AutismKB 2.0

Annotation Detail for TCF7L2


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Basic Information Top
Gene Symbol:TCF7L2 ( TCF-4,TCF4 )
Gene Full Name: transcription factor 7-like 2 (T-cell specific, HMG-box)
Band: 10q25.2-q25.3
Quick LinksEntrez ID:6934; OMIM: 602228; Uniprot ID:TF7L2_HUMAN; ENSEMBL ID: ENSG00000148737; HGNC ID: 11641
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa04310Wnt signaling pathway
hsa05216Thyroid cancer
hsa04520Adherens junction
hsa05221Acute myeloid leukemia
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa05217Basal cell carcinoma
hsa05215Prostate cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
200118AP-1 transcription factor network
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Metabolic diseases
Diabetes
H00409Type II diabetes mellitus
No data
Desease Name
CARDIOVASCULAR
Coronary Artery Disease
body mass cholesterol, HDL diabetes, type 2 glucose insulin metabolic syndrome triglycerides
CANCER
type 2 diabetes and other traits
two-hour glucose challenge
clinicopathological characteristics of hepatocellular carcinoma
fasting glucose-related traits
METABOLIC
diabetes, gestational
body mass insulin
type 2 diabetes
diabetes, type 2 glucose insulin
diabetes, type 2
Posttransplantation diabetes mellitus (PTDM)
Desease Name
Type 2 diabetes
Metabolic syndrome
Fasting glucose-related traits
Two-hour glucose challenge
Type 2 diabetes and other traits
Glycated hemoglobin levels
Desease Name
Diabetes mellitus, type 2, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in increased expression of TCF7L2 mRNAincreases expression 19901195
C006632 arsenic trioxide arsenic trioxide results in increased expression of TCF7L2 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TCF7L2 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TCF7L2 mRNAdecreases expression 20018196
19150397
C110904 capecitabine TCF7L2 results in decreased susceptibility to [Fluorouracil co-treated with capecitabine]affects cotreatment|decreases response to substance 18678097
D003474 Curcumin Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]affects binding|decreases reaction 19294764
D003474 Curcumin Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]affects binding|decreases activity 19294764
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of TCF7L2 mRNAdecreases expression 17490981
D004317 Doxorubicin Doxorubicin affects the expression of TCF7L2 proteinaffects expression 17415656
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TCF7L2 mRNAincreases expression 17606305
D005472 Fluorouracil TCF7L2 results in decreased susceptibility to [Fluorouracil co-treated with capecitabine]affects cotreatment|decreases response to substance 18678097
D007213 Indomethacin Indomethacin inhibits the reaction [[CTNNB1 protein binds to TCF7L2 protein] which binds to CCND1 promoter]affects binding|decreases reaction 11756231
C051890 irinotecan irinotecan analog results in decreased expression of TCF7L2 mRNAdecreases expression 18927307
D018021 Lithium Chloride Lithium Chloride inhibits the reaction [TCF7L2 protein binds to GCG promoter]affects binding|decreases reaction 19582394
D018021 Lithium Chloride Lithium Chloride inhibits the reaction [TCF7L2 protein binds to GIP promoter]affects binding|decreases reaction 19582394
C006253 pirinixic acid pirinixic acid results in decreased expression of TCF7L2 mRNAdecreases expression 18445702
D011794 Quercetin Quercetin results in decreased expression of TCF7L2 mRNAdecreases expression 19440933
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of TCF7L2 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of TCF7L2 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TCF7L2 mRNAincreases expression 19901195
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TCF7L2 mRNAdecreases expression 19465110
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of TCF7L2 mRNAdecreases expression 18087596
D019772 Topotecan TCF7L2 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of TCF7L2 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of TCF7L2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7915322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 13.3911798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 13.3917418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.3914692618
MESH:D000230 Adenocarcinoma Fluorouracil 13.3917638652
MESH:D000230 Adenocarcinoma Indomethacin 13.3916537180
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.4715814487
MESH:D000236 Adenoma Indomethacin 3.4111497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7016835633
MESH:D000419 Albuminuria Doxorubicin 4.4821441931
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0317887948
MESH:D016301 Alveolar Bone Loss Indomethacin 5.3217225004
MESH:D000544 Alzheimer Disease Curcumin 4.4515590663
MESH:D000544 Alzheimer Disease Indomethacin 4.4515579461 17627676
MESH:D000740 Anemia Fluorouracil 8.4817963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4811748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1817084956
MESH:D001014 Aortic Aneurysm Indomethacin 4.7810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.8110388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D018771 Arthralgia Indomethacin 5.112160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6215885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 7.5416807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 7.5411248219
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 7.5419898480
MESH:D001260 Ataxia Telangiectasia Quercetin 4.9215336622
MESH:D050197 Atherosclerosis Curcumin 3.2818704882
MESH:D001327 Autoimmune Diseases Curcumin 10.6519761891
MESH:D001327 Autoimmune Diseases Quercetin 10.6519761891
MESH:D001477 Bartter Syndrome Indomethacin 4.9210684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.9216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.9219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.9212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6414601052
MESH:D001929 Brain Edema Indomethacin 4.9711481608
MESH:D002545 Brain Ischemia Curcumin 10.1716770732
MESH:D002545 Brain Ischemia Indomethacin 10.1712524144
MESH:D001932 Brain Neoplasms Curcumin 8.7617596214
MESH:D001932 Brain Neoplasms Doxorubicin 8.7617150277
MESH:D001943 Breast Neoplasms capecitabine 3.7418473752 12972520
MESH:D001943 Breast Neoplasms Curcumin 3.7418593918 19250217 18462866 16243823
MESH:D001943 Breast Neoplasms Doxorubicin 3.7417983394 16264153 16115903 16096432 17369602 18695136 15993339 15136595 16595493 17426702 18234424 15567936 15692762 18382427 15634643 15939500 16935488 15668708 15994142 16322301 18628466 11325840 19526202 16826403
MESH:D001943 Breast Neoplasms Fluorouracil 3.7415136595 18357371 19217205 16557594 16110121 18608205 16595493
MESH:D001943 Breast Neoplasms Indomethacin 3.7417401462
MESH:D001943 Breast Neoplasms Quercetin 3.7418628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7420435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2711589617
MESH:D002056 Burns Indomethacin 4.6410459503
MESH:D002100 Cachexia Indomethacin 4.9415141370 15625704 11239499 16537180
MESH:D002105 Cadmium Poisoning Quercetin 5.4916962696
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8716050911
MESH:D002276 Carcinoid Tumor Doxorubicin 12.1716051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.1716051944
MESH:D002277 Carcinoma Curcumin 13.6618593918
MESH:D002277 Carcinoma Fluorouracil 13.6617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.6616835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.7915553829 14691202 11135700 15073043 16217749
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.7918059187 17876044 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.7917971768 16799960 17088986 16332177 17045692 18930000
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.7916391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.7912508355 19519916
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.6611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2911352223 18791128 14736730
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.8518414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 5.8511212258
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8917234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8219014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.7016201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.7018695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 10.7017341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0612490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 14.1818462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 14.186189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 14.1817066447 16757204 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 14.1815482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 14.1811212258
MESH:D006332 Cardiomegaly Quercetin 6.6819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6818670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4817131338 17928571 16364871 16278810 17007740 17329180 15792986 17924179 16612575 15476868 16242529 16109756 16455267 16269455 17974986 15505089 18627295 17351982 16651473 16952015 15811867 16731534 17382496 17308081 17519947
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9216243910 17334414
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.6820889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002764 Cholecystitis Indomethacin 5.1111181007
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5817333356 17681005 15861022 16919318 17110522 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 7.5819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815668235 16354765 12621046 8697196 15340226
MESH:D003092 Colitis Curcumin 9.4616804969 18200517 16782535
MESH:D003092 Colitis Selenium 9.4617936198
MESH:D003103 Coloboma Curcumin 4.4918809619
MESH:D003110 Colonic Neoplasms marker/mechanism 21383188
MESH:D003110 Colonic Neoplasms Curcumin 11.0119359593 16340194
MESH:D003110 Colonic Neoplasms Fluorouracil 11.0118772588 17725105 17018589 17172411 16510598 17169374 15001691 17016597 16340194 17287894
MESH:D003110 Colonic Neoplasms Indomethacin 11.0115936596 15625704 15637740 11260862 15963497 15786552
MESH:D003110 Colonic Neoplasms irinotecan 11.0117725105 17287894
MESH:D003110 Colonic Neoplasms Quercetin 11.0117191121 15741050 19056647 19440933 11134977 16640504 17148506
MESH:D015179 Colorectal Neoplasms arsenic trioxide 10.4320501625
MESH:D015179 Colorectal Neoplasms capecitabine 10.4318448328 18473752
MESH:D015179 Colorectal Neoplasms Doxorubicin 10.4318259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 10.4316331619 17594712 14970324 18288408 18509181 18802399 16303861 18949393 17695437 16391804 15148649 18448328 17401013 17255274 15289873 16282729 18383874 20501625 17454858 17016601 17094418 16524972
MESH:D015179 Colorectal Neoplasms Indomethacin 10.4318059344 12606626 11197048 17054584
MESH:D015179 Colorectal Neoplasms irinotecan 10.4316303861 18259882 18509181 17159606 15273666 17454858 16391804
MESH:D015179 Colorectal Neoplasms Quercetin 10.4318095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.8318497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1212609071
MESH:D003329 Coronary Vasospasm capecitabine 5.7417465463
MESH:D018352 Coronavirus Infections Indomethacin 5.6617302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7319769572
MESH:D007644 Darier Disease Fluorouracil 4.7316733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0315213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.6819496084
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism 17460697
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.3518403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3517107852
MESH:D003928 Diabetic Nephropathies Curcumin 3.9518204486
MESH:D003967 Diarrhea Indomethacin 3.737907874 7237001
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.1417416283
MESH:D056486 Drug-Induced Liver Injury Selenium 6.1415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1420420201
MESH:D004362 Drug Toxicity Doxorubicin 7.9418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9411462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0916133044 16326151 12774134 18446180 17190690 18043480
MESH:D004381 Duodenal Ulcer Curcumin 9.2117351913
MESH:D004381 Duodenal Ulcer Indomethacin 9.2117045617 17202747 16699067 11991626 17351913 10671773 17151854 11595415 11595431 11535926 17329845
MESH:C538011 Eales disease Vitamin E 4.659068938
MESH:D004487 Edema Indomethacin 11.0916100529 7990266 8985016 8273558 7907874 19703484 10653021
MESH:D004487 Edema pirinixic acid 11.0912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.0912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1212538720
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.8119148513
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.8117359293
MESH:D004715 Endometriosis Indomethacin 8.8715652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.8710568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1018037988
MESH:D019446 Endotoxemia Indomethacin 4.4418509659
MESH:D004751 Enteritis Indomethacin 4.6910567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.9217980183
MESH:D004802 Eosinophilia Indomethacin 3.9911298111
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.3020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.3012903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.3016785472 16481741 15173087 16337965 17638652
MESH:D004938 Esophageal Neoplasms Indomethacin 10.3011005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver arsenic trioxide 18.2715073043
MESH:D005234 Fatty Liver Curcumin 18.2719297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.2715345470
MESH:D005234 Fatty Liver pirinixic acid 18.2719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005334 Fever Indomethacin 4.0617627676 10431976 11852909
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5319069698
MESH:D005354 Fibrosarcoma Indomethacin 4.8310962813
MESH:D005355 Fibrosis Curcumin 20.7118705752
MESH:D005355 Fibrosis Indomethacin 20.7117994277
MESH:D005355 Fibrosis Quercetin 20.7119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.7120067830
MESH:D005499 Folliculitis Indomethacin 5.1111298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2016904648
MESH:D005756 Gastritis Indomethacin 4.6915046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6318462866
MESH:D005909 Glioblastoma Curcumin 16.6517596214
MESH:D005909 Glioblastoma Doxorubicin 16.6517150277
MESH:D005909 Glioblastoma Indomethacin 16.6512870263
MESH:D005909 Glioblastoma Quercetin 16.6519804834
MESH:D005910 Glioma Fluorouracil 9.8516145905
MESH:D005910 Glioma Indomethacin 9.8516487511 18371953
MESH:D005910 Glioma Quercetin 9.8517643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.2311849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006073 Gout Indomethacin 5.2911248219
MESH:D006258 Head and Neck Neoplasms Curcumin 18.1318462866 18829502
MESH:D006258 Head and Neck Neoplasms Doxorubicin 18.1315692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 18.1318337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Indomethacin 18.1315482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4511294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.4516080930
MESH:D006331 Heart Diseases Doxorubicin 3.4416244372 16330681 17875725 12587719 18006777 17888722 16879835 18674790 16495754 16144979 14766674 16707910 16244371
MESH:D006333 Heart Failure Doxorubicin 11.5717481944
MESH:D006333 Heart Failure pirinixic acid 11.5720558911
MESH:D006333 Heart Failure Selenium 11.5717162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8415692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.5115633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.6215135802
MESH:D006529 Hepatomegaly pirinixic acid 8.0519772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0512621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9817701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6816863852 16490937
MESH:D006689 Hodgkin Disease Doxorubicin 3.3517606976 18501091 15147373
MESH:D019584 Hot Flashes Vitamin E 3.9214716179
MESH:D006869 Hydronephrosis Lithium Chloride 12.8419797860
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 12.8418606429 16959395 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Indomethacin 3.7212727271
MESH:D034321 Hyperamylasemia Indomethacin 5.6617883296
MESH:D006937 Hypercholesterolemia Curcumin 3.9918704882
MESH:D006940 Hyperemia Indomethacin 4.9412524144
MESH:D006943 Hyperglycemia pirinixic acid 9.0420558911
MESH:D006943 Hyperglycemia Quercetin 9.0411834736 18262572
MESH:D006949 Hyperlipidemias Indomethacin 4.1017546600
MESH:D006965 Hyperplasia marker/mechanism 21383188
MESH:D006973 Hypertension Quercetin 5.1418356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.9718306037 10574470
MESH:D007079 Ileitis Indomethacin 5.2916133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.3216133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4417937319
MESH:D007249 Inflammation Curcumin 11.7617151092 18403477 16956363
MESH:D007249 Inflammation Indomethacin 11.7612568917 7812673 3291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.7612878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 11.7618590791
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1818596194 18200517
MESH:D007251 Influenza, Human Quercetin 18.3116624496
MESH:D007251 Influenza, Human Selenium 18.3116624496
MESH:D007251 Influenza, Human Vitamin E 18.3116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5916306350
MESH:D007410 Intestinal Diseases Indomethacin 4.2615831440 18236018 17994277 11855677 15610444 11686837 10210152 11713966 17329856
MESH:D007414 Intestinal Neoplasms Curcumin 4.1610783313
MESH:D019586 Intracranial Hypertension Indomethacin 5.3215241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007579 Jejunal Diseases Indomethacin 4.9716133968 18306037 10574470
MESH:D007627 Keloid Quercetin 4.8917086741
MESH:D007674 Kidney Diseases Doxorubicin 14.2115699352 15369732 16775033
MESH:D007674 Kidney Diseases Indomethacin 14.2117190690
MESH:D007674 Kidney Diseases Quercetin 14.2116962696
MESH:D007674 Kidney Diseases Vitamin E 14.2112488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.7816707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.7816518626
MESH:D007680 Kidney Neoplasms Fluorouracil 3.2516985049
MESH:D007889 Leiomyoma Curcumin 4.5118555241
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.8512228301 11703811 10320625
MESH:D007938 Leukemia arsenic trioxide 10.3915070760
MESH:D007938 Leukemia Curcumin 10.3918462866
MESH:D007938 Leukemia Quercetin 10.3917468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1016085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.5617077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.5616106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.3914633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 8.3910785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0516467208 19850784 20471514 16968895 17050201
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.0518360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1719075265 19225113 17869043 15336539 17712046 11468182 17649720 16966277 11161223 15748426 9834237 16112521 19642359 16330433 15213294 19035177 16891316 17217047 15622746 12018890 12679006 16331271 12712474 16823087 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.5016882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.5016106398
MESH:D007964 Leukocytosis Indomethacin 5.3216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.6617980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.6611479899
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 10.8217355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 10.8216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 10.8218194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.8215474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.8212741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.8212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.8216169303
MESH:D008107 Liver Diseases Curcumin 2.6016956363
MESH:D008113 Liver Neoplasms arsenic trioxide 13.9814682389
MESH:D008113 Liver Neoplasms Fluorouracil 13.9815113037 16603448 18383874 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 13.9820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 13.9818980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.9816984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.8120377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.8117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Quercetin 13.8119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.8112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3015213294
MESH:D008171 Lung Diseases Vitamin E 3.1316863852
MESH:D008175 Lung Neoplasms arsenic trioxide 15.3119825857 11798837
MESH:D008175 Lung Neoplasms Curcumin 15.3119359593 18462866 16243823
MESH:D008175 Lung Neoplasms Doxorubicin 15.316189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 15.3115246190
MESH:D008175 Lung Neoplasms Indomethacin 15.3116537180 11497255 11053908
MESH:D008175 Lung Neoplasms Quercetin 15.3116280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.3111884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 15.3111091918 3440675 16288123 12111688
MESH:D008175 Lung Neoplasms Vitamin E 15.3111062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7315086387
MESH:D008223 Lymphoma Curcumin 7.6318462866
MESH:D008223 Lymphoma Doxorubicin 7.6316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7317654614
MESH:D016399 Lymphoma, T-Cell Curcumin 11.3516173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 11.3515621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.0515458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.0515318939
MESH:D008545 Melanoma Curcumin 3.5718462866 17885582
MESH:D008545 Melanoma Doxorubicin 3.5716827129
MESH:D008569 Memory Disorders Curcumin 4.0917263510
MESH:D008654 Mesothelioma Doxorubicin 6.2017638057
MESH:D008654 Mesothelioma Selenium 6.2015107826
MESH:D008881 Migraine Disorders Indomethacin 3.6311903285
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4415792986
MESH:D009062 Mouth Neoplasms Fluorouracil 14.2816757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 14.2812636206
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 14.2815006635
MESH:D052016 Mucositis Doxorubicin 12.2117415656
MESH:D052016 Mucositis irinotecan 12.2117159606
MESH:D009101 Multiple Myeloma arsenic trioxide 7.2819549372 14977855 11468182 19417148 15949261
MESH:D009101 Multiple Myeloma Curcumin 7.2819372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1016882451 16105982
MESH:D009203 Myocardial Infarction Doxorubicin 9.3515857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 9.3519151258
MESH:D009203 Myocardial Infarction Quercetin 9.3519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.2619207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 10.1116624393
MESH:D009361 Neoplasm Invasiveness Curcumin 10.1118495463
MESH:D009362 Neoplasm Metastasis capecitabine 13.5112972520
MESH:D009362 Neoplasm Metastasis Doxorubicin 13.5118259882
MESH:D009362 Neoplasm Metastasis Indomethacin 13.5111239499 16537180 11053908
MESH:D009362 Neoplasm Metastasis irinotecan 13.5118259882
MESH:D009369 Neoplasms capecitabine 11.6916374040
MESH:D009369 Neoplasms Fluorouracil 11.6918600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 11.6917405874
MESH:D009369 Neoplasms Quercetin 11.6915185748
MESH:D009374 Neoplasms, Experimental Indomethacin 4.0710663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.4812497104
MESH:D009401 Nephrosis Doxorubicin 4.7016636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9416889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1514600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.5718462866
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0710525206
MESH:D009447 Neuroblastoma Doxorubicin 11.3915555623
MESH:D009447 Neuroblastoma irinotecan 11.398761367
MESH:D009447 Neuroblastoma Topotecan 11.3915176712
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.8812349958
MESH:D017599 Neuroectodermal Tumors irinotecan 4.678761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.3017929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3916436463
MESH:D009765 Obesity Curcumin 4.5519297423
MESH:D009765 Obesity pirinixic acid 4.5520558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.116374098
MESH:D010003 Osteoarthritis Indomethacin 3.637009135
MESH:D010024 Osteoporosis Curcumin 3.4318719352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.1619495926
MESH:D012516 Osteosarcoma Doxorubicin 4.0615930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.8812452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 7.8818462866 19020741
MESH:D010051 Ovarian Neoplasms Quercetin 7.8819005980
MESH:D010146 Pain Indomethacin 3.4113679232 17627676 3291741 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.6218702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.1915580305
MESH:D010190 Pancreatic Neoplasms Curcumin 12.1917440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Fluorouracil 12.1916929163 19003803 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 12.1916965848
MESH:D010195 Pancreatitis Indomethacin 3.8615028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1019927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.6616537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.0612349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.6611903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010437 Peptic Ulcer Indomethacin 5.0911148446
MESH:D010518 Periodontitis Indomethacin 4.8617225004
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1017983394
MESH:D010954 Plasmacytoma Selenium 4.8315087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1017638057
MESH:D011141 Polyuria Lithium Chloride 5.9419692487
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Quercetin 3.9219056647
MESH:D047928 Premature Birth Indomethacin 5.0617000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8919131511
MESH:D011471 Prostatic Neoplasms Curcumin 1.8912497104 11398177 18226269 10851300 18156803 18769126 15129424
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8915749863 15897917 16729912 16868541 18437689 16888761
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8919082440 18626508
MESH:D011471 Prostatic Neoplasms Quercetin 1.8914715546 17292933
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011507 Proteinuria Indomethacin 4.1011849393
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D011656 Pulmonary Emphysema Curcumin 4.4719168576
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9518722050 16160472 18286688 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 4.1617922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9610666014 18379247
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.5618410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012509 Sarcoma Curcumin 9.3718462866
MESH:D012509 Sarcoma Doxorubicin 9.3717710206 18313854 15625365 15675481 17203757 16767912
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.0716646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 10.0714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7317846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.4916862918
MESH:D018805 Sepsis Curcumin 4.0218389075
MESH:D012871 Skin Diseases Vitamin E 2.4218709164
MESH:D012878 Skin Neoplasms Doxorubicin 9.4115692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4116192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 9.4118590791
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5017203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D013272 Stomach Diseases Indomethacin 4.3616184426 15472012 17638125 10192188 16113693 10486359 16280098 17160473 18545984 15038085 18209964 10215738 17207306
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.7317007042
MESH:D013274 Stomach Neoplasms Fluorouracil 4.7319015929 17522103 15786421 16424979 17172411 17498489 18396642 16951190 19084572 18567086
MESH:D013274 Stomach Neoplasms Indomethacin 4.7315609394
MESH:D013274 Stomach Neoplasms irinotecan 4.7315723263
MESH:D013276 Stomach Ulcer Curcumin 7.3719188055 16631530
MESH:D013276 Stomach Ulcer Indomethacin 7.3718431645 1323529 16150113 17977527 14567935 17895592 17627676 18193104 12467913 10878458 10750652 10423059 18543354 18237397 17135157 18181030 11729361 16934674 12077510 11595431 17918041 18209962 15138204 11523592 15104355 11906479 18087811 15255614 16397915 17654042 16755016 11595415 18299717 18726076 11145282 16252198 12498302 12500499 16169175 17657623 16631530 12787963
MESH:D020521 Stroke Vitamin E 3.4716517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.8119014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.8117909728 16010429
MESH:D013964 Thyroid Neoplasms Indomethacin 11.8111352223 18791128 14736730
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9316280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9015213294
MESH:D014456 Ulcer Indomethacin 4.8317380554 10574470
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.5720435036 11780464 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Curcumin 15.5718593936
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.5717653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 15.5716720314
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 15.5712846360
MESH:D014565 Urogenital Neoplasms Curcumin 5.2018462866
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8216803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4815869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1617638931 17334414 16364871 17678736
MESH:D014839 Vomiting Indomethacin 4.6911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04520 Adherens junction
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:05217 Basal cell carcinoma
KEGG:05210 Colorectal cancer
KEGG:05213 Endometrial cancer
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:05216 Thyroid cancer
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36394
    • No data
    Releated disease ID Related disease Name
    PA447306diabetes mellitus type 2 and obesity
    PA444938Metabolic Diseases
    PA447159Metabolic Syndrome X
    PA444528Hyperlipidemias
    PA162370415metabolic syndrome
    PA443886Diabetes Mellitus
    PA443890Diabetes Mellitus, Type 2
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA152238062Pitt-Hopkins Syndrome
    PA446460Angelman Syndrome
    PA152238063Mowat-Wilson Syndrome
    PA446191Rett Syndrome
    PA443890Diabetes Mellitus, Type 2
    PA443756Colonic Neoplasms
    Releated drug ID Related drug Name
    PA451234repaglinide
    PA10390sulfonamides, urea derivatives
    PA164749238exenatide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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