AutismKB 2.0

Annotation Detail for SULT2A1


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Basic Information Top
Gene Symbol:SULT2A1 ( DHEA-ST,DHEAS,HST,ST2,ST2A1,ST2A3,STD,hSTa )
Gene Full Name: sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Band: 19q13.33
Quick LinksEntrez ID:6822; OMIM: 125263; Uniprot ID:ST2A1_HUMAN; ENSEMBL ID: ENSG00000105398; HGNC ID: 11458
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Biological oxidations
Pathway IDPathway Name
200027E2F transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
polycystic ovary syndrome
prostate cancer
CANCER
METABOLIC
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene results in increased expression of SULT2A1 mRNAincreases expression 17070881
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SULT2A1 mRNAincreases expression 15004031
15986414
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SULT2A1 proteinincreases expression 15986414
C033146 1-hydroxypyrene Dimethylformamide inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]decreases reaction|increases sulfation 14570759
C033146 1-hydroxypyrene Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]decreases reaction|increases sulfation 14570759
C033146 1-hydroxypyrene Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT2A1 protein]decreases activity|increases reaction 14570759
C035314 1-nitropropane 1-nitropropane results in increased expression of SULT2A1 mRNAincreases expression 17070881
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SULT2A1 mRNAdecreases expression 9566755
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of SULT2A1 mRNAdecreases expression 17070881
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SULT2A1 mRNAaffects expression 21346803
C029905 2,5-dichlorobiphenyl 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein affects the metabolism of Dehydroepiandrosterone]affects metabolic processing|decreases reaction 17112228
C010925 2,5-dihydroxybenzoic acid 2,5-dihydroxybenzoic acid results in increased expression of SULT2A1 mRNAincreases expression 16443358
C025235 2,6-diaminotoluene 2,6-diaminotoluene results in increased expression of SULT2A1 mRNAincreases expression 17070881
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in increased expression of SULT2A1 mRNAincreases expression 17070881
C016617 2-nitropropane 2-nitropropane results in decreased expression of SULT2A1 mRNAdecreases expression 17070881
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in increased expression of SULT2A1 mRNAincreases expression 17070881
C032171 4-coumaric acid 4-coumaric acid results in increased activity of SULT2A1 proteinincreases activity 16443358
C032171 4-coumaric acid 4-coumaric acid results in increased expression of SULT2A1 mRNAincreases expression 16443358
C082137 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide results in increased expression of SULT2A1 mRNAincreases expression 15681896
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of SULT2A1 mRNAdecreases expression 15982314
D000082 Acetaminophen Acetaminophen results in decreased expression of SULT2A1 mRNAdecreases expression 15084756
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SULT2A1 proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in decreased expression of SULT2A1 mRNAdecreases expression 15982314
C103016 antalarmin antalarmin results in decreased expression of SULT2A1 mRNAdecreases expression 16014403
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in decreased expression of SULT2A1 mRNAaffects cotreatment|decreases expression 17639512
C104416 astressin astressin results in decreased expression of SULT2A1 mRNAdecreases expression 16014403
D019324 beta-Naphthoflavone beta-Naphthoflavone results in decreased expression of SULT2A1 mRNAdecreases expression 9566755
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SULT2A1 mRNAaffects cotreatment|decreases expression 18164116
C095105 bexarotene bexarotene results in decreased expression of SULT2A1 mRNAdecreases expression 16648578
D001647 Bile Acids and Salts SULT2A1 protein results in increased sulfation of Bile Acids and Saltsincreases sulfation 15635043
D001647 Bile Acids and Salts SULT2A1 protein results in increased sulfation of Bile Acids and Saltsincreases sulfation 15986414
C105934 celecoxib celecoxib affects the activity of SULT2A1 proteinaffects activity 17239972
C105934 celecoxib celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]affects cotreatment|affects reaction|affects sulfation 15483193
D019826 Cholic Acid Cholic Acid results in increased expression of SULT2A1 mRNAincreases expression 17521389
C019304 ciprofibrate ciprofibrate results in increased expression of and results in increased activity of SULT2A1 proteinincreases activity|increases expression 15635043
C019304 ciprofibrate ciprofibrate results in increased expression of SULT2A1 mRNAincreases expression 15635043
D003022 Clotrimazole Clotrimazole results in decreased expression of SULT2A1 mRNAdecreases expression 9566755
C018021 cobaltous chloride cobaltous chloride results in increased expression of SULT2A1 mRNAincreases expression 20105288
D016572 Cyclosporine Cyclosporine results in decreased expression of SULT2A1 mRNAdecreases expression 20106945
D003687 Dehydroepiandrosterone 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein affects the metabolism of Dehydroepiandrosterone]affects metabolic processing|decreases reaction 17112228
D003687 Dehydroepiandrosterone Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]decreases reaction|increases sulfation 14570759
D003687 Dehydroepiandrosterone SULT2A1 protein results in increased sulfation of Dehydroepiandrosteroneincreases sulfation 19646966
14570759
10752640
D003907 Dexamethasone Dexamethasone results in increased expression of SULT2A1 mRNAincreases expression 15541768
D003907 Dexamethasone Dexamethasone affects the expression of SULT2A1 mRNAaffects expression 15102944
D003907 Dexamethasone Dexamethasone results in increased expression of SULT2A1 mRNAincreases expression 9566755
15635043
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SULT2A1 mRNAaffects cotreatment|decreases expression 18164116
D004126 Dimethylformamide Dimethylformamide inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]decreases reaction|increases sulfation 14570759
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of SULT2A1 mRNAdecreases expression 17072980
C071192 entacapone entacapone binds to SULT2A1 proteinaffects binding 19783845
D004958 Estradiol Estradiol results in decreased expression of SULT2A1 mRNAdecreases expression 20106945
D000431 Ethanol Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]decreases reaction|increases sulfation 14570759
D000431 Ethanol Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]decreases reaction|increases sulfation 14570759
D000431 Ethanol Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT2A1 protein]decreases activity|increases reaction 14570759
D000431 Ethanol Ethanol results in decreased activity of SULT2A1 proteindecreases activity 14570759
D004997 Ethinyl Estradiol celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]affects cotreatment|affects reaction|affects sulfation 15483193
D004997 Ethinyl Estradiol [Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiolaffects cotreatment|affects sulfation 15483193
D004997 Ethinyl Estradiol SULT2A1 protein affects the metabolism of [Phosphoadenosine Phosphosulfate co-treated with Ethinyl Estradiol]affects cotreatment|affects metabolic processing 15483193
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SULT2A1 mRNAincreases expression 15953391
17108234
C004999 ferulic acid ferulic acid results in increased expression of SULT2A1 mRNAincreases expression 16443358
D005419 Flavonoids Flavonoids results in increased expression of SULT2A1 mRNAincreases expression 18035473
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in decreased expression of SULT2A1 mRNAdecreases expression 17070881
D005576 Forskolin Forskolin results in decreased expression of SULT2A1 mRNAdecreases expression 17080404
D005576 Forskolin Lindane promotes the reaction [Forskolin results in decreased expression of SULT2A1 mRNA]decreases expression|increases reaction 17080404
D005707 Gallic Acid Gallic Acid results in increased activity of SULT2A1 proteinincreases activity 16443358
D005707 Gallic Acid Gallic Acid results in increased expression of SULT2A1 mRNAincreases expression 16443358
D006533 Heptachlor Heptachlor results in decreased expression of SULT2A1 mRNAdecreases expression 9566755
D006881 Hydroxyacetylaminofluorene SULT2A1 protein results in increased sulfation of Hydroxyacetylaminofluoreneincreases sulfation 10752640
D006914 Hydroxysteroids SULT2A1 protein results in increased sulfation of Hydroxysteroidsincreases sulfation 15635043
C099406 L 742694 L 742694 affects the expression of SULT2A1 mRNAaffects expression 15102944
D001556 Lindane Lindane promotes the reaction [Forskolin results in decreased expression of SULT2A1 mRNA]decreases expression|increases reaction 17080404
D001556 Lindane Lindane results in decreased expression of SULT2A1 mRNAdecreases expression 17080404
D001556 Lindane Lindane results in decreased expression of SULT2A1 mRNAdecreases expression 9566755
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of SULT2A1 mRNAdecreases expression 9566755
D017239 Paclitaxel Paclitaxel analog results in increased expression of SULT2A1 mRNAincreases expression 15585946
D017239 Paclitaxel Paclitaxel results in increased expression of SULT2A1 mRNAincreases expression 15585946
D010278 Parathion Parathion results in increased activity of SULT2A1 proteinincreases activity 15351727
D010278 Parathion Parathion results in increased expression of SULT2A1 mRNAincreases expression 15351727
D010278 Parathion Parathion results in increased expression of SULT2A1 proteinincreases expression 15351727
D010634 Phenobarbital Phenobarbital results in increased expression of SULT2A1 mRNAincreases expression 15986414
D010634 Phenobarbital Phenobarbital results in increased expression of SULT2A1 proteinincreases expression 15986414
D010634 Phenobarbital Phenobarbital results in decreased expression of SULT2A1 mRNAdecreases expression 9566755
D010672 Phenytoin Phenytoin results in decreased expression of SULT2A1 mRNAdecreases expression 9566755
D010724 Phosphoadenosine Phosphosulfate celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]affects cotreatment|affects reaction|affects sulfation 15483193
D010724 Phosphoadenosine Phosphosulfate [Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiolaffects cotreatment|affects sulfation 15483193
D010724 Phosphoadenosine Phosphosulfate SULT2A1 protein affects the metabolism of [Phosphoadenosine Phosphosulfate co-treated with Ethinyl Estradiol]affects cotreatment|affects metabolic processing 15483193
C006253 pirinixic acid pirinixic acid results in increased expression of and results in increased activity of SULT2A1 proteinincreases activity|increases expression 15635043
D011078 Polychlorinated Biphenyls SULT2A1 protein affects the metabolism of Polychlorinated Biphenyls metaboliteaffects metabolic processing 17112228
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile results in increased expression of SULT2A1 mRNAincreases expression 15541768
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in decreased expression of SULT2A1 mRNAaffects cotreatment|decreases expression 17639512
D015474 Isotretinoin Isotretinoin results in increased expression of SULT2A1 mRNAincreases expression 15982314
C488333 Ro 65-7199 Ro 65-7199 affects the expression of SULT2A1 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of SULT2A1 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 results in increased expression of SULT2A1 mRNAincreases expression 14610520
C017947 sodium arsenite sodium arsenite results in decreased expression of SULT2A1 mRNAdecreases expression 17451858
D014284 Triiodothyronine Triiodothyronine results in increased expression of SULT2A1 mRNAincreases expression 15953391
D013629 Tamoxifen Tamoxifen results in increased expression of SULT2A1 proteinincreases expression 19812351
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of SULT2A1 mRNAaffects expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SULT2A1 mRNAdecreases expression 16054898
18178546
9566755
D013963 Thyroid Hormones SULT2A1 protein affects the metabolism of Thyroid Hormonesaffects metabolic processing 15004031
C066340 tolcapone tolcapone binds to SULT2A1 proteinaffects binding 19783845
D014212 Tretinoin Tretinoin metabolite results in decreased expression of SULT2A1 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of SULT2A1 mRNAdecreases expression 15982314
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.8414745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 19.4517676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 19.4518769834
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 19.456195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 19.458986270 10563481 9118846 3425630 6195326 9677735
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 19.4514514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.3518769834
MESH:D000138 Acidosis Ethanol 3.8111192467
MESH:D017486 Acneiform Eruptions Isotretinoin 5.5816232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 9.6517505938
MESH:D000152 Acne Vulgaris Isotretinoin 9.6518769834 16185265
MESH:D055371 Acute Lung Injury pirinixic acid 2.4818653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 5.7316033868
MESH:D000230 Adenocarcinoma Estradiol 5.7311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 5.7314692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 16.3410737359
MESH:D000236 Adenoma beta-Naphthoflavone 16.3419389873
MESH:D000236 Adenoma Diethylnitrosamine 16.3410737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 16.3419555203
MESH:D000236 Adenoma Methylcholanthrene 16.3410545420 6695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.306705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.2116434500 17162532 19052882 18056438 17620307 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.2117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.2116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.2116835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 4.4716215675 19003578
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 3.9915276417
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.0917302879
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.1917306315 16712894
MESH:D000382 Agricultural Workers' Diseases Heptachlor 10.8812661182
MESH:D000382 Agricultural Workers' Diseases Lindane 10.8812661182
MESH:D000382 Agricultural Workers' Diseases Parathion 10.8811874814 17119214
MESH:D017109 Akathisia, Drug-Induced tolcapone 5.5911080934
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.6115451039 15451040
MESH:D000505 Alopecia Tretinoin 3.0515955085
MESH:D000544 Alzheimer Disease entacapone 4.5020150427
MESH:D000544 Alzheimer Disease tolcapone 4.5020150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.3411748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.6117084956
MESH:D000799 Angioedema Acetaminophen 3.1410982225
MESH:D000853 Anophthalmos Ethanol 4.1415513904
MESH:D001008 Anxiety Disorders Ethanol 3.4411141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.7911256880
MESH:D001169 Arthritis, Experimental Dexamethasone 9.5717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 9.5715885639
MESH:D001169 Arthritis, Experimental Tretinoin 9.5716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.0616292516
MESH:D001249 Asthma Tretinoin 2.1016456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.2815336622
MESH:D050197 Atherosclerosis Methylcholanthrene 5.7011922910
MESH:D050197 Atherosclerosis Phenytoin 5.7015136057
MESH:D001321 Autistic Disorder Acetaminophen 1.5318445737
MESH:D001327 Autoimmune Diseases Quercetin 3.7319761891
MESH:D001471 Barrett Esophagus Tretinoin 3.7416935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 11.6619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 11.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 11.6616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.0915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.2815746008
MESH:D001859 Bone Neoplasms Paclitaxel 3.9315867366
MESH:D001919 Bradycardia antalarmin 5.6716710322
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 12.3011921183
MESH:D001943 Breast Neoplasms alitretinoin 12.3016344269
MESH:D001943 Breast Neoplasms Ascorbic Acid 12.3016443354
MESH:D001943 Breast Neoplasms bexarotene 12.3016818667 16344269
MESH:D001943 Breast Neoplasms Diethylnitrosamine 12.3017474063
MESH:D001943 Breast Neoplasms Estradiol 12.3017261762 19861407 14630087 12948864 17289903 17018787 18497071 16675129
MESH:D001943 Breast Neoplasms Heptachlor 12.308738476
MESH:D001943 Breast Neoplasms Lindane 12.3014688026
MESH:D001943 Breast Neoplasms Methylcholanthrene 12.3017474063
MESH:D001943 Breast Neoplasms Paclitaxel 12.3018223236 16244791 11325840 16273361 16115903 18323546 18234424 15136595
MESH:D001943 Breast Neoplasms Parathion 12.3012762645
MESH:D001943 Breast Neoplasms Quercetin 12.3018628248
MESH:D001943 Breast Neoplasms Tamoxifen 12.3018351453 20390343 19103187 19221464 18984771 18815881 11161223 15565566 19059307 20544844 19066611 19115204 19189212 19487384 15668708 19200415 20135344 17440819 18997820 19410462 19142967 17893378 18425577 20859285 16818667 17261762 19155303 16873071 19084267 17049068 16202921 19288272 18629630 21152245 18821012 19289846 17242785 21138602 20065188 16273361 20005174 19244106 19011961 18855134 19189210
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 12.3020435547
MESH:D001943 Breast Neoplasms Tretinoin 12.3016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9016813970
MESH:D002056 Burns Ethanol 3.9816374292
MESH:D002105 Cadmium Poisoning Quercetin 4.8416962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7716111702
MESH:D002252 Carbon Tetrachloride Poisoning ferulic acid 5.2116011737
MESH:D002277 Carcinoma Dimethylnitrosamine 10.8019555203
MESH:D002277 Carcinoma Methylcholanthrene 10.8010545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 10.8016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8319066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.4516168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 27.9716705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 27.9710737359 3581430 6705139 17761372 3084413
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 27.973084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 27.9721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 27.9718494052 18971187 19052882 3581430 20512989 19418558 20214788 18665156 16569478 20935162 17162532 18785209 16502159 21159647 20727157 19335982 19919837 18506893 16540662 10737359 17055752 19701751 19383236 16807293 16830150 17978847 19107877 20524982 19208518 11831363 18788625 16288022 16878318 19822196 16935385 18978308 20514400 19539802 16328049 17761372 18210153 20084675 16698587 20432363 20101231 17173139 10672840 17138121 18393292 19394651 20007298 18056438 3084413 18691550 16681979 19171122 17428255 19519916 16779866
MESH:D006528 Carcinoma, Hepatocellular Estradiol 27.9716924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 27.9718788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 27.9716313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 27.971701930 17173139 6705139 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Quercetin 27.9719519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 27.9715276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 27.9716924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 27.971917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 2.9416247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.2817234771
MESH:D002292 Carcinoma, Renal Cell celecoxib 3.8116369983
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 8.6716033868
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 8.6711237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 8.6718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.6716096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.0117572228
MESH:D006332 Cardiomegaly Ethanol 8.9619332462
MESH:D006332 Cardiomegaly Quercetin 8.9619794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 8.9618670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 5.7310977129
MESH:D002386 Cataract Tretinoin 5.7317460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.7612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.7621159647 7505956 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.7618566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 15.7616192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.7620056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 9.424080065
MESH:D002493 Central Nervous System Diseases Phenytoin 9.424080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9016129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.3519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.3516835633
MESH:D002779 Cholestasis Cyclosporine 10.2419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.2416919318 17110522 17681005 11677210 17333356 16105132 15861022
MESH:D002779 Cholestasis pirinixic acid 10.2419176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.1711748493
MESH:D002822 Choriocarcinoma Tretinoin 4.4516461808
MESH:D002971 Cleft Lip Ethanol 6.5715513904
MESH:D002971 Cleft Lip Phenytoin 6.572227380
MESH:D002972 Cleft Palate Ethanol 11.2615513904
MESH:D002972 Cleft Palate Phenytoin 11.262227380 10789828 6856622 3877104 6862529 1687470
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 11.2616354765 8697196 12621046 15668235 15340226
MESH:D002972 Cleft Palate Tretinoin 11.269407595
MESH:D003092 Colitis Tretinoin 3.0417035595
MESH:D003103 Coloboma Phenytoin 4.529212184
MESH:D003110 Colonic Neoplasms celecoxib 4.9916004971
MESH:D003110 Colonic Neoplasms Dexamethasone 4.9915824018
MESH:D003110 Colonic Neoplasms Quercetin 4.9917148506 17191121 19440933 11134977 15741050 19056647 16640504
MESH:D015179 Colorectal Neoplasms celecoxib 4.1211197048 18349538
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.1218802399
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.1215531428
MESH:D015179 Colorectal Neoplasms Quercetin 4.1218852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 4.7717323712
MESH:D000013 Congenital Abnormalities Phenytoin 7.4110627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.4117141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 7.9317728286
MESH:D019465 Craniofacial Abnormalities Ethanol 7.9319302082 15451040 15451039 15513904 10194807 11873399 11198716
MESH:D019465 Craniofacial Abnormalities Isotretinoin 7.9318769834 9879862
MESH:D019465 Craniofacial Abnormalities Phenytoin 7.9319952982 9212184 8986270
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.9320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.939125849 14991402 8800419 9664655 9224671 17551590 9211117 10589399 9142499 16925845
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.3418551238
MESH:D003704 Dementia Polychlorinated Biphenyls 4.0816140633
MESH:D003711 Demyelinating Diseases Tamoxifen 3.6819031437
MESH:D003866 Depressive Disorder entacapone 7.047768276
MESH:D003866 Depressive Disorder tolcapone 7.0411224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 4.3110440460
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 5.3316823706 11298694 15059100
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 5.3312438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.0618249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.1619496084
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.4416616286
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 5.8216506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 5.8220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 5.8217107852
MESH:D003928 Diabetic Nephropathies Estradiol 6.8719279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 6.8719279558
MESH:D003967 Diarrhea Dexamethasone 3.067237001
OMIM:607208 DRAVET SYNDROME Phenytoin 4.7111748493
MESH:D003875 Drug Eruptions Phenytoin 4.8215024534
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 23.6618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 23.6616445897 20517888 15804453
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 23.6617906064 16781746 12153990 12594235 10774834 11834606 14550746 11461765 12705907 17562736 18713872 16109766 11529661 12958197 10663392 16081117 18071297 19420014 11743745 2444490 11739529 17522070 12540782 19923254 16485898 10915739 16227642 19164858 12392966 16177239 11421492 14986274 19739265 15968718 19085960 19370779 19416960 15619225 14725611 16393943 11287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 23.6619107877
MESH:D056486 Drug-Induced Liver Injury Dimethylformamide 23.663732212
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 23.668172417
MESH:D056486 Drug-Induced Liver Injury entacapone 23.6619783845
MESH:D056486 Drug-Induced Liver Injury Ethanol 23.6611566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 23.6620420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 23.6619783845 16604736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.3919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.2311462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 4.6911455177
MESH:D004421 Dystonia Phenobarbital 3.361851702
MESH:C538011 Eales disease Ascorbic Acid 4.779068938
MESH:D004485 Eczema Dexamethasone 3.8012438553
MESH:D004487 Edema Dexamethasone 7.8919703484
MESH:D004487 Edema pirinixic acid 7.8912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.8911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.6016714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 9.6018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 11.6512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 11.6517654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 11.6519031437
MESH:D016889 Endometrial Neoplasms Estradiol 9.6018566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 9.6019155303 20544844 16202921 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 9.6016569247
MESH:D004715 Endometriosis celecoxib 7.3515652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.3510568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.5420235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.536251365 1399206
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.433659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.013922381 11558140
MESH:D004828 Epilepsies, Partial Phenytoin 8.0111558140 17116037
MESH:D004827 Epilepsy Phenobarbital 5.6820417680
MESH:D004827 Epilepsy Phenytoin 5.68821787 11434505 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 2.956401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.427750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 9.427750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.553659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 8.553659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.4116302075
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 6.0917016578
MESH:D004938 Esophageal Neoplasms Ethanol 6.0916704527
MESH:D004938 Esophageal Neoplasms Paclitaxel 6.0916481741
MESH:D004942 Esophagitis, Peptic Bile Acids and Salts 5.8511346197
MESH:D054908 Extensively Drug-Resistant Tuberculosis entacapone 12.3619578428
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 12.3619578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 7.0416938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 22.6919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.6921071580 20387270
MESH:D005234 Fatty Liver Ethanol 22.6916409862 18620774 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.6915345470
MESH:D005234 Fatty Liver pirinixic acid 22.6919236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 22.6919224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 4.9617920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.7716709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.6016946407 10194807 15513904 15451040
MESH:D005313 Fetal Death Phenytoin 8.4910627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 8.4911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.8314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.4919069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.2514633661 10962813
MESH:D005355 Fibrosis Cyclosporine 15.6512168785 12639820
MESH:D005355 Fibrosis Quercetin 15.6519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.6520067830
MESH:D005355 Fibrosis Tretinoin 15.6517994277
MESH:D005756 Gastritis Acetaminophen 8.7916983495
MESH:D005756 Gastritis Ethanol 8.7915046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 3.9916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 10.618708960
MESH:D005885 Gingival Hyperplasia Phenytoin 10.619029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.5316390469 14659971
MESH:D005909 Glioblastoma Quercetin 5.6519804834
MESH:D005909 Glioblastoma Tretinoin 5.6517312396
MESH:D005910 Glioma Quercetin 2.7317643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.8910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.6916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.4516084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 8.8316080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 8.8311294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 8.839664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.0820558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.616705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 3.796705139
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.7315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7111000095
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 15.2316109766
MESH:D006529 Hepatomegaly Phenobarbital 15.2316109766
MESH:D006529 Hepatomegaly pirinixic acid 15.2319176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.2315340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 5.2516863852 16490937
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.257520565
MESH:D006558 Herpes Genitalis Estradiol 4.3215709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.5912676792
MESH:D019584 Hot Flashes Estradiol 3.0517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.348697196 15340226 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 9.8316870215
MESH:D006930 Hyperalgesia Ethanol 9.8318783367
MESH:D006930 Hyperalgesia Tretinoin 9.8316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.8916778211
MESH:D006943 Hyperglycemia pirinixic acid 7.2220558911
MESH:D006943 Hyperglycemia Quercetin 7.2211834736 18262572
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.0810459572
MESH:D006973 Hypertension Cyclosporine 9.7010903974
MESH:D006973 Hypertension Dexamethasone 9.7017042910
MESH:D006973 Hypertension Quercetin 9.7018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.7018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.1316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.8212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 8.5417937319
MESH:D007248 Infertility, Male Parathion 8.5416029889
MESH:D007248 Infertility, Male sodium arsenite 8.5415346721 12646999
MESH:D007249 Inflammation Dexamethasone 11.5111099482 8960868
MESH:D007249 Inflammation Diethylnitrosamine 11.5118785209
MESH:D007249 Inflammation Flavonoids 11.5117296493
MESH:D007249 Inflammation Tamoxifen 11.5119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.5112200463 12878042
MESH:D007251 Influenza, Human Quercetin 3.8016624496
MESH:D007333 Insulin Resistance Estradiol 5.5816393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 5.5816306350
MESH:D007410 Intestinal Diseases Tretinoin 3.1017994277
MESH:D007569 Jaw Abnormalities Ethanol 13.5715513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 13.5716580747
MESH:D007569 Jaw Abnormalities Tretinoin 13.5717551590 15992940
MESH:D007627 Keloid Quercetin 4.2817086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.7315604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 4.9416144296
MESH:D007674 Kidney Diseases Acetaminophen 14.3615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 14.3610903974 18776723 8314463
MESH:D007674 Kidney Diseases Estradiol 14.3615618244
MESH:D007674 Kidney Diseases Quercetin 14.3616962696
MESH:D007674 Kidney Diseases sodium arsenite 14.3620008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.0516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.0512371664
MESH:D007680 Kidney Neoplasms Estradiol 13.0515610895
MESH:D007680 Kidney Neoplasms Tamoxifen 13.0518625569
MESH:D007859 Learning Disorders Ethanol 3.5415451040
MESH:D007938 Leukemia Quercetin 5.1417468513
MESH:D007938 Leukemia Tretinoin 5.1417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.0816932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9316294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.6712679006 16891316 17649720 9834237 19029980 16766008 17301526 17107899 16935935 17339181 17506722 17361223 17217047 16331271 19225113 19075265 16140955 17712046 16823087 17368321 17294898 15748426 19642359 19035177 16788101
MESH:D017880 Limb Deformities, Congenital Ethanol 6.5817676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 6.589224671
MESH:D008064 Lipidoses Tamoxifen 2.6415342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.1817353645
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 8.6018522880 18407596 20032147 19638242 18665156
MESH:D008103 Liver Cirrhosis Ethanol 8.6015289165
MESH:D008103 Liver Cirrhosis Phenobarbital 8.6021047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.4018295389
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 17072980
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 15.2816718785
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 15.2815138612 18567088 15479170 14659978 15067225 17534399 15081153 18210741 17724770 15366600 17666798 14726149 17432682 18237412 18672772 16270385 17348192 17203207 17719030 15339415 15577212 17201889 15942678 15383259 17036385 15733078 15492853 16603200 15571005 15591649 18364076 15298665 17465448 16544323 15099470 12925901 16169303 17640959 18095165 15798949 16042886 15369754 15864749 14643895 14709902 15161499 15763062 18629640 16009107 15504291 17198567 17196135 18239293 15842777 14568256 15793283 18637143 15086199 17881167 16627068 15744066 18371158 15723089 12918455 16570917
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 15.2814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 15.2818166357
MESH:D008106 Liver Cirrhosis, Experimental ferulic acid 15.2816011737
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 15.2815474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 15.2812741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 15.2818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 15.2812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 15.2818397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 9.9412587719 19014921 11587558 12969438 19784758 16611625 16610002 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 9.9417034775
MESH:D008107 Liver Diseases Lindane 9.941715830
MESH:D008107 Liver Diseases Phenobarbital 9.9419363144
MESH:D008107 Liver Diseases Phenytoin 9.9414986274
MESH:D008108 Liver Diseases, Alcoholic Ethanol 3.9817207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 7.6517185352 16871587
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 7.6517457977
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 50.7618644402 16835634
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 50.7618001218 10672840 16273603 11376686 14678523 10737359
MESH:D008113 Liver Neoplasms Aflatoxin B1 50.7615890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 50.7619389873 21295105
MESH:D008113 Liver Neoplasms ciprofibrate 50.7612771043
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 50.7618709148
MESH:D008113 Liver Neoplasms Diethylnitrosamine 50.7619812893 19850985 19642983 19996281 21047994 18977376 20118626 20101389 19090486 18644402 20405173 19294768 18978307 20583210 20492335 19255062 10737359 15175105 16942905 19254457 21278145 20434301 19499222 15885732 19427195 18648771 20137499 18754104 2862719 19073162 12771043 19690152 19551842 2422723 19638242 19833225 21071580 20501860 20452335 21167192 9163691 12112319 19426721 19256749
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 50.7615890375 3113478
MESH:D008113 Liver Neoplasms Heptachlor 50.762422723 9544696
MESH:D008113 Liver Neoplasms Hydroxyacetylaminofluorene 50.769163691
MESH:D008113 Liver Neoplasms Phenobarbital 50.7619482888 19812893 15975961 8742319 19073162 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 50.7620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 50.7618980244
MESH:D008113 Liver Neoplasms sodium arsenite 50.7615276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 50.7616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 50.7616984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 42.16534488 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 42.168603461
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 42.1618544905
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 42.1618164116
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 42.168603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 42.1618079962 16267830 18544905 17854601 18775883 18282651 3124819 21159647 2563599 19539802 17174075 19009564 18164116 9362446 16842330 17942915 19126423 19519916 18253720 18093689 19004024 18308698
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 42.166150874 15603536 1848544
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 42.161399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 42.161399818 6150874 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 42.161423854
MESH:D008114 Liver Neoplasms, Experimental Quercetin 42.1619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 42.1612151625
MESH:D008171 Lung Diseases Ascorbic Acid 6.0716863852
MESH:D008171 Lung Diseases sodium arsenite 6.0719095001
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 24.8311376686
MESH:D008175 Lung Neoplasms Aflatoxin B1 24.8314755239
MESH:D008175 Lung Neoplasms alitretinoin 24.8316413115
MESH:D008175 Lung Neoplasms Ascorbic Acid 24.8316401635
MESH:D008175 Lung Neoplasms bexarotene 24.8317849452
MESH:D008175 Lung Neoplasms Dexamethasone 24.8315824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 24.8320512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 24.8316061637 19555203 11884234
MESH:D008175 Lung Neoplasms Isotretinoin 24.8315899809
MESH:D008175 Lung Neoplasms Methylcholanthrene 24.8321163286 15390079 6695378 1399818 9230183 16271038 16337739 20970405 7750092 17909032 11893704 10545420 20512841
MESH:D008175 Lung Neoplasms Quercetin 24.8316280456
MESH:D008175 Lung Neoplasms sodium arsenite 24.8315276417 19931552 17306315 16712894 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 24.8318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 24.8311884234 19555203
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.5214749477
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.4711161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.0719428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 17.3911921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 17.3915591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 17.3919196722 12104042
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 17.3916457693
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.3911408345 16891317 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 17.3911731420 14580682 16827153 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 10.3019453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.3019453300
MESH:D008527 Medulloblastoma Tretinoin 2.4617453147
MESH:D008545 Melanoma Isotretinoin 7.8917237267
MESH:D008545 Melanoma Paclitaxel 7.8916342250 12025231 12040289
MESH:D008545 Melanoma sodium arsenite 7.8919082730 16487513
MESH:D008545 Melanoma Tamoxifen 7.8919393235 12393984
MESH:D008545 Melanoma Tretinoin 7.8916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.4915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.1719513568
MESH:D008546 Melanoma, Experimental Gallic Acid 9.1719577552
MESH:D008569 Memory Disorders Ethanol 3.5318411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 3.7516940565
MESH:D008607 Mental Retardation Phenytoin 3.399212184
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.0816801185
MESH:D009101 Multiple Myeloma celecoxib 9.4016123214
MESH:D009101 Multiple Myeloma Dexamethasone 9.4016118317 15867202 15744524
MESH:D009101 Multiple Myeloma Paclitaxel 9.4014749477
MESH:D009135 Muscular Diseases pirinixic acid 2.8316239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.079809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.0717596541
MESH:D009203 Myocardial Infarction pirinixic acid 4.5819151258
MESH:D009203 Myocardial Infarction Quercetin 4.5819595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.4612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.0116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.0116411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 11.0119207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 10.1917484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 10.1917484760
MESH:D009224 Myotonia Congenita Phenytoin 4.721896199
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.6818551238
MESH:D009336 Necrosis 2-nitropropane 8.6812195237
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 7.609029167 3581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 7.6015867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 7.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2419410462
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 17.988820588
MESH:D009369 Neoplasms alitretinoin 17.9816946489
MESH:D009369 Neoplasms Lindane 17.9816818664 12807735
MESH:D009369 Neoplasms pirinixic acid 17.9817405874
MESH:D009369 Neoplasms Quercetin 17.9815185748
MESH:D009369 Neoplasms sodium arsenite 17.9811559025
MESH:D009369 Neoplasms Tretinoin 17.9816594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.0020056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 14.3719196722
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 14.3719196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 14.3719189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.0517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.7317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.6919348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 12.5311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 12.5314600291
MESH:D009421 Nervous System Malformations Tretinoin 12.539125849
MESH:D009436 Neural Tube Defects Phenytoin 9.479118846
MESH:D009436 Neural Tube Defects sodium arsenite 9.4712854658
MESH:D009436 Neural Tube Defects Tretinoin 9.479142499
MESH:D009447 Neuroblastoma Isotretinoin 3.6417368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.2718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.2720387270
MESH:D020078 Neurogenic Inflammation Quercetin 3.7217929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.4120387270
MESH:D009765 Obesity Ascorbic Acid 3.9817217161
MESH:D009765 Obesity pirinixic acid 3.9820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 2.8216049721 12819281
MESH:D010014 Osteolysis Paclitaxel 4.2915867366
MESH:D010018 Osteomalacia Phenobarbital 9.7717016548
MESH:D010018 Osteomalacia Phenytoin 9.7717016548
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 8.3516397352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.3519495926
MESH:D010051 Ovarian Neoplasms Estradiol 11.9819401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 11.9811161223
MESH:D010051 Ovarian Neoplasms Quercetin 11.9819005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.9817306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 11.9816936753
MESH:D010146 Pain Acetaminophen 8.0616870215
MESH:D010146 Pain Phenytoin 8.0615215642
MESH:D010146 Pain Tretinoin 8.0616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 13.0016540662
MESH:D010190 Pancreatic Neoplasms Ethanol 13.0012384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 13.0016965848
MESH:D010190 Pancreatic Neoplasms Quercetin 13.0016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 13.0015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0411578682
MESH:D010300 Parkinson Disease entacapone 7.2719783845 19578428 11586115 17089403 20334432
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 7.2716702228
MESH:D010300 Parkinson Disease tolcapone 7.2711432539 11746615 20216409 17089403 9305320 18328768 16758261 9754991 11586115 19578428 8739811 8635184 9708959 20334432 9591521 11793426 10651109 1977408 7566641 9333106 19783845
MESH:D020734 Parkinsonian Disorders entacapone 4.7918722529
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5412520081
MESH:D017689 Polydactyly Phenytoin 4.459212184
MESH:D017499 Porokeratosis alitretinoin 5.3016144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9018163543
MESH:D011230 Precancerous Conditions Cyclosporine 17.0312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 17.032563599
MESH:D011230 Precancerous Conditions Phenobarbital 17.032563599
MESH:D011230 Precancerous Conditions Quercetin 17.0319056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.1121297632
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 7.5618769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.5611399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.2620887781
MESH:D011471 Prostatic Neoplasms celecoxib 2.5715570007 17908994
MESH:D011471 Prostatic Neoplasms Estradiol 2.5716740699
MESH:D011471 Prostatic Neoplasms Heptachlor 2.5712661182
MESH:D011471 Prostatic Neoplasms Lindane 2.5714688026 12661182
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.5717172428 16729912 16356831 17136230
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.5715721890
MESH:D011471 Prostatic Neoplasms Quercetin 2.5717292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5715067354
MESH:D011507 Proteinuria Tretinoin 2.9716636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.6316919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 10.2112752131
MESH:D019310 Pseudolymphoma Phenytoin 10.218603615 1419762 12752131
MESH:D011565 Psoriasis Cyclosporine 1.9416882103
MESH:D011596 Psychomotor Disorders Isotretinoin 5.2218769834
MESH:D011625 Pterygium Tretinoin 4.1016723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.6314606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.0019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.3818379247 11700416
MESH:D012135 Respiratory Sounds Parathion 4.6217119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.1818990726
MESH:D012140 Respiratory Tract Diseases Parathion 4.8517119214
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.0716849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.4616283617 16116481
MESH:D012554 Schistosomiasis japonica Quercetin 4.8416862918
MESH:D012640 Seizures 2,4-dinitrotoluene 13.3418551238
MESH:D012640 Seizures Ethanol 13.349754883
MESH:D012640 Seizures Lindane 13.347539098 12842176 15475178
MESH:D012640 Seizures Phenobarbital 13.343137016 4039156 11442880 16876388
MESH:D012640 Seizures Phenytoin 13.349844417 16876388 19919933 11044598 3691417 10029267 3137016 15946322
MESH:D003294 Seizures, Febrile Phenobarbital 4.136407741
MESH:D012871 Skin Diseases Ascorbic Acid 2.9918709164
MESH:D012878 Skin Neoplasms sodium arsenite 7.2119524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.2116192470
MESH:D012878 Skin Neoplasms Tretinoin 7.2116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 9.2216709447
MESH:D013088 Spermatocele Tamoxifen 9.2216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.3519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.2412854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.5612587719
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.4820235791
MESH:D013272 Stomach Diseases Dexamethasone 3.6315472012
MESH:D013274 Stomach Neoplasms celecoxib 6.8915609394
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.8918456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 6.8916033868
MESH:D013274 Stomach Neoplasms Ethanol 6.8918456281
MESH:D013274 Stomach Neoplasms Paclitaxel 6.8918396642 18506536
MESH:D013274 Stomach Neoplasms Tretinoin 6.8917261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 8.6818726076
MESH:D013276 Stomach Ulcer Dexamethasone 8.6815138204
MESH:D013276 Stomach Ulcer Ethanol 8.6811906479 16755016 9562338 17918041 17189318 9211565
MESH:D020521 Stroke Ascorbic Acid 3.7316403987 16517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.659754883
MESH:D024801 Tauopathies Paclitaxel 4.1216930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.9811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.5615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 8.837505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.831399818
MESH:D013964 Thyroid Neoplasms Tretinoin 8.8316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 3.9819048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.1816051514
MESH:D014376 Tuberculosis Tretinoin 2.7616040207
MESH:D018088 Tuberculosis, Multidrug-Resistant entacapone 12.3619578428
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 12.3619578428
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.2816049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 12.2815867355 1399818 15289314
MESH:D001749 Urinary Bladder Neoplasms Quercetin 12.2816720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.2816712894 16452187 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.2817572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.6210091137
MESH:D014581 Urticaria Acetaminophen 2.3410982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 7.3911813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.3916129372
MESH:D014594 Uterine Neoplasms celecoxib 7.6618645019
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.6614692618
MESH:D014604 Uveal Neoplasms Tretinoin 3.9016752155
MESH:D014605 Uveitis Cyclosporine 9.431336536
MESH:D014605 Uveitis Dexamethasone 9.431336536
MESH:D014652 Vascular Diseases sodium arsenite 3.7317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.8912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.9114671159 15869587
MESH:D014820 Vitiligo tolcapone 8.9010573327
MESH:D014820 Vitiligo Tretinoin 8.9016761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5415886252
MESH:D009396 Wilms Tumor Tretinoin 3.3716287080
MESH:D014985 Xerophthalmia Cyclosporine 3.7317120751
Pathway ID Pathway Name
KEGG:04976 Bile secretion
REACT:13433 Biological oxidations
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00140 Steroid hormone biosynthesis
KEGG:00920 Sulfur metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA346
    • Releated gene ID Related gene Name
    PA346SULT2A1
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA447304estrogen-dependent carcinogenesis
    Releated drug ID Related drug Name
    PA449396dopamine
    PA449512estrone
    PA450913phenol
    PA4519933-beta-hydroxy-5-androsten-17-one
    PA133822447catecholamines
    PA449503estradiol
    PA451581tamoxifen
    PA452604xenobiotics
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01708 - 3-Beta-Hydroxy-5-Androsten-17-One Adjuvants, Immunologic
    DB01812 - Adenosine-3'-5'-Diphosphate
    DB02854 - Aetiocholanolone
    DB04445 - Mercury Diiodide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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