolite results in decreased expression of STK4 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of STK4 mRNAdecreases expression 15956246
C051890 irinotecan STK4 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of STK4 mRNAincreases expression 12377990
D014810 Vitamin E Vitamin E results in decreased expression of STK4 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Fluorouracil 9.7115504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.7111748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0315136595 16110121 18608205 16557594 16595493 18357371 19217205
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 9.0417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.0416835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.2016705839
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2016332177 16799960 17045692 17088986 18930000 17971768
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5617066447 16757204 16280240 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2116354765 15668235 8697196 15340226 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 4.1217169374 17287894 17016597 18772588 17018589 17172411 16510598 17725105 16340194 15001691
MESH:D003110 Colonic Neoplasms irinotecan 4.1217287894 17725105
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7916524972 17016601 17695437 16331619 16282729 18802399 18448328 18949393 16391804 20501625 17094418 17255274 17454858 18288408 16303861 14970324 18383874 17401013 15148649 17594712 18509181 15289873
MESH:D015179 Colorectal Neoplasms irinotecan 2.7918509181 17159606 16303861 15273666 16391804 18259882 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5519769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7320426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7315173087 16481741 16785472 17638652 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5918337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 7.0616080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3112621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5718606429 15340226 8697196 16354765 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.7316624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Vitamin E 2.9612488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.3916705839
MESH:D007680 Kidney Neoplasms Fluorouracil 8.3916985049
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4216169303
MESH:D008113 Liver Neoplasms Fluorouracil 4.8218383874 15113037 16603448 17045692
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D008175 Lung Neoplasms Fluorouracil 3.5815246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5811884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.5811062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8716757204 18986760
MESH:D052016 Mucositis irinotecan 5.4717159606
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009362 Neoplasm Metastasis irinotecan 3.2718259882
MESH:D009369 Neoplasms Fluorouracil 2.7418239605 18600527 16928823
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009447 Neuroblastoma irinotecan 3.628761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.198761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7312819281 16049721
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7519003803 15113037 16500647 16929163
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2819082440 18626508
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3018286688 16160472 15538739 18722050
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7719084572 17498489 17522103 19015929 16424979 16951190 15786421 18567086 17172411 18396642
MESH:D013274 Stomach Neoplasms irinotecan 2.7715723263
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
KEGG:05223 Non-small cell lung cancer
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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