AutismKB 2.0

Annotation Detail for MAP3K7


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Basic Information Top
Gene Symbol:MAP3K7 ( MEKK7,TAK1,TGF1a )
Gene Full Name: mitogen-activated protein kinase kinase kinase 7
Band: 6q15
Quick LinksEntrez ID:6885; OMIM: 602614; Uniprot ID:M3K7_HUMAN; ENSEMBL ID: ENSG00000135341; HGNC ID: 6859
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa04310Wnt signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04520Adherens junction
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200123BMP receptor signaling
200005BCR signaling pathway
200129JNK signaling in the CD4+ TCR pathway
200130C-MYB transcription factor network
200016Noncanonical Wnt signaling pathway
200014p38 MAPK signaling pathway
200086TNF receptor signaling pathway
200173Ephrin B reverse signaling
200075IL1-mediated signaling events
200195TGF-beta receptor signaling
200052Presenilin action in Notch and Wnt signaling
No data
Pathway IDPathway Name
500482Downstream TCR signaling
500449TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade
500490Interleukin-1 signaling
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
Celiac Disease
IMMUNE
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MAP3K7 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MAP3K7 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MAP3K7 mRNAincreases expression 20127859
C006780 bisphenol A bisphenol A results in decreased expression of MAP3K7 mRNAdecreases expression 16029874
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MAP3K7 mRNAdecreases expression 15336504
D003609 Dactinomycin Dactinomycin results in decreased expression of MAP3K7 mRNAdecreases expression 16001973
C020748 ferrous sulfate ferrous sulfate affects the localization of MAP3K7 proteinaffects localization 17172471
C020748 ferrous sulfate ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]affects binding|increases reaction 17172471
C020748 ferrous sulfate ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]increases phosphorylation|increases reaction 17172471
C020748 ferrous sulfate ferrous sulfate results in increased activity of MAP3K7 proteinincreases activity 17172471
C020748 ferrous sulfate Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]decreases reaction|increases phosphorylation|increases reaction 17172471
C020748 ferrous sulfate Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]decreases reaction|increases activity 17172471
C020748 ferrous sulfate MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]affects reaction|increases phosphorylation 17172471
C020748 ferrous sulfate MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]affects reaction|increases phosphorylation 17172471
C020748 ferrous sulfate MAP3K7 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]affects reaction|increases secretion 17172471
D005372 Filipin Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]decreases reaction|increases phosphorylation|increases reaction 17172471
D005372 Filipin Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]decreases reaction|increases activity 17172471
D005372 Filipin Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]decreases reaction|increases phosphorylation|increases reaction 17172471
D005372 Filipin Filipin inhibits the reaction [Iron results in increased activity of MAP3K7 protein]decreases reaction|increases activity 17172471
D007501 Iron Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]decreases reaction|increases phosphorylation|increases reaction 17172471
D007501 Iron Filipin inhibits the reaction [Iron results in increased activity of MAP3K7 protein]decreases reaction|increases activity 17172471
D007501 Iron Iron affects the localization of MAP3K7 proteinaffects localization 17172471
D007501 Iron Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]affects binding|increases reaction 17172471
D007501 Iron Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]increases phosphorylation|increases reaction 17172471
D007501 Iron Iron results in increased activity of MAP3K7 proteinincreases activity 17172471
D007501 Iron MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]affects reaction|increases phosphorylation 17172471
D007501 Iron MAP3K7 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]affects reaction|increases phosphorylation 17172471
D007501 Iron MAP3K7 protein affects the reaction [Iron results in increased secretion of TNF protein]affects reaction|increases secretion 17172471
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of MAP3K7 mRNAincreases expression 12057914
D009151 Mustard Gas Mustard Gas results in increased expression of MAP3K7 mRNAincreases expression 18955075
C008776 pelargonic acid pelargonic acid results in decreased expression of MAP3K7 mRNAdecreases expression 11379042
D012643 Selenium Selenium results in decreased expression of MAP3K7 mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of MAP3K7 mRNAincreases expression 18175754
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of MAP3K7 mRNAdecreases expression 11379042
D014415 Tunicamycin Tunicamycin results in increased expression of MAP3K7 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.0411850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9820464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.6716640825
MESH:D000544 Alzheimer Disease Iron 3.0016640825 16563566
MESH:D000740 Anemia Iron 4.3716434484 16566752
MESH:D018798 Anemia, Iron-Deficiency Iron 4.6517163184 16569441 17147795 17162259 17375513
MESH:D000756 Anemia, Sideroblastic Iron 4.8216910769
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001145 Arrhythmias, Cardiac Iron 4.3716604332
MESH:D001249 Asthma Mustard Gas 5.4110378619
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 5.4110934080 20032816 3040596 12585506 170078 12762349 19187332 16210060 15590891 6091946 15590890 11742282 18394133 11077013 6091945 12684321 17015710 11467998 7684630 16792590 8156442 10797510 15855793
MESH:D001260 Ataxia Telangiectasia Iron 5.4715336622
MESH:D050197 Atherosclerosis Iron 3.7116640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001424 Bacterial Infections Iron 5.2116640825
MESH:D001768 Blister Mustard Gas 5.1819167455
MESH:D001778 Blood Coagulation Disorders ferrous sulfate 5.306421970
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.5714601052
MESH:D001862 Bone Resorption bisphenol A 3.8711985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0620146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.0617123778
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 2.0611921183
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.5415590891 12507178 8156442
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0117687719 10378619
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.8216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.823084413
MESH:D002278 Carcinoma in Situ bisphenol A 5.0117123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0520419170
MESH:D009202 Cardiomyopathies Iron 4.0416640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.4616604332
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.776135515
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7615894690
MESH:D003092 Colitis Selenium 3.7917936198
MESH:D003110 Colonic Neoplasms Iron 2.8916640825
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0318551238
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 4.1115491423 12956900 18759878
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 4.7917010967
MESH:D003920 Diabetes Mellitus Iron 9.4916604332 16640825
MESH:D003920 Diabetes Mellitus Sodium Selenite 9.4916285004
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.3616506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 3.0916506275
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.0021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0012540782 14986274 19923254 15968718 12153990 11461765 19370779 19416960 11743745 14550746 15619225 19739265 12594235 17522070 16109766 11834606 16393943 10915739 16485898 11421492 10774834 16227642 17562736 14725611 11529661 11287661 12392966 16781746 10663392 17906064 2444490 12705907 19420014 18071297 16081117 19085960 11739529 12958197 18713872 16177239 19164858
MESH:D056486 Drug-Induced Liver Injury Selenium 9.0015131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.0015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004487 Edema Mustard Gas 3.3111428631 9260866 11428647 11402378
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4215821434 17637181 15328337
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.668156442
MESH:D004890 Erythema Mustard Gas 5.189357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.7718447907
MESH:D005234 Fatty Liver Iron 4.0916640825
MESH:D005334 Fever Lipopolysaccharides 4.029205823 11852909
MESH:D005621 Friedreich Ataxia Iron 5.4416604332 16640825
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6620471113
MESH:D006333 Heart Failure Selenium 3.0717162251
MESH:D006432 Hemochromatosis Iron 4.4916604332 17236123 17255318 16574947 17053826 16640825
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3916366002
MESH:D006486 Hemosiderosis Iron 5.2416604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.5016640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.9517182432
MESH:D006529 Hepatomegaly Iron 4.3316890145
MESH:D015658 HIV Infections Iron 3.6716597321
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.6011019492 10880147
MESH:D007006 Hypogonadism Iron 4.4016640825
MESH:D007037 Hypothyroidism Iron 5.0916640825
MESH:D007249 Inflammation Lipopolysaccharides 5.4212878042 9205823 17237260 17255318 17963957
MESH:D007249 Inflammation Mustard Gas 5.429260866 11428647 17524151 16001271 11428620 11402378 8975870 9357497 11428631
MESH:D007251 Influenza, Human Selenium 4.2316624496
MESH:D007333 Insulin Resistance bisphenol A 7.5616393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.5614714311
MESH:D019189 Iron Metabolism Disorders Iron 11.6217163184
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 11.6217255318
MESH:D007674 Kidney Diseases Acetaminophen 2.2015629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 3.8916518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9816705839
MESH:D007970 Leukopenia Lipopolysaccharides 4.7215821434
MESH:D020961 Lewy Body Disease Iron 5.4416563566
MESH:D008103 Liver Cirrhosis Iron 3.7316640825
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.2612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6316610002 19014921 11587558 19784758 16611625 19460945 12587719 12969438
MESH:D008108 Liver Diseases, Alcoholic Iron 5.0217207112 16737972
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.557678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5521137059 20195826
MESH:D008113 Liver Neoplasms Iron 7.5516640825 20302851
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.542876784 6135515 2876786
MESH:D008171 Lung Diseases Mustard Gas 3.4518161513 18702808
MESH:D055370 Lung Injury Lipopolysaccharides 4.0221114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5918569708 6695378 18816296 20464547 20064080 17053015 20135361 20869020 18520028
MESH:D008175 Lung Neoplasms Iron 3.5916640825
MESH:D008175 Lung Neoplasms Mustard Gas 3.598781369 3148597
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0614737004
MESH:D008268 Macular Degeneration Iron 3.9816640825
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7615318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008654 Mesothelioma Selenium 2.7915107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.7017086897
MESH:D009181 Mycoses Iron 5.5016640825
MESH:D017202 Myocardial Ischemia Iron 4.4416604332
MESH:D015428 Myocardial Reperfusion Injury Iron 4.2716604332
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8818551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1711141357
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.751670384
MESH:D009404 Nephrotic Syndrome Iron 4.5217178036
MESH:D009421 Nervous System Malformations bisphenol A 3.9811399458 16427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5218514411
MESH:D019636 Neurodegenerative Diseases Iron 8.5216604332 17296847
MESH:D009503 Neutropenia Mustard Gas 3.9816761898 7688884
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3716049721
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 9.378156442 18394133 12585506 3040596 6091946 11077013 6091945
MESH:D010003 Osteoarthritis Iron 3.9716640825
MESH:D010024 Osteoporosis Iron 3.8616640825 16648989
MESH:D010049 Ovarian Diseases bisphenol A 5.0111985600
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010212 Papilloma Iron 4.5012065085
MESH:D020447 Parasomnias Iron 6.0517352947
MESH:D010300 Parkinson Disease Iron 3.3216563566 16640825
MESH:D010900 Pituitary Diseases Iron 5.7016604332
MESH:D010954 Plasmacytoma Selenium 4.9215087411
MESH:D011014 Pneumonia Lipopolysaccharides 4.5712224865 11605937
MESH:D011041 Poisoning Iron 9.0216604332
MESH:D011041 Poisoning Mustard Gas 9.0215727166
MESH:D017119 Porphyria Cutanea Tarda Iron 4.9916640825
MESH:D011225 Pre-Eclampsia Iron 4.4216640825
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.9710548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2120887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17199135
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5816740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5818760546
MESH:D011528 Protozoan Infections Iron 6.0516640825
MESH:D011537 Pruritus Mustard Gas 4.1118058305
MESH:D011629 Puberty, Precocious bisphenol A 4.8110548101
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.6514606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9317894541 17620002 17266442 17720292 10334151
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 8.6310835634
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 8.637692837 16940033 20219652
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 5.1518447907
MESH:D012148 Restless Legs Syndrome Iron 4.5516930377
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.5819050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.3112617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.5419075512
MESH:D012512 Sarcoma, Ewing's Dactinomycin 5.0914601052
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5418551238
MESH:D012871 Skin Diseases Mustard Gas 2.7115451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.6010029692 19755658
MESH:D012878 Skin Neoplasms Iron 9.6012065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.608532709
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.5419050374 19075512
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019966 Substance-Related Disorders bisphenol A 4.0016684133 16045194
MESH:D013398 Sudden Infant Death Iron 5.4716640825
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1715821434
MESH:D014376 Tuberculosis Iron 4.0916597321
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.9716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9717053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3410091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014591 Uterine Diseases bisphenol A 5.0414652134
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:05140 Leishmaniasis
KEGG:04010 MAPK signaling pathway
KEGG:05162 Measles
KEGG:04621 NOD-like receptor signaling pathway
KEGG:04380 Osteoclast differentiation
KEGG:04622 RIG-I-like receptor signaling pathway
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05145 Toxoplasmosis
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30603
    • No data
    No data
    Releated drug ID Related drug Name
    PA449972imiquimod
    PA449247dexamethasone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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