AutismKB 2.0

Annotation Detail for VAMP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:VAMP1 ( DKFZp686H12131,SYB1,VAMP-1 )
Gene Full Name: vesicle-associated membrane protein 1 (synaptobrevin 1)
Band: 12p13.31
Quick LinksEntrez ID:6843; OMIM: 185880; Uniprot ID:VAMP1_HUMAN; ENSEMBL ID: ENSG00000139190; HGNC ID: 12642
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04130SNARE interactions in vesicular transport
Pathway IDPathway Name
Botulinum neurotoxicity
No data
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04391Oxytocin receptor mediated signaling pathway
P04379Beta3 adrenergic receptor signaling pathway
P00001Adrenaline and noradrenaline biosynthesis
P04377Beta1 adrenergic receptor signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00044Nicotinic acetylcholine receptor signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P00037Ionotropic glutamate receptor pathway
P04380Cortocotropin releasing factor receptor signaling pathway
P00002Alpha adrenergic receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P05734Synaptic vesicle trafficking
P043765HT4 type receptor mediated signaling pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P043755HT3 type receptor mediated signaling pathway
P043735HT1 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
hip geometry
Desease Name
Hip geometry
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VAMP1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of VAMP1 mRNAincreases expression 20382639
19150397
C096325 botulinum toxin type D botulinum toxin type D results in increased cleavage of VAMP1 proteinincreases cleavage 17666428
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of VAMP1 mRNAdecreases expression 15336504
D003024 Clozapine Clozapine results in increased expression of VAMP1 mRNAincreases expression 15860345
D006220 Haloperidol Haloperidol results in decreased expression of VAMP1 mRNAdecreases expression 15860345
D006220 Haloperidol Haloperidol results in increased expression of VAMP1 mRNAincreases expression 15860345
D009151 Mustard Gas Mustard Gas results in decreased expression of VAMP1 mRNAdecreases expression 15674843
C096323 rimabotulinumtoxinB rimabotulinumtoxinB results in increased cleavage of VAMP1 proteinincreases cleavage 17666428
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of VAMP1 mRNA]affects reaction|decreases expression 16891777
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of VAMP1 mRNAdecreases expression 16891777
D024505 Tocopherols Tocopherols results in increased expression of VAMP1 mRNAincreases expression 17654050
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000380 Agranulocytosis Clozapine 5.2716160616 14617031 12649775
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001321 Autistic Disorder Haloperidol 2.7318080171 19368416
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2417687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 16120746 18670907
MESH:D002375 Catalepsy Haloperidol 5.1515215559 1977408
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8420889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 15340226 16354765 8697196 12621046
MESH:D003072 Cognition Disorders Clozapine 5.1817123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.0320210726
MESH:D003704 Dementia Haloperidol 4.7511575062
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.6316402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6317107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8215331141
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Clozapine 4.3016402076
MESH:D004487 Edema Mustard Gas 7.419260866 11428631 11428647 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16354765 16959395 15340226 18606429
MESH:D006948 Hyperkinesis Clozapine 5.1516046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007249 Inflammation Mustard Gas 5.3216001271 9357497 11428647 8975870 11402378 11428620 11428631 17524151 9260866
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D008064 Lipidoses Clozapine 4.0817567588
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008171 Lung Diseases Mustard Gas 3.5618161513 18702808
MESH:D008175 Lung Neoplasms Mustard Gas 2.453148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4511884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.1817927505
MESH:D001523 Mental Disorders Clozapine 9.1616856516
MESH:D001523 Mental Disorders Haloperidol 9.1616856516
MESH:D008654 Mesothelioma Tocopherols 4.1615878867
MESH:D024821 Metabolic Syndrome X Clozapine 4.5619142101
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009503 Neutropenia Mustard Gas 4.157688884 16761898
MESH:D009765 Obesity Clozapine 3.0518515891 19142110
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Tocopherols 4.5712504091
MESH:D011537 Pruritus Mustard Gas 4.3318058305
MESH:D011595 Psychomotor Agitation Haloperidol 5.1711575062
MESH:D011618 Psychotic Disorders Clozapine 9.5615331141
MESH:D011618 Psychotic Disorders Haloperidol 9.5611575062
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9817894541 17620002 17266442 10334151 17720292
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012559 Schizophrenia Clozapine 4.1720521326 18855531 19369910 20168265 20452607 17726453 11763009 20107430 11151749 18806925 20521320 16141801 17123785 17667964 20580759
MESH:D012559 Schizophrenia Haloperidol 4.1718513383 1830565 20107430 19369910
MESH:D012871 Skin Diseases Mustard Gas 2.7512880345 15451306 16961503
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.838532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8316192470
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.9020210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Clozapine 4.6217502770 20521320 20564506 16402076 20107430 16141801
MESH:D015431 Weight Loss Clozapine 5.3117933447
Pathway ID Pathway Name
REACT:11184 Botulinum neurotoxicity
KEGG:04145 Phagosome
KEGG:04130 SNARE interactions in vesicular transport
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00042 binder Botulinum Toxin Type B Antidystonic Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved