AutismKB 2.0

Annotation Detail for TAP1


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Basic Information Top
Gene Symbol:TAP1 ( ABC17,ABCB2,APT1,D6S114E,FLJ26666,FLJ41500,PSF1,RING4,TAP1*0102N,TAP1N )
Gene Full Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Band: 6p21.32
Quick LinksEntrez ID:6890; OMIM: 170260; Uniprot ID:TAP1_HUMAN; ENSEMBL ID: ENSG00000168394; HGNC ID: 43
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa02010ABC transporters
hsa05340Primary immunodeficiency
hsa04612Antigen processing and presentation
No data
Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00093Combined immunodeficiencies
Immune system diseases
Primary immunodeficiency
No data
Desease Name
cystic fibrosis
urinary calculus
CANCER
Asthma
inflammatory urogenital disease
IMMUNE
glaucoma, primary open-angle
Graves' disease
Reiter's syndrome
METABOLIC
VISION
psoriasis
cervical cancer
recurrent respiratory papillomatosis
No data
Desease Name
Bare lymphocyte syndrome, type I
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TAP1 mRNAaffects expression 21346803
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of TAP1 mRNAincreases expression 14600272
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TAP1 mRNAincreases expression 14600272
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TAP1 proteinaffects expression 20106945
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of TAP1 mRNAincreases expression 14600272
C430898 AGN 194204 AGN 194204 results in decreased expression of TAP1 mRNAdecreases expression 16339527
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TAP1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TAP1 mRNAdecreases expression 19128835
C015001 arsenite arsenite results in decreased expression of TAP1 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of TAP1 mRNA]affects reaction|decreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TAP1 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TAP1 mRNAdecreases expression 19150397
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TAP1 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TAP1 mRNAincreases expression 15003993
14729362
D002166 Camptothecin Camptothecin results in increased expression of TAP1 mRNAincreases expression 17374387
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TAP1 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TAP1 mRNA]affects reaction|increases expression 18038451
D016572 Cyclosporine Cyclosporine results in increased expression of TAP1 mRNAincreases expression 20106945
D003630 Daunorubicin Daunorubicin results in increased expression of TAP1 mRNAincreases expression 17374387
C007262 deoxynivalenol deoxynivalenol results in decreased expression of TAP1 mRNAdecreases expression 15766417
C007262 deoxynivalenol deoxynivalenol results in decreased expression of TAP1 proteindecreases expression 15766417
C121718 dicyclanil dicyclanil results in decreased expression of TAP1 mRNAdecreases expression 15664270
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of TAP1 mRNAincreases expression 14600272
D000431 Ethanol Ethanol results in decreased expression of TAP1 mRNAdecreases expression 15353170
D005047 Etoposide Etoposide results in increased expression of TAP1 mRNAincreases expression 17374387
D005419 Flavonoids Flavonoids results in increased expression of TAP1 mRNAincreases expression 18035473
D005472 Fluorouracil Fluorouracil results in increased expression of TAP1 mRNAincreases expression 17982676
D005472 Fluorouracil TP53 protein promotes the reaction [Fluorouracil results in increased expression of TAP1 mRNA]increases expression|increases reaction 17982676
D008942 Mitoxantrone TAP1 protein affects the susceptibility to Mitoxantroneaffects response to substance 17523305
D015376 Nimustine TAP1 protein affects the susceptibility to Nimustineaffects response to substance 17523305
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of TAP1 mRNAincreases expression 17616710
C011272 perfosfamide TAP1 protein affects the susceptibility to perfosfamideaffects response to substance 18473730
D012643 Selenium Selenium results in increased expression of TAP1 mRNAincreases expression 19244175
D014212 Tretinoin Tretinoin results in increased expression of TAP1 mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.6817676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 9.6518287403
MESH:D000138 Acidosis Ethanol 9.6511192467
MESH:D000230 Adenocarcinoma arsenic trioxide 9.6819825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.6820127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 9.6816033868
MESH:D000230 Adenocarcinoma Fluorouracil 9.6817638652
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.5516176798
MESH:D000236 Adenoma Benzo(a)pyrene 10.556695378
MESH:D000236 Adenoma Dimethylnitrosamine 10.5519555203
MESH:D018248 Adenoma, Liver Cell dicyclanil 4.8417162532
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0715451040 15451039
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000740 Anemia Fluorouracil 3.5016511603 15504547 17963324
MESH:D000853 Anophthalmos Ethanol 4.5815513904
MESH:D001008 Anxiety Disorders Ethanol 3.8111141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001169 Arthritis, Experimental Tretinoin 2.9316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2716456186
OMIM:604571 BARE LYMPHOCYTE SYNDROME, TYPE I marker/mechanism
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.4416206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.4416197459 16206674
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.9114601052
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.2920146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2917474063 20146248
MESH:D001943 Breast Neoplasms Etoposide 2.2916322251
MESH:D001943 Breast Neoplasms Fluorouracil 2.2916110121 18608205 19217205 16557594 18357371 16595493 15136595
MESH:D001943 Breast Neoplasms Tretinoin 2.2916443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1011589617
MESH:D002056 Burns Ethanol 4.4116374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5416124888 16227642 16011737 15721981 3786805 15673190 18705752 16097048 15700767 16192424 10355542 16050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4216051944
MESH:D002277 Carcinoma Dimethylnitrosamine 8.0019555203
MESH:D002277 Carcinoma Fluorouracil 8.0017121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.2016705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.2012907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.2015073043 16217749 11135700 15553829 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.2018788625
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 16.2017162532
MESH:D006528 Carcinoma, Hepatocellular Ethanol 16.2015289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.2017088986 17971768 16332177 16799960 17045692 18930000
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.201917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6319014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9018695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.2120419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 10.2116033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.2116280240 18986760 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.2116096774 16051514
MESH:D006332 Cardiomegaly Ethanol 3.3019332462
MESH:D002386 Cataract Tretinoin 2.9517460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.176135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.1720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.1712371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D002779 Cholestasis Cyclosporine 2.7419486331
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002971 Cleft Lip Ethanol 3.4615513904
MESH:D002972 Cleft Palate Ethanol 5.8115513904
MESH:D002972 Cleft Palate Tretinoin 5.819407595
MESH:D003092 Colitis Selenium 8.6917936198
MESH:D003092 Colitis Tretinoin 8.6917035595
MESH:D003110 Colonic Neoplasms arsenite 3.8015037631
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8015001691 17018589 17725105 16340194 16510598 17016597 18772588 17172411 17169374 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.4920501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.4917401013 17594712 17695437 14970324 16524972 18288408 18448328 15148649 18802399 17255274 16331619 15289873 16391804 18383874 16282729 18949393 20501625 17016601 17094418 16303861 18509181 17454858
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7410525206
MESH:D019465 Craniofacial Abnormalities Ethanol 3.7410194807 19302082 11198716 15451040 11873399 15513904 15451039
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.749224671 17551590 9211117 9125849 9142499 10589399 14991402 9664655 8800419 16925845
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7818551238
MESH:D007644 Darier Disease Fluorouracil 4.5416733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8715213294
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.2318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.2310092053 7120509 21278145 16227642 10915739 6623471 2869522 16177239 15998439 4309450 15968718 3732212 9327722 11566570 6884620 19085960 7179309 17522070 3786805 7440962 15027814 19336974
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 11.238172417
MESH:D056486 Drug-Induced Liver Injury Ethanol 11.2311566570
MESH:D056486 Drug-Induced Liver Injury Selenium 11.2315131321
MESH:D004489 Edema, Cardiac Tretinoin 4.2218230668
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9516569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.2720426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 20.2712903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 20.2716530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 20.2717016578
MESH:D004938 Esophageal Neoplasms Ethanol 20.2716704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 20.2716481741 17638652 16785472 16337965 15173087
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 20.2716704527 16805852 15547733 15150132 15264214 15547721 16510608 15878914 15623463
MESH:D005124 Eye Abnormalities Tretinoin 3.409664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 22.3315073043
MESH:D005234 Fatty Liver arsenite 22.3318296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.3319224547 17595544 12631006 15959796 12795759 16045604 61145 16239168
MESH:D005234 Fatty Liver Cyclosporine 22.3319224547
MESH:D005234 Fatty Liver Ethanol 22.3319236843 16409862 18620774
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4217920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0510194807 16946407 15451040 15513904
MESH:D005355 Fibrosis arsenite 19.2018296743
MESH:D005355 Fibrosis Carbon Tetrachloride 19.2018705752
MESH:D005355 Fibrosis Cyclosporine 19.2012168785 12639820
MESH:D005355 Fibrosis Tretinoin 19.2017994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0316904648
MESH:D005756 Gastritis Ethanol 4.4415046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Tretinoin 2.8517312396
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.8216524712 15173396
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.2518337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.2516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2320471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.239664655 14991402
MESH:D006331 Heart Diseases Mitoxantrone 3.9816019553
MESH:D006333 Heart Failure Selenium 2.9317162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3619900420 19110552
MESH:D006561 Herpes Simplex Etoposide 4.3210809021
MESH:D006689 Hodgkin Disease Etoposide 3.6716200630 17606976 15147373 16135485 18180244
MESH:D006930 Hyperalgesia Ethanol 7.3618783367
MESH:D006930 Hyperalgesia Tretinoin 7.3616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006973 Hypertension Cyclosporine 2.0110903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D007249 Inflammation Flavonoids 2.5317296493
MESH:D007251 Influenza, Human Selenium 3.9516624496
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007569 Jaw Abnormalities Ethanol 9.5915513904
MESH:D007569 Jaw Abnormalities Tretinoin 9.5915992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Cyclosporine 2.208314463 18776723 10903974
MESH:D007676 Kidney Failure, Chronic Selenium 3.6716518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.2616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.2612371664
MESH:D007680 Kidney Neoplasms Fluorouracil 11.2616985049
MESH:D007859 Learning Disorders Ethanol 3.9715451040
MESH:D007938 Leukemia arsenic trioxide 5.9315070760
MESH:D007938 Leukemia Tretinoin 5.9317143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6818172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.7419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7416932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7217050201 16467208 16968895 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.119834237 17869043 17107899 15622746 11468182 15213294 16112521 11161223 19642359 19225113 12712474 19075265 19035177 16966277 16330433 12679006 17712046 16823087 12018890 15336539 16331271 17649720 15748426 16891316 17217047
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1119035177 12679006 17339181 16823087 17107899 19075265 17649720 16935935 16140955 17506722 19642359 16766008 9834237 17301526 17712046 19029980 17294898 19225113 16788101 17217047 17368321 17361223 15748426 16891316 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1216882451
MESH:D017880 Limb Deformities, Congenital Ethanol 7.7417676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.749224671
MESH:D008103 Liver Cirrhosis arsenite 10.3818296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3821278145 17157831 16221502 16943688 11903743 16239168 11408273 17174718 17334410
MESH:D008103 Liver Cirrhosis Ethanol 10.3815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8518295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7718205269 16116963 18395914 15893842 17823541 14512876 18156304 14620537 17708605 14716833 18472094 15931870 16015684 15057751 15730626 16033810 12546737 15052691 12649538 15370692 12741479 17922224 18472332 18317297 15673190 12445418 15123356 12609069 17761835 17976157 12958196 17721639 18429990 18705752 17557913 16638106 17766677 17900296 18251166 18054572 17640975 17565644 17869086 18279442 17714472 18006644 13678700 15959796 17481882 10355542 14748882 15650968 16136751 18395095 14716496 17944888 15818738 12389079 18339082 17698563 17525996 18166357 17805973 16011737 15362042 18481824 18412020 18263696 15338365 20821823 16027843 15925388 12632514 18420326 12898905 11481614 16192424 16097048 17631135 14724832 15876570 15996030 12445421 16248980 18376398 12667390 18210741 18418968 18277467 12586293 18187930 12666154 12632512
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 4.7715842777 16042886 15161499 16270385 16570917 15571005 17203207 18210741 15504291 16169303 18371158 17881167 16544323 18364076 15591649 15081153 15366600 17640959 18567088 18672772 15793283 15763062 17534399 15339415 18629640 15577212 15298665 15942678 15733078 14568256 17196135 17348192 16603200 17465448 15723089 14643895 12918455 15086199 15744066 17724770 18239293 15383259 15798949 14659978 18637143 17198567 16627068 15492853 12925901 17666798 14709902 15369754 14726149 17036385 15099470 15138612 17719030 15067225 18237412 18095165 17432682 17201889 15479170 15864749 16009107
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.7718166357
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7718397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0316246199 16964402 15830285 15720792 17285989
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4117347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.1314706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.1317457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 32.447678174
MESH:D008113 Liver Neoplasms 2-nitrofluorene 32.4415890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 32.4415890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 32.4418177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 32.4414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 32.4421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 32.4419294768
MESH:D008113 Liver Neoplasms dicyclanil 32.4420118626
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 32.4415890375 3113478
MESH:D008113 Liver Neoplasms Fluorouracil 32.4415113037 18383874 16603448 17045692
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.052876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.058603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.0520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.0512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 17.051848544 15603536 6150874
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1715213294
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.219255578 16061637 12438228 14755239 15893417 18813816 17139156 19931552 16401635 15172992 18508827
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.2114755239
MESH:D008175 Lung Neoplasms arsenic trioxide 10.2111798837 19825857
MESH:D008175 Lung Neoplasms arsenite 10.2116809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.2118569708 20464547 20064080 6695378 20135361 18816296 20869020 17053015 18520028
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 10.2116061637 11884234 19555203
MESH:D008175 Lung Neoplasms Fluorouracil 10.2115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5415086387
MESH:D008223 Lymphoma Etoposide 3.7512854902 12556972
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.6115318939
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Tretinoin 1.9116752155
MESH:D018328 Melanoma, Amelanotic Nimustine 6.7515990972
MESH:D008569 Memory Disorders Ethanol 3.9518411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008654 Mesothelioma Selenium 2.6915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.9116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.9116757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9319549372 15949261 19417148 14977855 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.9316882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9317596541
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.627678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7316624393
MESH:D009369 Neoplasms Benzo(a)pyrene 10.9111141357
MESH:D009369 Neoplasms Fluorouracil 10.9116928823 18239605 18600527
MESH:D009369 Neoplasms Mitoxantrone 10.9116640825
MESH:D009369 Neoplasms Tretinoin 10.9116946489 16594593
MESH:D009389 Neovascularization, Pathologic arsenite 4.1715738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 3.549125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.7710525206
MESH:D009436 Neural Tube Defects Tretinoin 6.779142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2716436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2216049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.6112452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6116936753
MESH:D010146 Pain Tretinoin 2.7116870215
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 19.3512384795
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 19.3515580305
MESH:D010190 Pancreatic Neoplasms Ethanol 19.3512384795
MESH:D010190 Pancreatic Neoplasms Etoposide 19.3519003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 19.3519003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 19.3515976015
MESH:D010235 Paraganglioma arsenic trioxide 3.9319927285
MESH:D010954 Plasmacytoma Selenium 4.6415087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.0212371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Daunorubicin 4.6421297632
MESH:D011471 Prostatic Neoplasms AGN 194204 1.9116000583
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9117292933
MESH:D011471 Prostatic Neoplasms Etoposide 1.9117172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9118626508 19082440
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8016160472 18286688 15538739 18722050
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.6716646077
MESH:D012512 Sarcoma, Ewing's Etoposide 9.6714601052
MESH:D012640 Seizures 2,6-dinitrotoluene 5.5618551238
MESH:D012640 Seizures Ethanol 5.569754883
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8019755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.808532709
MESH:D012878 Skin Neoplasms Tretinoin 8.8016467112
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.0212587719
MESH:D013274 Stomach Neoplasms arsenic trioxide 9.9917007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 9.992093021 20155912
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 9.9916033868
MESH:D013274 Stomach Neoplasms Ethanol 9.9918456281
MESH:D013274 Stomach Neoplasms Fluorouracil 9.9915786421 16951190 17522103 18567086 17498489 19015929 19084572 18396642 17172411 16424979
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 9.9912958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 9.9917261132
MESH:D013276 Stomach Ulcer Ethanol 3.3216755016 9211565 17189318 11906479 9562338 17918041
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.049754883
MESH:D024801 Tauopathies Camptothecin 11.4016930453
MESH:D024801 Tauopathies Daunorubicin 11.4016930453
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.6019014326
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6016026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1216280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.1216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7215213294
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.7216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.7211780464 12973940 12845720 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.7217053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0710091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.7416803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.7416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
KEGG:02010 ABC transporters
KEGG:04612 Antigen processing and presentation
KEGG:04145 Phagosome
KEGG:05340 Primary immunodeficiency
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35021
    • Releated gene ID Related gene Name
    PA35021TAP1
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    PA449014cisplatin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03431 - Adenosine-5'-Diphosphate
    No data
    Drugbank ID Action Drug Name Description
    DB01259 inhibitor Lapatinib Antineoplastic Agents;Protein Kinase Inhibitors
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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