AutismKB 2.0

Annotation Detail for TAF6


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Basic Information Top
Gene Symbol:TAF6 ( DKFZp781E21155,MGC:8964,TAF(II)70,TAF(II)80,TAF2E,TAFII-70,TAFII-80,TAFII70,TAFII80,TAFII85 )
Gene Full Name: TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Band: 7q22.1
Quick LinksEntrez ID:6878; OMIM: 602955; Uniprot ID:TAF6_HUMAN; ENSEMBL ID: ENSG00000106290; HGNC ID: 11540
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03022Basal transcription factors
Pathway IDPathway Name
Transcription
Gene Expression
HIV Infection
No data
Pathway IDPathway Name
P00023General transcription regulation
P00055Transcription regulation by bZIP transcription factor
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TAF6 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TAF6 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TAF6 mRNAaffects expression 16483693
D001241 Aspirin Aspirin results in decreased expression of TAF6 mRNAdecreases expression 11906190
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TAF6 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TAF6 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TAF6 mRNAaffects cotreatment|increases expression 17942748
D013629 Tamoxifen Tamoxifen affects the expression of TAF6 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TAF6 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in decreased expression of TAF6 mRNAdecreases expression 16604517
D014810 Vitamin E Vitamin E results in increased expression of TAF6 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.6015885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.6016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.8712372130 20485159
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.6316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001932 Brain Neoplasms Aspirin 4.6115481559
MESH:D001943 Breast Neoplasms Aspirin 2.0015161893
MESH:D001943 Breast Neoplasms Tamoxifen 2.0019142967 16273361 16202921 19189210 18629630 19487384 18855134 19084267 19289846 19103187 18815881 21138602 19221464 19200415 20065188 20390343 19155303 17261762 19066611 21152245 18351453 19189212 18425577 19244106 17893378 19410462 18821012 15668708 17242785 19011961 16818667 17049068 11161223 20005174 18997820 18984771 20135344 20544844 19115204 19059307 16873071 15565566 20859285 17440819 19288272
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D001943 Breast Neoplasms Tretinoin 2.0016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.801917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 16120746 18850075
MESH:D002386 Cataract Tretinoin 3.2017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0211677210 15861022 16919318 17110522 17333356 16105132 17681005
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0212621046 8697196 15668235 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 6.029407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D003110 Colonic Neoplasms Aspirin 3.0112411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8710048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.879211117 8800419 9142499 14991402 16925845 10589399 9224671 17551590 9125849 9664655
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8719769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema Aspirin 7.7417259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.0318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 13.0318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.8619155303 17893378 16202921 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 7.8616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.3411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.349664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3815345470
MESH:D005234 Fatty Liver Tamoxifen 8.3819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5020067830
MESH:D005355 Fibrosis Tretinoin 9.5017994277
MESH:D005909 Glioblastoma Aspirin 7.8912870263
MESH:D005909 Glioblastoma Tretinoin 7.8917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006261 Headache Aspirin 5.2815240983
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.7111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.7114991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 11.7116080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 16959395 15340226 16354765
MESH:D012001 Hyperacusis Aspirin 6.0815240983
MESH:D006930 Hyperalgesia Tretinoin 3.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.6316580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.6317551590 15992940
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.4316705839
MESH:D007680 Kidney Neoplasms Tamoxifen 13.4318625569
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2817339181 16935935 17712046 16766008 9834237 17301526 16140955 16891316 19035177 17361223 19642359 19075265 17107899 17649720 17368321 15748426 12679006 17506722 17294898 17217047 19029980 16788101 19225113 16331271 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008064 Lipidoses Tamoxifen 3.3017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.1218397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.1216169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.787678174
MESH:D008113 Liver Neoplasms Tamoxifen 7.7816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.142876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1412151625
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Tamoxifen 3.4918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4919555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.4911062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7414580682 19196722 19196723 11731420 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tamoxifen 3.3812393984 19393235
MESH:D008545 Melanoma Tretinoin 3.3816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D008881 Migraine Disorders Aspirin 4.2115240983
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009203 Myocardial Infarction Aspirin 3.6312692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009325 Nausea Aspirin 5.5315240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.3218551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms Tretinoin 2.4916946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219200415 19196722 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.3214600291
MESH:D009421 Nervous System Malformations Tretinoin 10.329125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010003 Osteoarthritis Aspirin 4.177009135
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Aspirin 7.706995502 6363464
MESH:D010146 Pain Tretinoin 7.7016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.8211156591
MESH:D020795 Photophobia Aspirin 6.0815240983
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11896295 11118676 11222880
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2115067354
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2115084515
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216283617 16116481
MESH:D012220 Rhinitis Aspirin 4.5712372130
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.5212269725
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D012878 Skin Neoplasms Tretinoin 5.8516467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Aspirin 9.4716403987
MESH:D020521 Stroke Vitamin E 9.4716517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Aspirin 9.8117672075
MESH:D013927 Thrombosis Ethinyl Estradiol 9.8115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7016049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.708653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014581 Urticaria Aspirin 4.6620485159 10982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
Pathway ID Pathway Name
KEGG:03022 Basal transcription factors
REACT:71 Gene Expression
REACT:6185 HIV Infection
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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