AutismKB 2.0

Annotation Detail for SYN2


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Basic Information Top
Gene Symbol:SYN2 ( SYNII,SYNIIa,SYNIIb )
Gene Full Name: synapsin II
Band: 3p25.2
Quick LinksEntrez ID:6854; OMIM: 600755; Uniprot ID:Q86VA8_HUMAN; ENSEMBL ID: ENSG00000157152; HGNC ID: 11495
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P05734Synaptic vesicle trafficking
No data
Related Diseases/Disorders Top
No data
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Desease Name
PSYCH
schizophrenia
METABOLIC
type 2 diabetes
Desease Name
Type 2 diabetes
Desease Name
Schizophrenia, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SYN2 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of SYN2 mRNAincreases expression 20739668
D003024 Clozapine Clozapine results in decreased expression of SYN2 mRNAdecreases expression 17266109
D003024 Clozapine Clozapine results in increased expression of SYN2 mRNAincreases expression 15860345
D005419 Flavonoids Flavonoids results in increased expression of SYN2 mRNAincreases expression 18035473
D006220 Haloperidol Haloperidol results in increased expression of SYN2 mRNAincreases expression 15860345
D005996 Nitroglycerin Nitroglycerin results in increased expression of SYN2 mRNAincreases expression 12102619
D010622 Phencyclidine Phencyclidine results in decreased expression of SYN2 mRNAdecreases expression 17266109
C006253 pirinixic acid NCF1 protein inhibits the reaction [pirinixic acid results in decreased expression of SYN2 mRNA]decreases expression|decreases reaction 17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of SYN2 mRNAdecreases expression 17950772
C006253 pirinixic acid pirinixic acid results in increased expression of SYN2 mRNAincreases expression 12832660
D013619 Tacrine Tacrine results in increased expression of SYN2 mRNAincreases expression 12832660
D024505 Tocopherols Tocopherols results in increased expression of SYN2 mRNAincreases expression 17654050
D014635 Valproic Acid Valproic Acid results in increased expression of SYN2 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of SYN2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.648875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000380 Agranulocytosis Clozapine 5.1914617031 16160616 12649775
MESH:D000544 Alzheimer Disease Tacrine 3.9412725862
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D001008 Anxiety Disorders Valproic Acid 9.1517497229
MESH:D001008 Anxiety Disorders vinclozolin 9.1519015723
MESH:D001321 Autistic Disorder Haloperidol 2.3418080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.3417688650 17157402 17507914 18177632 18316065 18985861 18396377 15238991 18775368 20603192 19460635 18940202 19232924 18558336 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.1320046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.478888407
MESH:D001862 Bone Resorption bisphenol A 3.9711985600
MESH:D001943 Breast Neoplasms bisphenol A 2.4617123778
MESH:D002278 Carcinoma in Situ bisphenol A 5.1417123778
MESH:D002375 Catalepsy Haloperidol 5.0615215559 1977408
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D003072 Cognition Disorders Clozapine 5.1017123785
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 8888407 17688650
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9620210726
MESH:D003704 Dementia Haloperidol 4.6911575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9916402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.7315331141
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.201733752 19641884
MESH:D050171 Dyslipidemias Clozapine 4.2616402076
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.293659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.687562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D005234 Fatty Liver pirinixic acid 8.0919236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.0914986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.268888407 18558336
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D006261 Headache Nitroglycerin 5.3611554966 11284996
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1319772884 18467677 16221962 19176532
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006948 Hyperkinesis Clozapine 5.0616046005
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007249 Inflammation Flavonoids 2.7017296493
MESH:D007333 Insulin Resistance bisphenol A 7.5516393666
MESH:D007333 Insulin Resistance pirinixic acid 7.5516306350
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008064 Lipidoses Clozapine 4.0417567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.8520007298 16377806 15890375
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.1417927505
MESH:D001523 Mental Disorders Clozapine 8.8816856516
MESH:D001523 Mental Disorders Haloperidol 8.8816856516
MESH:D008654 Mesothelioma Tocopherols 4.1415878867
MESH:D024821 Metabolic Syndrome X Clozapine 4.5019142101
MESH:D008708 Methemoglobinemia Nitroglycerin 4.853537620
MESH:D008881 Migraine Disorders Valproic Acid 3.2718803445 18765137
MESH:D020326 Migraine without Aura Nitroglycerin 5.2514659530
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D009203 Myocardial Infarction Nitroglycerin 6.1614729435
MESH:D009203 Myocardial Infarction pirinixic acid 6.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009421 Nervous System Malformations bisphenol A 4.1016427766 11399458
MESH:D009436 Neural Tube Defects Valproic Acid 3.208888407 16359493
MESH:D009765 Obesity Clozapine 4.7819142110 18515891
MESH:D009765 Obesity pirinixic acid 4.7820558911
MESH:D010049 Ovarian Diseases bisphenol A 5.1411985600
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 17.2810548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.2820603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.2818042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.8016740699
MESH:D011471 Prostatic Neoplasms Tocopherols 3.8012504091
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.7111422049 12752131
MESH:D011595 Psychomotor Agitation Haloperidol 5.0911575062
MESH:D011618 Psychotic Disorders Clozapine 9.4215331141
MESH:D011618 Psychotic Disorders Haloperidol 9.4211575062
MESH:D011629 Puberty, Precocious bisphenol A 4.9410548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012559 Schizophrenia marker/mechanism
MESH:D012559 Schizophrenia Clozapine 5.8120452607 11151749 20521326 20107430 11763009 17667964 17726453 16141801 18806925 17123785 20521320 19369910 20168265 18855531 20580759
MESH:D012559 Schizophrenia Haloperidol 5.8120107430 18513383 1830565 19369910
MESH:D012559 Schizophrenia Valproic Acid 5.8115737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8116876388 15475178 1511512 3137016 11044598 14763951 11738929 17978042
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D019966 Substance-Related Disorders bisphenol A 4.1416684133 16045194
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.8320210726
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014591 Uterine Diseases bisphenol A 5.1814652134
MESH:D015430 Weight Gain Clozapine 4.5717502770 20564506 20107430 16402076 20521320 16141801
MESH:D015431 Weight Loss Clozapine 5.2317933447
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36277
    • No data
    Releated disease ID Related disease Name
    PA444065Epilepsy
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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