AutismKB 2.0

Annotation Detail for T


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Basic Information Top
Gene Symbol:T ( MGC104817,TFT )
Gene Full Name: T, brachyury homolog (mouse)
Band: 6q27
Quick LinksEntrez ID:6862; OMIM: 601397; Uniprot ID:BRAC_HUMAN; ENSEMBL ID: ENSG00000164458; HGNC ID: 11515
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLYCLEAV-PWYglycine cleavage complex
No data
No data
Pathway IDPathway Name
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Pathway IDPathway Name
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
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Desease Name
Neural tube defects, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012729 2-amino-4-phosphonobutyric acid 2-amino-4-phosphonobutyric acid results in increased expression of T mRNAincreases expression 16806298
D001151 Arsenic T mRNA results in increased susceptibility to Arsenicincreases response to substance 17976673
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate affects the expression of T mRNAaffects expression 19615344
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of T mRNA]decreases expression|decreases reaction 19615344
C408604 PD 169316 PD 169316 results in decreased expression of T mRNAdecreases expression 14685156
D020849 Raloxifene Raloxifene results in increased expression of T mRNAincreases expression 16202921
C017947 sodium arsenite monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of T mRNA]decreases expression|decreases reaction 19615344
C017947 sodium arsenite sodium arsenite results in decreased expression of T mRNAdecreases expression 19615344
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma Arsenic 15.5917306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 15.5917306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.9817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D020261 Arsenic Poisoning Arsenic 2.9318414634 16251483 12569548 16835338
MESH:D050197 Atherosclerosis Arsenic 3.4219371607 12928151
MESH:D001930 Brain Injuries Raloxifene 4.8916580743
MESH:D001943 Breast Neoplasms Raloxifene 2.6317261762 17595753 17893378 16837676 15758505 17049068 16912660 15775269 15572757 17440819 17952589 17242785
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.3516507464 17306315
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.3516507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.0815504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0818572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 10.7018640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.7017572228
MESH:D002318 Cardiovascular Diseases Arsenic 8.2617938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Raloxifene 8.2615775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.6016973168 18022660
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1919524636 20056578
MESH:D002817 Chordoma marker/mechanism 19801981
MESH:D003072 Cognition Disorders Raloxifene 5.0415800139
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4517474826
MESH:D003928 Diabetic Nephropathies Raloxifene 4.2215920148 17308373 17451421
MESH:D004487 Edema Raloxifene 3.6615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.3815845917
MESH:D005234 Fatty Liver Raloxifene 3.9517473493
MESH:D005534 Foot Diseases Arsenic 6.086392382
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.1416452187
MESH:D006331 Heart Diseases Raloxifene 3.7411110106
MESH:D006689 Hodgkin Disease sodium arsenite 3.4312676792
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7617050553
MESH:D006973 Hypertension Arsenic 5.9111953799 16076760 9931084
MESH:D006973 Hypertension Raloxifene 5.9117577099 15787275
MESH:D006987 Hypesthesia Arsenic 6.0816093927
MESH:D007248 Infertility, Male sodium arsenite 3.1915346721 12646999
MESH:D007642 Keratosis Arsenic 5.4512749816 16930632
MESH:D007674 Kidney Diseases sodium arsenite 2.9620008137
MESH:D007889 Leiomyoma Raloxifene 4.8516973256
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7417339181
MESH:D008107 Liver Diseases Arsenic 2.6011134558
MESH:D008113 Liver Neoplasms Arsenic 5.1316368122
MESH:D008113 Liver Neoplasms sodium arsenite 5.1316712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.3719095001
MESH:D008175 Lung Neoplasms Arsenic 2.7319168569 17306315 17976673
MESH:D008175 Lung Neoplasms sodium arsenite 2.7319931552 17306315 16712894 15276417 17077188
MESH:D008545 Melanoma sodium arsenite 2.0619082730 16487513
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6516497877
MESH:D017202 Myocardial Ischemia Arsenic 4.2415371236
MESH:D009232 Myxoma Raloxifene 6.0816343187
MESH:D009369 Neoplasms sodium arsenite 2.6311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009436 Neural Tube Defects marker/mechanism
MESH:D009436 Neural Tube Defects Arsenic 8.1016620997
MESH:D009436 Neural Tube Defects sodium arsenite 8.1012854658
MESH:D020078 Neurogenic Inflammation Arsenic 4.7317056641
MESH:D010024 Osteoporosis Raloxifene 3.5717882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5815758505 15579764 17893378 17823083
MESH:D010051 Ovarian Neoplasms Arsenic 5.3017306315
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.3015276417 17306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.456392382 16905509 15371236
MESH:D011471 Prostatic Neoplasms Arsenic 2.6316140617
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6316536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6316039940
MESH:D011507 Proteinuria Arsenic 4.3521343184
MESH:D011693 Purpura Raloxifene 6.0815770314
MESH:D012871 Skin Diseases Arsenic 2.8117938729 16353154 15952646 19834688 18709164 17050553 17453740 6392382 16702368 17548696 16759981
MESH:D012878 Skin Neoplasms Arsenic 6.3817029826 19538983 17050553 16251483 15504454 17976673
MESH:D012878 Skin Neoplasms sodium arsenite 6.3818572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D020521 Stroke Raloxifene 4.0816837676
MESH:D013978 Tibial Fractures Raloxifene 5.7319048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 9.0617976673 17306315 19322015 19429237 11144890 18640142 15987713
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 9.0617572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 9.0611723127 17306315 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0711813266
MESH:D014652 Vascular Diseases Arsenic 13.4417056641
MESH:D014652 Vascular Diseases sodium arsenite 13.4417056641
MESH:D054556 Venous Thromboembolism Raloxifene 5.7316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0816343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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