AutismKB 2.0

Annotation Detail for STX1A


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Basic Information Top
Gene Symbol:STX1A ( HPC-1,P35-1,STX1,SYN1A )
Gene Full Name: syntaxin 1A (brain)
Band: 7q11.23
Quick LinksEntrez ID:6804; OMIM: 186590; Uniprot ID:STX1A_HUMAN; ENSEMBL ID: ENSG00000106089; HGNC ID: 11433
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04130SNARE interactions in vesicular transport
Pathway IDPathway Name
Botulinum neurotoxicity
Synaptic Transmission
Diabetes pathways
Integration of energy metabolism
Pathway IDPathway Name
200160Effects of Botulinum toxin
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00044Nicotinic acetylcholine receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P05734Synaptic vesicle trafficking
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Pathway IDPathway Name
500153Acetylcholine Neurotransmitter Release Cycle
500147Neurotransmitter Release Cycle
500148Norepinephrine Neurotransmitter Release Cycle
500149Serotonin Neurotransmitter Release Cycle
500151Dopamine Neurotransmitter Release Cycle
500150Glutamate Neurotransmitter Release Cycle
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
diabetes, type 2
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of STX1A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of STX1A mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of STX1A proteindecreases expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of STX1A mRNAincreases expression 18687144
C006780 bisphenol A bisphenol A results in decreased expression of STX1A mRNAdecreases expression 15223131
C096324 botulinum toxin type C botulinum toxin type C results in increased cleavage of STX1A proteinincreases cleavage 17666428
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of STX1A mRNAaffects expression 16239168
D003024 Clozapine Clozapine results in increased expression of STX1A mRNAincreases expression 15860345
D016572 Cyclosporine Cyclosporine results in increased expression of STX1A mRNAincreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of STX1A mRNAdecreases expression 17005392
D005419 Flavonoids Flavonoids results in increased expression of STX1A mRNAincreases expression 18035473
D006220 Haloperidol Haloperidol results in increased expression of STX1A mRNAincreases expression 15860345
C008493 methylselenic acid methylselenic acid affects the expression of STX1A mRNAaffects expression 14617803
D020849 Raloxifene Raloxifene results in increased expression of STX1A mRNAincreases expression 15849065
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of STX1A mRNAdecreases expression 19465110
D024505 Tocopherols Tocopherols results in increased expression of STX1A mRNAincreases expression 17654050
D014212 Tretinoin Tretinoin results in increased expression of STX1A mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8714514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000380 Agranulocytosis Clozapine 5.0714617031 16160616 12649775
MESH:D000419 Albuminuria Raloxifene 4.6017451421 17308373
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.4915469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.0816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder marker/mechanism 18593506
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1219368416 18080171
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.9516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001862 Bone Resorption bisphenol A 3.8711985600
MESH:D001930 Brain Injuries Raloxifene 4.4916580743
MESH:D001943 Breast Neoplasms bisphenol A 2.3417123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3417129689 15324884
MESH:D001943 Breast Neoplasms Raloxifene 2.3415758505 17595753 17952589 17242785 15572757 16912660 17893378 17440819 17049068 16837676 17261762 15775269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3416443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7910355542 16011737 16050911 16227642 3786805 16124888 16192424 15721981 16097048 15673190 15700767 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.583084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.5818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.5815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.581917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.0117123778
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2916096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.0817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3716120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4515775269
MESH:D002375 Catalepsy Haloperidol 4.9315215559 1977408
MESH:D002386 Cataract Acetaminophen 7.2310977129
MESH:D002386 Cataract Tretinoin 7.2317460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5312371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Cyclosporine 2.9219486331
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7715340226 16354765 8697196 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 5.779407595
MESH:D003072 Cognition Disorders Clozapine 11.7317123785
MESH:D003072 Cognition Disorders Raloxifene 11.7315800139
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4515322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4517551590 9211117 14991402 9224671 9664655 16925845 10589399 8800419 9142499 9125849
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5716002989 12952375
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.8520210726
MESH:D003704 Dementia Haloperidol 4.5811575062
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1617474826
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.5116402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 3.9415920148 17308373 17451421
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5815331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1314550746 16485898 10915739 12705907 12153990 16109766 11529661 16393943 17906064 10774834 12540782 19085960 10663392 11421492 11743745 17522070 18713872 19923254 18071297 19420014 11287661 19370779 11739529 12958197 12594235 16177239 19164858 19739265 17562736 2444490 14986274 19416960 16081117 11461765 16781746 15968718 14725611 12392966 16227642 15619225 11834606
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.133732212 10915739 16227642 19085960 6623471 15968718 7120509 4309450 16177239 17522070 15998439 9327722 7440962 21278145 3786805 7179309 19336974 10092053 11566570 6884620 2869522 15027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D050171 Dyslipidemias Clozapine 4.1916402076
MESH:D004487 Edema Raloxifene 6.8715860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.0518230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 12.0518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.0115845917
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.7116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.6016804899 15700306
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.8411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.849664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.1912795759 16239168 15959796 17595544 12631006 16045604 19224547 61145
MESH:D005234 Fatty Liver Cyclosporine 13.1919224547
MESH:D005234 Fatty Liver Raloxifene 13.1917473493
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6616513791 16002989 16611131 15751030 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 21.2718705752
MESH:D005355 Fibrosis Cyclosporine 21.2712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 21.2720067830
MESH:D005355 Fibrosis Tretinoin 21.2717994277
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.9716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5411294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.5414991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.5411110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9116120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816354765 15340226 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Tretinoin 7.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006948 Hyperkinesis Clozapine 4.9316046005
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4514722030 12960047
MESH:D006973 Hypertension Cyclosporine 8.5910903974
MESH:D006973 Hypertension Raloxifene 8.5915787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007021 Hypospadias Diethylstilbestrol 4.5916002989
MESH:D007246 Infertility Diethylstilbestrol 4.3615036965
MESH:D007249 Inflammation Flavonoids 5.0017296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0012200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 3.2916393666
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.9516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.9515992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.808314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4612371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.4616762066 14681315 15003126
MESH:D007859 Learning Disorders Diethylstilbestrol 4.0717184923
MESH:D007889 Leiomyoma Raloxifene 4.5016973256
MESH:D007938 Leukemia Tretinoin 2.7717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0817596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1516140955 17294898 16331271 12679006 16891316 17301526 9834237 16788101 17339181 16823087 17217047 16766008 17712046 19225113 19035177 16935935 19075265 17506722 17368321 19029980 17107899 17361223 19642359 17649720 15748426
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008064 Lipidoses Clozapine 3.9617567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8117334410 16943688 21278145 17157831 11903743 17174718 16221502 11408273 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4514724832 18412020 15650968 12632514 18705752 16248980 18420326 18429990 16015684 17708605 14620537 15673190 15931870 15996030 17922224 17805973 17900296 14748882 16097048 12898905 18187930 15123356 12649538 12586293 12666154 17557913 16033810 15338365 16116963 17761835 18472094 16027843 18054572 15362042 18277467 18251166 12445418 18472332 20821823 15730626 12632512 17481882 17631135 18210741 17721639 17869086 18156304 16136751 10355542 12741479 15893842 15818738 17944888 17714472 15925388 18339082 18279442 18376398 15052691 18395914 18481824 12546737 16638106 14512876 18418968 15057751 18166357 12667390 17525996 17640975 15959796 12445421 12389079 14716833 17565644 18263696 17698563 18317297 15876570 16192424 16011737 15370692 14716496 11481614 17823541 13678700 17766677 18006644 17976157 18205269 12609069 18395095 12958196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4516248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.9019784758 19460945 12587719 19014921 11587558 12969438 16610002 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9016246199 16964402 17285989 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.4216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.4216899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.4519294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.4515890375 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.7612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7612151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0417365036
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2319555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.1715166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5516002989
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.0817927505
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D001523 Mental Disorders Clozapine 8.4316856516
MESH:D001523 Mental Disorders Haloperidol 8.4316856516
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.8216966607 18303189 16166281
MESH:D008654 Mesothelioma Tocopherols 6.8215878867
MESH:D024821 Metabolic Syndrome X Clozapine 4.4119142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4416497877
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D009232 Myxoma Raloxifene 5.5816343187
MESH:D009369 Neoplasms Diethylstilbestrol 5.2115313581
MESH:D009369 Neoplasms Tretinoin 5.2116946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 23.5611399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 23.5611399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 23.5614600291
MESH:D009421 Nervous System Malformations Tretinoin 23.569125849
MESH:D009436 Neural Tube Defects Tretinoin 3.059142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity Clozapine 3.0219142110 18515891
MESH:D010024 Osteoporosis Raloxifene 3.3919059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2315579764 17893378 15758505 17823083
MESH:D010049 Ovarian Diseases bisphenol A 5.0111985600
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3516936753
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Tretinoin 6.5916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4615976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.6816977796 15687265
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9110923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 16.4210548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 16.4217184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.4211222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9116740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9115846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.9116205645
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9116536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tocopherols 1.9112504091
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.9711575062
MESH:D011618 Psychotic Disorders Clozapine 9.1615331141
MESH:D011618 Psychotic Disorders Haloperidol 9.1611575062
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D011629 Puberty, Precocious bisphenol A 4.8110548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0317365031 17322281 17975199 15814490
MESH:D011693 Purpura Raloxifene 5.5815770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1116283617 16116481
MESH:D012559 Schizophrenia Clozapine 4.1018806925 16141801 19369910 17667964 20521326 20168265 11763009 11151749 17726453 20580759 20107430 20521320 20452607 18855531 17123785
MESH:D012559 Schizophrenia Haloperidol 4.1019369910 20107430 18513383 1830565
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.5616467112
MESH:D013088 Spermatocele Diethylstilbestrol 4.7416002989 16709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Raloxifene 3.8216837676
MESH:D019966 Substance-Related Disorders bisphenol A 4.0016045194 16684133
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.7220210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0317045167 16026305
MESH:D013978 Tibial Fractures Raloxifene 5.2419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.3916712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.3917572228
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.5216175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.5216129372
MESH:D014591 Uterine Diseases bisphenol A 13.9214652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 13.9214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.0815809267 16690809
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4516002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2416837676
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D015430 Weight Gain Clozapine 4.4720564506 20521320 20107430 16141801 16402076 17502770
MESH:D015431 Weight Loss Clozapine 5.1017933447
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
REACT:11184 Botulinum neurotoxicity
REACT:15380 Diabetes pathways
REACT:1505 Integration of energy metabolism
KEGG:04130 SNARE interactions in vesicular transport
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36233
    • No data
    No data
    Releated drug ID Related drug Name
    PA451898vitamin c
    PA10090l-glutamine
    PA450197l-leucine
    PA448976choline
    PA449396dopamine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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