AutismKB 2.0

Annotation Detail for TAC1


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Basic Information Top
Gene Symbol:TAC1 ( Hs.2563,NK2,NKNA,NPK,TAC2 )
Gene Full Name: tachykinin, precursor 1
Band: 7q21.3
Quick LinksEntrez ID:6863; OMIM: 162320; Uniprot ID:TKN1_HUMAN; ENSEMBL ID: ENSG00000006128; HGNC ID: 11517
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500407Tachykinin receptors bind tachykinins
Related Diseases/Disorders Top
No data
No data
Desease Name
multiple sclerosis
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C038983 1,3-dimethylthiourea 1,3-dimethylthiourea inhibits the reaction [Lipopolysaccharides results in increased expression of TAC1 mRNA]decreases reaction|increases expression 12738685
C499293 (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide results in decreased secretion of TAC1 proteindecreases secretion 16953190
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TAC1 mRNAincreases expression 19933214
C026942 2,6-diisocyanatotoluene [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 mRNAaffects cotreatment|increases expression 10673198
C026942 2,6-diisocyanatotoluene [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 proteinaffects cotreatment|increases expression 10673198
C080755 3-(2-methoxybenzylamino)-2-phenylpiperidine 3-(2-methoxybenzylamino)-2-phenylpiperidine inhibits the reaction [TAC1 protein results in increased expression of MMP12 mRNA]decreases reaction|increases expression 18441096
C080755 3-(2-methoxybenzylamino)-2-phenylpiperidine 3-(2-methoxybenzylamino)-2-phenylpiperidine inhibits the reaction [TAC1 protein results in increased expression of TACR1 mRNA]decreases reaction|increases expression 18441096
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in increased secretion of TAC1 proteinincreases secretion 17684094
D000082 Acetaminophen Acetaminophen results in increased expression of TAC1 proteinincreases expression 16449370
D000082 Acetaminophen Acetaminophen affects the expression of TAC1 mRNAaffects expression 17562736
D000109 Acetylcholine TAC1 protein affects the abundance of Acetylcholineaffects abundance 11020227
D000109 Acetylcholine Urethane affects the reaction [TAC1 protein affects the abundance of Acetylcholine]affects abundance|affects reaction 11020227
D000143 Acids Acids results in increased secretion of TAC1 proteinincreases secretion 20100279
D000171 Acrolein Acrolein results in increased expression of TAC1 proteinincreases expression 1696540
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TAC1 proteinaffects expression 20106945
D000420 Albuterol Albuterol promotes the reaction [Paraoxon results in increased secretion of TAC1 protein]increases reaction|increases secretion 17158603
C004471 allyl isothiocyanate allyl isothiocyanate results in increased secretion of TAC1 proteinincreases secretion 16725114
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TAC1 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of TAC1 mRNAincreases expression 12558987
11566502
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of TAC1 mRNAincreases expression 11897087
11532335
12105094
D003913 Dextroamphetamine LY 306740 inhibits the reaction [Dextroamphetamine results in increased expression of TAC1 mRNA]decreases reaction|increases expression 11897087
D003913 Dextroamphetamine U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of TAC1 mRNA]decreases reaction|increases expression 11532335
D000661 Amphetamine Amphetamine results in increased expression of TAC1 mRNAincreases expression 15033416
D000661 Amphetamine Baclofen inhibits the reaction [Amphetamine results in increased expression of TAC1 mRNA]decreases reaction|increases expression 15033416
C114556 aprepitant aprepitant inhibits the reaction [TAC1 protein results in increased expression of MMP12 mRNA]decreases reaction|increases expression 18441096
C114556 aprepitant aprepitant inhibits the reaction [TAC1 protein results in increased expression of TACR1 mRNA]decreases reaction|increases expression 18441096
D001418 Baclofen Baclofen inhibits the reaction [Amphetamine results in increased expression of TAC1 mRNA]decreases reaction|increases expression 15033416
C080985 batimastat batimastat inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]decreases reaction|increases activity|increases phosphorylation 15319441
C080985 batimastat batimastat inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]decreases reaction|increases activity|increases phosphorylation 15319441
C080985 batimastat batimastat inhibits the reaction [TAC1 protein results in increased secretion of TGFA protein]decreases reaction|increases secretion 15319441
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TAC1 mRNAincreases expression 20106945
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA]decreases reaction|increases expression 9748608
D002087 Butyrates Butyrates results in increased expression of TAC1 proteinincreases expression 17187013
D002211 Capsaicin capsazepine inhibits the reaction [Capsaicin results in increased secretion of TAC1 protein]decreases reaction|increases secretion 7694442
D002211 Capsaicin Ruthenium Red inhibits the reaction [Capsaicin results in increased secretion of TAC1 protein]decreases reaction|increases secretion 7694442
D002211 Capsaicin Capsaicin results in decreased expression of TAC1 proteindecreases expression 17884737
D002211 Capsaicin Capsaicin affects the expression of TAC1 proteinaffects expression 18344596
D002211 Capsaicin Capsaicin inhibits the reaction [sodium arsenite results in increased secretion of TAC1 protein]decreases reaction|increases secretion 17056641
D002211 Capsaicin Capsaicin results in decreased expression of TAC1 mRNAdecreases expression 18441096
D002211 Capsaicin Capsaicin results in increased secretion of TAC1 protein alternative formincreases secretion 18845912
D002211 Capsaicin SCN10A protein affects the reaction [Capsaicin results in increased secretion of TAC1 protein alternative form]affects reaction|increases secretion 18845912
D002211 Capsaicin TAC1 protein affects the reaction [TRPV1 protein results in increased susceptibility to Capsaicin]affects reaction|increases response to substance 18203709
D002211 Capsaicin AMN protein inhibits the reaction [Capsaicin results in increased expression of TAC1 protein]decreases reaction|increases expression 16938409
D002211 Capsaicin Capsaicin results in decreased expression of TAC1 proteindecreases expression 16959413
3412491
D002211 Capsaicin Capsaicin results in increased expression of TAC1 mRNAincreases expression 16959413
D002211 Capsaicin Capsaicin results in increased expression of TAC1 proteinincreases expression 16938409
17574719
D002211 Capsaicin Capsaicin results in increased secretion of TAC1 proteinincreases secretion 17687396
18311519
D002211 Capsaicin Capsaicin results in increased secretion of TAC1 protein alternative formincreases secretion 19112407
D002211 Capsaicin GAL protein promotes the reaction [Capsaicin results in increased secretion of TAC1 protein alternative form]increases reaction|increases secretion 19112407
D002211 Capsaicin NGF protein promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]increases reaction|increases secretion 17687396
C071423 capsazepine capsazepine inhibits the reaction [Capsaicin results in increased secretion of TAC1 protein]decreases reaction|increases secretion 7694442
D002330 Carmustine Carmustine results in decreased expression of TAC1 mRNAdecreases expression 15980968
D003024 Clozapine Clozapine results in decreased expression of TAC1 mRNAdecreases expression 17266109
D003024 Clozapine Clozapine results in decreased expression of TAC1 mRNAdecreases expression 10974607
D016572 Cyclosporine Cyclosporine results in increased expression of TAC1 mRNAincreases expression 20106945
C017160 cypermethrin cypermethrin inhibits the reaction [Dopamine affects the activity of TAC1 protein]affects activity|decreases reaction 11487621
C017160 cypermethrin cypermethrin inhibits the reaction [Serotonin affects the activity of TAC1 protein]affects activity|decreases reaction 11487621
D004298 Dopamine cypermethrin inhibits the reaction [Dopamine affects the activity of TAC1 protein]affects activity|decreases reaction 11487621
D004958 Estradiol Estradiol results in increased expression of TAC1 mRNAincreases expression 20106945
D005476 Fluphenazine Fluphenazine results in decreased expression of TAC1 mRNAdecreases expression 15845098
D005557 Formaldehyde Formaldehyde results in increased expression of TAC1 proteinincreases expression 18197882
D006220 Haloperidol Haloperidol results in increased expression of TAC1 mRNAincreases expression 10974607
D006851 Hydrochloric Acid Hydrochloric Acid results in decreased expression of TAC1 proteindecreases expression 19957777
D006851 Hydrochloric Acid Hydrochloric Acid results in increased expression of and results in increased secretion of TAC1 proteinincreases expression|increases secretion 20616304
D006861 Hydrogen Peroxide TAC1 protein affects the metabolism of Hydrogen Peroxideaffects metabolic processing 20616304
D016627 Oxidopamine Oxidopamine results in decreased expression of TAC1 mRNAdecreases expression 15610165
D016627 Oxidopamine Oxidopamine results in increased expression of TAC1 mRNAincreases expression 15303306
D012701 Serotonin cypermethrin inhibits the reaction [Serotonin affects the activity of TAC1 protein]affects activity|decreases reaction 11487621
C052241 imirestat imirestat inhibits the reaction [Streptozocin results in decreased expression of TAC1 protein]decreases expression|decreases reaction 1374869
D007545 Isoproterenol TAC1 protein affects the susceptibility to Isoproterenolaffects response to substance 11270094
C098607 JP8 aviation fuel JP8 aviation fuel results in increased expression of TAC1 proteinincreases expression 17574719
C098607 JP8 aviation fuel SR 140333 inhibits the reaction [JP8 aviation fuel results in increased expression of TAC1 protein]decreases reaction|increases expression 17574719
C049985 K 252 K 252 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein]decreases reaction|increases expression 14672914
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TAC1 proteinincreases expression 17291600
D008070 Lipopolysaccharides resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TAC1 protein]decreases reaction|increases expression 17291600
D008070 Lipopolysaccharides 1,3-dimethylthiourea inhibits the reaction [Lipopolysaccharides results in increased expression of TAC1 mRNA]decreases reaction|increases expression 12738685
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TAC1 mRNAincreases expression 12738685
C102280 LY 306740 LY 306740 inhibits the reaction [Dextroamphetamine results in increased expression of TAC1 mRNA]decreases reaction|increases expression 11897087
D008628 Mercury Mercury results in increased expression of TAC1 mRNAincreases expression 16823088
D009151 Mustard Gas Mustard Gas results in increased expression of TAC1 proteinincreases expression 15388249
D009151 Mustard Gas olvanil inhibits the reaction [Mustard Gas results in increased expression of TAC1 protein]decreases reaction|increases expression 15388249
D009569 Nitric Oxide TAC1 protein results in increased abundance of Nitric Oxideincreases abundance 12672649
D005996 Nitroglycerin Nitroglycerin affects the expression of TAC1 proteinaffects expression 18197882
C054256 olvanil olvanil inhibits the reaction [Mustard Gas results in increased expression of TAC1 protein]decreases reaction|increases expression 15388249
C030110 oxaliplatin oxaliplatin results in increased expression of TAC1 proteinincreases expression 17418472
D010126 Ozone Ozone results in increased expression of TAC1 proteinincreases expression 16777450
D010126 Ozone Ozone results in decreased expression of TAC1 proteindecreases expression 9310018
D010261 Paraoxon Albuterol promotes the reaction [Paraoxon results in increased secretion of TAC1 protein]increases reaction|increases secretion 17158603
D010261 Paraoxon Paraoxon results in increased secretion of TAC1 proteinincreases secretion 17158603
D010622 Phencyclidine Phencyclidine results in decreased expression of TAC1 mRNAdecreases expression 17266109
D010656 Phenylephrine TAC1 protein affects the susceptibility to Phenylephrineaffects response to substance 11270094
C008876 phorbol-12,13-didecanoate phorbol-12,13-didecanoate results in increased secretion of TAC1 protein alternative formincreases secretion 19075100
C008876 phorbol-12,13-didecanoate Sodium Chloride, Dietary promotes the reaction [phorbol-12,13-didecanoate results in increased secretion of TAC1 protein alternative form]increases reaction|increases secretion 19075100
D011189 Potassium Chloride Potassium Chloride results in increased secretion of TAC1 protein alternative formincreases secretion 18845912
D011189 Potassium Chloride SCN10A protein affects the reaction [Potassium Chloride results in increased secretion of TAC1 protein alternative form]affects reaction|increases secretion 18845912
D011374 Progesterone SR 140333 inhibits the reaction [TAC1 protein results in decreased metabolism of Progesterone]decreases metabolic processing|decreases reaction 15951421
D011374 Progesterone TAC1 protein results in decreased metabolism of Progesteronedecreases metabolic processing 15951421
C024353 resiniferatoxin Ruthenium Red inhibits the reaction [resiniferatoxin results in increased secretion of TAC1 protein]decreases reaction|increases secretion 7694442
C024353 resiniferatoxin resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TAC1 protein]decreases reaction|increases expression 17291600
C024353 resiniferatoxin resiniferatoxin results in decreased expression of TAC1 proteindecreases expression 18219259
C116926 rofecoxib rofecoxib results in increased expression of TAC1 proteinincreases expression 16449370
C071693 RP 67580 RP 67580 inhibits the reaction [sodium arsenite results in increased secretion of TAC1 protein]decreases reaction|increases secretion 17056641
D012430 Ruthenium Red Ruthenium Red inhibits the reaction [Capsaicin results in increased secretion of TAC1 protein]decreases reaction|increases secretion 7694442
D012430 Ruthenium Red Ruthenium Red inhibits the reaction [resiniferatoxin results in increased secretion of TAC1 protein]decreases reaction|increases secretion 7694442
C009257 sidnocarb sidnocarb results in increased expression of TAC1 mRNAincreases expression 12105094
C017947 sodium arsenite Capsaicin inhibits the reaction [sodium arsenite results in increased secretion of TAC1 protein]decreases reaction|increases secretion 17056641
C017947 sodium arsenite RP 67580 inhibits the reaction [sodium arsenite results in increased secretion of TAC1 protein]decreases reaction|increases secretion 17056641
C017947 sodium arsenite sodium arsenite results in increased expression of and results in increased secretion of TAC1 proteinincreases expression|increases secretion 17056641
D017673 Sodium Chloride, Dietary Sodium Chloride, Dietary promotes the reaction [phorbol-12,13-didecanoate results in increased secretion of TAC1 protein alternative form]increases reaction|increases secretion 19075100
C026411 sorbinil sorbinil inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA]decreases reaction|increases expression 9748608
C085215 SR 140333 SR 140333 results in decreased activity of TAC1 proteindecreases activity 14561836
C085215 SR 140333 SR 140333 inhibits the reaction [JP8 aviation fuel results in increased expression of TAC1 protein]decreases reaction|increases expression 17574719
C085215 SR 140333 SR 140333 inhibits the reaction [TAC1 protein results in decreased metabolism of Progesterone]decreases metabolic processing|decreases reaction 15951421
C085215 SR 140333 SR 140333 inhibits the reaction [Xylenes results in increased expression of TAC1 protein]decreases reaction|increases expression 17574719
D013311 Streptozocin Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA]decreases reaction|increases expression 9748608
D013311 Streptozocin imirestat inhibits the reaction [Streptozocin results in decreased expression of TAC1 protein]decreases expression|decreases reaction 1374869
D013311 Streptozocin sorbinil inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA]decreases reaction|increases expression 9748608
D013311 Streptozocin Streptozocin results in decreased expression of TAC1 proteindecreases expression 1374869
D013311 Streptozocin Streptozocin results in increased expression of TAC1 mRNAincreases expression 9748608
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TAC1 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TAC1 mRNAincreases expression 19933214
17586704
D014051 Toluene 2,4-Diisocyanate K 252 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein]decreases reaction|increases expression 14672914
D014051 Toluene 2,4-Diisocyanate NGF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein]affects reaction|increases expression 14672914
D014051 Toluene 2,4-Diisocyanate [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 mRNAaffects cotreatment|increases expression 10673198
D014051 Toluene 2,4-Diisocyanate [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 proteinaffects cotreatment|increases expression 10673198
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in increased expression of TAC1 proteinincreases expression 14672914
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of TAC1 mRNAincreases expression 17982090
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]decreases reaction|increases activity|increases phosphorylation 15319441
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]decreases reaction|increases activity|increases phosphorylation 15319441
C045444 U 69593 U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of TAC1 mRNA]decreases reaction|increases expression 11532335
D014520 Urethane Urethane affects the reaction [TAC1 protein affects the abundance of Acetylcholine]affects abundance|affects reaction 11020227
D014635 Valproic Acid Valproic Acid inhibits the reaction [TAC1 protein results in increased expression of IL6 mRNA]decreases reaction|increases expression 12807426
D014635 Valproic Acid Valproic Acid inhibits the reaction [TAC1 protein results in increased secretion of IL6 protein]decreases reaction|increases secretion 12807426
D014635 Valproic Acid Valproic Acid inhibits the reaction [TAC1 protein results in increased expression of IL6 mRNA]decreases reaction|increases expression 12807426
D014635 Valproic Acid Valproic Acid inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of PRKCE protein]decreases reaction|increases activity|increases phosphorylation 12807426
D014635 Valproic Acid Valproic Acid inhibits the reaction [TAC1 protein results in increased secretion of IL6 protein]decreases reaction|increases secretion 12807426
D014992 Xylenes SR 140333 inhibits the reaction [Xylenes results in increased expression of TAC1 protein]decreases reaction|increases expression 17574719
D014992 Xylenes Xylenes results in increased expression of TAC1 proteinincreases expression 17574719
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 10.2318926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.2311752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 10.238875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.2819490988
MESH:D000138 Acidosis Ammonium Chloride 8.3418287403
MESH:D000138 Acidosis Hydrochloric Acid 8.3411574821 20872349 12771618 15920416 16144966 19262391
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 5.0717183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 5.0820597076
MESH:D058186 Acute Kidney Injury Capsaicin 7.6218460982
MESH:D058186 Acute Kidney Injury resiniferatoxin 7.6218460982
MESH:D055371 Acute Lung Injury Acrolein 11.7621297076 20525806
MESH:D055371 Acute Lung Injury Hydrochloric Acid 11.7619094174 16759491 19060228 19760209 11850527 11953099 15970105
MESH:D055371 Acute Lung Injury Lipopolysaccharides 11.7611850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 5.7420464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 5.7411473722
MESH:D000230 Adenocarcinoma Urethane 5.7418316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 4.9815814487
MESH:D000236 Adenoma Benzo(a)pyrene 5.506695378
MESH:D000236 Adenoma Urethane 5.506695378 16926031 10822126 17195641 11497255 10530776 17093202
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.6616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 3.9715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.1716712894 17306315
MESH:D000380 Agranulocytosis Clozapine 4.3514617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases cypermethrin 4.2216487989
MESH:D000505 Alopecia Capsaicin 4.1417569567
MESH:D000544 Alzheimer Disease Acrolein 5.5617570602 14715435 15207723
MESH:D000544 Alzheimer Disease Nitric Oxide 5.5617556102
MESH:D000544 Alzheimer Disease Ozone 5.5615513908
MESH:D000550 Amblyopia Valproic Acid 4.5017688650
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.3315010207 16459022 16916582 18475255
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.6110965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.3211748828
MESH:D000799 Angioedema Acetaminophen 3.1110982225
MESH:D000855 Anorexia Amphetamine 4.3816101753 12183048 12005258 16084549
MESH:D000860 Anoxia Hydrochloric Acid 4.5915090967
MESH:D001008 Anxiety Disorders Valproic Acid 2.9917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.3719183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 7.6817460149
MESH:D001145 Arrhythmias, Cardiac Xylenes 7.68513065
MESH:D001161 Arteriosclerosis Acrolein 4.3115014928
MESH:D001169 Arthritis, Experimental rofecoxib 3.8616690336
MESH:D001172 Arthritis, Rheumatoid Ozone 2.3515570426
MESH:D001249 Asthma Albuterol 9.039949315 11991558
MESH:D001249 Asthma Mustard Gas 9.0310378619
MESH:D001249 Asthma Ozone 9.0317854713 16373670
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 9.0311467998 19187332 11077013 18394133 170078 12585506 17015710 6091946 3040596 10797510 10934080 16210060 20032816 7684630 15855793 8156442 15590890 6091945 15590891 12762349 16792590 11742282 12684321
MESH:D050197 Atherosclerosis Acrolein 6.2316037261 17363696 16126721
MESH:D050197 Atherosclerosis Paraoxon 6.2316391483
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.1314699433
MESH:D001321 Autistic Disorder Acetaminophen 2.9818445737
MESH:D001321 Autistic Disorder Haloperidol 2.9819368416 18080171
MESH:D001321 Autistic Disorder Mercury 2.9817497416
MESH:D001321 Autistic Disorder Serotonin 2.9818062943 8570775 18361446 15132762 17157402 18405062 19221690
MESH:D001321 Autistic Disorder Valproic Acid 2.9817688650 18775368 17157402 18396377 18177632 20603192 17507914 18558336 18316065 19460635 18940202 18985861 19232924 15238991 16609825
MESH:D001327 Autoimmune Diseases Mercury 4.1716634805
MESH:D001714 Bipolar Disorder marker/mechanism 15845098
MESH:D001714 Bipolar Disorder Valproic Acid 2.6620046352 17594078
MESH:D001768 Blister Mustard Gas 4.4419167455
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 7.2215920416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.2212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.3515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.358888407
MESH:D001919 Bradycardia Capsaicin 19.2718207255
MESH:D001919 Bradycardia Isoproterenol 19.276740701
MESH:D001919 Bradycardia Phenylephrine 19.2715306635
MESH:D001919 Bradycardia Serotonin 19.278112388
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.6017868700
MESH:D001930 Brain Injuries Progesterone 3.5615845082 15380490 15665606
MESH:D002545 Brain Ischemia Capsaicin 4.2619211983
MESH:D001932 Brain Neoplasms Carmustine 3.7616187019
MESH:D001943 Breast Neoplasms 2,6-diisocyanatotoluene 3.8311921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.8317474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 3.8314630087 12948864 17261762 17289903 19861407 16675129 17018787 18497071
MESH:D001943 Breast Neoplasms Formaldehyde 3.8315986119
MESH:D001943 Breast Neoplasms Nitric Oxide 3.8315631943
MESH:D001943 Breast Neoplasms Progesterone 3.8316175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.8320435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 3.8311921183
MESH:D016535 Bronchial Hyperreactivity marker/mechanism 16777450
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 15.4912378975
MESH:D016535 Bronchial Hyperreactivity Ozone 15.4915516495 16777450 14754758 19059883 18315731 17626835 18417511
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 15.4915590891 12507178 8156442
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 15.4912794006
MESH:D001986 Bronchial Spasm Hydrochloric Acid 4.7415578804
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.4415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.2410378619 17687719
MESH:D002100 Cachexia Ozone 4.0216183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7416111702
MESH:D002276 Carcinoid Tumor Streptozocin 4.8716051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.2216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 5.173084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 5.1721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 5.1716924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 5.1715276417 16507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 3.6920419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 3.6918572023
MESH:D006332 Cardiomegaly Isoproterenol 8.977544033 11179087
MESH:D006332 Cardiomegaly Phenylephrine 8.9711754973 16170337 17124262 15728586 17287366 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 8.9718670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.1510334427
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 2.9916936243
MESH:D002375 Catalepsy Fluphenazine 9.631977408
MESH:D002375 Catalepsy Haloperidol 9.6315215559 1977408
MESH:D002386 Cataract Acetaminophen 2.1210977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 8.1212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 8.1218566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 8.1219524636 20056578
MESH:D002637 Chest Pain Acids 5.6715447763
MESH:D002659 Child Development Disorders, Pervasive Serotonin 5.3521254450
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 5.3520734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.5416835633
MESH:D002779 Cholestasis Cyclosporine 6.5019486331
MESH:D002779 Cholestasis Nitric Oxide 6.5016919318
MESH:D021081 Chronobiology Disorders Serotonin 5.9617157402
MESH:D016770 Ciliophora Infections Formaldehyde 4.9212113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.9516354765 12621046 8697196 15340226 15668235
MESH:D002972 Cleft Palate Urethane 4.9512810352
MESH:D003072 Cognition Disorders Clozapine 4.2617123785
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 3.8516474422 16804969 16782535 17936198 18023891 11698051 17991707 16867261 18200517
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.1517276891
MESH:D003110 Colonic Neoplasms Butyrates 5.1015936596
MESH:D003110 Colonic Neoplasms oxaliplatin 5.1016510598 16004971 16024531
MESH:D003110 Colonic Neoplasms rofecoxib 5.1012902858
MESH:D015179 Colorectal Neoplasms Acrolein 3.0517597105
MESH:D015179 Colorectal Neoplasms oxaliplatin 3.0517255274 17594712 18448328 17695437 17401013 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.4417141729 14669216
MESH:D003371 Cough Capsaicin 4.4510350223
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.1720055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.1716575769 8888407 17688650
MESH:D003556 Cystitis Acrolein 9.8312161096
MESH:D003556 Cystitis Hydrochloric Acid 9.8312599022 20719367 12853844 19279288
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 5.0817714534
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.1720210726
MESH:D003704 Dementia Haloperidol 3.9311575062
MESH:D015140 Dementia, Vascular Nitric Oxide 5.2417556102
MESH:D003865 Depressive Disorder, Major marker/mechanism 15845098
MESH:D017449 Dermatitis, Allergic Contact Formaldehyde 8.0812081698 15932584 14996049 15059100 16958921
MESH:D017449 Dermatitis, Allergic Contact Mercury 8.0816823706
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 8.0818759878 15491423 12956900
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 4.1317010967
MESH:D017453 Dermatitis, Irritant JP8 aviation fuel 12.7717574719
MESH:D017453 Dermatitis, Irritant Xylenes 12.7717574719
MESH:D003920 Diabetes Mellitus Streptozocin 4.1116285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 3.8912644472 19960420 19298542 18603373 15298345 12083368 1374869 11055810 17442507 15862027 6379147 7637645 8740154 16684804 12093613 11260395 12446591 15831366 16286809 18715473 19496084 17874149 2177838 19586609
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.3618603373
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 5.8916402076
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 5.8919586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 5.8917107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.0016025228
MESH:D003928 Diabetic Nephropathies Estradiol 7.2319279558
MESH:D003928 Diabetic Nephropathies Streptozocin 7.2319682444 19960420
MESH:D003929 Diabetic Neuropathies Progesterone 3.7917187935
MESH:D003930 Diabetic Retinopathy Streptozocin 4.7417662242
MESH:D003967 Diarrhea Serotonin 7.1911488427 8112388 10446763
MESH:D003967 Diarrhea SR 140333 7.199219603
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.8215331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.5416781746 17562736 16109766 16393943 11743745 19923254 14550746 2444490 11739529 12392966 12958197 10774834 12540782 16485898 14986274 19420014 19085960 12594235 15968718 19164858 12705907 15619225 10663392 17522070 19416960 11529661 11461765 19370779 18071297 11421492 14725611 16081117 11834606 19739265 11287661 16227642 17906064 12153990 16177239 18713872 10915739
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.5420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.5419641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.2111462148
MESH:D004381 Duodenal Ulcer Capsaicin 4.0111535926 10671773
MESH:D050171 Dyslipidemias Clozapine 3.6416402076
MESH:D004417 Dyspnea Albuterol 8.9120016425
MESH:D004417 Dyspnea cypermethrin 8.9116487989
MESH:D004421 Dystonia Valproic Acid 3.381851702
MESH:D004487 Edema (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide 11.4216953190
MESH:D004487 Edema Mustard Gas 11.4211402378 9260866 11428647 11428631
MESH:D004487 Edema Serotonin 11.4218841975
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.4211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.1718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.1017692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.4819148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 11.7416134523
MESH:D004715 Endometriosis rofecoxib 11.7415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 11.7410568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 3.6817637181 15821434 15328337
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 3.968156442
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.453659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.1916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.5220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 2.976254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.597750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.353659116
MESH:D004890 Erythema Mustard Gas 4.449357497
MESH:D004935 Esophageal Diseases Capsaicin 11.1119566590
MESH:D004935 Esophageal Diseases Hydrochloric Acid 11.1119566590
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.7916530937
MESH:D004941 Esophagitis Hydrochloric Acid 5.2712928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 5.2811346197 14621274 20516732
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.4511564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.0318447907
MESH:D005141 Eyelid Diseases Formaldehyde 5.6414996049
MESH:D005221 Fatigue Amphetamine 4.8819890266
MESH:D005234 Fatty Liver Cyclosporine 5.6319224547
MESH:D005234 Fatty Liver Valproic Acid 5.6319224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.7511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.4518558336 8888407
MESH:D005334 Fever Lipopolysaccharides 3.3811852909 9205823
MESH:D005355 Fibrosis Albuterol 20.4315467267
MESH:D005355 Fibrosis Cyclosporine 20.4312639820 12168785
MESH:D005355 Fibrosis Hydrochloric Acid 20.4318497604
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.4320067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 20.4317994277
MESH:D005393 Fish Diseases Formaldehyde 4.8812113305
MESH:D005739 Gas Poisoning Albuterol 10.1320016425
MESH:D005739 Gas Poisoning Hydrochloric Acid 10.1312378975
MESH:D005756 Gastritis Acetaminophen 2.9416983495
MESH:D005764 Gastroesophageal Reflux marker/mechanism 20616304
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 4.6419951613 20616304 12212954 20545468 20516732 19957777
MESH:D005833 Genital Neoplasms, Female sodium arsenite 3.9616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.508708960
MESH:D005909 Glioblastoma Capsaicin 6.1818405923
MESH:D005909 Glioblastoma Carmustine 6.1816187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.8610696789
MESH:D006261 Headache Nitric Oxide 8.9411554966 11284996
MESH:D006261 Headache Nitroglycerin 8.9411284996 11554966
MESH:D006356 Heartburn Capsaicin 11.1119566590
MESH:D006356 Heartburn Hydrochloric Acid 11.1119566590
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.0020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.0010048152 11294989
MESH:D006331 Heart Diseases Streptozocin 6.6212093613
MESH:D006331 Heart Diseases Urethane 6.6216046796
MESH:D006333 Heart Failure Isoproterenol 3.7618097624
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.7015720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.7516366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.6811000095
MESH:D006505 Hepatitis cypermethrin 4.4816487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.2112621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.3015709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.5612676792
MESH:D019584 Hot Flashes Estradiol 3.0317088409
MESH:D006849 Hydrocephalus Valproic Acid 4.1517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.318697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 9.9316870215
MESH:D006930 Hyperalgesia Capsaicin 9.9317043245 17434803
MESH:D006930 Hyperalgesia oxaliplatin 9.9317418472
MESH:D006940 Hyperemia Hydrochloric Acid 10.5712646421
MESH:D006940 Hyperemia Nitric Oxide 10.5711156591
MESH:D006948 Hyperkinesis Amphetamine 9.4114960337 1977408
MESH:D006948 Hyperkinesis Clozapine 9.4116046005
MESH:D006967 Hypersensitivity 2,6-diisocyanatotoluene 11.4310880147
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 11.4317604070
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 11.4310880147 11019492
MESH:D006973 Hypertension Cyclosporine 9.6510903974
MESH:D006973 Hypertension Phenylephrine 9.6512717712 8949925
MESH:D006973 Hypertension Sodium Chloride, Dietary 9.6518524855
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.6518670907 18850075
MESH:D006975 Hypertension, Portal Hydrochloric Acid 4.6516984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 7.0019262391
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 7.0015838368
MESH:D006984 Hypertrophy Isoproterenol 8.8312791704
MESH:D006984 Hypertrophy Phenylephrine 8.8318502941 12791704
MESH:D007022 Hypotension Dopamine 11.776740701
MESH:D007022 Hypotension Hydrochloric Acid 11.7711574821
MESH:D007022 Hypotension Isoproterenol 11.776740701
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.7015869954
MESH:D007248 Infertility, Male sodium arsenite 2.4912646999 15346721
MESH:D007249 Inflammation Capsaicin 14.4116956363
MESH:D007249 Inflammation Hydrochloric Acid 14.4111574821
MESH:D007249 Inflammation Lipopolysaccharides 14.419205823 12878042 17963957 17237260 17255318
MESH:D007249 Inflammation Mustard Gas 14.419260866 8975870 11428647 9357497 16001271 11428631 11428620 17524151 11402378
MESH:D007249 Inflammation Progesterone 14.4115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.4112200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.2318200517
MESH:D007299 Insect Bites and Stings cypermethrin 5.2415189238
MESH:D007333 Insulin Resistance Estradiol 2.4716627594 16393666
MESH:D007410 Intestinal Diseases Hydrochloric Acid 17.8411574821
MESH:D007410 Intestinal Diseases Nitric Oxide 17.8411574821 10210152 11713966
MESH:D007410 Intestinal Diseases rofecoxib 17.8415831440
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 17.8417994277
MESH:D007417 Intestinal Polyps rofecoxib 4.7011245490
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 3.9617255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.6816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 21.7712587719 15629191
MESH:D007674 Kidney Diseases Acrolein 21.7712488133
MESH:D007674 Kidney Diseases Cyclosporine 21.778314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 21.7715618244
MESH:D007674 Kidney Diseases Mercury 21.7717934191
MESH:D007674 Kidney Diseases sodium arsenite 21.7720008137
MESH:D007674 Kidney Diseases Streptozocin 21.7712093613
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.6216518626
MESH:D007680 Kidney Neoplasms Cyclosporine 5.3012371664
MESH:D007680 Kidney Neoplasms Estradiol 5.3015610895
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 5.6316498863
MESH:D007826 Laryngismus Hydrochloric Acid 5.6311510729
MESH:D007896 Leishmaniasis Nitric Oxide 4.0417218153
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0016294345 17596541
MESH:D007970 Leukopenia Lipopolysaccharides 3.9815821434
MESH:D008064 Lipidoses Clozapine 3.4217567588
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 3.6316984587
MESH:D008106 Liver Cirrhosis, Experimental 1,3-dimethylthiourea 5.3711682029
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.3714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.3712878042
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 5.3717565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.3712878042
MESH:D008107 Liver Diseases Acetaminophen 5.3616610002 16611625 12587719 19014921 11587558 19460945 12969438 19784758
MESH:D008107 Liver Diseases Capsaicin 5.3616956363
MESH:D008107 Liver Diseases cypermethrin 5.3615991261
MESH:D017114 Liver Failure, Acute Acetaminophen 2.6016871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.5615890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.5620195826 21137059
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 13.5618177683
MESH:D008113 Liver Neoplasms sodium arsenite 13.5616712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.5616984957
MESH:D008113 Liver Neoplasms Urethane 13.5617093202 16391232 17559639
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 4.208603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 4.2012151625
MESH:D008171 Lung Diseases Acrolein 17.6311504702
MESH:D008171 Lung Diseases Hydrochloric Acid 17.6316784557
MESH:D008171 Lung Diseases Mustard Gas 17.6318161513 18702808
MESH:D008171 Lung Diseases Ozone 17.638266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 17.6319095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.5317228818
MESH:D055370 Lung Injury Hydrochloric Acid 15.9616129981 17627322 20597076 21114838 19644408 11395602 18573544 18497604 18339021 15607125 19262391 21311175 15044056 15090967
MESH:D055370 Lung Injury Lipopolysaccharides 15.9621114838
MESH:D055370 Lung Injury Nitric Oxide 15.9611395602
MESH:D055370 Lung Injury Ozone 15.9620417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.5414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.5418816296 18520028 18569708 17053015 20464547 20064080 6695378 20135361 20869020
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 10.5419359593 16337739 11696405 15390079 19925653 11246140 18597497
MESH:D008175 Lung Neoplasms Mustard Gas 10.548781369 3148597
MESH:D008175 Lung Neoplasms Ozone 10.547614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 10.5417306315 19931552 17077188 15276417 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.5411884234 19555203
MESH:D008175 Lung Neoplasms Urethane 10.5411807781 11552296 11992545 10822126 11062179 10530776 6695378 12466968 16926031 16788158 11323394 15136453 10997738 11544531 17255336 12117781 16204055 16337739 11893704 10779650 12765245 11497255 15902970 16391232 16007126 16289808 15166089 12957351 17195641 17093202 11074608 11307925 14587096 7750092 11246140
MESH:D008223 Lymphoma Nitric Oxide 3.7516166326
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 7.241500032
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 7.2411807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 7.2417203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 3.7519453300
MESH:D008545 Melanoma Carmustine 3.1312393984
MESH:D008545 Melanoma sodium arsenite 3.1316487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 8.6519513568
MESH:D008546 Melanoma, Experimental Acrolein 8.6510803710
MESH:D001523 Mental Disorders Clozapine 9.4916856516
MESH:D001523 Mental Disorders Fluphenazine 9.4916856516
MESH:D001523 Mental Disorders Haloperidol 9.4916856516
MESH:D024821 Metabolic Syndrome X Clozapine 3.8119142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.0516801185
MESH:D008679 Metaplasia Ozone 4.3710496685
MESH:D008708 Methemoglobinemia Nitroglycerin 4.073537620
MESH:D008881 Migraine Disorders Nitric Oxide 6.1411701602
MESH:D008881 Migraine Disorders Valproic Acid 6.1418803445 18765137
MESH:D020326 Migraine without Aura marker/mechanism 11304026
MESH:D020326 Migraine without Aura Nitric Oxide 8.8814659530 11304026
MESH:D020326 Migraine without Aura Nitroglycerin 8.8814659530
MESH:D009041 Motion Sickness Dextroamphetamine 4.791613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.6216381670
MESH:D009101 Multiple Myeloma Capsaicin 3.6317505005
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.378888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.7017596541
MESH:D009203 Myocardial Infarction Hydrochloric Acid 7.8318534312
MESH:D009203 Myocardial Infarction Isoproterenol 7.8316697266 15740881 16538859 19595682 17052832 19172585 16584858
MESH:D009203 Myocardial Infarction Nitroglycerin 7.8314729435
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.4312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.7116810080
MESH:D009290 Narcolepsy marker/mechanism 17521418
MESH:D009369 Neoplasms Acrolein 8.5717329238
MESH:D009369 Neoplasms Benzo(a)pyrene 8.5711141357
MESH:D009369 Neoplasms sodium arsenite 8.5711559025
MESH:D009369 Neoplasms Urethane 8.5715625555
MESH:D009374 Neoplasms, Experimental 2,6-diisocyanatotoluene 16.241670384
MESH:D009374 Neoplasms, Experimental sodium arsenite 16.2420056578
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 16.241670384
MESH:D009374 Neoplasms, Experimental Urethane 16.2415582191
MESH:D009389 Neovascularization, Pathologic Estradiol 3.0217289903
MESH:D009393 Nephritis Acrolein 5.5512653641
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.6718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 7.1916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.1914600291
MESH:D009436 Neural Tube Defects sodium arsenite 5.6512854658
MESH:D009436 Neural Tube Defects Valproic Acid 5.658888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 15.3318514411
MESH:D019636 Neurodegenerative Diseases Acrolein 15.3311342003
MESH:D019636 Neurodegenerative Diseases Amphetamine 15.3315183010
MESH:D019636 Neurodegenerative Diseases Oxidopamine 15.3318514411
MESH:D020078 Neurogenic Inflammation marker/mechanism 17257769 17961222
MESH:D020078 Neurogenic Inflammation Capsaicin 9.3317961222
MESH:D020078 Neurogenic Inflammation Xylenes 9.3319159661
MESH:D009503 Neutropenia Mustard Gas 3.317688884 16761898
MESH:D009669 Nose Neoplasms Formaldehyde 4.644038687
MESH:D009765 Obesity Capsaicin 4.4719056576
MESH:D009765 Obesity Clozapine 4.4719142110 18515891
MESH:D009784 Occupational Diseases Hydrochloric Acid 7.7512378975
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 7.7511077013 6091945 8156442 3040596 12585506 6091946 18394133
MESH:D010003 Osteoarthritis rofecoxib 3.9016690336
MESH:D010051 Ovarian Neoplasms Estradiol 8.8919401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.8916525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.8917306315 15276417
MESH:D010051 Ovarian Neoplasms Urethane 8.8916391232
MESH:D010146 Pain Acetaminophen 8.2016870215
MESH:D010146 Pain Capsaicin 8.2017043245 18987195 17434803 17084039 16996476 19081190
MESH:D010146 Pain Xylenes 8.203412491 19159661
MESH:D010149 Pain, Postoperative rofecoxib 4.6616678543 18165598
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.5517698068
MESH:D010212 Papilloma Hydrogen Peroxide 3.3912065085
MESH:D010300 Parkinson Disease Acrolein 3.2817690948
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 4.7615893579 11771942
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5112520081
MESH:D010523 Peripheral Nervous System Diseases resiniferatoxin 5.3318219259
MESH:D010538 Peritonitis Ozone 3.4316369182
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 11.0211550810
MESH:D010787 Photosensitivity Disorders Acrolein 11.0211550810
MESH:D010911 Pituitary Neoplasms Urethane 4.7116391232
MESH:D011014 Pneumonia Butylated Hydroxytoluene 14.5311893704
MESH:D011014 Pneumonia Lipopolysaccharides 14.5312224865 11605937
MESH:D011014 Pneumonia Ozone 14.5318929643 18007984 18381685
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 9.5515970105 18497604 15607125 18573544
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 9.5518573544
MESH:D011041 Poisoning Mustard Gas 3.1415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.8718163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.6112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.0911118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 7.0920603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.2320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8917292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.8916740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.8916039940
MESH:D011537 Pruritus Mustard Gas 3.3818058305
MESH:D019310 Pseudolymphoma Valproic Acid 3.8111422049 12752131
MESH:D011565 Psoriasis Cyclosporine 1.9216882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.2511575062
MESH:D011618 Psychotic Disorders Clozapine 7.3315331141
MESH:D011618 Psychotic Disorders Haloperidol 7.3311575062
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 5.2820597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 8.9815090967
MESH:D011654 Pulmonary Edema Isoproterenol 8.9810903255
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 4.8914606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.6017266442 10334151 17620002 17894541 17720292
MESH:D051437 Renal Insufficiency Acrolein 4.3112732208
MESH:D015427 Reperfusion Injury Capsaicin 6.4419211983 18460982
MESH:D015427 Reperfusion Injury resiniferatoxin 6.4418460982
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 4.1018549715 16129981 16784557 18339021 17627322
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 10.849413022
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 10.8410835634
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 10.847692837 20219652 16940033
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 5.6311510729
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.1518990726
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 8.7920516732
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 8.7918447907
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.5019155313
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 3.9619050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 4.5515015336 12617775
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 4.7819075512
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.5518045962
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 4.769673227
MESH:D012559 Schizophrenia marker/mechanism 15845098
MESH:D012559 Schizophrenia Clozapine 4.7420521320 17726453 11151749 18855531 18806925 11763009 20452607 16141801 17123785 20580759 20521326 17667964 19369910 20168265 20107430
MESH:D012559 Schizophrenia Haloperidol 4.7420107430 18513383 19369910 1830565
MESH:D012559 Schizophrenia Valproic Acid 4.7415737665 19110320
MESH:D012595 Scleroderma, Systemic Formaldehyde 5.2014979077
MESH:D012640 Seizures Valproic Acid 2.2614763951 11738929 11044598 1511512 17978042 15475178 16876388 3137016
MESH:D012852 Sinusitis Phenylephrine 3.997327846
MESH:D012871 Skin Diseases Mustard Gas 2.4816961503 15451306 12880345
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.6919755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.6912065085
MESH:D012878 Skin Neoplasms sodium arsenite 13.6918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.6916192470
MESH:D012878 Skin Neoplasms Urethane 13.6911807781
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 4.7819075512 19050374
MESH:D013119 Spinal Cord Injuries Progesterone 3.5615862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 7.6312854658
MESH:D016135 Spinal Dysraphism Valproic Acid 7.6319490988
MESH:D013226 Status Epilepticus Valproic Acid 3.8112833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.691977408
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Hydrochloric Acid 5.9617189318 15309881 16755016
MESH:D013276 Stomach Ulcer Nitric Oxide 5.9615138204
MESH:D020521 Stroke Acrolein 3.9716269634
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.0220210726
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 4.9917997062
MESH:D013733 Testicular Diseases Xylenes 5.2110048760 10514026
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.5315821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.1712697716
MESH:D013964 Thyroid Neoplasms Butyrates 3.5217967635
MESH:D013978 Tibial Fractures Estradiol 3.9519048282
MESH:D014178 Translocation, Genetic Valproic Acid 4.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.803119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 3.9117053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 3.9116452187 17306315 11723127 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.948888407
MESH:D014570 Urologic Diseases cypermethrin 5.1316487989
MESH:D014581 Urticaria Acetaminophen 2.3210982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.1311813266
MESH:D014605 Uveitis Cyclosporine 3.251336536
MESH:D014652 Vascular Diseases sodium arsenite 3.7117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.8612125929
MESH:D019043 Vascular Neoplasms Urethane 5.1810620525
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 4.4218097624
MESH:D020257 Ventricular Remodeling Isoproterenol 4.9718097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5115886252
MESH:D015430 Weight Gain Clozapine 3.8520564506 20107430 16402076 16141801 20521320 17502770
MESH:D015431 Weight Loss Clozapine 4.3617933447
MESH:D014985 Xerophthalmia Cyclosporine 3.7117120751
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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