AutismKB 2.0

Annotation Detail for BST2


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Basic Information Top
Gene Symbol:BST2 ( CD317,TETHERIN )
Gene Full Name: bone marrow stromal cell antigen 2
Band: 19p13.11
Quick LinksEntrez ID:684; OMIM: 600534; Uniprot ID:BST2_HUMAN; ENSEMBL ID: ENSG00000130303; HGNC ID: 1119
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BST2 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of BST2 mRNAdecreases expression 17103032
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of BST2 mRNAdecreases expression 15336504
C014347 decitabine decitabine affects the expression of BST2 mRNAaffects expression 17145863
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of BST2 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of BST2 mRNA]decreases reaction|increases expression 17942915
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of BST2 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of BST2 mRNAincreases expression 19619570
C011890 kojic acid kojic acid results in decreased expression of BST2 mRNAdecreases expression 16595896
D008727 Methotrexate BST2 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D008942 Mitoxantrone BST2 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D012643 Selenium Selenium results in increased expression of BST2 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen results in increased expression of BST2 mRNAincreases expression 19155303
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of BST2 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of BST2 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BST2 mRNAincreases expression 20106945
C025643 vinclozolin vinclozolin affects the expression of BST2 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of BST2 mRNAincreases expression 19244175
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of BST2 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 8.7612039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.879612607
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D000236 Adenoma Diethylnitrosamine 2.8710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.2318056438 19061943 17620307 19052882 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.2316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6619015723
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1017286800
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms decitabine 2.9719208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9717474063
MESH:D001943 Breast Neoplasms Estradiol 2.9719861407 16675129 17261762 12948864 14630087 17018787 17289903 18497071
MESH:D001943 Breast Neoplasms Methotrexate 2.9716978400
MESH:D001943 Breast Neoplasms Tamoxifen 2.9721152245 15565566 19200415 19115204 16818667 18351453 17049068 19221464 16873071 11161223 20859285 19155303 19410462 20544844 16273361 20135344 17893378 15668708 19084267 18984771 19288272 19142967 21138602 18855134 19066611 20065188 20390343 18997820 19487384 18425577 19011961 19103187 19059307 20005174 17261762 18629630 18815881 16202921 19189212 18821012 17440819 19289846 17242785 19189210 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6020512989 19919837 19418558 20214788 20101231 10672840 17162532 16288022 20524982 17055752 19383236 20727157 19107877 18788625 20432363 16935385 18494052 19701751 21159647 17173139 16681979 16569478 18691550 18506893 18056438 20514400 16779866 19208518 19822196 16328049 18971187 16878318 10737359 16698587 20007298 16502159 3581430 16830150 19335982 18978308 18665156 16540662 17138121 18210153 20084675 17978847 17761372 19052882 17428255 19171122 18785209 3084413 20935162 19539802 19394651 11831363 18393292 19519916 16807293
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6016924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6019215824
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.767505956 2727394 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7618566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1115340226 8697196 12621046 16354765 15668235
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.8912039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8919769572
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D003550 Cystic Fibrosis Methotrexate 4.2619747007
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D003882 Dermatomyositis Methotrexate 5.1620191521
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2417107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.9219279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.9219279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2519107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.2515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3011462148
MESH:D004362 Drug Toxicity Zidovudine 8.3015040536
MESH:C538011 Eales disease Vitamin E 4.779068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9615322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.5719031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1819294695
MESH:D016889 Endometrial Neoplasms Estradiol 7.4511473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.4517893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Diethylnitrosamine 13.4221071580 20387270
MESH:D005234 Fatty Liver Tamoxifen 13.4214986274 19224547
MESH:D005234 Fatty Liver Zidovudine 13.4218299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9920067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.1916518429
MESH:D006258 Head and Neck Neoplasms decitabine 3.5019215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6210048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.6216080930
MESH:D006331 Heart Diseases Mitoxantrone 4.1716019553
MESH:D006333 Heart Failure Selenium 3.0917162251
MESH:D006402 Hematologic Diseases Zidovudine 4.7412579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9312621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7116863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D015658 HIV Infections Zidovudine 3.5011141242 11363243 17358032 11698656 20032539
MESH:D019584 Hot Flashes Estradiol 10.2617088409
MESH:D019584 Hot Flashes Vitamin E 10.2614716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116354765 8697196 18606429 16959395 15340226
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D007248 Infertility, Male decitabine 6.9917581917
MESH:D007248 Infertility, Male vinclozolin 6.9916467254
MESH:D007249 Inflammation Diethylnitrosamine 8.3518785209
MESH:D007249 Inflammation Tamoxifen 8.3519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3512878042 12200463
MESH:D007251 Influenza, Human Selenium 11.1716624496
MESH:D007251 Influenza, Human Vitamin E 11.1716624496
MESH:D007333 Insulin Resistance Estradiol 2.9816627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Estradiol 6.1615618244
MESH:D007674 Kidney Diseases Vitamin E 6.1612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9116518626
MESH:D007680 Kidney Neoplasms Estradiol 12.6615610895
MESH:D007680 Kidney Neoplasms Tamoxifen 12.6618625569
MESH:D007680 Kidney Neoplasms Zidovudine 12.6612579204
MESH:D007805 Language Development Disorders Methotrexate 5.139562676
MESH:D007938 Leukemia decitabine 3.0818980019 19235587
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8018172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.4420370541
MESH:D007951 Leukemia, Myeloid decitabine 4.0319117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3818206229 18460780 19387464 19010910 18704418 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5218055864
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D008064 Lipidoses Tamoxifen 3.1717567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9918522880 19638242 18665156 18407596 20032147
MESH:D008103 Liver Cirrhosis Methotrexate 6.9914986274
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.9716169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1117034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.4521278145 19690152 18648771 10737359 18977376 18754104 20583210 12112319 21071580 20492335 19642983 20452335 19255062 19256749 12771043 9163691 19638242 19812893 20137499 20405173 19996281 18644402 21167192 19833225 19426721 20501860 19499222 18978307 19254457 20118626 19294768 19427195 20101389 15885732 15175105 19073162 2862719 2422723 19090486 19850985 16942905 20434301 19551842 21047994
MESH:D008113 Liver Neoplasms Tamoxifen 7.4516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4516984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.9918093689 19009564 19126423 9362446 21159647 16267830 17174075 18308698 18253720 18282651 18164116 19539802 19004024 16842330 19519916 18079962 17854601 17942915 3124819 18544905 2563599 18775883
MESH:D008114 Liver Neoplasms, Experimental kojic acid 9.9918544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9912151625
MESH:D008171 Lung Diseases Vitamin E 3.1916863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.0818516814
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.6320970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 6.6318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6319555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 6.6311062179
MESH:D008175 Lung Neoplasms Zidovudine 6.6318800350
MESH:D008223 Lymphoma decitabine 7.9719470736
MESH:D008223 Lymphoma Methotrexate 7.9717352296
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.0616891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.0615318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.0616827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.8619453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.8619453300
MESH:D008545 Melanoma decitabine 3.4117785578 16505122
MESH:D008545 Melanoma Tamoxifen 3.4112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D008654 Mesothelioma Selenium 2.8015107826
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.9017358032
MESH:D052016 Mucositis Methotrexate 5.3317488658
MESH:D009101 Multiple Myeloma decitabine 3.3618172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4019010910 16882708 19157545 18608210
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3016810080
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.763581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms decitabine 5.6017925555 19116145 19470736
MESH:D009369 Neoplasms Mitoxantrone 5.6016640825
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Estradiol 9.5911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5914600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D010051 Ovarian Neoplasms decitabine 4.9419331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 4.9419401270
MESH:D010190 Pancreatic Neoplasms decitabine 5.3919294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3916540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.582563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6611399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.6619015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.7717616702
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5416740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5415067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5415084515
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011565 Psoriasis Methotrexate 3.4417410198
MESH:D051437 Renal Insufficiency Methotrexate 4.7517352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.4319155313
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.638532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013088 Spermatocele Tamoxifen 4.3516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0919457130
MESH:D013274 Stomach Neoplasms decitabine 3.5119037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.5118456281
MESH:D013274 Stomach Neoplasms Zidovudine 3.5117696246
MESH:D020521 Stroke Vitamin E 3.5416517955
MESH:D013576 Syndactyly Methotrexate 5.079562676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms decitabine 7.3517967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.357505956
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.2317616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2317572228 16712894 8653321
MESH:D014604 Uveal Neoplasms decitabine 4.9817785578
MESH:D014625 Vaginal Neoplasms Zidovudine 4.8012579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25436
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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