AutismKB 2.0

Annotation Detail for SYT4


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Basic Information Top
Gene Symbol:SYT4 ( HsT1192,KIAA1342 )
Gene Full Name: synaptotagmin IV
Band: 18q12.3
Quick LinksEntrez ID:6860; OMIM: 600103; Uniprot ID:SYT4_HUMAN; ENSEMBL ID: ENSG00000132872; HGNC ID: 11512
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SYT4 mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of SYT4 mRNAaffects cotreatment|increases expression 18636392
D003024 Clozapine Clozapine results in increased expression of SYT4 mRNAincreases expression 15860345
D003042 Cocaine Cocaine results in increased expression of SYT4 mRNAincreases expression 16459018
D006220 Haloperidol Haloperidol affects the expression of SYT4 mRNAaffects expression 15860345
D009151 Mustard Gas Mustard Gas results in increased expression of SYT4 mRNAincreases expression 15674844
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of SYT4 mRNAaffects cotreatment|increases expression 18636392
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SYT4 mRNAdecreases expression 16443690
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SYT4 mRNAincreases expression 18495758
C047426 venlafaxine venlafaxine results in increased expression of SYT4 mRNAincreases expression 16341940
C025643 vinclozolin vinclozolin affects the expression of SYT4 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury Chlorine 4.5120601635
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000380 Agranulocytosis Clozapine 5.2716160616 14617031 12649775
MESH:D000544 Alzheimer Disease Ozone 2.4715513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5915570426
MESH:D001249 Asthma Mustard Gas 5.2410378619
MESH:D001249 Asthma Ozone 5.2416373670 17854713
MESH:D001321 Autistic Disorder Haloperidol 2.7318080171 19368416
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8115516495 19059883 18315731 18417511 16777450 14754758 17626835
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2417687719 10378619
MESH:D002100 Cachexia Ozone 4.9816183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 16120746 18670907
MESH:D002375 Catalepsy Haloperidol 5.1515215559 1977408
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 15340226 16354765 12621046 8697196
MESH:D019970 Cocaine-Related Disorders Cocaine 5.9519606084
MESH:D003072 Cognition Disorders Clozapine 5.1817123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.0320210726
MESH:D003704 Dementia Haloperidol 4.7511575062
MESH:D003866 Depressive Disorder venlafaxine 4.9420305041
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.6316402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6317107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8215331141
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Clozapine 4.3016402076
MESH:D004417 Dyspnea Chlorine 4.8920016425
MESH:D004487 Edema Mustard Gas 7.4111402378 11428647 11428631 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005739 Gas Poisoning Chlorine 5.2720016425
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 15340226 12621046
MESH:D019584 Hot Flashes venlafaxine 5.8014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3118606429 16959395 15340226 8697196 16354765
MESH:D006948 Hyperkinesis Clozapine 5.1516046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007249 Inflammation Mustard Gas 5.3211428647 17524151 16001271 8975870 9357497 11428620 11402378 9260866 11428631
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008064 Lipidoses Clozapine 4.0817567588
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D017114 Liver Failure, Acute venlafaxine 5.5619857765
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008171 Lung Diseases Mustard Gas 7.9918702808 18161513
MESH:D008171 Lung Diseases Ozone 7.9919066396 8266340
MESH:D055370 Lung Injury Ozone 4.0620417186
MESH:D008175 Lung Neoplasms Mustard Gas 3.563148597 8781369
MESH:D008175 Lung Neoplasms Ozone 3.567614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5611884234 19555203
MESH:D008545 Melanoma marker/mechanism 21499247
MESH:D001523 Mental Disorders Clozapine 14.9216856516
MESH:D001523 Mental Disorders Haloperidol 14.9216856516
MESH:D001523 Mental Disorders venlafaxine 14.9216856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.5619142101
MESH:D008679 Metaplasia Ozone 5.3710496685
MESH:D008881 Migraine Disorders venlafaxine 4.8918803445
MESH:D009203 Myocardial Infarction Cocaine 4.0418072171
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009503 Neutropenia Mustard Gas 4.1516761898 7688884
MESH:D009765 Obesity Clozapine 3.0519142110 18515891
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 5.8417503984
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010538 Peritonitis Ozone 4.3516369182
MESH:D011014 Pneumonia Ozone 4.6318007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2911896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2918220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011537 Pruritus Mustard Gas 4.3318058305
MESH:D011595 Psychomotor Agitation Haloperidol 5.1711575062
MESH:D011618 Psychotic Disorders Clozapine 15.5415331141
MESH:D011618 Psychotic Disorders Cocaine 15.5416134406
MESH:D011618 Psychotic Disorders Haloperidol 15.5411575062
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9817894541 17720292 17266442 10334151 17620002
MESH:D012120 Respiration Disorders Chlorine 5.4818579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012559 Schizophrenia Clozapine 4.1720521320 17726453 20452607 20168265 11151749 20580759 17123785 16141801 11763009 20107430 19369910 18855531 20521326 17667964 18806925
MESH:D012559 Schizophrenia Haloperidol 4.1720107430 18513383 1830565 19369910
MESH:D012640 Seizures Cocaine 4.1510454489
MESH:D012871 Skin Diseases Mustard Gas 2.7512880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.9020210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Clozapine 4.6217502770 20521320 20107430 20564506 16402076 16141801
MESH:D015431 Weight Loss Clozapine 5.3117933447
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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