AutismKB 2.0

Annotation Detail for SYP


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Basic Information Top
Gene Symbol:SYP ( MRXSYP )
Gene Full Name: synaptophysin
Band: Xp11.23
Quick LinksEntrez ID:6855; OMIM: 313475; Uniprot ID:SYPH_HUMAN; ENSEMBL ID: ENSG00000102003; HGNC ID: 11506
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P05734Synaptic vesicle trafficking
No data
Related Diseases/Disorders Top
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Desease Name
PSYCH
attention deficit hyperactivity disorder
No data
Desease Name
Mental retardation, X-linked, with or without epilepsy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of SYP mRNAdecreases expression 12419474
C106538 abacavir abacavir results in increased expression of SYP proteinincreases expression 19358275
D020106 Acrylamide Acrylamide results in increased expression of SYP proteinincreases expression 15864552
C041524 aluminum sulfate aluminum sulfate results in decreased expression of SYP mRNAdecreases expression 15961160
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SYP mRNAaffects expression 16483693
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [AGT protein results in increased degradation of SYP protein]decreases reaction|increases degradation 18487452
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of SYP mRNAaffects cotreatment|increases expression 18636392
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of SYP proteindecreases expression 17229471
D020111 Chlorodiphenyl (54% Chlorine) IL6 gene mutant form inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SYP protein]decreases expression|decreases reaction 17229471
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of SYP proteinincreases expression 16174552
C010902 decabromobiphenyl ether decabromobiphenyl ether metabolite results in increased expression of SYP proteinincreases expression 19380496
D003907 Dexamethasone Dexamethasone results in increased expression of SYP proteinincreases expression 15965953
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of SYP geneincreases mutagenesis 16495775
D005473 Fluoxetine Fluoxetine results in increased expression of SYP mRNAincreases expression 17950272
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SYP mRNAaffects cotreatment|increases expression 17183730
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of SYP mRNAdecreases expression 12419474
C067713 lactacystin lactacystin inhibits the reaction [AGT protein results in increased degradation of SYP protein]decreases reaction|increases degradation 18487452
D008770 Methylnitrosourea Methylnitrosourea affects the expression of SYP proteinaffects expression 18155124
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of SYP mRNAaffects cotreatment|increases expression 18636392
C093973 PD 98059 PD 98059 inhibits the reaction [AGT protein results in increased degradation of SYP protein]decreases reaction|increases degradation 18487452
D013311 Streptozocin Streptozocin results in increased expression of SYP mRNAincreases expression 18487452
D013311 Streptozocin telmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]decreases expression|decreases reaction 18487452
D013311 Streptozocin valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]decreases expression|decreases reaction 18487452
C013690 styrene oxide styrene oxide results in decreased expression of SYP proteindecreases expression 17662326
C084178 telmisartan telmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]decreases expression|decreases reaction 18487452
C084178 telmisartan telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]decreases expression|decreases reaction 18487452
C084178 telmisartan telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]decreases reaction|increases ubiquitination 18487452
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SYP mRNAdecreases expression 19465110
D024505 Tocopherols Tocopherols results in increased expression of SYP mRNAincreases expression 17654050
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of SYP proteinaffects cotreatment|increases expression 17085092
C113580 U 0126 U 0126 inhibits the reaction [AGT protein results in increased degradation of SYP protein]decreases reaction|increases degradation 18487452
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SYP mRNAaffects cotreatment|increases expression 17183730
C081489 valsartan valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]decreases expression|decreases reaction 18487452
C081489 valsartan valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]decreases expression|decreases reaction 18487452
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]decreases reaction|increases ubiquitination 18487452
C047426 venlafaxine venlafaxine results in increased expression of SYP mRNAincreases expression 17950272
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4915322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.498875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7119490988
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000168 Acrocephalosyndactylia U 0126 5.2317694057
MESH:D055371 Acute Lung Injury Chlorine 4.1020601635
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.0615113128 15688392
MESH:D000236 Adenoma Ethylnitrosourea 3.586695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1316835633
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000544 Alzheimer Disease Ozone 2.3915513908
MESH:D000550 Amblyopia Valproic Acid 4.9817688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9510965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D001008 Anxiety Disorders Fluoxetine 8.6918083778
MESH:D001008 Anxiety Disorders Valproic Acid 8.6917497229
MESH:D001169 Arthritis, Experimental Dexamethasone 7.0317659584
MESH:D001169 Arthritis, Experimental Tretinoin 7.0316412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.4615570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4616292516
MESH:D001249 Asthma Ozone 4.6916373670 17854713
MESH:D001249 Asthma Tretinoin 4.6916456186
MESH:D001321 Autistic Disorder Fluoxetine 2.5719232924 18775368
MESH:D001321 Autistic Disorder Valproic Acid 2.5718985861 18940202 17507914 20603192 18558336 18177632 17688650 19232924 18316065 19460635 17157402 18775368 15238991 16609825 18396377
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9520046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.508888407
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6714991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.0815144691 16436596 16651633 18412241 16357521
MESH:D001943 Breast Neoplasms Acrylamide 2.0116253758 18183576
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.0114633655 16253758 11306469
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D001943 Breast Neoplasms Tretinoin 2.0116443354 16873071 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4915516495 17626835 19059883 16777450 14754758 18417511 18315731
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002100 Cachexia Ozone 4.4916183385
MESH:D002276 Carcinoid Tumor Streptozocin 5.3516051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.861917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2216096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6716120746 18670907 18850075
MESH:D006332 Cardiomegaly valsartan 6.6719597038
MESH:D009202 Cardiomyopathies valsartan 4.2816247790
MESH:D002318 Cardiovascular Diseases abacavir 11.6518753925
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 11.6516936243
MESH:D002318 Cardiovascular Diseases valsartan 11.6511230374
MESH:D002386 Cataract Methylnitrosourea 7.2712484553
MESH:D002386 Cataract Tretinoin 7.2717460283
MESH:D002418 Cattle Diseases Acrylamide 5.2012510666
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 6.8416003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 6.847505956 2727394
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7317160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4212621046 8697196 15340226 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Tretinoin 3.4617035595
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4515824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D003324 Coronary Artery Disease valsartan 3.8117719468
MESH:D003384 Coxsackievirus Infections valsartan 5.6020392896
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.1817728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.189142499 8800419 9211117 14991402 9224671 10589399 17551590 9125849 16925845 9664655
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.1816575769 8888407 17688650
MESH:D003866 Depressive Disorder Fluoxetine 8.2315014590
MESH:D003866 Depressive Disorder venlafaxine 8.2320305041
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.1812438553
MESH:D003920 Diabetes Mellitus Streptozocin 4.5216285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 8.4818715473 12093613 12446591 19960420 18603373 8740154 16286809 7637645 2177838 16684804 6379147 1374869 15862027 11055810 15298345 11260395 15831366 19496084 19586609 17874149 17442507 12083368 12644472 19298542
MESH:D003921 Diabetes Mellitus, Experimental valsartan 8.4811508273
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.5618603373
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 4.4419586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4417107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.4816025228
MESH:D003928 Diabetic Nephropathies Streptozocin 9.1019960420 19682444
MESH:D003928 Diabetic Nephropathies valsartan 9.1018630688 11427623
MESH:D003930 Diabetic Retinopathy Streptozocin 5.1917662242
MESH:D003967 Diarrhea Dexamethasone 3.477237001
MESH:D004342 Drug Hypersensitivity abacavir 5.2015867870 15024131
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 5.8917851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.891733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004417 Dyspnea Chlorine 4.3820016425
MESH:D004421 Dystonia Valproic Acid 3.821851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7318357618
MESH:D004485 Eczema Dexamethasone 4.2212438553
MESH:D004487 Edema Dexamethasone 10.4319703484
MESH:D004487 Edema Fluoxetine 10.4312798668
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1118230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.819294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.913659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.6716628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.386426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.823659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.249664655 16938888
MESH:D005234 Fatty Liver Valproic Acid 3.0914986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.9018558336 8888407
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.9811555667
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5420067830
MESH:D005355 Fibrosis Tretinoin 13.5417994277
MESH:D005355 Fibrosis valsartan 13.5416893502
MESH:D005739 Gas Poisoning Chlorine 4.7620016425
MESH:D005909 Glioblastoma Ethylnitrosourea 6.8916436596
MESH:D005909 Glioblastoma Tretinoin 6.8917312396
MESH:D005910 Glioma Ethylnitrosourea 6.2816651633 16357521 18412241
MESH:D005910 Glioma Methylnitrosourea 6.289825942
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.3116928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.1114991402 9664655
MESH:D006331 Heart Diseases Streptozocin 4.1112093613
MESH:D006333 Heart Failure valsartan 4.1019027736
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6512621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.997520565
MESH:D015658 HIV Infections abacavir 4.7617457083 12891065 11141242
MESH:D019584 Hot Flashes Fluoxetine 10.3714716179
MESH:D019584 Hot Flashes venlafaxine 10.3714716179
MESH:D006849 Hydrocephalus Valproic Acid 4.6217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8015340226 8697196 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.0216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006973 Hypertension Dexamethasone 11.7617042910
MESH:D006973 Hypertension telmisartan 11.7616077267
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.7618850075 18670907
MESH:D006973 Hypertension valsartan 11.7618344623 16475468 12692753 10903974 20102058 18390891 12850387 11427623
MESH:D006974 Hypertension, Malignant valsartan 6.1611560862
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.3816612254
MESH:D007247 Infertility, Female Acrylamide 4.9811020651
MESH:D007248 Infertility, Male Acrylamide 7.0415749267 12507653 15355880 11020651
MESH:D007248 Infertility, Male Methylnitrosourea 7.047193160
MESH:D007249 Inflammation Dexamethasone 7.7911099482 8960868
MESH:D007249 Inflammation Fluoxetine 7.7912798668
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.7912878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2017551590 15992940
MESH:D007674 Kidney Diseases Streptozocin 6.5312093613
MESH:D007674 Kidney Diseases valsartan 6.5316893502 10903974 12164870
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0516518626
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 3.7417379185
MESH:D007938 Leukemia Tretinoin 2.6517143497
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 11.2716972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 11.2716972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7316294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.7317596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9917339181 19029980 16140955 19075265 17649720 19225113 9834237 17294898 17107899 12679006 19642359 16766008 17712046 15748426 16891316 16331271 19035177 17368321 17301526 17361223 16935935 16788101 16823087 17217047 17506722
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 7.8815526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.889224671
MESH:D008064 Lipidoses Fluoxetine 4.4815342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.7716718785
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7718397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental valsartan 4.7715619341 16872305 15504291
MESH:D017114 Liver Failure, Acute venlafaxine 5.1919857765
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.6316984957
MESH:D008114 Liver Neoplasms, Experimental styrene oxide 5.9712562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9712151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.2216080182
MESH:D008171 Lung Diseases Ozone 3.218266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0117228818
MESH:D055370 Lung Injury Ozone 3.6120417186
MESH:D008175 Lung Neoplasms Dexamethasone 6.2915824018 11195469
MESH:D008175 Lung Neoplasms Ethylnitrosourea 6.296695378 16019985 16271038 17703301
MESH:D008175 Lung Neoplasms Methylnitrosourea 6.2918062963
MESH:D008175 Lung Neoplasms Ozone 6.298597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2911884234 19555203
MESH:D008223 Lymphoma Ethylnitrosourea 7.5415790496
MESH:D008223 Lymphoma Methylnitrosourea 7.5416257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.5414633661
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.8115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 9.4910838139 18041768 10767621
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 9.4914999141 12931682 16619500 10838139 11751437 17131329 15113128 16051031 16944150 17020996 15688392 16827153 15313902 19196723 11807958 14633655 10767621
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 9.4917927505
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Tretinoin 1.9116752155
MESH:D008579 Meningioma Ethylnitrosourea 5.7317943659
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D001523 Mental Disorders Fluoxetine 8.1116856516
MESH:D001523 Mental Disorders venlafaxine 8.1116856516
MESH:D038901 Mental Retardation, X-Linked marker/mechanism 19377476
OMIM:300802 MENTAL RETARDATION, X-LINKED, SYP-RELATED marker/mechanism
MESH:D008654 Mesothelioma Tocopherols 4.0115878867
MESH:D008679 Metaplasia Ozone 4.8610496685
MESH:D008881 Migraine Disorders Valproic Acid 7.5518803445 18765137
MESH:D008881 Migraine Disorders venlafaxine 7.5518803445
MESH:D009101 Multiple Myeloma Dexamethasone 3.3315744524 16118317 15867202
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.818888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 11.569809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.5617596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 11.5617596541
MESH:D009203 Myocardial Infarction abacavir 4.5818753925
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D009207 Myoclonus Fluoxetine 5.638041377
MESH:D009369 Neoplasms Methylnitrosourea 5.0115533788
MESH:D009369 Neoplasms Tretinoin 5.0116594593 16946489
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 8.8716707424
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.8712696579
MESH:D009410 Nerve Degeneration Acrylamide 4.5112387366 12387367 11264303
MESH:D009422 Nervous System Diseases Acrylamide 4.7812507653 12164553
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 8.739125849
MESH:D009436 Neural Tube Defects Tretinoin 6.789142499
MESH:D009436 Neural Tube Defects Valproic Acid 6.788888407 16359493
MESH:D009442 Neurilemmoma Ethylnitrosourea 12.4616003739 16651423 17160924
MESH:D009442 Neurilemmoma Methylnitrosourea 12.4611555667
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 10.9320418887
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 10.9317503984
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7317160924
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9816936753
MESH:D010051 Ovarian Neoplasms U 0126 4.9816211241
MESH:D010146 Pain Fluoxetine 6.6512798668
MESH:D010146 Pain Tretinoin 6.6516870215
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 5.3016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3015976015
MESH:D010212 Papilloma Hydrogen Peroxide 3.8512065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.8711510240
MESH:D010538 Peritonitis Ozone 3.8916369182
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.2511550810
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.768041377
MESH:D011014 Pneumonia Ozone 4.1518007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4121297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6411118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.6420603192
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 4.1712376480 15682402
MESH:D011471 Prostatic Neoplasms Tocopherols 4.1712504091
MESH:D011507 Proteinuria telmisartan 14.5016077267
MESH:D011507 Proteinuria Tretinoin 14.5016636307
MESH:D011507 Proteinuria valsartan 14.5017664856 18344623 12164870
MESH:D019310 Pseudolymphoma Valproic Acid 4.2911422049 12752131
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011658 Pulmonary Fibrosis valsartan 3.7217241526
MESH:D012120 Respiration Disorders Chlorine 4.9618579056
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7911700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.2318172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.2411555667
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.1016116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.1019155313
MESH:D012559 Schizophrenia marker/mechanism 11483314
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012640 Seizures Valproic Acid 2.5816876388 15475178 17978042 11044598 3137016 1511512 11738929 14763951
MESH:D020230 Serotonin Syndrome Fluoxetine 5.658704074
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 8.8112065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.8116467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2912833885
MESH:D013272 Stomach Diseases Dexamethasone 4.0815472012
MESH:D013274 Stomach Neoplasms Methylnitrosourea 3.6016257854 15930296 18593901
MESH:D013274 Stomach Neoplasms styrene oxide 3.6012562636
MESH:D013274 Stomach Neoplasms Tretinoin 3.6017261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.2715138204
MESH:D013733 Testicular Diseases Acrylamide 4.9815864552
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 11.4815790496
MESH:D013953 Thymus Neoplasms Methylnitrosourea 11.4811418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 6.907505956 3078959
MESH:D013964 Thyroid Neoplasms Tretinoin 6.9016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5716051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.9817262798
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.273119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.408888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4616129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014605 Uveitis Dexamethasone 4.571336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020257 Ventricular Remodeling valsartan 5.4519027736
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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