AutismKB 2.0

Annotation Detail for SULT1A3


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Basic Information Top
Gene Symbol:SULT1A3 ( HAST,HAST3,M-PST,MGC117469,ST1A5,STM,SULT1A4,TL-PST )
Gene Full Name: sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Band: 16p11.2
Quick LinksEntrez ID:6818; OMIM: 600641; Uniprot ID:ST1A3_HUMAN; ENSEMBL ID: ENSG00000213599; HGNC ID: 11455
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C033146 1-hydroxypyrene 1-hydroxypyrene results in decreased activity of SULT1A3 proteindecreases activity 14570759
C033146 1-hydroxypyrene Dimethylformamide inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene]decreases reaction|increases sulfation 14570759
C033146 1-hydroxypyrene Ethanol inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene]decreases reaction|increases sulfation 14570759
C033146 1-hydroxypyrene Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1A3 protein]decreases activity|increases reaction 14570759
C033146 1-hydroxypyrene SULT1A3 protein results in increased sulfation of 1-hydroxypyreneincreases sulfation 14570759
C029350 1-naphthol SULT1A3 protein results in increased sulfation of 1-naphtholincreases sulfation 15684482
C015802 2,6-dichloro-4-nitrophenol [2,6-dichloro-4-nitrophenol co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiolaffects cotreatment|decreases sulfation 15483196
C015802 2,6-dichloro-4-nitrophenol 2,6-dichloro-4-nitrophenol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 11425650
15531517
C077584 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine SULT1A3 protein results in increased sulfation of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridineincreases sulfation 11181495
C001390 2-hydroxyestradiol 2-hydroxyestradiol affects the sulfation of SULT1A3 proteinaffects sulfation 11358677
C030629 3,3'-diiodothyronine 3,3'-diiodothyronine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
C024836 4-nitrophenol SULT1A3 protein results in increased sulfation of 4-nitrophenolincreases sulfation 9566748
C026785 5-hydroxyindole SULT1A3 protein results in increased sulfation of 5-hydroxyindoleincreases sulfation 11181495
C012365 6-hydroxymelatonin SULT1A3 protein results in increased sulfation of 6-hydroxymelatoninincreases sulfation 11181495
D015081 2-Naphthylamine SULT1A3 protein results in increased sulfation of 2-Naphthylamineincreases sulfation 17433394
D000638 Amiodarone Amiodarone results in increased expression of SULT1A3 mRNAincreases expression 19774075
D001564 Benzo(a)pyrene SULT1A3 protein results in increased sulfation of Benzo(a)pyreneincreases sulfation 11181495
C040048 caffeic acid SULT1A3 protein results in increased sulfation of caffeic acidincreases sulfation 17433394
C034221 catechol SULT1A3 protein results in increased sulfation of catecholincreases sulfation 17433394
C004742 daidzein daidzein inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
D004126 Dimethylformamide Dimethylformamide inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene]decreases reaction|increases sulfation 14570759
D004298 Dopamine 2,6-dichloro-4-nitrophenol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
11425650
D004298 Dopamine 3,3'-diiodothyronine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
D004298 Dopamine daidzein inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
D004298 Dopamine Ethanol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 14570759
D004298 Dopamine Genistein inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
D004298 Dopamine Mefenamic Acid inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 11181495
D004298 Dopamine Sodium Chloride inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
11425650
D004298 Dopamine SULT1A3 protein results in increased sulfation of Dopamineincreases sulfation 14570759
19646966
11181495
D004298 Dopamine Thyroxine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
D004298 Dopamine Triiodothyronine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
D004298 Dopamine Triiodothyronine, Reverse inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
D004837 Epinephrine SULT1A3 protein results in increased sulfation of Epinephrineincreases sulfation 11181495
D004958 Estradiol Estradiol affects the sulfation of SULT1A3 proteinaffects sulfation 11358677
D004958 Estradiol SULT1A3 protein results in increased sulfation of Estradiolincreases sulfation 11181495
D004970 Estrone Estrone affects the sulfation of SULT1A3 proteinaffects sulfation 11358677
D004970 Estrone [Estrone co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiolaffects cotreatment|decreases sulfation 15483196
D000431 Ethanol Ethanol inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene]decreases reaction|increases sulfation 14570759
D000431 Ethanol Ethanol inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 14570759
D000431 Ethanol Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1A3 protein]decreases activity|increases reaction 14570759
D000431 Ethanol Ethanol results in decreased activity of SULT1A3 proteindecreases activity 14570759
D004997 Ethinyl Estradiol [2,6-dichloro-4-nitrophenol co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiolaffects cotreatment|decreases sulfation 15483196
D004997 Ethinyl Estradiol [Estrone co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiolaffects cotreatment|decreases sulfation 15483196
D004997 Ethinyl Estradiol [Quercetin co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiolaffects cotreatment|decreases sulfation 15483196
D004997 Ethinyl Estradiol SULT1A3 protein results in increased sulfation of Ethinyl Estradiolincreases sulfation 15483196
D019833 Genistein Genistein inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
C071834 glycidamide glycidamide results in increased expression of SULT1A3 mRNAincreases expression 17822822
C001326 harmol SULT1A3 protein results in increased sulfation of harmolincreases sulfation 11181495
D012701 Serotonin SULT1A3 protein results in increased sulfation of Serotoninincreases sulfation 11181495
D006917 Hydroxytryptophol SULT1A3 protein results in increased sulfation of Hydroxytryptopholincreases sulfation 11181495
D008528 Mefenamic Acid Mefenamic Acid inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 11181495
D008914 Minoxidil SULT1A3 protein results in increased sulfation of Minoxidilincreases sulfation 11181495
C005273 naringenin SULT1A3 protein results in increased sulfation of naringeninincreases sulfation 11181495
C014593 N-hydroxy-4-aminobiphenyl SULT1A3 protein results in increased sulfation of N-hydroxy-4-aminobiphenylincreases sulfation 17433394
C007350 nitrofen SULT1A3 protein results in increased activity of nitrofenincreases activity 14754874
D009638 Norepinephrine SULT1A3 protein results in increased sulfation of Norepinephrineincreases sulfation 11181495
D009647 Normetanephrine SULT1A3 protein results in increased sulfation of Normetanephrineincreases sulfation 11181495
D010646 Phentolamine SULT1A3 protein results in increased sulfation of Phentolamineincreases sulfation 11181495
D010724 Phosphoadenosine Phosphosulfate SULT1A3 protein results in increased sulfation of Phosphoadenosine Phosphosulfateincreases sulfation 11425650
C016063 pinocembrin SULT1A3 protein results in increased sulfation of pinocembrinincreases sulfation 11181495
D011794 Quercetin [Quercetin co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiolaffects cotreatment|decreases sulfation 15483196
C059514 resveratrol SULT1A3 protein results in increased sulfation of resveratrolincreases sulfation 16418064
D012965 Sodium Chloride Sodium Chloride inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
11425650
D014284 Triiodothyronine Triiodothyronine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
D013974 Thyroxine Thyroxine inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
D014212 Tretinoin Tretinoin results in decreased expression of SULT1A3 mRNAdecreases expression 17045167
D014285 Triiodothyronine, Reverse Triiodothyronine, Reverse inhibits the reaction [SULT1A3 protein results in increased sulfation of Dopamine]decreases reaction|increases sulfation 15531517
C057693 troglitazone SULT1A3 protein results in increased sulfation of troglitazoneincreases sulfation 11181495
D014439 Tyramine SULT1A3 protein results in increased sulfation of Tyramineincreases sulfation 11181495
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.4418926900 17676605
MESH:D000138 Acidosis Ethanol 4.0111192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4517505938
MESH:D058186 Acute Kidney Injury resveratrol 3.4216538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.9620127859 20464547
MESH:D000230 Adenocarcinoma daidzein 11.9611473722
MESH:D000230 Adenocarcinoma Estradiol 11.9611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.9614692618
MESH:D000230 Adenocarcinoma Genistein 11.9611473722
MESH:D000236 Adenoma Benzo(a)pyrene 5.826695378
MESH:D000236 Adenoma resveratrol 5.8215688382
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8215451040 15451039
MESH:D000505 Alopecia Minoxidil 8.8521359208
MESH:D000505 Alopecia Tretinoin 8.8515955085
MESH:D000544 Alzheimer Disease resveratrol 2.4516183991 16162502
MESH:D000743 Anemia, Hemolytic Quercetin 3.8017084956
MESH:D000853 Anophthalmos Ethanol 4.3415513904
MESH:D001008 Anxiety Disorders Ethanol 3.6211141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6019183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3818057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.4615885639
MESH:D001169 Arthritis, Experimental resveratrol 10.4617115116
MESH:D001169 Arthritis, Experimental Tretinoin 10.4616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1416292516
MESH:D001249 Asthma Tretinoin 2.1816456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4915336622
MESH:D050197 Atherosclerosis resveratrol 2.9817967414 16873680
MESH:D001281 Atrial Fibrillation Amiodarone 3.5419698954 18651412
MESH:D001321 Autistic Disorder Norepinephrine 3.118570775
MESH:D001321 Autistic Disorder Serotonin 3.1117157402 18405062 18062943 18361446 15132762 8570775 19221690
MESH:D001327 Autoimmune Diseases Quercetin 3.9319761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9416935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 7.8119483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.8116197459 16206674
MESH:D001919 Bradycardia Serotonin 4.998112388
MESH:D002545 Brain Ischemia resveratrol 3.8017600658
MESH:D001943 Breast Neoplasms 2-hydroxyestradiol 3.3816675129
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.3817474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 3.3814630087 12948864 17261762 16675129 17018787 18497071 19861407 17289903
MESH:D001943 Breast Neoplasms Genistein 3.3816873071 16541309 17200150
MESH:D001943 Breast Neoplasms Quercetin 3.3818628248
MESH:D001943 Breast Neoplasms resveratrol 3.3817534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tretinoin 3.3816443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1016813970
MESH:D002056 Burns Ethanol 4.1816374292
MESH:D002105 Cadmium Poisoning Quercetin 5.0516962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9816111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6616168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.1016924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 10.1015289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 10.1016924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 10.1012508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 10.1016227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.101917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1116675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4817234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.5820419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 6.5816227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.5816051514 16096774
MESH:D006332 Cardiomegaly Ethanol 14.1319332462
MESH:D006332 Cardiomegaly Norepinephrine 14.1311179087
MESH:D006332 Cardiomegaly Quercetin 14.1319794523
MESH:D006332 Cardiomegaly Thyroxine 14.1318093424
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7119225199 15710769
MESH:D002318 Cardiovascular Diseases daidzein 10.3716332659
MESH:D002318 Cardiovascular Diseases Genistein 10.3716332659
MESH:D002318 Cardiovascular Diseases resveratrol 10.3715458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6018974383
MESH:D002375 Catalepsy Norepinephrine 5.058216760
MESH:D002386 Cataract Tretinoin 2.8017460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.4418566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1016129372
MESH:D002659 Child Development Disorders, Pervasive Serotonin 3.9721254450
MESH:D002779 Cholestasis Ethinyl Estradiol 2.5111677210 15861022 17681005 17110522 16105132 17333356 16919318
MESH:D002822 Choriocarcinoma Tretinoin 4.6616461808
MESH:D021081 Chronobiology Disorders Serotonin 6.1917157402
MESH:D002971 Cleft Lip Ethanol 3.3215513904
MESH:D002972 Cleft Palate Ethanol 5.4115513904
MESH:D002972 Cleft Palate Tretinoin 5.419407595
MESH:D003092 Colitis resveratrol 8.0516474422
MESH:D003092 Colitis Tretinoin 8.0517035595
MESH:D003110 Colonic Neoplasms Genistein 5.2617182828
MESH:D003110 Colonic Neoplasms Quercetin 5.2616640504 11134977 19440933 15741050 17148506 17191121 19056647
MESH:D003110 Colonic Neoplasms resveratrol 5.2616338953
MESH:D015179 Colorectal Neoplasms Quercetin 2.6118095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 2.6116550006
MESH:D003327 Coronary Disease resveratrol 3.4316507316
MESH:D019465 Craniofacial Abnormalities Ethanol 3.7019302082 10194807 15451039 11873399 11198716 15451040 15513904
MESH:D019465 Craniofacial Abnormalities nitrofen 3.7011405365
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.708800419 9142499 14991402 9224671 9664655 17551590 9125849 9211117 10589399 16925845
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.2419496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.2416873680
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 6.6816647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.6816647724
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 6.6816023994
MESH:D003925 Diabetic Angiopathies troglitazone 5.1612601628
MESH:D003928 Diabetic Nephropathies Estradiol 7.6619279558
MESH:D003928 Diabetic Nephropathies resveratrol 7.6616286809
MESH:D003967 Diarrhea Serotonin 4.328112388 11488427 10446763
MESH:D056486 Drug-Induced Liver Injury Amiodarone 7.8115265979 18218290
MESH:D056486 Drug-Induced Liver Injury Dimethylformamide 7.813732212
MESH:D056486 Drug-Induced Liver Injury Ethanol 7.8111566570
MESH:D056486 Drug-Induced Liver Injury troglitazone 7.8114986274
MESH:D004487 Edema resveratrol 6.228985016
MESH:D004487 Edema Serotonin 6.2218841975
MESH:D004489 Edema, Cardiac Tretinoin 3.9718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.5912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 7.5917872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.1016402032
MESH:D016889 Endometrial Neoplasms daidzein 15.1411473722
MESH:D016889 Endometrial Neoplasms Estradiol 15.1411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 15.1411473722
MESH:D016889 Endometrial Neoplasms Tretinoin 15.1416569247
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3717923197
MESH:D004827 Epilepsy Epinephrine 6.91821787
MESH:D004827 Epilepsy Norepinephrine 6.91821787
MESH:D007172 Erectile Dysfunction daidzein 4.5514972507
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1116530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.1116704527
MESH:D005124 Eye Abnormalities Tretinoin 3.2116938888 9664655
MESH:D005234 Fatty Liver Amiodarone 10.7114986274
MESH:D005234 Fatty Liver Ethanol 10.7116409862 19236843 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 10.7115345470
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1717920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8116946407 15451040 15513904 10194807
MESH:D005355 Fibrosis Quercetin 7.4019474275
MESH:D005355 Fibrosis Tretinoin 7.4017994277
MESH:D005756 Gastritis Ethanol 4.2015046732
MESH:D005909 Glioblastoma Genistein 10.0416598420
MESH:D005909 Glioblastoma Quercetin 10.0419804834
MESH:D005909 Glioblastoma Tretinoin 10.0417312396
MESH:D005910 Glioma Quercetin 2.8517643826
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6616084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.7620471113
MESH:D006330 Heart Defects, Congenital nitrofen 9.7616080930
MESH:D006330 Heart Defects, Congenital Tretinoin 9.769664655 14991402
MESH:D006529 Hepatomegaly Amiodarone 3.2815265979
MESH:D006548 Hernia, Diaphragmatic nitrofen 3.7515756563 16080930 16292651 15707848 11051153 9476886 11409163 12746050 15578192 11588001 9859898 12194112 16720372 12547725 7576705 7760232 9698600 11685700 15793718 18280291 12759764 10370017 12021965 8863223 18958481 9575882 16863852 10898222 9473106 16473863 15088113 17270546 12904592 18280292 15136996 10646786 15764645 12407540 11584395 10370016 16490937 11076806 10359170 17618886 11329586 15185205 11057544 10541330 12505043 10693666 17245593 10898224 7520565
MESH:D006558 Herpes Genitalis Estradiol 4.5315709030
MESH:D006561 Herpes Simplex resveratrol 3.7016876885
MESH:D019584 Hot Flashes Estradiol 3.2617088409
MESH:D006930 Hyperalgesia Ethanol 6.7218783367
MESH:D006930 Hyperalgesia Tretinoin 6.7216870215
MESH:D006937 Hypercholesterolemia Amiodarone 7.879751232 8137927
MESH:D006937 Hypercholesterolemia resveratrol 7.8717188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0916778211
MESH:D006943 Hyperglycemia Quercetin 3.6118262572 11834736
MESH:D006949 Hyperlipidemias resveratrol 3.5816873680
MESH:D006973 Hypertension daidzein 7.8717169123
MESH:D006973 Hypertension Quercetin 7.8718356687
MESH:D006973 Hypertension Sodium Chloride 7.8711507004
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8817488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3316569931 16945680
MESH:D007022 Hypotension Dopamine 18.216740701
MESH:D007022 Hypotension Epinephrine 18.216740701
MESH:D007022 Hypotension Minoxidil 18.2110799342
MESH:D007022 Hypotension Norepinephrine 18.216740701
MESH:D007037 Hypothyroidism Amiodarone 4.0418020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1717600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.1617937319
MESH:D007249 Inflammation resveratrol 2.6016366677
MESH:D007251 Influenza, Human Quercetin 9.5416624496
MESH:D007251 Influenza, Human resveratrol 9.5416624496
MESH:D007333 Insulin Resistance Estradiol 2.6416393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.2917994277
MESH:D007569 Jaw Abnormalities Ethanol 8.8815513904
MESH:D007569 Jaw Abnormalities Tretinoin 8.8817551590 15992940
MESH:D007627 Keloid Quercetin 4.4817086741
MESH:D007674 Kidney Diseases Estradiol 5.2415618244
MESH:D007674 Kidney Diseases Quercetin 5.2416962696
MESH:D007680 Kidney Neoplasms Estradiol 6.7115610895
MESH:D007680 Kidney Neoplasms Estrone 6.7115610895
MESH:D007859 Learning Disorders Ethanol 3.7415451040
MESH:D016773 Leishmaniasis, Cutaneous Sodium Chloride 4.539499605
MESH:D007938 Leukemia Genistein 9.0217468513 18980019
MESH:D007938 Leukemia Quercetin 9.0217468513
MESH:D007938 Leukemia Tretinoin 9.0217143497
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.6416085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2616482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9917596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.6716087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.6719029980 19035177 19075265 16140955 17649720 17506722 16891316 16935935 17294898 16331271 17339181 12679006 19225113 16766008 16788101 17107899 16823087 17368321 17361223 9834237 15748426 17712046 17217047 17301526 19642359
MESH:D017880 Limb Deformities, Congenital Ethanol 7.1417676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.149224671
MESH:D008064 Lipidoses Amiodarone 3.1615342952 17567588
MESH:D008103 Liver Cirrhosis Ethanol 3.0915289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6118295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.7514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 7.7518166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 7.7517823541
MESH:D008106 Liver Cirrhosis, Experimental naringenin 7.7514709902
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 7.7512741479
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.7516248980 18397230
MESH:D008107 Liver Diseases naringenin 3.8216945181
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1817207112 17347304
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 6.3620195826 21137059
MESH:D008113 Liver Neoplasms Quercetin 6.3618980244
MESH:D008113 Liver Neoplasms resveratrol 6.3620405173 19073162 19812893 19321006
MESH:D008114 Liver Neoplasms, Experimental Quercetin 2.7619519916
MESH:D008133 Long QT Syndrome Amiodarone 3.2111989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 6.8512587719
MESH:D008171 Lung Diseases nitrofen 6.8516863852 17245593 9859898 9614859
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9818516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.3620464547 18569708 20869020 18816296 20064080 20135361 18520028 17053015 6695378
MESH:D008175 Lung Neoplasms Quercetin 2.3616280456
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8517088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7615688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.1811408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 8.1812929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 8.1811606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 3.9919453300
MESH:D008527 Medulloblastoma Tretinoin 2.5717453147
MESH:D008545 Melanoma resveratrol 3.1417992120
MESH:D008545 Melanoma Tretinoin 3.1416752155
MESH:D008569 Memory Disorders Ethanol 3.7318411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 3.9516940565
MESH:D008659 Metabolic Diseases resveratrol 3.9417112576
MESH:D008881 Migraine Disorders Tyramine 5.0010792367
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8116381670
MESH:D009101 Multiple Myeloma resveratrol 3.1216490592 17164350 17049120 14749477 16267019 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.3817962980
MESH:D009181 Mycoses Amiodarone 4.4012754197 17974566
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.7917596541
MESH:D009203 Myocardial Infarction Genistein 8.3017141266
MESH:D009203 Myocardial Infarction Quercetin 8.3019595682
MESH:D009203 Myocardial Infarction resveratrol 8.3016317513 17188708 17125593 16456233 17015251 16525036
MESH:D017202 Myocardial Ischemia resveratrol 3.6217125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Estradiol 17.3016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 17.3017141266
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 17.3015642760
MESH:D015428 Myocardial Reperfusion Injury Quercetin 17.3019207477
MESH:D009205 Myocarditis resveratrol 4.2717322642
MESH:D009369 Neoplasms Benzo(a)pyrene 9.8211141357
MESH:D009369 Neoplasms naringenin 9.8215185748
MESH:D009369 Neoplasms Quercetin 9.8215185748
MESH:D009369 Neoplasms Tretinoin 9.8216594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 3.538985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2517289903
MESH:D009421 Nervous System Malformations Estradiol 13.7716427766 11399458
MESH:D009421 Nervous System Malformations Genistein 13.7716427766
MESH:D009421 Nervous System Malformations Tretinoin 13.779125849
MESH:D009436 Neural Tube Defects Tretinoin 2.739142499
MESH:D019636 Neurodegenerative Diseases resveratrol 3.4117652729
MESH:D020078 Neurogenic Inflammation Quercetin 9.2017929310
MESH:D020078 Neurogenic Inflammation resveratrol 9.2017929310
MESH:D010024 Osteoporosis Genistein 2.9419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 14.3016169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 14.3019495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 14.3017513867
MESH:D010051 Ovarian Neoplasms Estradiol 9.8419401270
MESH:D010051 Ovarian Neoplasms Genistein 9.8419005980
MESH:D010051 Ovarian Neoplasms Quercetin 9.8419005980
MESH:D010051 Ovarian Neoplasms Tretinoin 9.8416936753
MESH:D010146 Pain Tretinoin 2.5216870215
MESH:D010190 Pancreatic Neoplasms Ethanol 7.5712384795
MESH:D010190 Pancreatic Neoplasms Quercetin 7.5716965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.5715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2411578682
MESH:D011230 Precancerous Conditions Quercetin 3.5719056647
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.7016679765
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9217292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.9216740699
MESH:D011471 Prostatic Neoplasms Genistein 1.9215256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Quercetin 1.9214715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 1.9216731767 17636462 15767336 17804756 17718901 17675339
MESH:D011507 Proteinuria Tretinoin 3.1616636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.8315861022 16919318
MESH:D011625 Pterygium Tretinoin 4.3016723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.5011597910 12832656 12490602
MESH:D011658 Pulmonary Fibrosis troglitazone 5.5018162602
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0916325855
MESH:D015427 Reperfusion Injury resveratrol 3.0216317513 16314181 17058453 17520802 15827377
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6516116481 16283617
MESH:D012554 Schistosomiasis japonica Quercetin 5.0516862918
MESH:D012640 Seizures Ethanol 2.859754883
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6018724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.0710029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 8.078985016 15837718
MESH:D012878 Skin Neoplasms Tretinoin 8.0716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4516709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.7720155912 2093021
MESH:D013274 Stomach Neoplasms Ethanol 5.7718456281
MESH:D013274 Stomach Neoplasms Sodium Chloride 5.7716646055
MESH:D013274 Stomach Neoplasms Tretinoin 5.7717261132
MESH:D013274 Stomach Neoplasms troglitazone 5.7715930296
MESH:D013276 Stomach Ulcer Amiodarone 6.0718087811
MESH:D013276 Stomach Ulcer Ethanol 6.0717918041 9562338 16755016 17189318 11906479 9211565
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0516321402
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.839754883
MESH:D013610 Tachycardia Amiodarone 9.5711238279
MESH:D013610 Tachycardia Norepinephrine 9.573261545
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7415669648
MESH:D013959 Thyroid Diseases Amiodarone 11.0419731979
MESH:D013959 Thyroid Diseases Thyroxine 11.0419910387
MESH:D013964 Thyroid Neoplasms Tretinoin 2.6616026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.3818020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.1919048282
MESH:D014062 Tongue Neoplasms resveratrol 8.5016227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.5016051514
MESH:D016171 Torsades de Pointes Amiodarone 3.7117467628 11989578
MESH:D014376 Tuberculosis Tretinoin 2.9116040207
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 7.2911144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.2917053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.2916720314
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.1317473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.1316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.9714692618
MESH:D014594 Uterine Neoplasms resveratrol 7.9717044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.1116752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1015869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.8317488730
MESH:D014820 Vitiligo Tretinoin 3.5916761959
MESH:D009396 Wilms Tumor Tretinoin 3.5616287080
Pathway ID Pathway Name
REACT:13433 Biological oxidations
REACT:15380 Diabetes pathways
KEGG:00920 Sulfur metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA344
    • No data
    Releated disease ID Related disease Name
    PA446893Gastroschisis
    PA443560Breast Neoplasms
    PA447304estrogen-dependent carcinogenesis
    Releated drug ID Related drug Name
    PA448015acetaminophen
    PA449396dopamine
    PA449512estrone
    PA450913phenol
    PA450649norepinephrine
    PA133822447catecholamines
    PA449396dopamine
    PA4519933-beta-hydroxy-5-androsten-17-one
    PA449503estradiol
    PA451581tamoxifen
    PA452604xenobiotics
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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