AutismKB 2.0

Annotation Detail for SULT1A2


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Basic Information Top
Gene Symbol:SULT1A2 ( HAST4,MGC142287,MGC142289,P-PST,ST1A2,STP2,TSPST2 )
Gene Full Name: sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
Band: 16p11.2
Quick LinksEntrez ID:6799; OMIM: 601292; Uniprot ID:ST1A2_HUMAN; ENSEMBL ID: ENSG00000197165; HGNC ID: 11454
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00920Sulfur metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
IMMUNE
inflammatory bowel disease (early onset)
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C017821 2-amino-3-methyl-9H-pyrido(2,3-b)indole SULT1A2 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indoleincreases activity 14729582
C117220 3-nitrobenzanthrone SULT1A2 protein results in increased activity of 3-nitrobenzanthroneincreases activity 15805261
D000082 Acetaminophen Acetaminophen affects the expression of SULT1A2 mRNAaffects expression 18246545
D000082 Acetaminophen Acetaminophen results in increased expression of SULT1A2 mRNAincreases expression 18246545
D015081 2-Naphthylamine SULT1A2 protein results in increased sulfation of 2-Naphthylamineincreases sulfation 17433394
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SULT1A2 mRNAincreases expression 19150397
C040048 caffeic acid SULT1A2 protein results in increased sulfation of caffeic acidincreases sulfation 17433394
C034221 catechol SULT1A2 protein results in increased sulfation of catecholincreases sulfation 17433394
D016572 Cyclosporine Cyclosporine results in decreased expression of SULT1A2 mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone affects the expression of SULT1A2 mRNAaffects expression 15102944
D002945 Cisplatin SULT1A2 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
C099406 L 742694 L 742694 affects the expression of SULT1A2 mRNAaffects expression 15102944
C014593 N-hydroxy-4-aminobiphenyl SULT1A2 protein results in increased sulfation of N-hydroxy-4-aminobiphenylincreases sulfation 17433394
C025299 polyphenols polyphenols results in decreased expression of SULT1A2 mRNAdecreases expression 16293270
C059514 resveratrol SULT1A2 protein results in increased sulfation of resveratrolincreases sulfation 16418064
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SULT1A2 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9014514962 15322242 11752688
MESH:D058186 Acute Kidney Injury Cisplatin 8.9817670903 12690470 15814532
MESH:D058186 Acute Kidney Injury resveratrol 8.9816538975
MESH:D000230 Adenocarcinoma Cisplatin 2.7611798837 17638652
MESH:D000236 Adenoma resveratrol 3.3315688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000544 Alzheimer Disease resveratrol 2.5716183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001169 Arthritis, Experimental Dexamethasone 7.7417659584
MESH:D001169 Arthritis, Experimental resveratrol 7.7417115116
MESH:D050197 Atherosclerosis resveratrol 3.2917967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.9514601052
MESH:D002545 Brain Ischemia resveratrol 4.3317600658
MESH:D001943 Breast Neoplasms Cisplatin 1.9718382427 19526202
MESH:D001943 Breast Neoplasms resveratrol 1.9717651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.6917982673
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.6916227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.6416675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0412023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.036189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell resveratrol 5.0316227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases resveratrol 3.4915458977
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.6212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Cyclosporine 2.9419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1112621046 8697196 15668235 15340226 16354765
MESH:D003092 Colitis resveratrol 4.1716474422
MESH:D003110 Colonic Neoplasms Dexamethasone 6.0215824018
MESH:D003110 Colonic Neoplasms polyphenols 6.0216293270
MESH:D003110 Colonic Neoplasms resveratrol 6.0216338953
MESH:D015179 Colorectal Neoplasms Cisplatin 2.8115273666
MESH:D015179 Colorectal Neoplasms resveratrol 2.8116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.7716507316
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.6217728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6210048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.4512438553
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7916873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.9916286809
MESH:D003967 Diarrhea Dexamethasone 3.737237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2610915739 16485898 18071297 12392966 19416960 16177239 12705907 12594235 11287661 12540782 16781746 14986274 19739265 11834606 16081117 19370779 14550746 12153990 11743745 2444490 16109766 15619225 17522070 10774834 10663392 12958197 18713872 19923254 17906064 19085960 14725611 19420014 15968718 16227642 11421492 19164858 11461765 17562736 11739529 16393943 11529661
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.2619370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Cisplatin 8.2512231392 15033597 12649298 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.2511462148
MESH:D004485 Eczema Dexamethasone 4.5012438553
MESH:D004487 Edema Dexamethasone 11.7319703484
MESH:D004487 Edema resveratrol 11.738985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.7312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.0617872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8917923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6520426865
MESH:D004938 Esophageal Neoplasms Cisplatin 4.6515464296 16481741 15173087 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Cyclosporine 2.8819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Cyclosporine 8.6212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7315102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.3219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4415464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3410048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9315340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.087520565
MESH:D006561 Herpes Simplex resveratrol 4.2316876885
MESH:D006689 Hodgkin Disease Cisplatin 3.6216170182 16200630
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1118606429 8697196 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006937 Hypercholesterolemia resveratrol 4.0317188708
MESH:D006949 Hyperlipidemias resveratrol 4.0616873680
MESH:D006973 Hypertension Cyclosporine 8.6510903974
MESH:D006973 Hypertension Dexamethasone 8.6517042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.6518670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3317488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6917600658
MESH:D007249 Inflammation Dexamethasone 12.158960868 11099482
MESH:D007249 Inflammation polyphenols 12.1516366677
MESH:D007249 Inflammation resveratrol 12.1516366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.1512878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.6116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2015464296
MESH:D007674 Kidney Diseases Acetaminophen 10.1615629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 10.1612231392 15190930 12649298 18289764 19839026
MESH:D007674 Kidney Diseases Cyclosporine 10.1610903974 8314463 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7612371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.8611231351
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.5916087638
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.4816718785
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4812878042
MESH:D008107 Liver Diseases Acetaminophen 4.1811587558 16611625 19460945 12969438 12587719 19784758 16610002 19014921
MESH:D008107 Liver Diseases polyphenols 4.1816698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms resveratrol 4.6119073162 20405173 19321006 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1212151625
MESH:D008175 Lung Neoplasms Cisplatin 3.5317225452 6189445 11798837
MESH:D008175 Lung Neoplasms Dexamethasone 3.5315824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5319555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 4.3317088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8914749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.3015688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.1311606380 8985016
MESH:D008545 Melanoma Cisplatin 3.6716248763 12393984 12883367 18505091 12374674 17761969 11135225 16809738 18332650 15577323 18176117 17023156 16432458
MESH:D008545 Melanoma resveratrol 3.6717992120
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Cisplatin 3.2517638057
MESH:D008659 Metabolic Diseases resveratrol 4.4117112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009101 Multiple Myeloma Dexamethasone 7.6315744524 16118317 15867202
MESH:D009101 Multiple Myeloma resveratrol 7.6316267019 17935668 17164350 14749477 17049120 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.9217962980
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.569809623
MESH:D009203 Myocardial Infarction resveratrol 3.0416456233 17188708 16317513 16525036 17015251 17125593
MESH:D017202 Myocardial Ischemia resveratrol 9.0817125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.0812213967
MESH:D009205 Myocarditis resveratrol 4.8117322642
MESH:D009369 Neoplasms Cisplatin 2.9516773208
MESH:D009374 Neoplasms, Experimental resveratrol 4.048985016
MESH:D009395 Nephritis, Interstitial Cisplatin 4.5515464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009447 Neuroblastoma Cisplatin 3.468761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4318514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.4317652729
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.758761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.4317929310
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.2917513867
MESH:D010051 Ovarian Neoplasms Cisplatin 2.8819769630 15464296 6897625 17225452
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0019003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.3415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.4117638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5621297632
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.7616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7611896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms resveratrol 3.6317636462 17675339 17804756 17718901 15767336 16731767
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D051437 Renal Insufficiency Cisplatin 4.4515464296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.6516325855
MESH:D015427 Reperfusion Injury resveratrol 3.2816314181 15827377 16317513 17520802 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0518379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.4614601052
MESH:D012878 Skin Neoplasms resveratrol 5.7615837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4115464296
MESH:D013272 Stomach Diseases Dexamethasone 4.3715472012
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 17522103 18396642
MESH:D013276 Stomach Ulcer Dexamethasone 3.5115138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5116321402
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.3117997062
MESH:D013736 Testicular Neoplasms Cisplatin 4.6617225452 15464296
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D014062 Tongue Neoplasms resveratrol 4.2416227395
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 5.8211144890
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.8217225452 12973940 15464296
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.8216803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.8217473185
MESH:D014594 Uterine Neoplasms resveratrol 4.1717044934
MESH:D014605 Uveitis Cyclosporine 11.981336536
MESH:D014605 Uveitis Dexamethasone 11.981336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.6515577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.3417488730
MESH:D014839 Vomiting Cisplatin 4.7811897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00920 Sulfur metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA341
    • Releated gene ID Related gene Name
    PA341SULT1A2
    Releated disease ID Related disease Name
    PA446411Endometrial Neoplasms
    PA443560Breast Neoplasms
    PA447304estrogen-dependent carcinogenesis
    Releated drug ID Related drug Name
    PA4519933-beta-hydroxy-5-androsten-17-one
    PA133822447catecholamines
    PA449503estradiol
    PA451581tamoxifen
    PA452604xenobiotics
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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