AutismKB 2.0

Annotation Detail for ABCC8


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Basic Information Top
Gene Symbol:ABCC8 ( ABC36,HHF1,HI,HRINS,MRP8,PHHI,SUR,SUR1,TNDM2 )
Gene Full Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Band: 11p15.1
Quick LinksEntrez ID:6833; OMIM: 600509; Uniprot ID:ABCC8_HUMAN; ENSEMBL ID: ENSG00000006071; HGNC ID: 59
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa02010ABC transporters
hsa04930Type II diabetes mellitus
Pathway IDPathway Name
Diabetes pathways
Integration of energy metabolism
Pathway IDPathway Name
200073FOXA2 and FOXA3 transcription factor networks
No data
Pathway IDPathway Name
500134Regulation of Insulin Secretion
Related Diseases/Disorders Top
No data
No data
Desease Name
high insulin concentrations in non-diabetic Mexican Ameri
PHARMACOGENOMIC
METABOLIC
diabetes, gestational
diabetes, type 2
No data
Desease Name
Diabetes mellitus, noninsulin-dependent
Diabetes mellitus, permanent neonatal
Hyperinsulinemic hypoglycemia, familial, 1
Hypoglycemia of infancy, leucine-sensitive
Diabetes mellitus, transient neonatal 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ABCC8 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen results in decreased expression of ABCC8 mRNAdecreases expression 15976192
D000109 Acetylcholine ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]]decreases reaction|increases reaction|increases transport 15894309
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ABCC8 mRNAaffects expression 16483693
C035982 beryllium fluoride beryllium fluoride results in decreased activity of ABCC8 proteindecreases activity 18025464
C035982 beryllium fluoride beryllium fluoride results in decreased activity of ABCC8 proteindecreases activity 17561960
C032036 bromobenzene bromobenzene results in decreased expression of ABCC8 mRNAdecreases expression 15976192
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ABCC8 mRNAdecreases expression 15976192
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ABCC8 proteindecreases expression 17544377
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of ABCC8 mRNAdecreases expression 15976192
D005419 Flavonoids Flavonoids results in increased expression of ABCC8 mRNAincreases expression 18035473
D005905 Glyburide resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein]affects binding|decreases reaction 17138562
D005905 Glyburide Glyburide binds to and results in decreased activity of ABCC8 proteinaffects binding|decreases activity 15652236
D015735 Mifepristone Mifepristone results in decreased expression of ABCC8 mRNAdecreases expression 17584828
D011188 Potassium ABCC8 protein results in increased transport of Potassiumincreases transport 10022826
D011188 Potassium ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]]decreases reaction|increases reaction|increases transport 15894309
C059514 resveratrol resveratrol binds to ABCC8 proteinaffects binding 17138562
C059514 resveratrol resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein]affects binding|decreases reaction 17138562
D016593 Terfenadine Terfenadine results in decreased activity of [KCNJ11 protein binds to ABCC8 protein]affects binding|decreases activity 10928959
D013853 Thioacetamide Thioacetamide results in decreased expression of ABCC8 mRNAdecreases expression 15976192
D014044 Tolbutamide Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]decreases reaction|increases activity 18025464
D014044 Tolbutamide Tolbutamide binds to and results in decreased activity of ABCC8 proteinaffects binding|decreases activity 15652236
D014501 Uranium Uranium affects the expression of ABCC8 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of ABCC8 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D058186 Acute Kidney Injury resveratrol 3.8116538975
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 2.8716033868
MESH:D000236 Adenoma Dimethylnitrosamine 7.0519555203
MESH:D000236 Adenoma resveratrol 7.0515688382
OMIM:607154 ALLERGIC RHINITIS Terfenadine 5.6316037679
MESH:D000544 Alzheimer Disease resveratrol 2.5616162502 16183991
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001169 Arthritis, Experimental resveratrol 3.4717115116
MESH:D050197 Atherosclerosis resveratrol 3.2516873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Thioacetamide 4.1319483382
MESH:D002545 Brain Ischemia resveratrol 4.2517600658
MESH:D001943 Breast Neoplasms resveratrol 2.7117651959 17534123 16393696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7416011737 15700767 3786805 15721981 16124888 16227642 18705752 15673190 10355542 16192424 16097048 16050911
MESH:D002277 Carcinoma Dimethylnitrosamine 3.9919555203
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.8116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.813084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.8118788625
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.8119321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 8.8117997003
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5616675471
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 5.0116033868
MESH:D002294 Carcinoma, Squamous Cell resveratrol 5.0116227395
MESH:D002318 Cardiovascular Diseases resveratrol 3.4415458977
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.2518291259
MESH:D003092 Colitis resveratrol 4.0916474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4516338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.7216507316
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9718551238
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7316873680
OMIM:606176 DIABETES MELLITUS, PERMANENT NEONATAL marker/mechanism
OMIM:610374 DIABETES MELLITUS, TRANSIENT NEONATAL, 2 marker/mechanism
MESH:D003922 Diabetes Mellitus, Type 1 marker/mechanism 18025464
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism
MESH:D003928 Diabetic Nephropathies resveratrol 3.9216286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.1218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.1211529661 14725611 11743745 11461765 12705907 16109766 11739529 16781746 12153990 19416960 18713872 11287661 18071297 19739265 17906064 16081117 12540782 10915739 14550746 16177239 19370779 15968718 10774834 19085960 19164858 19923254 16227642 10663392 17562736 16393943 2444490 11421492 16485898 14986274 12958197 15619225 17522070 19420014 12594235 11834606 12392966
MESH:D056486 Drug-Induced Liver Injury bromobenzene 15.1212628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.127440962 10092053 3786805 6884620 15998439 3732212 11566570 15027814 6623471 7179309 19085960 21278145 16177239 10915739 19336974 2869522 7120509 9327722 15968718 16227642 17522070 4309450
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 15.128172417
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 15.1212963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004487 Edema resveratrol 3.338985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.9817872969
MESH:D004715 Endometriosis Mifepristone 4.3316134523
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8117923197
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 2.9017016578
MESH:D005218 Fat Necrosis Thioacetamide 5.6916456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.1319224547 17595544 61145 16239168 12795759 12631006 16045604 15959796
MESH:D005355 Fibrosis Carbon Tetrachloride 3.4218705752
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5318665440 15929193 17276928
MESH:D006505 Hepatitis Carbon Tetrachloride 9.3519110552 19900420
MESH:D006505 Hepatitis Thioacetamide 9.3516456712
MESH:D006561 Herpes Simplex resveratrol 4.1416876885
MESH:D006930 Hyperalgesia Acetaminophen 2.6616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D006937 Hypercholesterolemia resveratrol 3.9617188708
MESH:C538372 Hyperinsulinemic hypoglycemia, familial, 1 marker/mechanism
MESH:D006949 Hyperlipidemias resveratrol 3.9916873680
MESH:D006967 Hypersensitivity Terfenadine 5.202570798
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2617488730
MESH:D007003 Hypoglycemia Glyburide 5.8910918110
MESH:C537150 Hypoglycemia, leucine-induced marker/mechanism
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.8219822448
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6117600658
MESH:D007249 Inflammation Flavonoids 5.2817296493
MESH:D007249 Inflammation resveratrol 5.2816366677
MESH:D007251 Influenza, Human resveratrol 4.5216624496
MESH:D007674 Kidney Diseases Acetaminophen 2.1712587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.9416705839
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.5516087638
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7817157831 16239168 11903743 16221502 16943688 21278145 11408273 17334410 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6611481614 12632514 18418968 18279442 17766677 18395914 13678700 18205269 20821823 18251166 18481824 15673190 18166357 17721639 15362042 15338365 18187930 18210741 18339082 12546737 18317297 15996030 17944888 17557913 18156304 16248980 18705752 17714472 15057751 15730626 16116963 16027843 12958196 18412020 17525996 12741479 17565644 17805973 12445421 17708605 17631135 12586293 12632512 18429990 16192424 18376398 17640975 10355542 15650968 12898905 15893842 18054572 14724832 14716496 12667390 16033810 15876570 12666154 15123356 15370692 17922224 17976157 17761835 16638106 14620537 16097048 18472094 15052691 17481882 18420326 12389079 16015684 12445418 16011737 12609069 18263696 15959796 18277467 16136751 15931870 18395095 18006644 14512876 15925388 15818738 14716833 18472332 12649538 17869086 17900296 14748882 17698563 17823541
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.6617203207 17534399 17201889 15842777 15383259 17640959 15591649 15339415 16603200 18371158 15369754 14659978 18637143 17881167 14643895 18672772 18629640 17196135 15504291 12918455 15744066 16544323 15723089 15161499 14568256 12925901 15793283 15298665 16570917 15733078 16627068 18210741 14726149 15366600 17198567 18567088 18239293 15864749 15763062 17348192 14709902 18237412 17666798 15086199 15479170 15138612 17719030 15798949 17724770 16270385 16009107 15942678 18364076 15571005 17036385 18095165 15492853 16169303 16042886 17432682 15577212 15099470 15081153 17465448 15067225
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.6615288472 18031379 11172339 17355460 16343077 16248980 17127702 18458672 15095483 18615449 16126171 18380797 15474484 16511523 18295389 17292413 18263696 15716488 17629604 15158331 18395095 16489207 15078482 12557150 11682029 15465738 15316131 15362042 18032466 15334695 17050028 12891558 18606216 14739098 12679928 12175628 16097051 12085344 10677585 12531686 15075984 15288473 11481614 18416461 16098781
MESH:D008107 Liver Diseases Acetaminophen 6.4916611625 19014921 12969438 19460945 16610002 19784758 12587719 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4915720792 15830285 17285989 16246199 16964402
MESH:D008107 Liver Diseases Thioacetamide 6.4916337175 18374380 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 22.9416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 22.9414706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 22.9417457977
MESH:D017114 Liver Failure, Acute Thioacetamide 22.9417276928 12479984 15313186 15633222
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.5219294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 7.523113478 15890375
MESH:D008113 Liver Neoplasms resveratrol 7.5219073162 19321006 19812893 20405173
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 6.121848544 15603536 6150874
MESH:D008133 Long QT Syndrome Terfenadine 5.058772706
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 2.4619555203 16061637 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8314749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.2115688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.0811606380 8985016
MESH:D008545 Melanoma resveratrol 2.3617992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008659 Metabolic Diseases resveratrol 4.3417112576
MESH:D009101 Multiple Myeloma resveratrol 3.4317049120 16267019 16490592 17164350 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8317962980
MESH:D009203 Myocardial Infarction resveratrol 3.0117125593 16456233 16317513 16525036 17015251 17188708
MESH:D017202 Myocardial Ischemia resveratrol 3.9717125593 17015251
MESH:D009205 Myocarditis resveratrol 4.7217322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8218551238
MESH:D009374 Neoplasms, Experimental resveratrol 3.968985016
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2318514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.2317652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.3617929310
MESH:D020258 Neurotoxicity Syndromes Glyburide 5.1816725203
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3916049721 12819281
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.2117513867
MESH:D010051 Ovarian Neoplasms Mifepristone 3.1116525653
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D044903 Persistent Hyperinsulinemia Hypoglycemia of Infancy marker/mechanism 15579781 10334322
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.1416679765
MESH:D011471 Prostatic Neoplasms resveratrol 3.6517675339 17636462 15767336 17804756 16731767 17718901
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5516325855
MESH:D015427 Reperfusion Injury resveratrol 3.2516314181 17520802 16317513 15827377 17058453
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 4.219413022
MESH:D012221 Rhinitis, Allergic, Perennial Terfenadine 5.898201490
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5018551238
MESH:D012878 Skin Neoplasms resveratrol 3.018985016 15837718
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.2412587719
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.4516033868
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4416321402
MESH:D014062 Tongue Neoplasms resveratrol 4.1716227395
MESH:D016171 Torsades de Pointes Terfenadine 5.668256756
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.2716049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2810091137
MESH:D014581 Urticaria Acetaminophen 9.0810982225
MESH:D014581 Urticaria Terfenadine 9.082569995 2885854 2565098 2859714 2568013
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.0617473185
MESH:D014594 Uterine Neoplasms resveratrol 4.0917044934
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2617488730
Pathway ID Pathway Name
KEGG:02010 ABC transporters
REACT:15380 Diabetes pathways
REACT:1505 Integration of energy metabolism
KEGG:04930 Type II diabetes mellitus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24395
    • Releated gene ID Related gene Name
    PA24395ABCC8
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    PA443622Carcinoma, Non-Small-Cell Lung
    PA152530787Diabetes, Permanent Neonatal (PNDM)
    PA443886Diabetes Mellitus
    Releated drug ID Related drug Name
    PA10390sulfonamides, urea derivatives
    PA10892gliclazide
    PA449761glimepiride
    PA449383docetaxel
    PA449014cisplatin
    PA449748gemcitabine
    PA451718tolbutamide
    PA452249antiarrhythmics, class i and iii
    PA449285diazoxide
    PA449782glibenclamide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
    DB00222 agonist Avandaryl Hypoglycemic Agents;Antiarrhythmic Agents;Immunosuppressive Agents;Sulfonylureas;Anti-Arrhythmia Agents
    DB00672 antagonist Chlorpropamide Hypoglycemic Agents;Sulfonylureas
    DB00731 inhibitor Nateglinide Hypoglycemic Agents;Meglitinides
    DB00912 inhibitor Repaglinide Hypoglycemic Agents;Meglitinides
    DB01016 modulator Glucovance Hypoglycemic Agents;Antiarrhythmic Agents;Sulfonylureas
    DB01067 antagonist Glipizide Hypoglycemic Agents
    DB01120 binder Gliclazide Hypoglycemic Agents;Sulfonylureas
    DB01124 antagonist Tolbutamide Hypoglycemic Agents;Sulfonylureas
    DB01251 antagonist Gliquidone Hypoglycemic Agents;Sulfonylureas
    DB01252 antagonist Mitiglinide Hypoglycemic Agents
    DB01289 antagonist Glisoxepide
    DB01382 agonist Glycodiazine Hypoglycemic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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