AutismKB 2.0

Annotation Detail for STRN


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Basic Information Top
Gene Symbol:STRN ( MGC125642,SG2NA )
Gene Full Name: striatin, calmodulin binding protein
Band: 2p22.2
Quick LinksEntrez ID:6801; OMIM: NA; Uniprot ID:STRN_HUMAN; ENSEMBL ID: ENSG00000115808; HGNC ID: 11424
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200029Plasma membrane estrogen receptor signaling
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of STRN mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of STRN mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of STRN mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of STRN mRNAaffects expression 12734012
D016572 Cyclosporine Cyclosporine results in increased expression of STRN mRNAincreases expression 20106945
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of STRN mRNAincreases expression 17490981
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of STRN mRNAaffects cotreatment|decreases expression 20360939
C006253 pirinixic acid pirinixic acid results in decreased expression of STRN mRNAdecreases expression 17426115
D014747 Vinblastine STRN protein affects the susceptibility to Vinblastineaffects response to substance 16217747
D014810 Vitamin E Vitamin E results in decreased expression of STRN mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma Diethylnitrosamine 2.946695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.9017162532 16434500 18056438 19061943 19052882 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9016434500
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.6610355542 15700767 16124888 15721981 16011737 16192424 18705752 16050911 16097048 15673190 3786805 16227642
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.6616050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.663084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6620512989 19052882 16540662 16288022 16681979 17173139 17055752 18393292 10737359 17761372 17428255 16328049 19107877 16502159 18056438 19171122 18978308 18506893 20935162 18785209 18691550 19208518 20101231 20007298 20214788 11831363 16935385 20514400 18665156 19335982 18494052 20084675 19418558 18788625 18971187 19394651 17162532 19701751 10672840 19822196 16569478 3084413 19383236 17138121 16830150 21159647 16698587 16878318 20432363 20727157 19919837 3581430 18210153 16779866 17978847 19519916 19539802 20524982 16807293
MESH:D002292 Carcinoma, Renal Cell Vinblastine 3.851485588
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.997505956 17174075 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D015179 Colorectal Neoplasms Vinblastine 2.7718802399
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4618713872 16109766 16781746 16393943 18071297 12958197 12153990 16485898 10915739 11739529 11287661 10663392 14725611 17562736 19416960 19370779 17906064 11743745 11461765 14986274 12705907 12392966 19739265 11834606 16081117 11421492 12540782 11529661 16177239 19420014 12594235 19923254 15968718 16227642 17522070 15619225 19164858 14550746 2444490 10774834 19085960
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.467440962 21278145 9327722 2869522 15998439 19336974 19085960 6884620 4309450 7179309 16227642 3786805 6623471 10915739 16177239 10092053 11566570 7120509 17522070 3732212 15968718 15027814
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4619107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2461145 15959796 19224547 12631006 12795759 16045604 16239168 17595544
MESH:D005234 Fatty Liver Cyclosporine 20.2419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 20.2420387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 20.2419236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4018705752
MESH:D005355 Fibrosis Cyclosporine 9.4012168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.2119176532 19772884 16221962 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D006689 Hodgkin Disease Vinblastine 4.1818501091 18180244
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007249 Inflammation Diethylnitrosamine 2.4618785209
MESH:D007251 Influenza, Human Vitamin E 4.4816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.7510783313
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 15.2412587719 15629191
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 15.2415369732
MESH:D007674 Kidney Diseases Cyclosporine 15.2418776723 8314463 10903974
MESH:D007674 Kidney Diseases Vitamin E 15.2412488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1016766008
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9011408273 11903743 17334410 16943688 21278145 16239168 17174718 16221502 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9020032147 19638242 18522880 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5718279442 18054572 12632514 14716833 18187930 15052691 12445421 15650968 18210741 18412020 12741479 15057751 12958196 17869086 15673190 17698563 16027843 17565644 14724832 16136751 15362042 17944888 15338365 17922224 17766677 12389079 15730626 15931870 11481614 12666154 18418968 18251166 18156304 15893842 17631135 18376398 20821823 14716496 15876570 18006644 13678700 14620537 10355542 17823541 15996030 15925388 12586293 18166357 15123356 16011737 17721639 14512876 16248980 12609069 18339082 18277467 18205269 14748882 17640975 16116963 17805973 18472094 12667390 17900296 17525996 17481882 12632512 18395095 18429990 16097048 16192424 12898905 17708605 12445418 17714472 18481824 15370692 18472332 16015684 16033810 18705752 18317297 15959796 12546737 18395914 17557913 18420326 12649538 17761835 16638106 15818738 18263696 17976157
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5716169303
MESH:D008107 Liver Diseases Acetaminophen 6.7012587719 16611625 19460945 12969438 19014921 19784758 16610002 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7015830285 16964402 17285989 15720792 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7017034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.7419996281 18754104 20501860 19638242 18977376 20101389 20583210 20452335 19642983 12771043 2862719 19426721 19551842 20405173 9163691 19427195 19255062 21278145 21071580 19254457 19833225 12112319 2422723 20137499 20118626 19073162 18978307 19812893 19256749 19294768 19090486 15175105 15885732 16942905 21167192 19499222 20434301 18644402 19850985 21047994 10737359 20492335 19690152 18648771
MESH:D008113 Liver Neoplasms pirinixic acid 7.7415890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.2917854601 17942915 9362446 18079962 19004024 19009564 16842330 3124819 2563599 19126423 18282651 18093689 17174075 18164116 18308698 18544905 19519916 16267830 21159647 18775883 18253720 19539802
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5420512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Vitamin E 2.5411062179
MESH:D008545 Melanoma Vinblastine 2.9318332650 18176117 15577320 18505091 17761969 16809738 12374674 16432458 15577323 16248763
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.623581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009503 Neutropenia Vinblastine 4.7517378895
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.4612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.462563599
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.117505956
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014625 Vaginal Neoplasms Vinblastine 5.2615577323
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36224
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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