AutismKB 2.0

Annotation Detail for SUV39H1


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Basic Information Top
Gene Symbol:SUV39H1 ( KMT1A,MG44,SUV39H )
Gene Full Name: suppressor of variegation 3-9 homolog 1 (Drosophila)
Band: Xp11.23
Quick LinksEntrez ID:6839; OMIM: 300254; Uniprot ID:SUV91_HUMAN; ENSEMBL ID: ENSG00000101945; HGNC ID: 11479
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00310Lysine degradation
No data
Pathway IDPathway Name
200191Regulation of retinoblastoma protein
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of SUV39H1 proteindecreases expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SUV39H1 mRNAdecreases expression 20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of SUV39H1 mRNAdecreases expression 20106945
D009151 Mustard Gas Mustard Gas results in increased expression of SUV39H1 mRNAincreases expression 15674844
C006253 pirinixic acid pirinixic acid results in increased expression of SUV39H1 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D001249 Asthma Mustard Gas 2.7910378619
MESH:D001768 Blister Mustard Gas 5.7019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.7015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.5917687719 10378619
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3512371664
MESH:D002779 Cholestasis Cyclosporine 8.6319486331
MESH:D002779 Cholestasis pirinixic acid 8.6319176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D004487 Edema Mustard Gas 8.1411428647 9260866 11428631 11402378
MESH:D004487 Edema pirinixic acid 8.1412083418
MESH:D004890 Erythema Mustard Gas 5.709357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005234 Fatty Liver Cyclosporine 8.8219224547
MESH:D005234 Fatty Liver pirinixic acid 8.8220131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.6212168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 19176532 19772884 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007249 Inflammation Mustard Gas 2.9416001271 9357497 11428631 11428647 11402378 8975870 17524151 11428620 9260866
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.528314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9215890375 16377806 20007298
MESH:D008171 Lung Diseases Mustard Gas 3.6718702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 2.173148597 8781369
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009503 Neutropenia Mustard Gas 4.3716761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D011041 Poisoning Mustard Gas 4.2015727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011537 Pruritus Mustard Gas 4.6318058305
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0317720292 10334151 17894541 17620002 17266442
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012871 Skin Diseases Mustard Gas 2.7815451306 12880345 16961503
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
Pathway ID Pathway Name
KEGG:00310 Lysine degradation
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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