AutismKB 2.0

Annotation Detail for TCF3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TCF3 ( E2A,ITF1,MGC129647,MGC129648,VDIR,bHLHb21 )
Gene Full Name: transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
Band: 19p13.3
Quick LinksEntrez ID:6929; OMIM: 147141; Uniprot ID:TFE2_HUMAN; ENSEMBL ID: ENSG00000071564; HGNC ID: 11633
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Myogenesis
Pathway IDPathway Name
200002Regulation of nuclear SMAD2/3 signaling
200135p38 signaling mediated by MAPKAP kinases
200196Notch-mediated HES/HEY network
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00001Acute lymphoblastic leukemia (ALL) (Precursor B lymphoblastic leukemia)
No data
No data
No data
Desease Name
Leukemia, acute lymphoblastic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TCF3 mRNAincreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of TCF3 mRNAdecreases expression 12419474
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the activity of TCF3 proteinaffects activity 20624995
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TCF3 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TCF3 mRNAdecreases expression 20713471
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TCF3 mRNAdecreases expression 12419474
15336504
D016572 Cyclosporine Cyclosporine results in increased expression of TCF3 mRNAincreases expression 20106945
C014347 decitabine decitabine results in decreased methylation of TCF3 genedecreases methylation 17581917
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of TCF3 mRNAdecreases expression 15171707
D004317 Doxorubicin TCF3 protein results in decreased susceptibility to Doxorubicindecreases response to substance 16886622
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TCF3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TCF3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TCF3 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of TCF3 mRNAdecreases expression 15465739
D010936 Plant Extracts Plant Extracts results in decreased expression of TCF3 mRNAdecreases expression 15465739
C025299 polyphenols polyphenols results in decreased expression of TCF3 mRNAdecreases expression 15465739
D013629 Tamoxifen Tamoxifen affects the expression of TCF3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TCF3 mRNAaffects cotreatment|increases expression 17942748
D019772 Topotecan TCF3 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C025643 vinclozolin vinclozolin results in decreased expression of TCF3 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8711752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0720127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 7.0717418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0714692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.603712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.606695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000419 Albuminuria Doxorubicin 4.5521441931
MESH:D000544 Alzheimer Disease Plant Extracts 3.0116962711
MESH:D000686 Amyloidosis Diethylstilbestrol 4.4915469931
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1010965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6419015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5315885639
MESH:D001169 Arthritis, Experimental Plant Extracts 7.5314686799
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0511289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.7314601052
MESH:D002545 Brain Ischemia Plant Extracts 4.7516041641
MESH:D001932 Brain Neoplasms Doxorubicin 3.8117150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9617474063 20146248
MESH:D001943 Breast Neoplasms decitabine 2.9618320071 19208741
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.9617129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 2.9616096432 16595493 18628466 17426702 11325840 18382427 17369602 16322301 16826403 15939500 17983394 15634643 15668708 19526202 16115903 15136595 15993339 16264153 18234424 15567936 16935488 15692762 15994142 18695136
MESH:D001943 Breast Neoplasms Tamoxifen 2.9615565566 19059307 19189210 17242785 21152245 16873071 19200415 20390343 20544844 19103187 19011961 11161223 17440819 19289846 19115204 20135344 20859285 16273361 19084267 19410462 15668708 21138602 19221464 18821012 19189212 18425577 17893378 18997820 18815881 18984771 17049068 17261762 18855134 18629630 19487384 18351453 20065188 19142967 16202921 19155303 20005174 19288272 19066611 16818667 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9620435547
MESH:D002051 Burkitt Lymphoma marker/mechanism 1967982 17244677
MESH:D002057 Burns, Chemical Plant Extracts 5.379625245
MESH:D002276 Carcinoid Tumor Doxorubicin 4.8416051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.917296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.9115948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.9116234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 8.9118834353
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.9116924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.557296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.5516201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.5920419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.5919215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.596189445
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6217572228
MESH:D006332 Cardiomegaly Plant Extracts 6.9817645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9818850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5317924179 17007740 17131338 17382496 16278810 16364871 15505089 17974986 17928571 16612575 17329180 16242529 16269455 15792986 16109756 17519947 16952015 17308081 17351982 15811867 18627295 15476868 16651473 16455267 16731534
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9417334414 16243910
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.587505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5812371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.409022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.4019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.4017110522 16105132 17333356 16919318 11677210 17681005 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.108697196 16354765 12621046 15668235 15340226
MESH:D003110 Colonic Neoplasms decitabine 4.0317616700
MESH:D003110 Colonic Neoplasms polyphenols 4.0316293270
MESH:D015179 Colorectal Neoplasms decitabine 2.6918981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6918259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 11.4012952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 11.4014966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.828970840 18759878 12868966 8156756 11906362 14531868 2524372 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.503621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 9.2219706694
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.2219279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.0311289319 16192314 18289764 8291058 18648102 1440618 6482804 6679447 9022650 9328219 18692083 7440962 9653073
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 9.0317416283
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.0319370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0320420201
MESH:D004362 Drug Toxicity Doxorubicin 8.1218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.1211462148
MESH:D004487 Edema Plant Extracts 7.0412787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9316714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.9812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.9819031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1519294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.7116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.5515700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.5517359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.5517893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 14.1618037988
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 14.1615268973
MESH:D004827 Epilepsy Plant Extracts 3.7319700373 19439326
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.363581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Cyclosporine 18.8519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.8515345470
MESH:D005234 Fatty Liver Plant Extracts 18.8515975614
MESH:D005234 Fatty Liver Tamoxifen 18.8514986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 8.2216611131 16002989 16534752 15751030 16513791
MESH:D052776 Female Urogenital Diseases Tamoxifen 8.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.056705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5514745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.5119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.5119069698
MESH:D005355 Fibrosis Cyclosporine 8.5312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5320067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.9716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma Doxorubicin 3.3517150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.047505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.9619215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.9615692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4511294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.4818674790 17875725 16707910 14766674 16144979 16879835 12587719 16244372 16244371 16495754 16330681 18006777 17888722
MESH:D006333 Heart Failure Doxorubicin 7.5417481944
MESH:D006333 Heart Failure Plant Extracts 7.5418097624
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9015692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.526705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9115340226 16120746 12621046
MESH:D006561 Herpes Simplex Plant Extracts 4.6410715843
MESH:D015658 HIV Infections Plant Extracts 3.6812878215
MESH:D006689 Hodgkin Disease Doxorubicin 3.4117606976 18501091 15147373
MESH:D019584 Hot Flashes Plant Extracts 4.7816566672 17454163 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0818606429 15340226 8697196 16959395 16354765
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.4616484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.4815975614 15268973
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.8815034207
MESH:D006965 Hyperplasia Diethylstilbestrol 10.8812960047 14722030
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 11.2916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.2916569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.3615036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male decitabine 11.2517581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.2517937319
MESH:D007248 Infertility, Male vinclozolin 11.2516467254
MESH:D007249 Inflammation Flavonoids 15.9217296493
MESH:D007249 Inflammation Plant Extracts 15.9216366677 19332304 15997105 12787963
MESH:D007249 Inflammation polyphenols 15.9216366677
MESH:D007249 Inflammation Tamoxifen 15.9219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.9212200463 12878042
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.6212628509 12584176 12351151
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.058074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Cyclosporine 6.1118776723 8314463 10903974
MESH:D007674 Kidney Diseases Doxorubicin 6.1116775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1616707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.796582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.7912371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 17.7914681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Tamoxifen 17.7918625569
MESH:D007859 Learning Disorders Diethylstilbestrol 4.0717184923
MESH:D007938 Leukemia decitabine 3.0719235587 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1916085563
MESH:D007951 Leukemia, Myeloid decitabine 4.0118454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3819010910 18704418 19387464 18460780 17679729 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4918055864
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D008064 Lipidoses Tamoxifen 3.1615342952 17567588
MESH:D008103 Liver Cirrhosis Plant Extracts 3.7417157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 5.0116439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 5.0115479170
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0112878042
MESH:D008107 Liver Diseases Plant Extracts 4.6717034775
MESH:D008107 Liver Diseases polyphenols 4.6716698588
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.2721137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 14.2716712894 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 14.2719168119
MESH:D008113 Liver Neoplasms Tamoxifen 14.2716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.2716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.853712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.8517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8512151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6017053015 6695378 20464547 18816296 18520028 18569708 20135361 20064080 20869020
MESH:D008175 Lung Neoplasms Doxorubicin 6.606189445 17418594
MESH:D008175 Lung Neoplasms Plant Extracts 6.6020869020
MESH:D008175 Lung Neoplasms Tamoxifen 6.6018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6019555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.1715166399
MESH:D008223 Lymphoma decitabine 12.6519470736
MESH:D008223 Lymphoma Diethylstilbestrol 12.6515700306
MESH:D008223 Lymphoma Doxorubicin 12.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5815621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5516002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.1515458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.1511731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.5819453300
MESH:D008545 Melanoma decitabine 5.1717785578 16505122
MESH:D008545 Melanoma Doxorubicin 5.1716827129
MESH:D008545 Melanoma Tamoxifen 5.1712393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D008654 Mesothelioma Doxorubicin 3.0617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5015792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D052016 Mucositis Doxorubicin 4.8117415656
MESH:D009101 Multiple Myeloma decitabine 3.3518172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3819157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Doxorubicin 2.9519429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.523581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.5218259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.5219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.3511141357
MESH:D009369 Neoplasms decitabine 8.3517925555 19470736 19116145
MESH:D009369 Neoplasms Diethylstilbestrol 8.3515313581
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319200415 19189210 19196722
MESH:D009401 Nephrosis Doxorubicin 4.7816636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.3118481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.3115640375 16889571
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.6711399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.916679447
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 5.2017168769
MESH:D009447 Neuroblastoma Doxorubicin 7.3015555623
MESH:D009447 Neuroblastoma Topotecan 7.3015176712
MESH:D009765 Obesity Plant Extracts 3.1419056576 20132043
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.426482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.053988306
MESH:D012516 Osteosarcoma Doxorubicin 4.1115930896
MESH:D010051 Ovarian Neoplasms decitabine 2.6519331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.7719294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.517296757
MESH:D010212 Papilloma Plant Extracts 9.5115173996 16517061
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 13.106228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 13.1011550810
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1917983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.6815687265 16977796
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 16.4117184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.4111222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.4118220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.7417616702
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8815846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8818437689 16888761 15749863 15897917 16729912 16868541
MESH:D011471 Prostatic Neoplasms Plant Extracts 1.8814666653 17804756
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D051437 Renal Insufficiency Doxorubicin 4.2317922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.383692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.4119155313
MESH:D012509 Sarcoma Doxorubicin 3.9915675481 16767912 17710206 15625365 18313854 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2514601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8117846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.9619755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 17.9615692506
MESH:D012878 Skin Neoplasms Plant Extracts 17.9615173996 16517061
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 17.968532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.9616192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5815625365 16767912 17203757
MESH:D013088 Spermatocele Diethylstilbestrol 20.3316709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 20.3316709447
MESH:D013088 Spermatocele Tamoxifen 20.3316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0619457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.462093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 2.4619037991
MESH:D013276 Stomach Ulcer Plant Extracts 3.9018193104 17135157 15255614 18237397 12787963
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 13.3817997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 13.3817997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.061399818 3712494 6582329 7505956 6587162
MESH:D013964 Thyroid Neoplasms decitabine 12.0617967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 12.0616010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 19.928074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 19.9217053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 19.9219087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 19.9216452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 19.9217653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 19.9216712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.0416175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.5116690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.5114692618
MESH:D014604 Uveal Neoplasms decitabine 4.9417785578
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4516513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 10.5517334414 17678736 16364871 17638931
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 10.5518097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.3418097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014947 Wounds and Injuries Plant Extracts 4.2520213670 19894650
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04520 Adherens junction
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:05217 Basal cell carcinoma
KEGG:05210 Colorectal cancer
KEGG:05213 Endometrial cancer
KEGG:04916 Melanogenesis
REACT:21303 Myogenesis
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:05216 Thyroid cancer
KEGG:04310 Wnt signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018