AutismKB 2.0

Annotation Detail for STX4


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Basic Information Top
Gene Symbol:STX4 ( STX4A,p35-2 )
Gene Full Name: syntaxin 4
Band: 16p11.2
Quick LinksEntrez ID:6810; OMIM: 186591; Uniprot ID:STX4_HUMAN; ENSEMBL ID: ENSG00000103496; HGNC ID: 11439
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04962Vasopressin-regulated water reabsorption
hsa04130SNARE interactions in vesicular transport
Pathway IDPathway Name
Botulinum neurotoxicity
Membrane Trafficking
Hemostasis
Pathway IDPathway Name
200155Stabilization and expansion of the E-cadherin adherens junction
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Pathway IDPathway Name
500941Disinhibition of SNARE formation
500013Clathrin derived vesicle budding
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of STX4 mRNAaffects expression 16483693
D003024 Clozapine Clozapine results in increased expression of STX4 mRNAincreases expression 15860345
D006220 Haloperidol Haloperidol results in increased expression of STX4 mRNAincreases expression 15860345
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of STX4 mRNAincreases expression 20106945
D014635 Valproic Acid Valproic Acid results in increased expression of STX4 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.1715322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 10.178875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000380 Agranulocytosis Clozapine 5.5416160616 14617031 12649775
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D001321 Autistic Disorder Haloperidol 2.3418080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.3418558336 16609825 19460635 18396377 15238991 18775368 19232924 17688650 18985861 17157402 20603192 18177632 18316065 18940202 17507914
MESH:D001714 Bipolar Disorder Valproic Acid 3.2317594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.7215746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.728888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418850075 16120746 18670907
MESH:D002375 Catalepsy Haloperidol 5.4515215559 1977408
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.228697196 12621046 16354765 15668235 15340226
MESH:D003072 Cognition Disorders Clozapine 5.4517123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5520055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.558888407 16575769 17688650
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.2520210726
MESH:D003704 Dementia Haloperidol 4.9511575062
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.7416402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7417107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 6.1715331141
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.0519641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D050171 Dyslipidemias Clozapine 4.4316402076
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5115322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.643659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.916426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Valproic Acid 3.6719224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.578888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 12621046 16120746
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6615340226 16959395 18606429 8697196 16354765
MESH:D006948 Hyperkinesis Clozapine 5.4516046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008064 Lipidoses Clozapine 4.2117567588
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D001523 Mental Disorders Clozapine 10.2216856516
MESH:D001523 Mental Disorders Haloperidol 10.2216856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.7219142101
MESH:D008881 Migraine Disorders Valproic Acid 3.4418765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.3416359493 8888407
MESH:D009765 Obesity Clozapine 3.0819142110 18515891
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.3311896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 11.3320603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.1512752131 11422049
MESH:D011595 Psychomotor Agitation Haloperidol 5.4411575062
MESH:D011618 Psychotic Disorders Clozapine 9.9915331141
MESH:D011618 Psychotic Disorders Haloperidol 9.9911575062
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Clozapine 5.9717123785 17726453 19369910 16141801 20521320 20107430 20168265 18855531 20521326 20580759 11151749 17667964 18806925 11763009 20452607
MESH:D012559 Schizophrenia Haloperidol 5.971830565 19369910 20107430 18513383
MESH:D012559 Schizophrenia Valproic Acid 5.9715737665 19110320
MESH:D012640 Seizures Valproic Acid 2.963137016 17978042 14763951 11738929 1511512 15475178 11044598 16876388
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D017180 Tachycardia, Ventricular Haloperidol 5.1520210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
MESH:D015430 Weight Gain Clozapine 4.7916402076 20107430 16141801 17502770 20521320 20564506
MESH:D015431 Weight Loss Clozapine 5.6217933447
Pathway ID Pathway Name
REACT:11184 Botulinum neurotoxicity
REACT:604 Hemostasis
REACT:11123 Membrane Trafficking
KEGG:04130 SNARE interactions in vesicular transport
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36236
    • No data
    No data
    Releated drug ID Related drug Name
    PA449773glucose
    PA451906warfarin
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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