AutismKB 2.0

Annotation Detail for SYN1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SYN1 ( SYN1a,SYN1b,SYNI )
Gene Full Name: synapsin I
Band: Xp11.3-p11.23
Quick LinksEntrez ID:6853; OMIM: 313440; Uniprot ID:SYN1_HUMAN; ENSEMBL ID: ENSG00000008056; HGNC ID: 11494
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P05734Synaptic vesicle trafficking
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Epilepsy, X-linked, with variable learning disabilities and behavior disorders
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SYN1 mRNAaffects expression 17562736
C041524 aluminum sulfate aluminum sulfate results in decreased expression of SYN1 mRNAdecreases expression 15961160
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SYN1 mRNAaffects expression 16483693
D020001 1-Butanol 1-Butanol inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]decreases reaction|increases expression 18004999
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SYN1 mRNAincreases expression 17108234
C063302 KN 62 KN 62 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]decreases reaction|increases expression 18004999
D010416 Pentachlorophenol Pentachlorophenol results in increased expression of SYN1 mRNAincreases expression 19082768
D010634 Phenobarbital Phenobarbital affects the expression of SYN1 mRNAaffects expression 19136022
C006253 pirinixic acid NCF1 protein inhibits the reaction [pirinixic acid results in decreased expression of SYN1 mRNA]decreases expression|decreases reaction 17950772
C006253 pirinixic acid pirinixic acid affects the expression of SYN1 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of SYN1 mRNAdecreases expression 17950772
D011189 Potassium Chloride 1-Butanol inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]decreases reaction|increases expression 18004999
D011189 Potassium Chloride CAMK2D protein affects the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]affects reaction|increases expression 18004999
D011189 Potassium Chloride KN 62 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]decreases reaction|increases expression 18004999
D011189 Potassium Chloride PLD2 protein affects the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]affects reaction|increases expression 18004999
D011189 Potassium Chloride Potassium Chloride results in increased expression of SYN1 mRNAincreases expression 18004999
D011189 Potassium Chloride Potassium Chloride results in increased expression of SYN1 proteinincreases expression 18004999
D011189 Potassium Chloride U 0126 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]decreases reaction|increases expression 18004999
D011189 Potassium Chloride U 0126 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 protein]decreases reaction|increases expression 18004999
D024505 Tocopherols Tocopherols results in increased expression of SYN1 mRNAincreases expression 17654050
C113580 U 0126 U 0126 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]decreases reaction|increases expression 18004999
C113580 U 0126 U 0126 inhibits the reaction [Potassium Chloride results in increased expression of SYN1 protein]decreases reaction|increases expression 18004999
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.596195326
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000168 Acrocephalosyndactylia U 0126 5.5917694057
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.6417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.6416434500
MESH:D000310 Adrenal Gland Neoplasms Pentachlorophenol 6.2810696769
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001259 Ataxia 1-Butanol 5.707820390
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.923084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.9220007298 1701930 20935162 17173139 6705139
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0115861022 16105132 17110522 17681005 16919318 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 8.0119176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6116109766 19416960 16227642 12594235 12392966 19420014 19085960 19739265 17522070 11287661 15968718 16485898 14725611 19164858 16081117 19370779 14986274 11739529 16781746 11461765 10774834 17906064 11834606 2444490 12958197 12705907 11421492 18713872 16177239 10663392 15619225 11743745 11529661 10915739 12153990 17562736 16393943 18071297 12540782 14550746 19923254
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.043922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
OMIM:300491 EPILEPSY, X-LINKED, WITH VARIABLE LEARNING DISABILITIES AND BEHAVIOR DISORDERS marker/mechanism
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9115345470
MESH:D005234 Fatty Liver pirinixic acid 7.9119236843 20131406
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006394 Hemangiosarcoma Pentachlorophenol 5.1615200160
MESH:D006529 Hepatomegaly Phenobarbital 8.9516109766
MESH:D006529 Hepatomegaly pirinixic acid 8.9518467677 19772884 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2615629191 12587719
MESH:D007948 Leukemia, Monocytic, Acute U 0126 5.4616972261
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9521047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 4.0116610002 12969438 19460945 19014921 19784758 16611625 12587719 11587558
MESH:D008107 Liver Diseases Phenobarbital 4.0119363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Pentachlorophenol 7.8510696769
MESH:D008113 Liver Neoplasms Phenobarbital 7.8519073162 8742319 19812893 21047994 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 7.8516377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.761399818 2563599 18308698 6150874 17172636
MESH:D008223 Lymphoma Pentachlorophenol 4.6912669308
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.1417927505
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Tocopherols 4.1415878867
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D018301 Neoplasms, Mesothelial Pentachlorophenol 6.8310696769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010051 Ovarian Neoplasms U 0126 3.4416211241
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D011230 Precancerous Conditions Phenobarbital 3.722563599
MESH:D011471 Prostatic Neoplasms Tocopherols 4.5812504091
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012640 Seizures Phenobarbital 2.7611442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013160 Splenic Neoplasms Pentachlorophenol 6.4810696769
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.141399818
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
Pathway ID Pathway Name
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01660 - Adenosine-5'-Diphosphate Monothiophosphate
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved