AutismKB 2.0

Annotation Detail for SYT1


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Basic Information Top
Gene Symbol:SYT1 ( DKFZp781D2042,P65,SVP65,SYT )
Gene Full Name: synaptotagmin I
Band: 12q21.2
Quick LinksEntrez ID:6857; OMIM: 185605; Uniprot ID:SYT1_HUMAN; ENSEMBL ID: ENSG00000067715; HGNC ID: 11509
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Botulinum neurotoxicity
Synaptic Transmission
Pathway IDPathway Name
200160Effects of Botulinum toxin
Pathway IDPathway Name
P05734Synaptic vesicle trafficking
Pathway IDPathway Name
500153Acetylcholine Neurotransmitter Release Cycle
500147Neurotransmitter Release Cycle
500148Norepinephrine Neurotransmitter Release Cycle
500149Serotonin Neurotransmitter Release Cycle
500151Dopamine Neurotransmitter Release Cycle
500150Glutamate Neurotransmitter Release Cycle
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
serum creatinine
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SYT1 mRNAaffects expression 17562736
D020106 Acrylamide Acrylamide binds to and affects the metabolism of SYT1 proteinaffects binding|affects metabolic processing 17698512
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SYT1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SYT1 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of SYT1 proteindecreases expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SYT1 mRNAdecreases expression 15336504
D002118 Calcium Calcium binds to SYT1 proteinaffects binding 16262243
D003300 Copper Copper affects the secretion of [FGF1 protein binds to SYT1 protein binds to S100A13 protein]affects binding|affects secretion 16262243
D003300 Copper Copper binds to and affects the folding of SYT1 proteinaffects binding|affects folding 16262243
D002117 Calcitriol Calcitriol results in increased expression of SYT1 mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in decreased expression of SYT1 mRNAdecreases expression 20106945
C051890 irinotecan irinotecan analog results in decreased expression of SYT1 mRNAdecreases expression 18927307
D014212 Tretinoin Tretinoin results in increased expression of SYT1 mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000544 Alzheimer Disease Copper 3.2616962711 17119284 16866297 16410023 16886094 16325427
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.3810694572
MESH:D018798 Anemia, Iron-Deficiency Copper 5.0116614410
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7516206674 16197459
MESH:D001932 Brain Neoplasms Copper 4.6817079463
MESH:D001943 Breast Neoplasms Acrylamide 2.4218183576 16253758
MESH:D001943 Breast Neoplasms Calcitriol 2.4211237771
MESH:D001943 Breast Neoplasms Copper 2.4217079463 15986119
MESH:D001943 Breast Neoplasms Estradiol 2.4219861407 17261762 17018787 16675129 17289903 14630087 18497071 12948864
MESH:D001943 Breast Neoplasms Tretinoin 2.4216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.723084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7212907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.721917145
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.9011237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9016096774 16051514
MESH:D006332 Cardiomegaly Copper 4.0917327471
MESH:D002386 Cataract Acetaminophen 7.4810977129
MESH:D002386 Cataract Tretinoin 7.4817460283
MESH:D002418 Cattle Diseases Acrylamide 5.6712510666
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D003110 Colonic Neoplasms irinotecan 2.6117287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3616391804 18259882 16303861 17159606 15273666 17454858 18509181
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8217551590 9224671 10589399 9211117 9125849 9142499 8800419 16925845 9664655 14991402
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6212540782 16227642 11739529 17906064 18713872 16109766 16781746 11834606 14550746 11287661 19739265 19923254 14725611 19420014 10663392 19085960 11743745 12392966 12153990 16081117 11529661 19164858 15619225 10774834 2444490 17562736 12705907 16393943 15968718 12958197 16177239 14986274 19370779 11421492 19416960 10915739 17522070 18071297 11461765 16485898 12594235
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0915138306
MESH:D016889 Endometrial Neoplasms Estradiol 7.7119148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7116569247
MESH:D005124 Eye Abnormalities Tretinoin 3.6816938888 9664655
MESH:D005355 Fibrosis Tretinoin 3.6917994277
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9614991402 9664655
MESH:D006521 Hepatitis, Chronic Copper 5.4917338147
MESH:D006527 Hepatolenticular Degeneration Copper 5.3417109627 19888908 17276780 17182432 16607473
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006930 Hyperalgesia Acetaminophen 8.0016870215
MESH:D006930 Hyperalgesia Tretinoin 8.0016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D007247 Infertility, Female Acrylamide 5.3511020651
MESH:D007248 Infertility, Male Acrylamide 4.3215749267 15355880 12507653 11020651
MESH:D007333 Insulin Resistance Estradiol 3.0516393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0417551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 6.1415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007676 Kidney Failure, Chronic Copper 5.0416518626
MESH:D007680 Kidney Neoplasms Estradiol 3.0915610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.2616316344
MESH:D007859 Learning Disorders Copper 4.9717134702
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2417368321 16140955 19029980 9834237 19225113 19642359 17506722 17361223 16935935 17217047 17301526 16331271 19075265 16823087 16891316 17339181 12679006 17294898 19035177 15748426 17649720 16788101 17107899 17712046 16766008
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 19784758 11587558 19014921 16610002 12969438 12587719 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 5.2118177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Copper 5.2120302851
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.828603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8714755239
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6411408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D007706 Menkes Kinky Hair Syndrome Copper 6.0817109627 17268249
MESH:D052016 Mucositis irinotecan 5.2017159606
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009362 Neoplasm Metastasis irinotecan 3.2218259882
MESH:D009369 Neoplasms Tretinoin 2.4716946489 16594593
MESH:D009389 Neovascularization, Pathologic Copper 11.0117308104
MESH:D009389 Neovascularization, Pathologic Estradiol 11.0117289903
MESH:D009410 Nerve Degeneration Acrylamide 4.8012387367 11264303 12387366
MESH:D009422 Nervous System Diseases Acrylamide 5.1112164553 12507653
MESH:D009421 Nervous System Malformations Estradiol 10.2211399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.149142499
MESH:D009447 Neuroblastoma irinotecan 3.548761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.928761367
MESH:D010024 Osteoporosis Calcium 3.8617882678
MESH:D010051 Ovarian Neoplasms Estradiol 4.9319401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9316936753
MESH:D010146 Pain Acetaminophen 6.9816870215
MESH:D010146 Pain Tretinoin 6.9816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 5.2711510240
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.7112479363 15754350 16289102 18247401 16644109
MESH:D011471 Prostatic Neoplasms Copper 2.7117079463 17308104
MESH:D011471 Prostatic Neoplasms Estradiol 2.7116740699
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516116481 16283617
MESH:D012559 Schizophrenia Copper 3.1016842975
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.008532709
MESH:D012878 Skin Neoplasms Tretinoin 6.0016467112
MESH:D013274 Stomach Neoplasms irinotecan 2.6715723263
MESH:D013274 Stomach Neoplasms Tretinoin 2.6717261132
MESH:D013733 Testicular Diseases Acrylamide 5.4215864552
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1317045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
Pathway ID Pathway Name
REACT:11184 Botulinum neurotoxicity
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36290
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA451898vitamin c
    PA10090l-glutamine
    PA450197l-leucine
    PA448976choline
    PA449396dopamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04184 - Acetate Ion Indicators and Reagents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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