AutismKB 2.0

Annotation Detail for TAC3


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Basic Information Top
Gene Symbol:TAC3 ( NKB,NKNB,PRO1155,ZNEUROK1 )
Gene Full Name: tachykinin 3
Band: 12q13.3
Quick LinksEntrez ID:6866; OMIM: 162330; Uniprot ID:TKNK_HUMAN; ENSEMBL ID: ENSG00000166863; HGNC ID: 11521
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by GPCR
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Pathway IDPathway Name
500407Tachykinin receptors bind tachykinins
Related Diseases/Disorders Top
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Desease Name
Hypogonadotropic hypogonadism
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TAC3 mRNAincreases expression 20382639
D002220 Carbamazepine Carbamazepine inhibits the reaction [REST protein results in increased expression of TAC3 mRNA]decreases reaction|increases expression 19539370
C029938 nickel sulfate nickel sulfate results in increased expression of TAC3 mRNAincreases expression 16780908
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 5.288986270
MESH:D055371 Acute Lung Injury nickel sulfate 4.8412718980 19131640 11954676 16100012
MESH:D001714 Bipolar Disorder Carbamazepine 4.3220046352 17594078
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.0120889678
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.969014606
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 4.3116780908 11298694 16823706
OMIM:607208 DRAVET SYNDROME Carbamazepine 6.1011748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.6416538176 20216337 16538175 15057820
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 3.3217465707
MESH:D004362 Drug Toxicity Carbamazepine 4.7820216337
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 5.3117654737
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.8418855540 19915237 16415921 20485159 16538176
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.8617275665
MESH:D004828 Epilepsies, Partial Carbamazepine 5.8415008574 16628512 17116037
MESH:D004827 Epilepsy Carbamazepine 4.1818234410 821787 17178248 19439326 17465707 19620853 7988514 9014606 20417680 19700373
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 6.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.863659116 15276670
MESH:D004916 Erythromelalgia Carbamazepine 6.4619549232
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005076 Exanthema Carbamazepine 6.2120485159
MESH:D020138 Hyperhomocysteinemia Carbamazepine 5.1410459572
MESH:D006965 Hyperplasia Carbamazepine 5.8618773962
MESH:D007006 Hypogonadism marker/mechanism 19079066
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.6616628512
MESH:D008607 Mental Retardation Carbamazepine 3.849014606
MESH:D009224 Myotonia Congenita Carbamazepine 6.2120399394
MESH:D009421 Nervous System Malformations Carbamazepine 5.4916990009
MESH:D010018 Osteomalacia Carbamazepine 6.2117016548
MESH:D010146 Pain Carbamazepine 4.4115215642
MESH:D010267 Parapsoriasis Carbamazepine 6.3516538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 6.6717145499 17679678
MESH:D011248 Pregnancy Complications Carbamazepine 5.809014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 5.639014606
MESH:D019310 Pseudolymphoma Carbamazepine 6.469591791 12752131
MESH:D012640 Seizures Carbamazepine 4.089046859 9844417 16938433 16876388 15946322 19414003 16180713
MESH:D012893 Sleep Disorders Carbamazepine 5.8619414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.8615057820 19694795 19915237 18855540 16538176 16415921 20485159
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018