AutismKB 2.0

Annotation Detail for BST1


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Basic Information Top
Gene Symbol:BST1 ( CD157 )
Gene Full Name: bone marrow stromal cell antigen 1
Band: 4p15.32
Quick LinksEntrez ID:683; OMIM: 600387; Uniprot ID:BST1_HUMAN; ENSEMBL ID: ENSG00000109743; HGNC ID: 1118
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
No data
No data
No data
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Related Diseases/Disorders Top
No data
No data
Desease Name
Parkinson's disease
NEUROLOGICAL
Desease Name
Parkinson's disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of BST1 mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of BST1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BST1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of BST1 mRNAdecreases expression 19654921
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BST1 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of BST1 mRNAdecreases expression 15336504
C423222 cotylenin A cotylenin A results in increased expression of BST1 mRNAincreases expression 16129123
D000431 Ethanol Ethanol results in decreased expression of BST1 mRNAdecreases expression 15353170
C006253 pirinixic acid pirinixic acid results in decreased expression of BST1 mRNAdecreases expression 17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of BST1 mRNAdecreases expression 17101203
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of BST1 mRNAdecreases expression 15289447
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.1217676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1215322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 11.1318287403
MESH:D000138 Acidosis Ethanol 11.1311192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.7515814487
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.5415451040 15451039
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D000853 Anophthalmos Ethanol 5.0015513904
MESH:D001008 Anxiety Disorders Ethanol 4.1211141031
MESH:D020261 Arsenic Poisoning Arsenic 2.9012569548 16251483 18414634 16835338
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2119898480
MESH:D050197 Atherosclerosis Arsenic 3.3319371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002056 Burns Ethanol 4.8316374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.773084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.7717306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.7715763234 18788625 15289165
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4711212258
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.2618922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.2611212258
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D006332 Cardiomegaly Ethanol 7.0919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0918850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 3.5417938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4316973168 18022660
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D002971 Cleft Lip Ethanol 3.6515513904
MESH:D002972 Cleft Palate Ethanol 6.1315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.138697196 16354765 15668235 15340226 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6715513904 11198716 11873399 19302082 15451040 15451039 10194807
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6720055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2914550746 10915739 12153990 12958197 12540782 11287661 10663392 12705907 19739265 11421492 11529661 17522070 11739529 18071297 11743745 16781746 18713872 17906064 11461765 14725611 19416960 16227642 15619225 11834606 15968718 14986274 12594235 16485898 19164858 12392966 16109766 19420014 2444490 19923254 16177239 16393943 19370779 17562736 10774834 19085960 16081117
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.2911566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7320426865
MESH:D004938 Esophageal Neoplasms Ethanol 4.7316704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Ethanol 8.3518620774 19236843 16409862
MESH:D005234 Fatty Liver pirinixic acid 8.3519236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4916946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D005756 Gastritis Acetaminophen 11.8716983495
MESH:D005756 Gastritis Ethanol 11.8715046732
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8516221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8512621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 18606429 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 8.1916870215
MESH:D006930 Hyperalgesia Ethanol 8.1918783367
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006973 Hypertension Arsenic 5.3916076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3918670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4712878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 5.4718590791
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Ethanol 10.5915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5916580747
MESH:D007642 Keratosis Arsenic 5.1812749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0916705839
MESH:D007859 Learning Disorders Ethanol 4.3915451040
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6417339181
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9117676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4415289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2918295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5418166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5412878042
MESH:D008107 Liver Diseases Acetaminophen 4.1719460945 12587719 19784758 16611625 12969438 11587558 19014921 16610002
MESH:D008107 Liver Diseases Arsenic 4.1711134558
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.8317347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.097678174
MESH:D008113 Liver Neoplasms Arsenic 11.0916368122
MESH:D008113 Liver Neoplasms pirinixic acid 11.0920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.012876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0112151625
MESH:D008175 Lung Neoplasms Arsenic 3.6417976673 17306315 19168569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6419555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 3.6411091918 12111688 16288123 3440675
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008569 Memory Disorders Ethanol 4.3518411066 15451040
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.4615006635
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Arsenic 9.3815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects Arsenic 3.5416620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010051 Ovarian Neoplasms Arsenic 2.7817306315
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0112384795
MESH:D010300 Parkinson Disease marker/mechanism 19915576
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1815371236 6392382 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Arsenic 3.5916140617
MESH:D011507 Proteinuria Arsenic 4.1521343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.8018410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4118551238
MESH:D012640 Seizures Ethanol 6.419754883
MESH:D012871 Skin Diseases Arsenic 2.7817453740 17548696 17938729 16353154 16702368 15952646 6392382 17050553 16759981 18709164 19834688
MESH:D012878 Skin Neoplasms Arsenic 14.1316251483 17029826 17050553 15504454 19538983 17976673
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.138532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.1316192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 14.1318590791
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.679211565 11906479 17189318 17918041 9562338 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.399754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7816049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.7815987713 17976673 19322015 19429237 11144890 18640142 17306315
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 8.7812846360
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:01100 Metabolic pathways
KEGG:00760 Nicotinate and nicotinamide metabolism
KEGG:04972 Pancreatic secretion
KEGG:04970 Salivary secretion
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01660 - Adenosine-5'-Diphosphate Monothiophosphate
DB02483 - Etheno-Nad
DB02701 - Nicotinamide Vitamin B Complex
DB03227 - Nicotinamide Mononucleotide
DB03732 - Etheno-Nadp
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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