AutismKB 2.0

Annotation Detail for VAMP2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:VAMP2 ( FLJ11460,SYB2,VAMP-2 )
Gene Full Name: vesicle-associated membrane protein 2 (synaptobrevin 2)
Band: 17p13.1
Quick LinksEntrez ID:6844; OMIM: 185881; Uniprot ID:VAMP2_HUMAN; ENSEMBL ID: ENSG00000220205; HGNC ID: 12643
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04962Vasopressin-regulated water reabsorption
hsa04130SNARE interactions in vesicular transport
hsa04970Salivary secretion
Pathway IDPathway Name
Botulinum neurotoxicity
Synaptic Transmission
Diabetes pathways
Membrane Trafficking
Integration of energy metabolism
Pathway IDPathway Name
200168Insulin-mediated glucose transport
200160Effects of Botulinum toxin
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04391Oxytocin receptor mediated signaling pathway
P04379Beta3 adrenergic receptor signaling pathway
P00001Adrenaline and noradrenaline biosynthesis
P04377Beta1 adrenergic receptor signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00044Nicotinic acetylcholine receptor signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P00037Ionotropic glutamate receptor pathway
P04380Cortocotropin releasing factor receptor signaling pathway
P00002Alpha adrenergic receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P05734Synaptic vesicle trafficking
P043765HT4 type receptor mediated signaling pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P043755HT3 type receptor mediated signaling pathway
P043735HT1 type receptor mediated signaling pathway
Pathway IDPathway Name
500714Integration of energy metabolism
500134Regulation of Insulin Secretion
500153Acetylcholine Neurotransmitter Release Cycle
500013Clathrin derived vesicle budding
500845BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin
500147Neurotransmitter Release Cycle
500148Norepinephrine Neurotransmitter Release Cycle
500149Serotonin Neurotransmitter Release Cycle
500127Diabetes pathways
500128Insulin Synthesis and Processing
500151Dopamine Neurotransmitter Release Cycle
500150Glutamate Neurotransmitter Release Cycle
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of VAMP2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of VAMP2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VAMP2 mRNAaffects expression 16483693
C096325 botulinum toxin type D botulinum toxin type D results in increased cleavage of VAMP2 proteinincreases cleavage 17666428
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of VAMP2 mRNAaffects expression 17484886
D003024 Clozapine Clozapine results in increased expression of VAMP2 mRNAincreases expression 15860345
D003840 Deoxycholic Acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of VAMP2 mRNAaffects cotreatment|increases expression 16556975
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of VAMP2 mRNAaffects expression 17555576
C030691 gluconic acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of VAMP2 mRNAaffects cotreatment|increases expression 16556975
D006220 Haloperidol Haloperidol results in decreased expression of VAMP2 mRNAdecreases expression 15860345
D006220 Haloperidol Haloperidol results in increased expression of VAMP2 mRNAincreases expression 15860345
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of VAMP2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of VAMP2 mRNA]decreases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of VAMP2 mRNAdecreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of VAMP2 mRNA]decreases expression|increases reaction 17950772
C096323 rimabotulinumtoxinB rimabotulinumtoxinB results in increased cleavage of VAMP2 proteinincreases cleavage 17666428
D013629 Tamoxifen Tamoxifen affects the expression of VAMP2 mRNAaffects expression 17555576
D024505 Tocopherols Tocopherols results in increased expression of VAMP2 mRNAincreases expression 17654050
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6414745880
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D000380 Agranulocytosis Clozapine 5.1316160616 14617031 12649775
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1218080171 19368416
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1211289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.2118815881 18855134 19084267 16273361 19115204 16873071 20544844 18984771 17049068 17242785 17893378 19059307 19011961 18629630 15668708 19410462 19221464 19200415 19189210 19103187 20390343 20859285 19288272 21138602 19189212 20065188 15565566 21152245 17261762 11161223 19487384 19142967 17440819 18821012 18997820 16202921 18351453 20005174 19289846 19155303 18425577 20135344 16818667 19244106 19066611
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8515721981 16097048 16227642 18705752 15700767 16192424 10355542 3786805 15673190 16124888 16050911 16011737
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5819066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.627296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.623084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6218788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6216924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6617572228
MESH:D002375 Catalepsy Haloperidol 4.9915215559 1977408
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.797505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.619022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.6116105132 17333356 16919318 17110522 11677210 15861022 17681005
MESH:D002779 Cholestasis pirinixic acid 13.6119176532
MESH:D003072 Cognition Disorders Clozapine 5.0417123785
MESH:D003110 Colonic Neoplasms Deoxycholic Acid 3.5716213893
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9020210726
MESH:D003704 Dementia Haloperidol 4.6311575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4319031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8718759878 2524372 11906362 11298694 8970840 8156756 12868966 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9816402076
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5219279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6515331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.276679447 8291058 9328219 6482804 16192314 18289764 7440962 11289319 9022650 18648102 9653073 1440618 18692083
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2718071297 19420014 14550746 11834606 10915739 12153990 11743745 10774834 11529661 15968718 11461765 16227642 19739265 10663392 12540782 2444490 17906064 19923254 14725611 17562736 16781746 16081117 11739529 12705907 19416960 11421492 11287661 14986274 12392966 19370779 16177239 19164858 17522070 18713872 12958197 16485898 15619225 12594235 19085960 16393943 16109766
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.277120509 6623471 15968718 15027814 3786805 10915739 19336974 10092053 4309450 6884620 3732212 2869522 7440962 11566570 9327722 15998439 17522070 7179309 16177239 21278145 19085960 16227642
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D050171 Dyslipidemias Clozapine 4.2216402076
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.1612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.1619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0816202921 19155303 17893378 20544844
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.2215959796 12795759 17595544 12631006 16045604 16239168 61145 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.2215345470
MESH:D005234 Fatty Liver pirinixic acid 19.2220131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 19.2214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2716709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2619069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5318705752
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.446705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.4419900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.0719772884 18467677 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006948 Hyperkinesis Clozapine 4.9916046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Tamoxifen 2.3819457130
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.2315629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.536582329
MESH:D007680 Kidney Neoplasms Tamoxifen 7.5318625569
MESH:D008064 Lipidoses Clozapine 8.2117567588
MESH:D008064 Lipidoses Tamoxifen 8.2117567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8311408273 16239168 16221502 17174718 17334410 21278145 11903743 17157831 16943688
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4918376398 18395914 12958196 18277467 17557913 12609069 12667390 14620537 12632512 10355542 15362042 17976157 12741479 18472094 18187930 12632514 12586293 17565644 18429990 15931870 17640975 16248980 12898905 15057751 17766677 15959796 18205269 18210741 16192424 18006644 17525996 14724832 17714472 18395095 15996030 20821823 18418968 18166357 13678700 18420326 12546737 12445418 17631135 15893842 18156304 16011737 16027843 17823541 15123356 18279442 15818738 17922224 12445421 15370692 15876570 17698563 18251166 12389079 18339082 16116963 15052691 18317297 14512876 16015684 18705752 16033810 18263696 17805973 15338365 18412020 14716496 18481824 15650968 14748882 18054572 17761835 15673190 16136751 17869086 18472332 16097048 15730626 17481882 11481614 14716833 15925388 17900296 12649538 17944888 12666154 16638106 17721639 17708605
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4918564211
MESH:D008107 Liver Diseases Acetaminophen 3.9419460945 12969438 19014921 11587558 19784758 16611625 16610002 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9416246199 15720792 16964402 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.5119294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.5120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 7.5116684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.26598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.2612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Deoxycholic Acid 10.266150874
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6411731420 19196723 14580682 19196722 16827153
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 6.6417927505
MESH:D020149 Manganese Poisoning Tamoxifen 4.6419453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D001523 Mental Disorders Clozapine 8.6416856516
MESH:D001523 Mental Disorders Haloperidol 8.6416856516
MESH:D008654 Mesothelioma Tocopherols 4.1215878867
MESH:D024821 Metabolic Syndrome X Clozapine 4.4619142101
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.763581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5319410462
MESH:D009369 Neoplasms pirinixic acid 1.9717405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1019200415 19189210 19196722
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity Clozapine 4.7418515891 19142110
MESH:D009765 Obesity pirinixic acid 4.7420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.476482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.7215067354
MESH:D011471 Prostatic Neoplasms Tocopherols 3.7212504091
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
MESH:D011595 Psychomotor Agitation Haloperidol 5.0311575062
MESH:D011618 Psychotic Disorders Clozapine 9.2915331141
MESH:D011618 Psychotic Disorders Haloperidol 9.2911575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012559 Schizophrenia Clozapine 4.1218855531 20580759 17726453 20521326 20107430 17667964 16141801 20452607 20521320 17123785 19369910 18806925 20168265 11763009 11151749
MESH:D012559 Schizophrenia Haloperidol 4.121830565 18513383 19369910 20107430
MESH:D013088 Spermatocele Ethinyl Estradiol 11.8916709447
MESH:D013088 Spermatocele Tamoxifen 11.8916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1219457130
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.7720210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.921399818 6587162 7505956 3712494 6582329
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.108074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1016712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D015430 Weight Gain Clozapine 4.5220107430 20564506 17502770 16141801 16402076 20521320
MESH:D015431 Weight Loss Clozapine 5.1617933447
Pathway ID Pathway Name
REACT:11184 Botulinum neurotoxicity
REACT:15380 Diabetes pathways
REACT:1505 Integration of energy metabolism
REACT:11123 Membrane Trafficking
KEGG:04970 Salivary secretion
KEGG:04130 SNARE interactions in vesicular transport
REACT:13685 Synaptic Transmission
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37267
    • No data
    No data
    Releated drug ID Related drug Name
    PA451898vitamin c
    PA448625biotin
    PA10090l-glutamine
    PA450197l-leucine
    PA449773glucose
    PA448976choline
    PA449396dopamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00042 binder Botulinum Toxin Type B Antidystonic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved