AutismKB 2.0

Annotation Detail for SUOX


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Basic Information Top
Gene Symbol:SUOX ( - )
Gene Full Name: sulfite oxidase
Band: 12q13.2
Quick LinksEntrez ID:6821; OMIM: 606887; Uniprot ID:SUOX_HUMAN; ENSEMBL ID: ENSG00000139531; HGNC ID: 11460
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5328superpathway of methionine degradation
PWY-5326sulfite oxidation IV
Pathway IDPathway Name
hsa00920Sulfur metabolism
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Related Diseases/Disorders Top
No data
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Desease Name
type 1 diabetes
IMMUNE
No data
Desease Name
Sulfite oxidase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C080417 4-octylphenol 4-octylphenol results in decreased expression of SUOX mRNAdecreases expression 16223563
D000082 Acetaminophen Acetaminophen affects the expression of SUOX mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SUOX mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of SUOX mRNAdecreases expression 20106945
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of SUOX mRNAdecreases expression 16223563
C042080 diisodecyl phthalate diisodecyl phthalate results in decreased expression of SUOX mRNAdecreases expression 16223563
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SUOX mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SUOX mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SUOX mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SUOX mRNAdecreases expression 18796159
D014212 Tretinoin Tretinoin results in increased expression of SUOX mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 9.686734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6814514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.5119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.5112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.5116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.953084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.951917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 7.6010977129
MESH:D002386 Cataract Tretinoin 7.6017460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0215668235 8697196 15340226 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 6.029407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.5017551590 10589399 9142499 16925845 8800419 9224671 9211117 14991402 9125849 9664655
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 7.2516882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 7.2518249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7319085960 15619225 19416960 11743745 11461765 12958197 17906064 16485898 10915739 19370779 16781746 10663392 15968718 16081117 14725611 17562736 12153990 16227642 19739265 2444490 18713872 16393943 18071297 19923254 12705907 11421492 11287661 11739529 12392966 11529661 17522070 14986274 16177239 19164858 12540782 14550746 12594235 19420014 11834606 10774834 16109766
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.0318230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 13.0318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.3411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.3416938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 8.2519224547
MESH:D005234 Fatty Liver pirinixic acid 8.2519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Cyclosporine 16.2912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.2920067830
MESH:D005355 Fibrosis Tretinoin 16.2917994277
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.869664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1412621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 8.1816870215
MESH:D006930 Hyperalgesia Tretinoin 8.1816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.6316580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.6317551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.1618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2817361223 17368321 17649720 17217047 16935935 17506722 17301526 19029980 16788101 15748426 16823087 19642359 17294898 17712046 19075265 17339181 16891316 19035177 9834237 12679006 16331271 19225113 17107899 16140955 16766008
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5018397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 12969438 16610002 16611625 19784758 12587719 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 7.9011940454
MESH:D008113 Liver Neoplasms pirinixic acid 7.9016377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms pirinixic acid 5.2117405874
MESH:D009369 Neoplasms Tretinoin 5.2116594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.3214600291
MESH:D009421 Nervous System Malformations Tretinoin 10.329125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Acetaminophen 7.1616870215
MESH:D010146 Pain Tretinoin 7.1616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5215976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11222880 11896295 11399792
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216116481 16283617
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D012878 Skin Neoplasms Tretinoin 5.8516467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
OMIM:272300 SULFOCYSTEINURIA marker/mechanism
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
KEGG:00920 Sulfur metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03014 - Heme
DB03983 - (Molybdopterin-S,S)-Dioxo-Thio-Molybdenum(V)
No data
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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