AutismKB 2.0

Annotation Detail for TAF4


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Basic Information Top
Gene Symbol:TAF4 ( FLJ41943,TAF2C,TAF2C1,TAF4A,TAFII130,TAFII135 )
Gene Full Name: TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
Band: 20q13.33
Quick LinksEntrez ID:6874; OMIM: 601796; Uniprot ID:TAF4_HUMAN; ENSEMBL ID: ENSG00000130699; HGNC ID: 11537
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa03022Basal transcription factors
Pathway IDPathway Name
Transcription
Gene Expression
HIV Infection
No data
Pathway IDPathway Name
P00029Huntington disease
P00023General transcription regulation
P00055Transcription regulation by bZIP transcription factor
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TAF4 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TAF4 mRNAdecreases expression 19150397
C017947 sodium arsenite sodium arsenite results in increased expression of TAF4 mRNAincreases expression 17879257
D013629 Tamoxifen Tamoxifen results in increased expression of TAF4 mRNAincreases expression 15590111
D015032 Zinc Zinc affects the expression of TAF4 mRNAaffects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.2714745880
MESH:D000169 Acrodermatitis Zinc 6.0316889938 17202136 17190629
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.6316712894 17306315
MESH:D000544 Alzheimer Disease Zinc 2.8216580781 16325427 16410023 17119284
MESH:D000755 Anemia, Sickle Cell Zinc 5.4116916123
MESH:D001249 Asthma Zinc 3.0417085522
MESH:D001930 Brain Injuries Zinc 5.2517109824
MESH:D001943 Breast Neoplasms Tamoxifen 2.1717049068 19487384 16818667 17261762 18821012 16873071 19142967 19115204 19066611 20135344 20005174 19410462 18855134 19221464 16202921 20859285 17242785 21138602 19059307 18815881 18984771 19189210 16273361 20390343 18997820 19011961 19103187 17440819 20065188 11161223 18629630 20544844 19244106 19200415 19289846 17893378 18425577 19288272 19084267 19155303 15565566 18351453 15668708 19189212 21152245
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.0719066611
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.2116507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.2116924424
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.2218572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.2216543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 4.0117572228
MESH:D002318 Cardiovascular Diseases Zinc 3.9216936243
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6120889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.6119524636 20056578
MESH:D019465 Craniofacial Abnormalities Zinc 2.4419302082
MESH:D003711 Demyelinating Diseases Tamoxifen 4.9219031437
MESH:D003920 Diabetes Mellitus Zinc 4.5716479319
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8419279558
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 4.0419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2917893378 16202921 20544844 19155303
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.9320426865
MESH:D004938 Esophageal Neoplasms Zinc 4.9316543248
MESH:D005234 Fatty Liver Tamoxifen 3.5914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.8119069698
MESH:D005756 Gastritis Zinc 5.5217241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.3116452187
MESH:D006130 Growth Disorders Zinc 4.1917217573
MESH:D006333 Heart Failure Zinc 3.8317162251
MESH:D006335 Heart Injuries Zinc 6.4917074742
MESH:D016481 Helicobacter Infections Zinc 5.0017241300
MESH:D006527 Hepatolenticular Degeneration Zinc 5.2517276780
MESH:D006689 Hodgkin Disease sodium arsenite 3.5212676792
MESH:D007248 Infertility, Male sodium arsenite 3.2412646999 15346721
MESH:D007249 Inflammation Tamoxifen 2.5319457130
MESH:D007511 Ischemia Zinc 5.1916584753
MESH:D007674 Kidney Diseases sodium arsenite 7.0620008137
MESH:D007674 Kidney Diseases Zinc 7.0616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.8516518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3818625569
MESH:D008064 Lipidoses Tamoxifen 3.4315342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms sodium arsenite 5.0415276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 5.0416684651
MESH:D008171 Lung Diseases sodium arsenite 3.4219095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.5815276417 17077188 17306315 19931552 16712894
MESH:D008175 Lung Neoplasms Tamoxifen 2.5818625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 7.0414580682 19196723 11731420 19196722 16827153
MESH:D008325 Mammary Neoplasms, Experimental Zinc 7.0412773700
MESH:D020149 Manganese Poisoning Tamoxifen 5.2719453300
MESH:D008545 Melanoma sodium arsenite 3.4916487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.4912393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.8115990972
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6119410462
MESH:D009369 Neoplasms sodium arsenite 2.6611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.2220056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.7219200415 19189210 19196722
MESH:D009436 Neural Tube Defects sodium arsenite 3.3812854658
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5317306315 15276417
MESH:D011225 Pre-Eclampsia Zinc 4.4817114810
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5815067354
MESH:D011471 Prostatic Neoplasms Zinc 2.5816700911 12429649 16517595 16606632
MESH:D012162 Retinal Degeneration Zinc 4.4216584753
MESH:D012878 Skin Neoplasms sodium arsenite 2.8518572023 19524636
MESH:D013088 Spermatocele Tamoxifen 5.0216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.6719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1012854658
MESH:D014062 Tongue Neoplasms Zinc 4.7916543248
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.5416452187 11723127 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.548653321 16712894 17572228
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1611813266
MESH:D014652 Vascular Diseases sodium arsenite 5.0617056641
Pathway ID Pathway Name
KEGG:03022 Basal transcription factors
REACT:71 Gene Expression
REACT:6185 HIV Infection
KEGG:05016 Huntington's disease
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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