AutismKB 2.0

Annotation Detail for TCEB2


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Basic Information Top
Gene Symbol:TCEB2 ( ELOB,SIII )
Gene Full Name: transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Band: 16p12.3
Quick LinksEntrez ID:6923; OMIM: 600787; Uniprot ID:ELOB_HUMAN; ENSEMBL ID: ENSG00000103363; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
hsa05211Renal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Elongation arrest and recovery
Pausing and recovery of elongation
Transcription
Gene Expression
HIV Infection
Pathway IDPathway Name
200030HIF-2-alpha transcription factor network
200122Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
No data
Pathway IDPathway Name
500949RNA Polymerase II Pre-transcription Events
500752Vif-mediated degradation of APOBEC3G
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of TCEB2 mRNAdecreases expression 16514628
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TCEB2 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TCEB2 mRNAdecreases expression 15336504
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TCEB2 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TCEB2 mRNA]decreases reaction|increases expression 17942915
D004958 Estradiol Estradiol results in decreased expression of TCEB2 mRNAdecreases expression 16514628
D005419 Flavonoids Flavonoids results in decreased expression of TCEB2 mRNAdecreases expression 18035473
C070081 fulvestrant fulvestrant results in decreased expression of TCEB2 mRNAdecreases expression 16514628
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of TCEB2 mRNAaffects cotreatment|increases expression 17183730
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of TCEB2 mRNAincreases expression 17616710
D011794 Quercetin Quercetin results in decreased expression of TCEB2 mRNAdecreases expression 15309432
D020849 Raloxifene Raloxifene results in decreased expression of TCEB2 mRNAdecreases expression 16514628
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TCEB2 mRNAdecreases expression 19465110
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of TCEB2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7014514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.708875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D000236 Adenoma Diethylnitrosamine 2.8910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.4517162532 19052882 16434500 19061943 17620307 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4516835633
MESH:D000419 Albuminuria Raloxifene 4.6917451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5515800139
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.3217084956
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0915336622
MESH:D001284 Atrophy fulvestrant 4.9411514358
MESH:D001321 Autistic Disorder Valproic Acid 2.0019460635 18177632 17157402 16609825 18396377 20603192 18316065 18940202 17688650 18985861 17507914 18775368 19232924 15238991 18558336
MESH:D001327 Autoimmune Diseases Quercetin 4.5119761891
MESH:D001714 Bipolar Disorder Valproic Acid 3.1117594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.198888407
MESH:D001930 Brain Injuries Raloxifene 4.5816580743
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.0017474063
MESH:D001943 Breast Neoplasms Estradiol 3.0018497071 17289903 17261762 12948864 14630087 16675129 17018787 19861407
MESH:D001943 Breast Neoplasms fulvestrant 3.0018984771
MESH:D001943 Breast Neoplasms Quercetin 3.0018628248
MESH:D001943 Breast Neoplasms Raloxifene 3.0016912660 17595753 17893378 17440819 17242785 17261762 15572757 17952589 15758505 17049068 16837676 15775269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0020435547
MESH:D002105 Cadmium Poisoning Quercetin 5.6816962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7119107877 19335982 18785209 3084413 18691550 16878318 18665156 16569478 19919837 18210153 16698587 20727157 16540662 19052882 19383236 16288022 19418558 19822196 20432363 19171122 16681979 17428255 18056438 19701751 20101231 16935385 19208518 18788625 16830150 20214788 18971187 20524982 16807293 19539802 17055752 20007298 10737359 20935162 18494052 17173139 17162532 16328049 18978308 17761372 10672840 19394651 20512989 20514400 11831363 17978847 16502159 18506893 3581430 19519916 21159647 17138121 16779866 18393292 20084675
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.7112508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0617234771
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1517572228
MESH:D006332 Cardiomegaly Quercetin 6.9419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9416120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5015775269
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.887505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8818566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 12621046 8697196 15668235 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.7215800139
MESH:D003110 Colonic Neoplasms Quercetin 2.4311134977 19440933 15741050 19056647 16640504 17191121 17148506
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5016575769 8888407 17688650
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2317474826
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8019496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.2519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.2515920148 17308373 17451421
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.3419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.341733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:D004487 Edema Raloxifene 7.1215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.0915845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.9619148513
MESH:D016889 Endometrial Neoplasms Estradiol 7.9619148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.263659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0516628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.667562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7915150132 15623463 16805852 16704527 16510608 15264214 15878914 15547721 15547733
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Diethylnitrosamine 13.7120387270 21071580
MESH:D005234 Fatty Liver Raloxifene 13.7117473493
MESH:D005234 Fatty Liver Valproic Acid 13.7119224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005355 Fibrosis Quercetin 9.1119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1120067830
MESH:D005909 Glioblastoma Quercetin 3.4419804834
MESH:D005910 Glioma Quercetin 3.0817643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.5911110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16959395 18606429 8697196 16354765
MESH:D006943 Hyperglycemia Quercetin 4.1118262572 11834736
MESH:D006973 Hypertension Quercetin 8.8518356687
MESH:D006973 Hypertension Raloxifene 8.8515787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.8518850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7316612254
MESH:D007248 Infertility, Male fulvestrant 3.8011514358
MESH:D007249 Inflammation Diethylnitrosamine 8.5418785209
MESH:D007249 Inflammation Flavonoids 8.5417296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5412200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.6416624496
MESH:D007333 Insulin Resistance Estradiol 3.0216393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007627 Keloid Quercetin 5.0617086741
MESH:D007674 Kidney Diseases Estradiol 6.3615618244
MESH:D007674 Kidney Diseases Quercetin 6.3616962696
MESH:D007680 Kidney Neoplasms Estradiol 3.0515610895
MESH:D007889 Leiomyoma Raloxifene 4.5816973256
MESH:D007938 Leukemia Quercetin 3.1917468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1617596541 16294345
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8720032147 18665156 19638242 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.5412741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1217034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.6219642983 20405173 19996281 12112319 18648771 19427195 20101389 18644402 20583210 19638242 19551842 18754104 19090486 21278145 21071580 19833225 19255062 20492335 21167192 19499222 19850985 19294768 20434301 12771043 21047994 19073162 18978307 19690152 2862719 10737359 18977376 20137499 20118626 16942905 15175105 19812893 19254457 9163691 20501860 20452335 2422723 19256749 15885732 19426721
MESH:D008113 Liver Neoplasms Quercetin 7.6218980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6216984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.1418093689 18282651 17942915 9362446 19539802 3124819 19009564 21159647 16267830 18308698 18164116 16842330 18253720 2563599 18544905 19004024 18079962 17174075 19126423 19519916 18775883 17854601
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.1419519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1412151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4820512841 21163286 6695378 20970405
MESH:D008175 Lung Neoplasms Quercetin 3.4816280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4811884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6116891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6915863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4916497877
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2017596541
MESH:D009203 Myocardial Infarction Quercetin 3.0219595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7716810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.7719207477
MESH:D009232 Myxoma Raloxifene 5.6916343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009369 Neoplasms Quercetin 2.8315185748
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Estradiol 9.7811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.1816359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.4517929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D010024 Osteoporosis Raloxifene 3.4415775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.4919495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 10.4915579764 17893378 15758505 17823083
MESH:D010051 Ovarian Neoplasms Estradiol 5.0219401270
MESH:D010051 Ovarian Neoplasms Quercetin 5.0219005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4816540662
MESH:D010190 Pancreatic Neoplasms Quercetin 5.4816965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.472563599
MESH:D011230 Precancerous Conditions Quercetin 9.4719056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8611896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.8620603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.6416740699
MESH:D011471 Prostatic Neoplasms Quercetin 2.6417292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6416536755 15731164 16220300
MESH:D019310 Pseudolymphoma Valproic Acid 4.6712752131 11422049
MESH:D011693 Purpura Raloxifene 5.6915770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012554 Schistosomiasis japonica Quercetin 5.6816862918
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.793137016 14763951 11044598 1511512 11738929 16876388 17978042 15475178
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.718532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7116192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6318456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6312958204 17575124
MESH:D020521 Stroke Raloxifene 3.8916837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.047505956
MESH:D013978 Tibial Fractures Estradiol 14.1719048282
MESH:D013978 Tibial Fractures Raloxifene 14.1719048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.4916720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.4917572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.3416837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
REACT:1892 Elongation arrest and recovery
REACT:71 Gene Expression
REACT:6185 HIV Infection
KEGG:05200 Pathways in cancer
REACT:769 Pausing and recovery of elongation
KEGG:05211 Renal cell carcinoma
REACT:1788 Transcription
KEGG:04120 Ubiquitin mediated proteolysis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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