AutismKB 2.0

Annotation Detail for ADAM17


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Basic Information Top
Gene Symbol:ADAM17 ( ADAM18,CD156B,CSVP,MGC71942,TACE )
Gene Full Name: ADAM metallopeptidase domain 17
Band: 2p25.1
Quick LinksEntrez ID:6868; OMIM: 603639; Uniprot ID:ADA17_HUMAN; ENSEMBL ID: ENSG00000151694; HGNC ID: 195
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05010Alzheimer's disease
hsa04330Notch signaling pathway
Pathway IDPathway Name
Signalling by NGF
Signaling by EGFR
Pathway IDPathway Name
200009ErbB4 signaling events
200086TNF receptor signaling pathway
200103p75(NTR)-mediated signaling
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00004Alzheimer disease-presenilin pathway
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ADAM17 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ADAM17 mRNAincreases expression 18648102
D000171 Acrolein ADAM17 protein promotes the reaction [Acrolein results in increased expression of MUC5AC mRNA]increases expression|increases reaction 15531749
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADAM17 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of ADAM17 mRNAdecreases expression 11134558
C065179 atorvastatin atorvastatin results in decreased expression of ADAM17 proteindecreases expression 18360054
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADAM17 mRNAdecreases expression 20018196
C006780 bisphenol A bisphenol A results in decreased expression of ADAM17 mRNAdecreases expression 20678512
C011724 cholest-5-en-3 beta,7 alpha-diol cholest-5-en-3 beta,7 alpha-diol results in decreased activity of ADAM17 proteindecreases activity 15591071
D003474 Curcumin Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA]decreases reaction|increases expression 17666914
D016572 Cyclosporine Cyclosporine results in increased expression of ADAM17 mRNAincreases expression 20106945
D004391 Dust Dust results in increased expression of ADAM17 mRNAincreases expression 17805423
D000431 Ethanol Ethanol results in decreased expression of ADAM17 mRNAdecreases expression 17920746
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ADAM17 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADAM17 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM17 mRNAaffects cotreatment|increases expression 17942748
D010656 Phenylephrine ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]affects reaction|increases cleavage|increases secretion 16760267
D010656 Phenylephrine ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 16760267
D010656 Phenylephrine ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 16760267
D013629 Tamoxifen Tamoxifen affects the expression of ADAM17 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM17 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADAM17 mRNAincreases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of ADAM17 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of ADAM17 mRNAdecreases expression 19244175
C088658 zoledronic acid ADAM17 protein promotes the reaction [zoledronic acid results in decreased expression of TNFSF11 protein]decreases expression|increases reaction 14753746
C088658 zoledronic acid zoledronic acid results in decreased activity of ADAM17 proteindecreases activity 14753746
C088658 zoledronic acid zoledronic acid results in increased expression of ADAM17 proteinincreases expression 14753746
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4714745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.1918926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 10.1818287403
MESH:D000138 Acidosis Ethanol 10.1811192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D058186 Acute Kidney Injury zoledronic acid 4.3819715164
MESH:D055371 Acute Lung Injury Acrolein 4.6221297076 20525806
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.4020200999
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7914692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.703712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2916835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1317306315
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.2415451039 15451040
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0017887948
MESH:D000544 Alzheimer Disease Acrolein 4.6417570602 14715435 15207723
MESH:D000544 Alzheimer Disease Curcumin 4.6415590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D000853 Anophthalmos Ethanol 4.7315513904
MESH:D001008 Anxiety Disorders Ethanol 8.7711141031
MESH:D001008 Anxiety Disorders vinclozolin 8.7719015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0317460149
MESH:D020261 Arsenic Poisoning Arsenic 2.8416251483 12569548 18414634 16835338
MESH:D001161 Arteriosclerosis Acrolein 10.0315014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.0311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7216807698
MESH:D050197 Atherosclerosis Acrolein 10.9017363696 16126721 16037261
MESH:D050197 Atherosclerosis Arsenic 10.9019371607 12928151
MESH:D050197 Atherosclerosis Curcumin 10.9018704882
MESH:D001327 Autoimmune Diseases Curcumin 4.4019761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.941440618 11289319
MESH:D001768 Blister marker/mechanism 19167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D001859 Bone Neoplasms zoledronic acid 4.8719442620 15867366 17312309 11697798 16778634 16121404
MESH:D001862 Bone Resorption bisphenol A 9.5211985600
MESH:D001862 Bone Resorption zoledronic acid 9.5215845617 16769263 11869084 18404659 18496637 8053405
MESH:D001919 Bradycardia Phenylephrine 4.4615306635
MESH:D002545 Brain Ischemia Curcumin 4.2516770732
MESH:D001932 Brain Neoplasms Curcumin 3.8617596214
MESH:D001943 Breast Neoplasms bisphenol A 2.3317123778
MESH:D001943 Breast Neoplasms Curcumin 2.3319250217 18462866 16243823 18593918
MESH:D001943 Breast Neoplasms Tamoxifen 2.3316202921 18351453 20135344 20005174 18629630 19289846 19115204 19103187 18855134 16818667 19142967 18984771 15668708 19066611 15565566 19244106 11161223 18997820 20544844 18425577 20859285 20065188 18815881 19155303 17242785 18821012 19410462 16273361 19084267 21138602 19221464 19059307 21152245 17049068 17440819 17261762 19189210 19288272 19487384 19189212 17893378 16873071 19200415 19011961 20390343
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3320435547
MESH:D001943 Breast Neoplasms zoledronic acid 2.3316096432 18695136
MESH:D002056 Burns Ethanol 4.5616374292
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8416050911
MESH:D002277 Carcinoma Curcumin 8.0518593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0516835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5415504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4219066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.7416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.747296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.7416507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Ethanol 8.7415763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.7416924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.9017123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.8718414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 5.8719233551
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.677296757
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 6.6718507039
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.8915504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.8918462866
MESH:D002295 Carcinoma, Transitional Cell Arsenic 9.2418640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.2417572228
MESH:D006332 Cardiomegaly atorvastatin 16.0118360054
MESH:D006332 Cardiomegaly Ethanol 16.0119332462
MESH:D006332 Cardiomegaly Phenylephrine 16.0117124262 17287366 11754973 11179087 15728586 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 16.0116120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 3.3919152805 15738583 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.2318022660 16973168
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.506135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.507505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.5020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.5012371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.009022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.0019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.0017681005 16105132 17110522 16919318 17333356 11677210 15861022
MESH:D002971 Cleft Lip Ethanol 3.5415513904
MESH:D002972 Cleft Palate Ethanol 5.8315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.838697196 15340226 16354765 12621046 15668235
MESH:D003092 Colitis Curcumin 4.0918200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 4.4718809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4919359593 16340194
MESH:D015179 Colorectal Neoplasms Acrolein 2.9217597105
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.8118497527
MESH:D003324 Coronary Artery Disease atorvastatin 4.1116368305
MESH:D019465 Craniofacial Abnormalities Ethanol 3.7819302082 15451040 10194807 11873399 11198716 15513904 15451039
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7810048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7819769572
MESH:D003456 Cryptorchidism vinclozolin 4.2514966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9318551238
MESH:D003556 Cystitis Acrolein 5.3112161096
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2819031437
MESH:D003715 Dengue cholest-5-en-3 beta,7 alpha-diol 6.2919427377
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7211298694 8156756 18759878 11906362 8970840 2524372 12868966 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.412952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.3418403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3417107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.8018204486
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.8019279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.7718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.779653073 6679447 1440618 9328219 16192314 9022650 18648102 18692083 7440962 11289319 8291058 18289764 6482804
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.7711566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.7720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D004381 Duodenal Ulcer Curcumin 3.9617351913
MESH:C538011 Eales disease Vitamin E 4.629068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.6612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.6619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9919155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.949294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.153581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1520426865
MESH:D004938 Esophageal Neoplasms Ethanol 7.1516704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Curcumin 23.7919297423
MESH:D005234 Fatty Liver Cyclosporine 23.7919224547
MESH:D005234 Fatty Liver Ethanol 23.7918620774 16409862 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.7915345470
MESH:D005234 Fatty Liver Tamoxifen 23.7919224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5817920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1816709447
MESH:D005264 Femoral Fractures zoledronic acid 5.7416234978
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.2110194807 15513904 15451040 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.946705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1019069698
MESH:D005355 Fibrosis Curcumin 14.2818705752
MESH:D005355 Fibrosis Cyclosporine 14.2812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2820067830
MESH:D005534 Foot Diseases Arsenic 5.486392382
MESH:D005756 Gastritis Ethanol 4.6115046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6118462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2216417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Curcumin 3.4217596214
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.957505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.6018462866 18829502
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4211294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.4216080930
MESH:D006333 Heart Failure atorvastatin 4.4416360360
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.436705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8115340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9517701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6716863852 16490937
MESH:D019584 Hot Flashes Vitamin E 3.8914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9618606429 8697196 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Ethanol 8.1418783367
MESH:D006930 Hyperalgesia zoledronic acid 8.1416769263
MESH:D006934 Hypercalcemia zoledronic acid 4.9619622757 18089816
MESH:D006937 Hypercholesterolemia atorvastatin 9.5011583720
MESH:D006937 Hypercholesterolemia Curcumin 9.5018704882
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3817050553
MESH:D006938 Hyperlipoproteinemia Type II atorvastatin 5.0816238680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8515034207
MESH:D006973 Hypertension Arsenic 16.079931084 16076760 11953799
MESH:D006973 Hypertension atorvastatin 16.0717042910
MESH:D006973 Hypertension Cyclosporine 16.0710903974
MESH:D006973 Hypertension Phenylephrine 16.0712717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 16.0718670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.4718502941 12791704
MESH:D006987 Hypesthesia Arsenic 5.4816093927
MESH:D006996 Hypocalcemia zoledronic acid 6.1112669777
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4617937319
MESH:D007248 Infertility, Male vinclozolin 6.4616467254
MESH:D007249 Inflammation atorvastatin 11.6716908763
MESH:D007249 Inflammation Curcumin 11.6716956363 17151092 18403477
MESH:D007249 Inflammation Tamoxifen 11.6719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.6712878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1718200517 18596194
MESH:D007251 Influenza, Human Vitamin E 4.1316624496
MESH:D007333 Insulin Resistance bisphenol A 3.2316393666
MESH:D007414 Intestinal Neoplasms Curcumin 4.1410783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.948074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 9.8415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007642 Keratosis Arsenic 4.9012749816 16930632
MESH:D007674 Kidney Diseases Acrolein 9.9312488133
MESH:D007674 Kidney Diseases Cyclosporine 9.9318776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 9.9312488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.1316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.136582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.1312371664
MESH:D007680 Kidney Neoplasms Tamoxifen 17.1318625569
MESH:D007859 Learning Disorders Ethanol 4.1215451040
MESH:D007889 Leiomyoma Curcumin 4.4918555241
MESH:D007938 Leukemia Curcumin 3.2018462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.8516106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 9.8518089816
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4917339181
MESH:D015458 Leukemia, T-Cell Curcumin 4.6816106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6516417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7517676605
MESH:D008064 Lipidoses Tamoxifen 3.0915342952 17567588
MESH:D008103 Liver Cirrhosis Ethanol 3.3215289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.0118295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.149327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental atorvastatin 8.6217347453
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.6218006644 17355460 18705752
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.6218166357
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.6218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.6212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.6216169303
MESH:D008107 Liver Diseases Arsenic 4.3511134558
MESH:D008107 Liver Diseases Curcumin 4.3516956363
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5617347304 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.437678174
MESH:D008113 Liver Neoplasms Arsenic 10.4316368122
MESH:D008113 Liver Neoplasms Tamoxifen 10.4316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.456135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.451399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4512151625
MESH:D008171 Lung Diseases Acrolein 7.6311504702
MESH:D008171 Lung Diseases Vitamin E 7.6316863852
MESH:D008175 Lung Neoplasms Arsenic 6.4819168569 17306315 17976673
MESH:D008175 Lung Neoplasms Curcumin 6.4818462866 19359593 16243823
MESH:D008175 Lung Neoplasms Tamoxifen 6.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 6.4811062179
MESH:D008223 Lymphoma Curcumin 3.5218462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.6116173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6719428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2119196723 19196722 16827153 14580682 11731420
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 6.2117312309
MESH:D020149 Manganese Poisoning Tamoxifen 4.4719453300
MESH:D008545 Melanoma Curcumin 3.4117885582 18462866
MESH:D008545 Melanoma Tamoxifen 3.4119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1015990972
MESH:D008546 Melanoma, Experimental Acrolein 5.1210803710
MESH:D008569 Memory Disorders Curcumin 9.4717263510
MESH:D008569 Memory Disorders Ethanol 9.4718411066 15451040
MESH:D008654 Mesothelioma zoledronic acid 3.7216675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D009101 Multiple Myeloma Curcumin 7.5819372569
MESH:D009101 Multiple Myeloma zoledronic acid 7.5816996129 18089719 19621390
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8317962980
MESH:D009135 Muscular Diseases atorvastatin 5.3816239165
MESH:D017202 Myocardial Ischemia Arsenic 8.7615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7612213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.787678174 18551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.2818495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.403581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.4019393235
MESH:D009362 Neoplasm Metastasis zoledronic acid 9.4019139120 17312309 15867366
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Acrolein 3.5017329238
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.5712497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.5719200415 19196722 19189210
MESH:D009393 Nephritis Acrolein 6.2112653641
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome atorvastatin 9.4619348381
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.4619348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 9.3011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3014600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.5518462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.186679447
MESH:D009436 Neural Tube Defects Arsenic 7.1816620997
MESH:D019636 Neurodegenerative Diseases Acrolein 4.4411342003
MESH:D020078 Neurogenic Inflammation Arsenic 4.2917056641
MESH:D009765 Obesity Curcumin 2.7319297423
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.626482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.943988306
MESH:D010014 Osteolysis zoledronic acid 5.2815867366
MESH:D010024 Osteoporosis Curcumin 7.4718719352
MESH:D010024 Osteoporosis zoledronic acid 7.4717882678
MESH:D010049 Ovarian Diseases bisphenol A 4.9011985600
MESH:D010051 Ovarian Neoplasms Arsenic 5.0817306315
MESH:D010051 Ovarian Neoplasms Curcumin 5.0818462866 19020741
MESH:D010146 Pain zoledronic acid 3.8616475674
MESH:D010190 Pancreatic Neoplasms Curcumin 5.5217440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Ethanol 5.5212384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.407296757
MESH:D010300 Parkinson Disease Acrolein 3.5617690948
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.9015371236 6392382 16905509
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 12.816228378
MESH:D010787 Photosensitivity Disorders Acrolein 12.8111550810
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 15.7610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.7611118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.7618220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.8518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1220887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8916140617
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Curcumin 1.8911398177 15129424 10851300 18769126 18226269 12497104 18156803
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011471 Prostatic Neoplasms zoledronic acid 1.8919103299 12438248
MESH:D011472 Prostatitis vinclozolin 4.8518629315
MESH:D011507 Proteinuria Arsenic 3.9221343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.2315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7010548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.4519168576
MESH:D051437 Renal Insufficiency Acrolein 4.9212732208
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9418379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.313692021
MESH:D012509 Sarcoma Curcumin 4.0418462866
MESH:D012512 Sarcoma, Ewing's zoledronic acid 4.8516121404
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9018551238
MESH:D012640 Seizures Ethanol 5.909754883
MESH:D018805 Sepsis Curcumin 4.0018389075
MESH:D012852 Sinusitis Phenylephrine 4.627327846
MESH:D012871 Skin Diseases Arsenic 4.9616702368 15952646 16353154 17548696 16759981 17938729 19834688 17050553 6392382 17453740 18709164
MESH:D012871 Skin Diseases Vitamin E 4.9618709164
MESH:D012878 Skin Neoplasms Arsenic 5.5717050553 17976673 16251483 15504454 17029826 19538983
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2916709447
MESH:D013088 Spermatocele Tamoxifen 11.2916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9519457130
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Curcumin 7.2816631530 19188055
MESH:D013276 Stomach Ulcer Ethanol 7.2811906479 9562338 17918041 16755016 9211565 17189318
MESH:D020521 Stroke Acrolein 8.7416269634
MESH:D020521 Stroke Vitamin E 8.7416517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.9016684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.179754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.821399818 6582329 6587162 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.4516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.458074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 15.4519429237 17306315 18640142 17976673 15987713 11144890 19322015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 15.4518593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.458653321 17572228 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 5.1818462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2310091137
MESH:D014591 Uterine Diseases bisphenol A 4.9314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014652 Vascular Diseases Arsenic 4.6517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
KEGG:04330 Notch signaling pathway
REACT:9417 Signaling by EGFR
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB06943 - (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL
DB07079 - 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol
DB07121 - 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
DB07145 - (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE
DB07147 - methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate
DB07189 - (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid
DB07233 - N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan
DB07964 - (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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