AutismKB 2.0

Annotation Detail for ZEB1


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Basic Information Top
Gene Symbol:ZEB1 ( AREB6,BZP,DELTAEF1,FECD6,MGC133261,NIL2A,TCF8,ZFHEP,ZFHX1A )
Gene Full Name: zinc finger E-box binding homeobox 1
Band: 10p11.22
Quick LinksEntrez ID:6935; OMIM: 189909; Uniprot ID:ZEB1_HUMAN; ENSEMBL ID: ENSG00000148516; HGNC ID: 11642
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Waist-hip ratio
Desease Name
Corneal dystrophy, Fuchs endothelial, 6
Corneal dystrophy, posterior polymorphous, 3
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ZEB1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZEB1 mRNAdecreases expression 19150397
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of ZEB1 mRNAincreases expression 17553608
C459604 candoxin candoxin results in decreased expression of ZEB1 mRNAdecreases expression 16309724
D016572 Cyclosporine Cyclosporine results in increased expression of ZEB1 mRNAincreases expression 20106945
C007262 deoxynivalenol deoxynivalenol results in decreased activity of ZEB1 proteindecreases activity 11893416
C007262 deoxynivalenol [Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [deoxynivalenol results in decreased expression of ZEB1 protein]affects cotreatment|decreases expression|increases reaction 11893416
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of ZEB1 mRNAdecreases expression 15289156
D004958 Estradiol Estradiol results in decreased expression of ZEB1 mRNAdecreases expression 15289156
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZEB1 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in decreased expression of ZEB1 mRNAdecreases expression 15289156
D007213 Indomethacin Indomethacin results in increased expression of ZEB1 mRNAincreases expression 16984733
D007213 Indomethacin Indomethacin results in increased expression of ZEB1 mRNAincreases expression 16184411
D007213 Indomethacin rebamipide inhibits the reaction [Indomethacin results in increased expression of ZEB1 mRNA]decreases reaction|increases expression 16184411
D015759 Ionomycin [Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [deoxynivalenol results in decreased expression of ZEB1 protein]affects cotreatment|decreases expression|increases reaction 11893416
C030110 oxaliplatin oxaliplatin results in decreased expression of ZEB1 mRNAdecreases expression 17762391
D020849 Raloxifene Raloxifene results in decreased expression of ZEB1 mRNAdecreases expression 16497877
C052785 rebamipide rebamipide inhibits the reaction [Indomethacin results in increased expression of ZEB1 mRNA]decreases reaction|increases expression 16184411
D012643 Selenium Selenium results in decreased expression of ZEB1 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased expression of ZEB1 mRNAincreases expression 12760830
C004648 testosterone enanthate testosterone enanthate affects the expression of ZEB1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZEB1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ZEB1 mRNAincreases expression 15644576
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZEB1 mRNAaffects cotreatment|affects expression 16979875
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [deoxynivalenol results in decreased expression of ZEB1 protein]affects cotreatment|decreases expression|increases reaction 11893416
D019772 Topotecan ZEB1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014810 Vitamin E Vitamin E results in decreased expression of ZEB1 mRNAdecreases expression 19244175
D015032 Zinc Zinc affects the expression of ZEB1 mRNAaffects expression 16979875
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZEB1 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7015322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D000169 Acrodermatitis Zinc 5.2517202136 16889938 17190629
MESH:D000230 Adenocarcinoma Estradiol 9.8811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.8814692618
MESH:D000230 Adenocarcinoma Genistein 9.8811473722
MESH:D000230 Adenocarcinoma Indomethacin 9.8816537180
MESH:D000236 Adenoma Indomethacin 3.3611497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7517306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.4517451421 17308373
MESH:D016301 Alveolar Bone Loss Indomethacin 5.2217225004
MESH:D000544 Alzheimer Disease Indomethacin 6.5815579461 17627676
MESH:D000544 Alzheimer Disease Raloxifene 6.5815800139
MESH:D000544 Alzheimer Disease Zinc 6.5816580781 16325427 17119284 16410023
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3315469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.7516916123
MESH:D001014 Aortic Aneurysm Indomethacin 4.7010231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.7210388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D018771 Arthralgia Indomethacin 5.022160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7911248219
MESH:D001249 Asthma Zinc 2.9117085522
MESH:D001477 Bartter Syndrome Indomethacin 4.8310684365
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001929 Brain Edema Indomethacin 4.8711481608
MESH:D001930 Brain Injuries Raloxifene 10.6216580743
MESH:D001930 Brain Injuries Zinc 10.6217109824
MESH:D002545 Brain Ischemia Indomethacin 4.2712524144
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.8915324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 2.8917018787 12948864 17261762 16675129 14630087 17289903 19861407 18497071
MESH:D001943 Breast Neoplasms Genistein 2.8916873071 16541309 17200150
MESH:D001943 Breast Neoplasms Indomethacin 2.8917401462
MESH:D001943 Breast Neoplasms Raloxifene 2.8915572757 17261762 17893378 15775269 16837676 17049068 17595753 17952589 16912660 17440819 17242785 15758505
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8920435547
MESH:D002056 Burns Indomethacin 4.5510459503
MESH:D002100 Cachexia Indomethacin 4.8515625704 11239499 15141370 16537180
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7816050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.6316924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.6316924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.6316924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.6316391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.6317306315 16507464 15276417
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5711053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2018791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3017341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.5215482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.5218572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 10.5218922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 10.5216543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.9417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Genistein 11.6716332659
MESH:D002318 Cardiovascular Diseases Raloxifene 11.6715775269
MESH:D002318 Cardiovascular Diseases Zinc 11.6716936243
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.1620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.1612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.1618566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.1620056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002764 Cholecystitis Indomethacin 5.0211181007
MESH:D002779 Cholestasis Cyclosporine 7.4019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4017333356 16919318 15861022 16105132 17110522 17681005 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0416354765 15340226 8697196 12621046 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.4715800139
MESH:D003092 Colitis Selenium 3.6317936198
MESH:D003110 Colonic Neoplasms Genistein 5.8817182828
MESH:D003110 Colonic Neoplasms Indomethacin 5.8815625704 15786552 11260862 15637740 15963497 15936596
MESH:D003110 Colonic Neoplasms oxaliplatin 5.8816004971 16510598 16024531
MESH:D015179 Colorectal Neoplasms Indomethacin 3.0412606626 18059344 17054584 11197048
MESH:D015179 Colorectal Neoplasms oxaliplatin 3.0418509181 18448328 17401013 17695437 17594712 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
OMIM:613270 CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 marker/mechanism
OMIM:609141 CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 marker/mechanism
MESH:D018352 Coronavirus Infections Indomethacin 5.5717302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7520055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7519769572
MESH:D019465 Craniofacial Abnormalities Zinc 3.7519302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4116002989 12952375
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0317474826
MESH:D003920 Diabetes Mellitus Zinc 4.0716479319
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2016647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.5819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.5817451421 15920148 17308373
MESH:D003967 Diarrhea Indomethacin 3.657907874 7237001
MESH:D056486 Drug-Induced Liver Injury Selenium 3.6315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0018446180 17190690 16326151 18043480 12774134 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.9911595415 17329845 16699067 17045617 17351913 17202747 17151854 11991626 11535926 10671773 11595431
MESH:C538011 Eales disease Vitamin E 4.559068938
MESH:D004487 Edema Indomethacin 15.3819703484 8985016 7907874 10653021 16100529 8273558 7990266
MESH:D004487 Edema Raloxifene 15.3815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.3811000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 15.3811698051 9599246 8273558 15177302 7812673 8113982 16716910
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.6215845917
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.3816402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.3816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.9515700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 11.9511473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 11.9511473722
MESH:D004715 Endometriosis Indomethacin 8.6215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.6210568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.3518509659
MESH:D004751 Enteritis Indomethacin 4.5910567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.8317980183
MESH:D004802 Eosinophilia Indomethacin 3.9011298111
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1620426865
MESH:D004938 Esophageal Neoplasms Indomethacin 7.1611005569
MESH:D004938 Esophageal Neoplasms Zinc 7.1616543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Cyclosporine 12.3119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.3115345470
MESH:D005234 Fatty Liver Raloxifene 12.3117473493
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5616611131 16534752 16002989 16513791 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005334 Fever Indomethacin 3.9811852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.7410962813
MESH:D005355 Fibrosis Cyclosporine 13.9212168785 12639820
MESH:D005355 Fibrosis Indomethacin 13.9217994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.9220067830
MESH:D005499 Folliculitis Indomethacin 5.0211298111
MESH:D005756 Gastritis Indomethacin 11.0615046732
MESH:D005756 Gastritis Zinc 11.0617241300
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.3016452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.3016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005909 Glioblastoma Genistein 7.0916598420
MESH:D005909 Glioblastoma Indomethacin 7.0912870263
MESH:D005910 Glioma Indomethacin 3.1716487511 18371953
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.8916524712 15173396
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1611849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006073 Gout Indomethacin 5.2011248219
MESH:D006130 Growth Disorders Zinc 3.8717217573
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.6415482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3110048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.3116080930
MESH:D006331 Heart Diseases Raloxifene 3.4311110106
MESH:D006333 Heart Failure Selenium 7.0417162251
MESH:D006333 Heart Failure Zinc 7.0417162251
MESH:D006335 Heart Injuries Zinc 5.6217074742
MESH:D016481 Helicobacter Infections Zinc 4.3917241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.4315633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5315135802
MESH:D006527 Hepatolenticular Degeneration Zinc 4.5417276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7415340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6516863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6017440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.0312676792
MESH:D019584 Hot Flashes Estradiol 9.5517088409
MESH:D019584 Hot Flashes Vitamin E 9.5514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8916354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Indomethacin 8.0412727271
MESH:D006930 Hyperalgesia oxaliplatin 8.0417418472
MESH:D034321 Hyperamylasemia Indomethacin 5.5717883296
MESH:D006940 Hyperemia Indomethacin 4.8512524144
MESH:D006949 Hyperlipidemias Indomethacin 4.0217546600
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2912960047 14722030
MESH:D006973 Hypertension Cyclosporine 8.2510903974
MESH:D006973 Hypertension Raloxifene 8.2517577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2518670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 10.7416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.7416945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.8710574470 18306037
MESH:D007079 Ileitis Indomethacin 5.2010651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.2216133044
MESH:D007246 Infertility Diethylstilbestrol 4.2115036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.3117937319
MESH:D007248 Infertility, Male sodium arsenite 6.3112646999 15346721
MESH:D007249 Inflammation Indomethacin 7.9912568917 3291741 7812673
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9912878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 7.998273558 15177302 7562506 11698051 7812673
MESH:D007251 Influenza, Human Selenium 10.4516624496
MESH:D007251 Influenza, Human Vitamin E 10.4516624496
MESH:D007333 Insulin Resistance Estradiol 2.8716393666 16627594
MESH:D007410 Intestinal Diseases Indomethacin 9.9010210152 11855677 17329856 17994277 15610444 15831440 11713966 18236018 11686837
MESH:D007410 Intestinal Diseases rebamipide 9.9011686837
MESH:D019586 Intracranial Hypertension Indomethacin 5.2215241188
MESH:D007511 Ischemia Zinc 4.4816584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007579 Jejunal Diseases Indomethacin 4.8710574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Cyclosporine 22.7518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 22.7515618244
MESH:D007674 Kidney Diseases Indomethacin 22.7517190690
MESH:D007674 Kidney Diseases sodium arsenite 22.7520008137
MESH:D007674 Kidney Diseases Vitamin E 22.7512488133
MESH:D007674 Kidney Diseases Zinc 22.7516960431
MESH:D007676 Kidney Failure, Chronic Selenium 9.6216518626
MESH:D007676 Kidney Failure, Chronic Zinc 9.6216518626
MESH:D007680 Kidney Neoplasms Cyclosporine 11.7112371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.7116762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 11.7115610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9117184923
MESH:D007889 Leiomyoma Raloxifene 4.3516973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7810320625 12228301 11703811
MESH:D007938 Leukemia Genistein 2.9518980019 17468513
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.8116572323 10785260 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6118360721
MESH:D007964 Leukocytosis Indomethacin 5.2216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.5717980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.5711479899
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.5417823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.5418194892
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5412878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.5416169303
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.1315890375 16712894
MESH:D008113 Liver Neoplasms sodium arsenite 7.1315276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.1316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0212151625
MESH:D008171 Lung Diseases sodium arsenite 7.1119095001
MESH:D008171 Lung Diseases Vitamin E 7.1116863852
MESH:D008175 Lung Neoplasms Indomethacin 6.4116537180 11497255 11053908
MESH:D008175 Lung Neoplasms sodium arsenite 6.4117306315 17077188 15276417 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4119555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 6.4111807781
MESH:D008175 Lung Neoplasms Vitamin E 6.4111062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3616002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.8211408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 17.8214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 17.8215318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 17.828985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 17.8212773700
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008545 Melanoma sodium arsenite 2.0116487513 19082730
MESH:D008654 Mesothelioma Selenium 2.7315107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D008881 Migraine Disorders Indomethacin 3.5711903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.4015863610
MESH:D009062 Mouth Neoplasms Indomethacin 3.8712636206
MESH:D009101 Multiple Myeloma Raloxifene 3.3316497877
MESH:D009203 Myocardial Infarction Genistein 2.8017141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.1317141266
MESH:D009232 Myxoma Raloxifene 5.4016343187
MESH:D009362 Neoplasm Metastasis Indomethacin 3.1111239499 11053908 16537180
MESH:D009369 Neoplasms Diethylstilbestrol 5.0015313581
MESH:D009369 Neoplasms sodium arsenite 5.0011559025
MESH:D009374 Neoplasms, Experimental Indomethacin 8.7810663608 15625704
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.7820056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1518481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 22.2411399458
MESH:D009421 Nervous System Malformations Estradiol 22.2416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 22.2416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.2414600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0512854658
MESH:D009447 Neuroblastoma Topotecan 3.7715176712
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.8212349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.026374098
MESH:D010003 Osteoarthritis Indomethacin 3.587009135
MESH:D010024 Osteoporosis Genistein 7.0219401787
MESH:D010024 Osteoporosis Raloxifene 7.0217882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.6716169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.6715579764 15758505 17893378 17823083
MESH:D010051 Ovarian Neoplasms Estradiol 7.6319401270
MESH:D010051 Ovarian Neoplasms Genistein 7.6319005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.6317306315 15276417
MESH:D010146 Pain Indomethacin 3.3417440234 3291741 17627676 13679232
MESH:D010149 Pain, Postoperative Indomethacin 4.5312538197 18702446
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.0815976015
MESH:D010195 Pancreatitis Indomethacin 3.7817883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.1418922899 8330346 12065085 18404319
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.5716537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.9812349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.5711903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010437 Peptic Ulcer Indomethacin 5.0011148446
MESH:D010518 Periodontitis Indomethacin 4.7617225004
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5215687265 16977796
MESH:D010954 Plasmacytoma Selenium 4.7415087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0912371664
MESH:D011225 Pre-Eclampsia Zinc 4.0617114810
MESH:D047928 Premature Birth Indomethacin 4.9817000239
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.0617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0611399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0815846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0815378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0816536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0816039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0815084515
MESH:D011471 Prostatic Neoplasms Zinc 2.0816517595 16700911 12429649 16606632
MESH:D011507 Proteinuria Indomethacin 4.0211849393
MESH:D011537 Pruritus Ethinyl Estradiol 3.1616919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011693 Purpura Raloxifene 5.4015770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012162 Retinal Degeneration Zinc 4.0116584753
MESH:D012871 Skin Diseases Vitamin E 2.4018709164
MESH:D012878 Skin Neoplasms sodium arsenite 9.1118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1116192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.118985016 12065085 8330346 11807781 18404319
MESH:D013088 Spermatocele Diethylstilbestrol 11.2116002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2116709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013272 Stomach Diseases Indomethacin 10.2117638125 17160473 17207306 10192188 18209964 10486359 16184426 10215738 16280098 18545984 15472012 15038085 16113693
MESH:D013272 Stomach Diseases rebamipide 10.2116184426
MESH:D013274 Stomach Neoplasms Indomethacin 3.1215609394
MESH:D013274 Stomach Neoplasms rebamipide 3.1215993841
MESH:D013276 Stomach Ulcer Indomethacin 3.4518193104 17627676 12787963 17895592 18209962 10750652 11906479 16150113 11595431 15138204 17654042 12077510 17918041 12500499 17657623 10423059 18726076 12467913 16934674 11595415 16169175 16631530 16755016 1323529 16397915 12498302 18237397 15104355 17135157 11145282 18543354 10878458 15255614 18431645 18181030 11523592 17977527 11729361 14567935 16252198 18087811 18299717
MESH:D020521 Stroke Raloxifene 8.3116837676
MESH:D020521 Stroke Vitamin E 8.3116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Indomethacin 3.4711352223 18791128 14736730
MESH:D013978 Tibial Fractures Estradiol 13.2119048282
MESH:D013978 Tibial Fractures Raloxifene 13.2119048282
MESH:D014062 Tongue Neoplasms Zinc 4.2616543248
MESH:D014456 Ulcer Indomethacin 4.7410574470 17380554
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.1016452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.1017572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.1016712894 16452187 11723127 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.1016175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.1011813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.9816690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9814692618
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2916513791 16002989
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0616837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D014839 Vomiting Indomethacin 4.5911897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.4016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162409589
    • No data
    No data
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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