AutismKB 2.0

Annotation Detail for TCF4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TCF4 ( E2-2,ITF2,MGC149723,MGC149724,PTHS,SEF2,SEF2-1,SEF2-1A,SEF2-1B,bHLHb19 )
Gene Full Name: transcription factor 4
Band: 18q21.2
Quick LinksEntrez ID:6925; OMIM: 602272; Uniprot ID:ITF2_HUMAN; ENSEMBL ID: ENSG00000196628; HGNC ID: 11634
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Myogenesis
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
PSYCH
schizophrenia
Desease Name
Fuch's corneal dystrophy
Schizophrenia
Desease Name
Pitt-Hopkins syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of TCF4 mRNAincreases expression 17011747
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TCF4 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of TCF4 mRNAincreases expression 15761015
D001241 Aspirin Aspirin results in decreased activity of TCF4 proteindecreases activity 11593435
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TCF4 mRNAdecreases expression 20064835
C471992 bosutinib bosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein]affects binding|decreases reaction 16489032
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TCF4 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of TCF4 mRNAincreases expression 16239168
D016572 Cyclosporine Cyclosporine results in decreased expression of TCF4 mRNAdecreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of TCF4 mRNAincreases expression 17011747
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of TCF4 mRNAaffects cotreatment|decreases expression 17404688
D004958 Estradiol Estradiol results in decreased expression of TCF4 mRNAdecreases expression 20068009
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TCF4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TCF4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TCF4 mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in decreased expression of TCF4 mRNAdecreases expression 18035473
D019833 Genistein Genistein results in decreased expression of TCF4 mRNAdecreases expression 15256057
C010176 halofuginone halofuginone results in increased expression of TCF4 mRNAincreases expression 17180598
D007657 Ketone Bodies Ketone Bodies results in increased expression of TCF4 mRNAincreases expression 16807920
C029938 nickel sulfate nickel sulfate results in decreased expression of TCF4 mRNAdecreases expression 16780908
D005996 Nitroglycerin Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]affects binding|decreases reaction 17030184
D005996 Nitroglycerin Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]affects binding|decreases reaction 17030184
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of TCF4 mRNAaffects cotreatment|decreases expression 17404688
D011794 Quercetin Quercetin affects the expression of TCF4 proteinaffects expression 15670774
D011794 Quercetin Quercetin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]affects binding|decreases reaction 15670774
D013467 Sulindac Sulindac results in decreased activity of TCF4 proteindecreases activity 11593435
D013629 Tamoxifen Tamoxifen affects the expression of TCF4 mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate results in increased expression of TCF4 mRNAincreases expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of TCF4 mRNAaffects expression 16611356
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TCF4 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TCF4 mRNAincreases expression 18796159
18172886
15328365
D014108 Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]affects binding|decreases reaction 17030184
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 12.3814745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 12.3814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D058186 Acute Kidney Injury Sulindac 4.147897758
MESH:D055371 Acute Lung Injury nickel sulfate 4.1319131640 16100012 12718980 11954676
MESH:D000230 Adenocarcinoma arsenic trioxide 16.4919825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 16.4920464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 16.4911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 16.4914692618
MESH:D000230 Adenocarcinoma Genistein 16.4911473722
MESH:D000230 Adenocarcinoma Sulindac 16.4911910360
MESH:D000236 Adenoma Benzo(a)pyrene 6.616695378
MESH:D000236 Adenoma Sulindac 6.6110223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1916835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.4317611924 16460482 11535846 11874996 15623613 12394442 19003578
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3015469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0717084956
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4515885639
MESH:D001169 Arthritis, Experimental Tosylphenylalanyl Chloromethyl Ketone 7.4518706406
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.5420485159 12372130
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7815336622
MESH:D001327 Autoimmune Diseases Quercetin 4.2219761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.3916206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001913 Bowen's Disease Sulindac 5.1611207687
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1417868700
MESH:D001930 Brain Injuries Progesterone 4.0715665606 15380490 15845082
MESH:D001932 Brain Neoplasms Aspirin 4.2515481559
MESH:D001943 Breast Neoplasms Aspirin 6.8215161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.8220146248 17474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 6.8217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 6.8214630087 16675129 12948864 17261762 17289903 17018787 18497071 19861407
MESH:D001943 Breast Neoplasms Genistein 6.8217200150 16541309 16873071
MESH:D001943 Breast Neoplasms Progesterone 6.8217614352 15562024 16175315
MESH:D001943 Breast Neoplasms Quercetin 6.8218628248
MESH:D001943 Breast Neoplasms Sulindac 6.8216642371
MESH:D001943 Breast Neoplasms Tamoxifen 6.8216873071 20005174 19084267 18351453 21152245 16202921 19487384 11161223 19200415 18425577 17049068 19155303 20544844 20135344 18821012 19289846 19244106 18855134 17440819 19142967 19115204 19066611 15668708 18629630 16818667 17242785 18815881 18984771 19011961 16273361 17893378 17261762 19221464 20065188 19410462 19189212 20390343 19059307 21138602 19288272 19103187 19189210 20859285 18997820 15565566
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.8220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002105 Cadmium Poisoning Quercetin 5.3516962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5915673190 16124888 18705752 16011737 16227642 10355542 3786805 16192424 16097048 15721981 15700767 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.6015073043 16217749 15553829 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.6018788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.6015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.6016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.6016924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.6012508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.6016924424
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0020419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4517572228
MESH:D006332 Cardiomegaly Quercetin 6.4519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.1716332659
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.1412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1418566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002779 Cholestasis Cyclosporine 7.3119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3115861022 11677210 17110522 17681005 17333356 16919318 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 15668235 15340226 16354765 8697196
MESH:D003110 Colonic Neoplasms Aspirin 8.1012411196
MESH:D003110 Colonic Neoplasms Genistein 8.1017182828
MESH:D003110 Colonic Neoplasms Quercetin 8.1019440933 11134977 19056647 15741050 17148506 17191121 16640504
MESH:D003110 Colonic Neoplasms Sulindac 8.1012902858 12458338
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.7320501625
MESH:D015179 Colorectal Neoplasms Aspirin 4.7317047198
MESH:D015179 Colorectal Neoplasms Quercetin 4.7318095365 18852136
MESH:D015179 Colorectal Neoplasms Sulindac 4.7310666051 18059344 11197048 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D019465 Craniofacial Abnormalities marker/mechanism 17436254
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4110048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3716002989 12952375
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.4916780908 16823706 11298694
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5819496084
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1717107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.3019279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3017187935
MESH:D003930 Diabetic Retinopathy Sulindac 4.9912861449 17621415
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.5419336974 21278145 16227642 2869522 7440962 10915739 4309450 10092053 6623471 15968718 3732212 9327722 19085960 15998439 7120509 6884620 11566570 17522070 3786805 7179309 15027814 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004487 Edema Aspirin 6.4917259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7115322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.2512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.2517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.2519031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.2516402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.2516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.7815700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 16.7811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 16.7811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.7816202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Progesterone 14.3816134523
MESH:D004715 Endometriosis Sulindac 14.3815652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.389294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.0612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0616530937
MESH:D004938 Esophageal Neoplasms Sulindac 7.0612235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver arsenic trioxide 22.8015073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.8012795759 15959796 19224547 16045604 12631006 17595544 61145 16239168
MESH:D005234 Fatty Liver Cyclosporine 22.8019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.8015345470
MESH:D005234 Fatty Liver Tamoxifen 22.8014986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.8315751030 16611131 16002989 16513791 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.8316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 12.3114745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 12.3114745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 11.0019069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.0019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 19.5918705752
MESH:D005355 Fibrosis Cyclosporine 19.5912168785 12639820
MESH:D005355 Fibrosis Quercetin 19.5919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.5920067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0816904648
MESH:D005764 Gastroesophageal Reflux Sulindac 4.8311910360
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma Aspirin 11.3512870263
MESH:D005909 Glioblastoma Genistein 11.3516598420
MESH:D005909 Glioblastoma Quercetin 11.3519804834
MESH:D005910 Glioma Quercetin 2.9817643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006261 Headache Aspirin 10.6515240983
MESH:D006261 Headache Nitroglycerin 10.6511554966 11284996
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1211294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4119110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7116120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.5517440010
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.858697196 16354765 18606429 16959395 15340226
MESH:D012001 Hyperacusis Aspirin 5.5715240983
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006943 Hyperglycemia Quercetin 3.8611834736 18262572
MESH:D006965 Hyperplasia Diethylstilbestrol 10.6812960047 14722030
MESH:D006965 Hyperplasia halofuginone 10.6811874485
MESH:D006973 Hypertension Cyclosporine 8.1510903974
MESH:D006973 Hypertension Quercetin 8.1518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.6116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.6116569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2115869954
MESH:D007246 Infertility Diethylstilbestrol 4.1715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3617937319
MESH:D007249 Inflammation Flavonoids 14.8317296493
MESH:D007249 Inflammation Progesterone 14.8315869954
MESH:D007249 Inflammation Sulindac 14.833291741
MESH:D007249 Inflammation Tamoxifen 14.8319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.8312878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.3216624496
MESH:D007333 Insulin Resistance Estradiol 2.8416393666 16627594
MESH:D007414 Intestinal Neoplasms Sulindac 4.4712663524 10223192 12351151 12628509 10213222 12584176
MESH:D007417 Intestinal Polyps Sulindac 4.8111245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007627 Keloid Quercetin 4.7717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Cyclosporine 9.468314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 9.4615618244
MESH:D007674 Kidney Diseases Quercetin 9.4616962696
MESH:D007680 Kidney Neoplasms Cyclosporine 16.4912371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.4915003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 16.4915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.4918625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8717184923
MESH:D007938 Leukemia arsenic trioxide 10.0015070760
MESH:D007938 Leukemia Genistein 10.0018980019 17468513
MESH:D007938 Leukemia Quercetin 10.0017468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1116968895 16467208 19850784 17050201 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0911468182 17217047 19642359 19075265 17712046 17869043 19035177 15622746 12712474 17649720 17107899 15213294 16330433 19225113 16112521 12679006 9834237 16823087 12018890 11161223 16331271 15336539 16891316 15748426 16966277
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1716882451
MESH:D008064 Lipidoses Tamoxifen 3.0215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7116221502 16943688 16239168 17157831 21278145 11408273 11903743 17174718 17334410
MESH:D008103 Liver Cirrhosis halofuginone 6.7117180598
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.1112468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.5512632512 17721639 18395914 15370692 18472094 15650968 12898905 17922224 17823541 17698563 12741479 12389079 17869086 14620537 12632514 18006644 15730626 16033810 12586293 20821823 16015684 18481824 12666154 15052691 12546737 14724832 16027843 15925388 18429990 15893842 12649538 15057751 15876570 18166357 18205269 17944888 17766677 16638106 18187930 18395095 15673190 18279442 17525996 15959796 18472332 12445418 15996030 11481614 13678700 17976157 17640975 14512876 12667390 16011737 17557913 15931870 18339082 18054572 18376398 12609069 15818738 14716833 12445421 18705752 17714472 18317297 12958196 17565644 14716496 18263696 15123356 16116963 14748882 18420326 16136751 17900296 18418968 10355542 17805973 16097048 15362042 18412020 15338365 17481882 16192424 17708605 18251166 16248980 18156304 18277467 18210741 17631135 17761835
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.5514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.5517823541
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 10.5514739098 16489207 11172339 18458672 12175628
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.5512741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.5518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.5512878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2515830285 16964402 15720792 16246199 17285989
MESH:D008107 Liver Diseases Sulindac 4.2516867024 14986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5216899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 20.7914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.7921137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.7919294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.7916712894 15890375
MESH:D008113 Liver Neoplasms Quercetin 20.7918980244
MESH:D008113 Liver Neoplasms Tamoxifen 20.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.7916984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.1620377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.1612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 13.1619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.1612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 8.2411798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2420464547 20135361 20064080 18520028 6695378 20869020 18816296 17053015 18569708
MESH:D008175 Lung Neoplasms Quercetin 8.2416280456
MESH:D008175 Lung Neoplasms Sulindac 8.2419359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 8.2418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2419555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9615166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3415700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3216002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.2811408345 17203775 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.2814578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.2811408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.2819196722 14580682 19196723 11731420 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.0019453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0019453300
MESH:D008545 Melanoma Sulindac 3.5016642371
MESH:D008545 Melanoma Tamoxifen 3.5012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D008708 Methemoglobinemia Nitroglycerin 4.563537620
MESH:D008831 Microcephaly marker/mechanism 18728071
MESH:D008881 Migraine Disorders Aspirin 3.9315240983
MESH:D020326 Migraine without Aura Nitroglycerin 4.9414659530
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0416381670
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9719549372 15949261 14977855 19417148 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0316105982 16882451
MESH:D009203 Myocardial Infarction Aspirin 13.0312692751
MESH:D009203 Myocardial Infarction Genistein 13.0317141266
MESH:D009203 Myocardial Infarction Nitroglycerin 13.0314729435
MESH:D009203 Myocardial Infarction Quercetin 13.0319595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.4416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.4417141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.4419207477
MESH:D009325 Nausea Aspirin 5.0215240983
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7816624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.8111141357
MESH:D009369 Neoplasms Diethylstilbestrol 7.8115313581
MESH:D009369 Neoplasms Quercetin 7.8115185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.9411399458
MESH:D009421 Nervous System Malformations Estradiol 21.9416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 21.9416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.9414600291
MESH:D009436 Neural Tube Defects arsenic trioxide 2.9910525206
MESH:D019636 Neurodegenerative Diseases Sulindac 4.1117266991 16850258
MESH:D020078 Neurogenic Inflammation Quercetin 4.1817929310
MESH:D010003 Osteoarthritis Aspirin 3.947009135
MESH:D010024 Osteoporosis Genistein 3.1419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.5416169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.5419495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.3412452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 14.3419401270
MESH:D010051 Ovarian Neoplasms Genistein 14.3419005980
MESH:D010051 Ovarian Neoplasms Progesterone 14.3417393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 14.3419005980
MESH:D010146 Pain Aspirin 6.946995502 6363464
MESH:D010146 Pain Sulindac 6.943291741
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.3915580305
MESH:D010190 Pancreatic Neoplasms Quercetin 8.3916965848
MESH:D010190 Pancreatic Neoplasms Sulindac 8.3916820089 11504793
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.3511156591
MESH:D020795 Photophobia Aspirin 5.5715240983
MESH:C537403 Pitt-Hopkins syndrome marker/mechanism 18728071 17436254
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4816977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.5612371664
MESH:D011230 Precancerous Conditions Quercetin 8.5619056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.9317184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9311399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0715846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0715256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Quercetin 2.0717292933 14715546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1216919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012220 Rhinitis Aspirin 4.2112372130
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7918045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7816646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.3516862918
MESH:D012640 Seizures marker/mechanism 18728071
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.0712269725
MESH:D012871 Skin Diseases halofuginone 3.4611874485
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8810029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.888532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8816192470
MESH:D013088 Spermatocele Diethylstilbestrol 19.0116002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 19.0116709447
MESH:D013088 Spermatocele Tamoxifen 19.0116709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.2315862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.2319457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.3217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3220155912 2093021
MESH:D020521 Stroke Aspirin 4.2316403987
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Aspirin 8.6617672075
MESH:D013927 Thrombosis Ethinyl Estradiol 8.6615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.9419014326
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7715213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.0211780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.0217053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.0216452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Quercetin 15.0216720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.028653321 17572228 16712894
MESH:D014581 Urticaria Aspirin 4.2620485159 10982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8716175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 15.0715809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 15.0714692618
MESH:D014594 Uterine Neoplasms Sulindac 15.0718645019
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2516513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
REACT:21303 Myogenesis
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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