AutismKB 2.0

Annotation Detail for TACR3


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Basic Information Top
Gene Symbol:TACR3 ( MGC148060,MGC148061,NK-3R,NK3R,NKR,TAC3RL )
Gene Full Name: tachykinin receptor 3
Band: 4q24
Quick LinksEntrez ID:6870; OMIM: 162332; Uniprot ID:NK3R_HUMAN; ENSEMBL ID: ENSG00000169836; HGNC ID: 11528
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500407Tachykinin receptors bind tachykinins
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
slow transit constipation
Cocaine-Related Disorders
alcoholism
No data
Desease Name
Hypogonadotropic hypogonadism
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TACR3 mRNAaffects expression 16483693
D002211 Capsaicin TACR3 protein affects the susceptibility to Capsaicinaffects response to substance 18207255
C004742 daidzein [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of TACR3 mRNAaffects cotreatment|increases expression 16963248
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of TACR3 mRNAincreases expression 15620428
D005419 Flavonoids Flavonoids results in increased expression of TACR3 mRNAincreases expression 18035473
D019833 Genistein [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of TACR3 mRNAaffects cotreatment|increases expression 16963248
C086566 glycitein [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of TACR3 mRNAaffects cotreatment|increases expression 16963248
D006851 Hydrochloric Acid TACR3 affects the susceptibility to Hydrochloric Acidaffects response to substance 12212954
D006851 Hydrochloric Acid TACR3 protein affects the susceptibility to Hydrochloric Acidaffects response to substance 11730984
C502587 (N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide) (N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide) binds to TACR3 proteinaffects binding 15925360
C091554 SR 142801 SR 142801 binds to and results in decreased activity of TACR3 proteinaffects binding|decreases activity 18207255
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 4.7618926900
MESH:D000138 Acidosis Ammonium Chloride 11.5318287403
MESH:D000138 Acidosis Hydrochloric Acid 11.5312771618 19262391 15920416 16144966 11574821 20872349
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 5.9917183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 6.0820597076
MESH:D058186 Acute Kidney Injury Capsaicin 4.7118460982
MESH:D055371 Acute Lung Injury Hydrochloric Acid 4.9615970105 11953099 19060228 11850527 16759491 19094174 19760209
MESH:D000230 Adenocarcinoma daidzein 5.0811473722
MESH:D000230 Adenocarcinoma Genistein 5.0811473722
MESH:D000505 Alopecia Capsaicin 4.8717569567
MESH:D000860 Anoxia Hydrochloric Acid 5.5415090967
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 4.9815920416
MESH:D001919 Bradycardia Capsaicin 5.2918207255
MESH:D002545 Brain Ischemia Capsaicin 5.2119211983
MESH:D001943 Breast Neoplasms Genistein 2.5116873071 17200150 16541309
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 4.7212378975
MESH:D001986 Bronchial Spasm Hydrochloric Acid 5.7315578804
MESH:D006528 Carcinoma, Hepatocellular Genistein 2.1616924424
MESH:D002318 Cardiovascular Diseases daidzein 8.1816332659
MESH:D002318 Cardiovascular Diseases Genistein 8.1816332659
MESH:D003110 Colonic Neoplasms Genistein 2.3117182828
MESH:D003371 Cough Capsaicin 5.4410350223
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.6516037377
MESH:D003556 Cystitis Hydrochloric Acid 5.7320719367 12853844 12599022 19279288
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 6.0817714534
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 5.1016647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 5.1016647724
MESH:D004381 Duodenal Ulcer Capsaicin 4.8910671773 11535926
MESH:D004714 Endometrial Hyperplasia Genistein 4.8316402032
MESH:D016889 Endometrial Neoplasms daidzein 8.3511473722
MESH:D016889 Endometrial Neoplasms Genistein 8.3511473722
MESH:D007172 Erectile Dysfunction daidzein 5.2114972507
MESH:D004935 Esophageal Diseases Capsaicin 14.3119566590
MESH:D004935 Esophageal Diseases Hydrochloric Acid 14.3119566590
MESH:D004941 Esophagitis Hydrochloric Acid 6.2312928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 6.2820516732 14621274 11346197
MESH:D005355 Fibrosis Hydrochloric Acid 4.9318497604
MESH:D005739 Gas Poisoning Hydrochloric Acid 5.7312378975
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 5.5219957777 12212954 20545468 19951613 20616304 20516732
MESH:D005909 Glioblastoma Capsaicin 7.9818405923
MESH:D005909 Glioblastoma Genistein 7.9816598420
MESH:D006356 Heartburn Capsaicin 14.3119566590
MESH:D006356 Heartburn Hydrochloric Acid 14.3119566590
MESH:D006930 Hyperalgesia Capsaicin 4.4617043245 17434803
MESH:D006940 Hyperemia Hydrochloric Acid 5.8912646421
MESH:D006973 Hypertension daidzein 3.7217169123
MESH:D006975 Hypertension, Portal Hydrochloric Acid 5.5616984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.5719262391
MESH:D007006 Hypogonadism marker/mechanism 19079066
MESH:D007022 Hypotension Hydrochloric Acid 4.9411574821
MESH:D007249 Inflammation Capsaicin 9.1916956363
MESH:D007249 Inflammation Flavonoids 9.1917296493
MESH:D007249 Inflammation Hydrochloric Acid 9.1911574821
MESH:D007410 Intestinal Diseases Hydrochloric Acid 5.1811574821
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 6.6316498863
MESH:D007826 Laryngismus Hydrochloric Acid 6.6311510729
MESH:D007938 Leukemia Genistein 3.1018980019 17468513
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 4.1516984587
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008107 Liver Diseases Capsaicin 3.2916956363
MESH:D008171 Lung Diseases Hydrochloric Acid 4.3916784557
MESH:D055370 Lung Injury Hydrochloric Acid 4.9715607125 17627322 15044056 21114838 18573544 15090967 20597076 16129981 18497604 19644408 18339021 21311175 19262391 11395602
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0414578162 12929590
MESH:D009101 Multiple Myeloma Capsaicin 4.2717505005
MESH:D009203 Myocardial Infarction Genistein 6.5017141266
MESH:D009203 Myocardial Infarction Hydrochloric Acid 6.5018534312
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7917141266
MESH:D009421 Nervous System Malformations Genistein 4.2316427766
MESH:D020078 Neurogenic Inflammation Capsaicin 5.2717961222
MESH:D009765 Obesity Capsaicin 3.4219056576
MESH:D009784 Occupational Diseases Hydrochloric Acid 4.9212378975
MESH:D010024 Osteoporosis Genistein 3.3519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2716169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6419005980
MESH:D010146 Pain Capsaicin 4.1617043245 19081190 17434803 17084039 16996476 18987195
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 5.6115970105 15607125 18573544 18497604
MESH:D011471 Prostatic Neoplasms Genistein 3.4416925846 15256057 15378649
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 6.2820597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 5.4815090967
MESH:D015427 Reperfusion Injury Capsaicin 4.0418460982 19211983
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 4.9416129981 18549715 17627322 18339021 16784557
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 6.6311510729
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 5.4320516732
MESH:D013276 Stomach Ulcer Hydrochloric Acid 4.4017189318 16755016 15309881
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.9917997062
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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